POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1elv	COMPLEMENT C1S COMPONENT (Homo sapiens)	6 / 8	ASP A 611 SER A 612 SER A 617 VAL A 638 GLY A 641 GLY A 648	None None SO4  A2001 ( 2.7A) None None None	0.37A	24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1fq3	GRANZYME B (Homo sapiens)	4 / 8	SER A 190 SER A 195 VAL A 213 GLY A 216	None SO4  A 800 (-2.4A) None None	0.70A	32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1fxy	COAGULATION FACTOR XA-TRYPSIN CHIMERA (Homo sapiens)	6 / 8	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	0G6  A   1 (-2.8A) 0G6  A   1 (-2.8A) 0G6  A   1 (-1.4A) None 0G6  A   1 (-3.9A) 0G6  A   1 (-3.3A)	0.32A	34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1gvl	KALLIKREIN 6 (Homo sapiens)	4 / 8	SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.63A	38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1h4w	TRYPSIN IVA (Homo sapiens)	6 / 8	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	BEN  A 250 (-2.9A) BEN  A 250 (-2.9A) BEN  A 250 (-3.6A) None BEN  A 250 (-3.9A) BEN  A 250 (-3.3A)	0.27A	38.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	6 / 8	ASP H 189 GLN H 192 SER H 195 VAL H 213 GLY H 216 GLY H 226	CR9  H 256 (-2.4A) CR9  H 256 ( 4.4A) CR9  H 256 (-1.5A) CR9  H 256 (-4.3A) CR9  H 256 ( 3.8A) CR9  H 256 (-3.0A)	0.44A	37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1orf	GRANZYME A (Homo sapiens)	5 / 8	ASP A 189 SER A 190 SER A 195 GLY A 216 GLY A 226	0G6  A   1 (-2.9A) 0G6  A   1 (-2.9A) 0G6  A   1 (-1.3A) 0G6  A   1 (-3.3A) 0G6  A   1 (-3.5A)	0.40A	29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1q3x	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	6 / 8	ASP A 627 SER A 628 SER A 633 VAL A 653 GLY A 656 GLY A 667	NA  A 800 ( 4.6A) GOL  A 701 (-3.4A) GOL  A 701 (-3.0A) GOL  A 701 (-4.9A) GOL  A 701 ( 4.1A) GOL  A 701 ( 4.0A)	0.38A	26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1zlr	COAGULATION FACTOR XI (Homo sapiens)	4 / 8	ASP A 189 SER A 195 GLY A 216 GLY A 226	368  A 901 (-2.8A) 368  A 901 (-1.4A) 368  A 901 (-3.6A) 368  A 901 (-3.5A)	0.39A	34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	6 / 8	ASP A 189 GLN A 192 SER A 195 VAL A 213 GLY A 216 GLY A 226	DT8  A 700 (-3.5A) DT8  A 700 (-3.9A) DT8  A 700 ( 3.9A) DT8  A 700 ( 4.1A) DT8  A 700 (-3.5A) DT8  A 700 (-3.5A)	0.47A	32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2ik8	GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (Homo sapiens)	4 / 8	SER A  44 SER A  47 GLY A 203 GLY A  40	GDP  A 401 (-3.6A) MG  A 356 ( 1.9A) ALF  A 355 (-3.3A) None	0.76A	20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2oq5	TRANSMEMBRANE PROTEASE, SERINE 11E (Homo sapiens)	5 / 8	ASP A 189 SER A 195 VAL A 213 GLY A 216 GLY A 226	BEN  A 245 (-3.0A) BEN  A 245 (-3.3A) None BEN  A 245 ( 3.8A) BEN  A 245 (-3.4A)	0.30A	35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	5 / 8	ASP C 229 SER C 235 VAL C 255 GLY C 258 GLY C 268	G44  C 101 (-2.6A) G44  C 101 (-3.5A) None G44  C 101 (-3.3A) G44  C 101 (-3.0A)	0.47A	19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2psy	KALLIKREIN-5 (Homo sapiens)	6 / 8	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.43A	35.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	4 / 8	SER A  54 SER A  57 GLY A 101 GLY A  50	GNP  A 401 (-3.5A) MG  A 301 ( 2.1A) GNP  A 401 (-3.2A) None	0.75A	19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2qy0	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	6 / 8	ASP B 631 GLN B 634 SER B 637 VAL B 657 GLY B 660 GLY B 668	None	0.60A	30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2r0l	HEPATOCYTE GROWTH FACTOR ACTIVATOR (Homo sapiens)	5 / 8	ASP A 189 GLN A 192 SER A 195 GLY A 216 GLY A 226	None	0.51A	38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	5 / 8	ASP U 189 SER U 190 VAL U 213 GLY U 216 GLY U 226	4PG  U 300 (-2.8A) 4PG  U 300 (-2.7A) None 4PG  U 300 (-3.3A) 4PG  U 300 (-3.2A)	0.31A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	4 / 8	SER U 190 SER U 195 VAL U 213 GLY U 216	4PG  U 300 (-2.7A) 4PG  U 300 (-3.5A) None 4PG  U 300 (-3.3A)	0.77A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2wpm	COAGULATION FACTOR IXA HEAVY CHAIN (Homo sapiens)	5 / 8	ASP S 189 SER S 190 SER S 195 GLY S 216 GLY S 226	None	0.30A	30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2zec	TRYPTASE BETA 2 (Homo sapiens)	7 / 8	ASP A 203 SER A 204 GLN A 206 SER A 209 VAL A 227 GLY A 230 GLY A 240	11N  A   1 (-2.6A) 11N  A   1 (-3.5A) None 11N  A   1 (-3.3A) None 11N  A   1 (-3.9A) 11N  A   1 (-3.6A)	0.36A	35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	5 / 8	ASP H 189 SER H 195 VAL H 213 GLY H 216 GLY H 226	0G6  H   1 (-2.8A) 0G6  H   1 (-1.8A) None 0G6  H   1 (-3.8A) 0G6  H   1 ( 3.9A)	0.48A	35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	3gov	MASP-1 (Homo sapiens)	5 / 8	ASP B 640 SER B 646 VAL B 666 GLY B 669 GLY B 679	None	0.64A	30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	3gym	PROSTASIN (Homo sapiens)	5 / 8	ASP A 189 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.48A	36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	5 / 8	ASP B 189 SER B 195 VAL B 213 GLY B 216 GLY B 226	None	0.45A	31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	3w6o	DYNAMIN-1-LIKE PROTEIN (Homo sapiens)	4 / 8	SER A  36 SER A  39 GLY A 149 GLY A  32	GCP  A 801 (-4.0A) MG  A 802 ( 2.0A) GCP  A 801 (-3.6A) None	0.79A	21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	3zjc	GTPASE IMAP FAMILY MEMBER 7 (Homo sapiens)	4 / 8	SER A  19 SER A  22 GLY A  66 GLY A  15	GNP  A1297 (-3.9A) MG  A1296 ( 2.4A) GNP  A1297 ( 4.3A) None	0.69A	21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	4ci8	ECHINODERM MICROTUBULE-ASSOCIAT ED PROTEIN-LIKE 1 (Homo sapiens)	5 / 8	ASP A 647 SER A 645 GLN A 588 GLY A 606 GLY A 625	None	1.39A	17.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	4d9r	COMPLEMENT FACTOR D (Homo sapiens)	5 / 8	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 226	None	0.63A	32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	4dgj	ENTEROPEPTIDASE CATALYTIC LIGHT CHAIN (Homo sapiens)	4 / 8	ASP A 181 SER A 182 GLY A 208 GLY A 218	None	0.29A	34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	4fxg	MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN (Homo sapiens)	5 / 8	ASP H 627 SER H 628 VAL H 653 GLY H 656 GLY H 667	None	0.41A	31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	5 / 8	ASP E 639 SER E 645 VAL E 665 GLY E 668 GLY E 680	None	0.39A	30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	4k8y	KALLIKREIN-4 (Homo sapiens)	6 / 8	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.38A	33.85