POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens)		4 / 8PRO A 283
TYR A 303
SER A 455
SER A 287
None
1.13A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		1nbq JUNCTIONAL ADHESION
MOLECULE 1
(Homo
sapiens)		4 / 8PRO A 131
TYR A 218
SER A  98
ASN A  43
None
1.13A15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		1p49 STERYL-SULFATASE
(Homo
sapiens)		4 / 8PRO A 405
PHE A 118
SER A  78
ASN A 400
None
None
ALS  A  75 ( 4.7A)
None
0.72A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		1p49 STERYL-SULFATASE
(Homo
sapiens)		4 / 8TYR A 286
PHE A 299
ASN A  54
SER A 296
None
1.13A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		2hi4 CYTOCHROME P450 1A2
(Homo
sapiens)		4 / 8PRO A 383
TYR A 495
PHE A 381
SER A 379
None
None
HEM  A 900 (-4.5A)
None
0.98A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		3mv9 ALPHA CHAIN OF THE
TK3 TCR
(Homo
sapiens)		4 / 8SER D 158
ASP D 157
PRO D 133
ASN D 129
None
1.12A13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens)		4 / 8ASP A 604
TYR A 572
SER A 650
ASN A 651
None
1.01A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		4 / 8PRO A 383
TYR A 494
PHE A 381
SER A 379
None
None
HEM  A 601 (-4.8A)
None
1.02A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		4ll9 LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens)		4 / 8SER A   3
PRO A   6
SER A  85
SER A  58
None
1.09A14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8ASP D 121
PHE D 123
SER D 958
ASN D 128
None
1.13A23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 8SER A 423
PRO A 373
SER A 570
SER A 370
None
1.02A7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens)		4 / 8SER A 183
ASP A 186
SER A 408
SER A 203
None
0.90A8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens)		5 / 9SER A  70
PRO A  81
TYR A 123
LEU A 107
SER A  26
None
1.43A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens)		5 / 9SER A 828
PRO A 830
TYR A 923
LEU A 833
SER A 758
None
1.34A7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT
(Homo
sapiens)		5 / 9ASP A 441
LEU B  22
PHE A 468
SER B 114
ASN B 115
None
1.38A7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		1hjv CHITINASE-3 LIKE
PROTEIN 1
(Homo
sapiens)		4 / 7PRO A 142
TYR A 189
PHE A 106
SER A  95
None
1.23A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		1mek PROTEIN DISULFIDE
ISOMERASE
(Homo
sapiens)		4 / 7ASP A  92
PRO A  96
TYR A  77
PHE A  87
None
1.24A9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens)		4 / 7PRO A 514
TYR A 417
SER A 138
ASN A 133
EDO  A1002 ( 4.7A)
None
None
EDO  A1002 (-3.1A)
1.11A22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens)		4 / 7SER B 280
ASP A  76
PRO A  77
SER B 274
None
1.14A13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		3ppx VON WILLEBRAND
FACTOR
(Homo
sapiens)		4 / 7PRO A1632
PHE A1654
SER A1506
ASN A1610
None
1.16A12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		3w0w T36-5 TCR BETA CHAIN
(Homo
sapiens)		4 / 7ASP E  38
PRO E  39
SER E  82
ASN E  84
None
1.18A14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		3w1g DNA LIGASE 4
(Homo
sapiens)		4 / 7ASP A 441
PRO A 440
TYR A 438
SER A 292
None
None
None
SO4  A 703 (-2.3A)
1.26A23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens)		4 / 7PRO A 147
TYR A 195
PHE A 111
SER A 100
None
1.13A19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		4owx SOSS COMPLEX SUBUNIT
B1
(Homo
sapiens)		4 / 7SER B 109
PRO B 111
SER B  53
ASN B  51
None
1.23A13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		4 / 7SER A 336
TYR A 176
SER A 375
ASN A 101
None
1.25A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 7SER A 254
ASP A 245
PRO A 218
ASN A 278
None
CA  A 607 (-2.1A)
None
None
1.21A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7SER A 149
ASP A 292
PRO A 291
TYR A 289
None
1.24A18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 7SER C3432
ASP C3435
PHE C3382
ASN C3430
None
1.21A11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens)		4 / 7ASP B  99
PRO B 100
TYR A  48
PHE B 108
None
1.24A15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens)		5 / 10PHE A 379
ASP A 362
LEU A 360
SER A 138
ASN A 140
None
1.33A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B
(Homo
sapiens;
Mus
musculus)		5 / 10PRO E 884
TYR R  71
ASN R  74
LEU R  56
ASN E 887
None
1.42A22.39