POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 12THR A 582
THR A 583
THR A 394
ALA A 584
GLY A 398
None
1.18A13.15
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3bvh FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens)		5 / 12THR C 374
ALA C 370
SER C 355
ALA C 364
THR C 359
None
1.18A22.08
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		5 / 12THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
None
1.03A18.91
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		5 / 12THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
None
1.06A19.92
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4f9o HEXOKINASE-1
(Homo
sapiens)		6 / 12THR A 153
THR A 457
ALA A 460
SER A 449
GLY A 450
THR A 216
0NZ  A1002 ( 4.6A)
None
None
0NZ  A1002 (-2.8A)
None
None
1.49A13.99
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens)		5 / 12THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
None
1.19A21.43
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens)		5 / 12TYR A 247
THR A 293
ALA A 297
GLY A 289
ALA A 287
None
1.13A20.00
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 12THR K   1
THR K  21
ALA K  27
LYS K  33
GLY K  47
None
0.65A27.35
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		6 / 12TYR K 134
THR K   2
THR K   1
SER K 173
GLY K 172
ALA K 164
None
1.28A27.35
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 12THR K   1
ALA K  28
SER K  46
GLY K  47
ALA K  49
7DX  K 301 (-3.3A)
7DX  K 301 ( 4.6A)
None
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
0.86A26.07
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 12THR K   1
LYS K  33
SER K  46
GLY K  47
ALA K  49
7DX  K 301 (-3.3A)
7DX  K 301 (-4.2A)
None
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
0.43A26.07
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		6 / 12TYR K 134
THR K   2
THR K   1
SER K 173
GLY K 172
ALA K 164
None
None
7DX  K 301 (-3.3A)
None
None
MG  K 302 (-4.8A)
1.32A26.07
29.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5t0h PROTEASOME SUBUNIT
BETA TYPE-7
(Homo
sapiens)		5 / 12THR O   1
LYS O  33
GLY O  47
ALA O  49
THR O  52
None
0.99A100.00
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		6 / 12THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
None
0.76Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12TYR M 656
THR M 606
THR M 595
SER M 259
GLY M 258
None
1.01A18.57
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		5 / 12THR B   1
THR B  21
ALA B  27
LYS B  33
GLY B  47
None
0.75Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		5 / 12THR B  21
ALA B  27
LYS B  33
GLY B  47
ALA B  49
None
0.70Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-8
(Homo
sapiens)		5 / 12THR C   1
ALA C  28
SER C  46
GLY C  47
ALA C  49
BZ7  C 301 (-4.0A)
BZ7  C 301 (-3.4A)
None
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
1.02Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-8
(Homo
sapiens)		5 / 12THR C   1
LYS C  33
SER C  46
GLY C  47
ALA C  49
BZ7  C 301 (-4.0A)
BZ7  C 301 ( 4.8A)
None
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
0.68Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-9
(Homo
sapiens)		5 / 12THR A   1
LYS A  33
SER A  46
GLY A  47
ALA A  49
None
0.64Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
(Homo
sapiens)		5 / 12TYR A1407
THR A1424
THR A1425
ALA A1419
THR A1355
None
1.18Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2ibu ACETYL-COA
ACETYLTRANSFERASE
(Homo
sapiens)		5 / 11ALA A  47
THR A  48
GLU A 234
ALA A 150
GLY A 151
None
1.13A18.09
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2pe4 HYALURONIDASE-1
(Homo
sapiens)		5 / 11ALA A 355
ALA A 316
GLY A 317
ALA A 311
LEU A 303
None
1.13A20.39
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens)		5 / 11ALA A 487
ALA A 365
GLY A 366
THR A 369
LEU A 674
None
1.13A15.88
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens)		5 / 11ALA A 183
THR A 184
ALA A  89
GLY A  90
ALA A 105
None
1.12A22.04
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 11THR K   1
ALA K  20
ALA K  46
GLY K  47
ALA K  49
None
0.64A27.35
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 11THR K   1
ALA K  20
THR K  21
ALA K  46
GLY K  47
None
0.61A27.35
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5t0g PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		5 / 11THR R   1
ALA R  20
ALA R  46
GLY R  47
ALA R  49
None
0.92A27.31
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5t0h PROTEASOME SUBUNIT
BETA TYPE-7
(Homo
sapiens)		6 / 11ALA O  20
CYH O  31
ALA O  46
GLY O  47
ALA O  49
THR O  52
None
0.96A100.00
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5t0h PROTEASOME SUBUNIT
BETA TYPE-7
(Homo
sapiens)		6 / 11THR O   1
CYH O  31
ALA O  46
GLY O  47
ALA O  49
THR O  52
None
0.99A100.00
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		5 / 11THR R   1
ALA R  20
THR R  21
GLY R  47
ALA R  49
None
0.62Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		7 / 11THR B   1
ALA B  20
THR B  21
CYH B  31
ALA B  46
GLY B  47
ALA B  49
None
0.76Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens)		5 / 11THR A 154
ALA A 155
VAL A 141
GLY A 147
GLY A 148
None
0.90A20.31
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens)		5 / 11THR P 165
ALA P 166
GLY P 158
GLY P 159
ALA P 160
None
0.90A23.70
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		3jwe MGLL PROTEIN
(Homo
sapiens)		5 / 11THR A 141
ALA A 142
GLY A 134
GLY A 135
ALA A 136
None
0.95A20.31
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		7 / 11THR K   1
ALA K  20
THR K  21
ALA K  22
VAL K  31
LYS K  33
GLY K  47
None
0.53A83.09
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		6 / 11THR K   1
ALA K  20
THR K  21
VAL K  31
LYS K  33
GLY K  47
None
1.01A83.09
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		7 / 11THR K   1
ALA K  20
VAL K  31
LYS K  33
GLY K  47
GLY K  48
ALA K  49
None
0.59A83.09
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		7 / 11THR K   1
ALA K  20
ALA K  22
VAL K  31
LYS K  33
MET K  45
GLY K  47
7DX  K 301 (-3.3A)
7DX  K 301 ( 4.0A)
None
7DX  K 301 (-4.2A)
7DX  K 301 (-4.2A)
7DX  K 301 ( 3.8A)
7DX  K 301 (-3.8A)
0.48A66.18
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		6 / 11THR K   1
ALA K  20
VAL K  31
LYS K  33
MET K  45
GLY K  47
7DX  K 301 (-3.3A)
7DX  K 301 ( 4.0A)
7DX  K 301 (-4.2A)
7DX  K 301 (-4.2A)
7DX  K 301 ( 3.8A)
7DX  K 301 (-3.8A)
0.94A66.18
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		7 / 11THR K   1
ALA K  20
VAL K  31
LYS K  33
MET K  45
GLY K  47
ALA K  49
7DX  K 301 (-3.3A)
7DX  K 301 ( 4.0A)
7DX  K 301 (-4.2A)
7DX  K 301 (-4.2A)
7DX  K 301 ( 3.8A)
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
0.60A66.18
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5t0g PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		8 / 11THR R   1
ALA R  20
ALA R  22
VAL R  31
LYS R  33
GLY R  47
GLY R  48
ALA R  49
None
1.10A100.00
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5t0g PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		7 / 11THR R   1
ALA R  20
THR R  21
ALA R  22
VAL R  31
LYS R  33
GLY R  47
None
1.33A100.00
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		9 / 11THR R   1
ALA R  20
THR R  21
ALA R  22
VAL R  31
LYS R  33
GLY R  47
GLY R  48
ALA R  49
None
0.76Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		6 / 11THR B   1
ALA B  20
THR B  21
LYS B  33
GLY B  47
ALA B  49
None
0.69Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		6 / 11THR B 193
THR B 160
ALA B 161
GLY B 171
GLY B 170
ASP B 166
None
1.47Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-8
(Homo
sapiens)		6 / 11ALA C  20
ALA C  22
VAL C  31
LYS C  33
MET C  45
GLY C  47
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 ( 4.8A)
BZ7  C 301 ( 4.7A)
BZ7  C 301 (-4.5A)
1.10Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-8
(Homo
sapiens)		8 / 11THR C   1
ALA C  20
ALA C  22
VAL C  31
LYS C  33
MET C  45
GLY C  47
ALA C  49
BZ7  C 301 (-4.0A)
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 ( 4.8A)
BZ7  C 301 ( 4.7A)
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
0.68Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-9
(Homo
sapiens)		5 / 11THR A   1
ALA A  22
LYS A  33
GLY A  47
ALA A  49
None
0.57Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 12THR A 582
THR A 583
THR A 394
ALA A 584
GLY A 398
None
1.18A13.15
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3bvh FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens)		5 / 12THR C 374
ALA C 370
SER C 355
ALA C 364
THR C 359
None
1.19A22.08
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		5 / 12THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
None
1.04A18.91
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		5 / 12THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
None
1.06A19.92
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens)		5 / 12THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
None
1.19A21.43
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens)		5 / 12TYR A 247
THR A 293
ALA A 297
GLY A 289
ALA A 287
None
1.12A20.00
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 12THR K   1
THR K  21
ALA K  27
LYS K  33
GLY K  47
None
0.62A27.35
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		6 / 12TYR K 134
THR K   2
THR K   1
SER K 173
GLY K 172
ALA K 164
None
1.30A27.35
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 12THR K   1
ALA K  28
SER K  46
GLY K  47
ALA K  49
7DX  K 301 (-3.3A)
7DX  K 301 ( 4.6A)
None
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
0.86A26.07
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 12THR K   1
LYS K  33
SER K  46
GLY K  47
ALA K  49
7DX  K 301 (-3.3A)
7DX  K 301 (-4.2A)
None
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
0.44A26.07
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		6 / 12TYR K 134
THR K   2
THR K   1
SER K 173
GLY K 172
ALA K 164
None
None
7DX  K 301 (-3.3A)
None
None
MG  K 302 (-4.8A)
1.34A26.07
29.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5t0h PROTEASOME SUBUNIT
BETA TYPE-7
(Homo
sapiens)		5 / 12THR O   1
LYS O  33
GLY O  47
ALA O  49
THR O  52
None
1.01A100.00
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		6 / 12THR R   1
THR R  21
ALA R  27
LYS R  33
GLY R  47
ALA R  49
None
0.77Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12TYR M 656
THR M 606
THR M 595
SER M 259
GLY M 258
None
1.03A18.57
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		5 / 12THR B   1
THR B  21
ALA B  27
LYS B  33
GLY B  47
None
0.74Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		5 / 12THR B  21
ALA B  27
LYS B  33
GLY B  47
ALA B  49
None
0.69Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-8
(Homo
sapiens)		5 / 12THR C   1
ALA C  28
SER C  46
GLY C  47
ALA C  49
BZ7  C 301 (-4.0A)
BZ7  C 301 (-3.4A)
None
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
1.02Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-8
(Homo
sapiens)		5 / 12THR C   1
LYS C  33
SER C  46
GLY C  47
ALA C  49
BZ7  C 301 (-4.0A)
BZ7  C 301 ( 4.8A)
None
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
0.67Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-9
(Homo
sapiens)		5 / 12THR A   1
LYS A  33
SER A  46
GLY A  47
ALA A  49
None
0.63Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
(Homo
sapiens)		5 / 12TYR A1407
THR A1424
THR A1425
ALA A1419
THR A1355
None
1.18Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2ibu ACETYL-COA
ACETYLTRANSFERASE
(Homo
sapiens)		5 / 11ALA A  47
THR A  48
GLU A 234
ALA A 150
GLY A 151
None
1.11A18.09
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2pe4 HYALURONIDASE-1
(Homo
sapiens)		5 / 11ALA A 355
ALA A 316
GLY A 317
ALA A 311
LEU A 303
None
1.11A20.39
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		4o0e ISOASPARTYL
PEPTIDASE/L-ASPARAGI
NASE
(Homo
sapiens)		5 / 11ALA A 183
THR A 184
ALA A  89
GLY A  90
ALA A 105
None
1.11A22.04
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5g1n CAD PROTEIN
(Homo
sapiens)		5 / 11ALA A2091
GLY A2084
THR A2145
ASP A2059
LEU A2058
None
1.13A21.01
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 11THR K   1
ALA K  20
ALA K  46
GLY K  47
ALA K  49
None
0.61A27.35
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		5 / 11THR K   1
ALA K  20
THR K  21
ALA K  46
GLY K  47
None
0.59A27.35
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5t0g PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		5 / 11THR R   1
ALA R  20
ALA R  46
GLY R  47
ALA R  49
None
0.89A27.31
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5t0h PROTEASOME SUBUNIT
BETA TYPE-7
(Homo
sapiens)		6 / 11ALA O  20
CYH O  31
ALA O  46
GLY O  47
ALA O  49
THR O  52
None
0.95A100.00
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5t0h PROTEASOME SUBUNIT
BETA TYPE-7
(Homo
sapiens)		6 / 11THR O   1
CYH O  31
ALA O  46
GLY O  47
ALA O  49
THR O  52
None
0.98A100.00
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		5 / 11THR R   1
ALA R  20
THR R  21
GLY R  47
ALA R  49
None
0.61Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		7 / 11THR B   1
ALA B  20
THR B  21
CYH B  31
ALA B  46
GLY B  47
ALA B  49
None
0.75Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens)		5 / 11THR A 154
ALA A 155
VAL A 141
GLY A 147
GLY A 148
None
0.90A20.31
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens)		5 / 11THR P 165
ALA P 166
GLY P 158
GLY P 159
ALA P 160
None
0.91A23.70
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		3jwe MGLL PROTEIN
(Homo
sapiens)		5 / 11THR A 141
ALA A 142
GLY A 134
GLY A 135
ALA A 136
None
0.95A20.31
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		7 / 11THR K   1
ALA K  20
THR K  21
ALA K  22
VAL K  31
LYS K  33
GLY K  47
None
0.53A83.09
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		6 / 11THR K   1
ALA K  20
THR K  21
VAL K  31
LYS K  33
GLY K  47
None
0.99A83.09
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5l5w PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		7 / 11THR K   1
ALA K  20
VAL K  31
LYS K  33
GLY K  47
GLY K  48
ALA K  49
None
0.60A83.09
24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		7 / 11THR K   1
ALA K  20
ALA K  22
VAL K  31
LYS K  33
MET K  45
GLY K  47
7DX  K 301 (-3.3A)
7DX  K 301 ( 4.0A)
None
7DX  K 301 (-4.2A)
7DX  K 301 (-4.2A)
7DX  K 301 ( 3.8A)
7DX  K 301 (-3.8A)
0.46A66.18
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		6 / 11THR K   1
ALA K  20
VAL K  31
LYS K  33
MET K  45
GLY K  47
7DX  K 301 (-3.3A)
7DX  K 301 ( 4.0A)
7DX  K 301 (-4.2A)
7DX  K 301 (-4.2A)
7DX  K 301 ( 3.8A)
7DX  K 301 (-3.8A)
0.92A66.18
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5m2b PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
(Saccharomyces
cerevisiae;
Homo
sapiens)		7 / 11THR K   1
ALA K  20
VAL K  31
LYS K  33
MET K  45
GLY K  47
ALA K  49
7DX  K 301 (-3.3A)
7DX  K 301 ( 4.0A)
7DX  K 301 (-4.2A)
7DX  K 301 (-4.2A)
7DX  K 301 ( 3.8A)
7DX  K 301 (-3.8A)
7DX  K 301 (-3.2A)
0.60A66.18
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5t0g PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		8 / 11THR R   1
ALA R  20
ALA R  22
VAL R  31
LYS R  33
GLY R  47
GLY R  48
ALA R  49
None
1.11A100.00
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5t0g PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		7 / 11THR R   1
ALA R  20
THR R  21
ALA R  22
VAL R  31
LYS R  33
GLY R  47
None
1.31A100.00
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5vfr PROTEASOME SUBUNIT
BETA TYPE-5
(Homo
sapiens)		9 / 11THR R   1
ALA R  20
THR R  21
ALA R  22
VAL R  31
LYS R  33
GLY R  47
GLY R  48
ALA R  49
None
0.74Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		6 / 11THR B   1
ALA B  20
THR B  21
LYS B  33
GLY B  47
ALA B  49
None
0.68Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-10
(Homo
sapiens)		6 / 11THR B 193
THR B 160
ALA B 161
GLY B 171
GLY B 170
ASP B 166
None
1.45Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-8
(Homo
sapiens)		6 / 11ALA C  20
ALA C  22
VAL C  31
LYS C  33
MET C  45
GLY C  47
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 ( 4.8A)
BZ7  C 301 ( 4.7A)
BZ7  C 301 (-4.5A)
1.07Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-8
(Homo
sapiens)		8 / 11THR C   1
ALA C  20
ALA C  22
VAL C  31
LYS C  33
MET C  45
GLY C  47
ALA C  49
BZ7  C 301 (-4.0A)
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 (-3.5A)
BZ7  C 301 ( 4.8A)
BZ7  C 301 ( 4.7A)
BZ7  C 301 (-4.5A)
BZ7  C 301 (-2.8A)
0.66Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6avo PROTEASOME SUBUNIT
BETA TYPE-9
(Homo
sapiens)		5 / 11THR A   1
ALA A  22
LYS A  33
GLY A  47
ALA A  49
None
0.57Aundetectable