POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		1c07 PROTEIN (EPIDERMAL
GROWTH FACTOR
RECEPTOR PATHWAY
SUBSTRATE 15)
(Homo
sapiens)		4 / 6LEU A  80
LEU A  60
SER A  59
THR A  63
None
1.02A23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		1xx0 PLECKSTRIN
(Homo
sapiens)		4 / 6LEU A 275
ALA A 341
LEU A 292
SER A 346
None
1.04A16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		2h3n IG LAMBDA-5
(Homo
sapiens)		4 / 6LEU B  96
ALA B  94
LEU B 142
THR B 145
None
1.04A23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		2kc3 APOLIPOPROTEIN E
(Homo
sapiens)		4 / 6LEU A  78
ALA A 164
SER A  22
THR A  18
None
1.03A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens)		4 / 6LEU A 482
ALA A 503
SER A 527
THR A 529
None
0.90A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens)		4 / 6LEU B 216
ALA B 209
LEU B 211
SER B 173
None
0.93A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER
(Homo
sapiens)		4 / 6LYS A  46
ALA A  44
LEU A  40
SER A  41
None
0.94A22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		6 / 6LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.34A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens)		4 / 6LEU L 132
ALA L 130
LEU L 178
THR L 181
None
1.01A22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		4 / 6LYS A  68
LEU A  39
ALA A  65
SER A  44
None
1.02A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens)		4 / 6LEU A  23
ALA A  21
LEU A  80
THR A  93
None
1.00A23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens)		4 / 6LEU L 136
ALA L 134
LEU L 182
THR L 185
None
1.01A22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3sag EXOSOME COMPONENT 10
(Homo
sapiens)		4 / 6LEU A 396
ALA A 392
LEU A 398
THR A 389
LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
0.91A14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens)		4 / 6LEU L 133
ALA L 131
LEU L 179
THR L 182
None
1.03A25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Homo
sapiens)		4 / 6LYS A 323
ALA A 168
SER A  92
THR A  94
None
0.91A17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens)		4 / 6LEU A 133
ALA A 131
LEU A 179
THR A 182
None
0.98A23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		4llq MUTATED LIGHT CHAIN
CLAMBDA
(Homo
sapiens)		4 / 6LEU B 136
ALA B 134
LEU B 182
THR B 185
None
1.04A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		4llu LIGHT CHAIN CLAMBDA
(Homo
sapiens)		4 / 6LEU B 133
ALA B 131
LEU B 179
THR B 182
None
1.02A25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens)		4 / 6LEU L 132
ALA L 130
LEU L 178
THR L 181
None
0.98A24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)		4 / 6LYS A 409
LEU A 411
LEU A 454
THR A 447
None
None
None
SEP  A 695 ( 4.8A)
0.69A14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens)		4 / 6LEU L 132
ALA L 130
LEU L 178
THR L 181
None
1.00A24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		4rnr PGT130 LIGHT CHAIN
(Homo
sapiens)		4 / 6LEU B 132
ALA B 130
LEU B 178
THR B 181
None
1.02A23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		1jmy BILE-SALT-ACTIVATED
LIPASE
(Homo
sapiens)		4 / 6LYS A 361
LEU A 357
ALA A 360
THR A 352
None
1.22A12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		1zzp PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)		4 / 6LEU A 101
ALA A  66
LEU A  64
SER A  61
None
1.23A24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens)		4 / 6LEU A 304
LEU A 334
SER A 335
THR A 300
None
1.13A14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens)		4 / 6LEU B 216
ALA B 209
LEU B 211
SER B 173
None
0.92A21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		6 / 6LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.30A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		4 / 6LYS A  68
LEU A  39
ALA A  65
SER A  44
None
1.04A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens)		4 / 6LEU L 136
ALA L 134
LEU L 182
THR L 185
None
1.03A22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens)		4 / 6LYS A 411
ALA A 414
SER A 341
THR A 418
None
1.16A14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		4b4s BCL-2-LIKE PROTEIN
10
(Homo
sapiens)		4 / 6LEU A 130
LEU A  16
SER A  19
THR A  95
None
1.23A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens)		4 / 6LEU A 133
ALA A 131
LEU A 179
THR A 182
None
1.00A23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens)		4 / 6LEU L 132
ALA L 130
LEU L 178
THR L 181
None
1.00A24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		5ei0 SERPIN A12
(Homo
sapiens)		4 / 6LYS A 155
LEU A 151
ALA A 160
THR A 137
None
1.17A16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens)		4 / 6LEU A 413
ALA A 224
LEU A 228
SER A 326
None
1.10A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		5m76 LIGHT CHAIN DIMER
(Homo
sapiens)		4 / 6LEU A 135
ALA A 133
LEU A 181
THR A 184
None
1.03A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 6LYS A1775
LEU A1778
LEU A1825
SER A1824
None
1.21A2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6LYS A 167
LEU A 169
LEU A 145
SER A 115
None
1.08A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Homo
sapiens;
Homo
sapiens)		4 / 6LEU i  71
ALA k  44
LEU k  40
SER k  39
None
1.28A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		4 / 4LYS A  29
LEU A  14
ALA A  12
LEU A  61
None
1.27A21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens)		4 / 4LYS A 146
LEU A  49
ALA A 158
LEU A 148
None
1.41A25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		4 / 4LYS A  15
LEU A  17
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
1.01A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens)		4 / 4LYS A 222
LEU A 328
ALA A 223
LEU A 323
None
1.47A15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		4wau CENTROMERE PROTEIN M
(Homo
sapiens)		4 / 4LYS A  50
LEU A  28
ALA A  49
LEU A  20
None
1.48A24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens)		4 / 4LYS A 439
LEU A 436
ALA A 438
LEU A 420
None
1.33A9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens)		4 / 4LYS A 220
LEU A 326
ALA A 221
LEU A 321
None
1.49A17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		4 / 4LYS A  29
LEU A  14
ALA A  12
LEU A  61
None
1.26A21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens)		4 / 4LYS A 146
LEU A  49
ALA A 158
LEU A 148
None
1.39A25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		4 / 4LYS A  15
LEU A  17
ALA A 108
LEU A 110
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
1.01A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens)		4 / 4LYS A 222
LEU A 328
ALA A 223
LEU A 323
None
1.45A15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		4wau CENTROMERE PROTEIN M
(Homo
sapiens)		4 / 4LYS A  50
LEU A  28
ALA A  49
LEU A  20
None
1.46A24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens)		4 / 4LYS A 439
LEU A 436
ALA A 438
LEU A 420
None
1.33A9.46