POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		1xx0 PLECKSTRIN
(Homo
sapiens)		4 / 6LEU A 275
ALA A 341
LEU A 292
SER A 346
None
1.04A16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		2kc3 APOLIPOPROTEIN E
(Homo
sapiens)		4 / 6LEU A  78
ALA A 164
SER A  22
THR A  18
None
0.98A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens)		4 / 6LEU A 482
ALA A 503
SER A 527
THR A 529
None
0.84A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens)		4 / 6LEU B 216
ALA B 209
LEU B 211
SER B 173
None
0.94A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER
(Homo
sapiens)		4 / 6LYS A  46
ALA A  44
LEU A  40
SER A  41
None
0.81A22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2
(Homo
sapiens)		4 / 6LEU A  42
LEU A  39
SER A  36
THR A  34
None
1.08A22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		6 / 6LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.51A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens)		4 / 6LEU L 132
ALA L 130
LEU L 178
THR L 181
None
1.04A22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens)		4 / 6LEU A  23
ALA A  21
LEU A  80
THR A  93
None
1.01A23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens)		4 / 6LEU L 136
ALA L 134
LEU L 182
THR L 185
None
1.06A22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3sag EXOSOME COMPONENT 10
(Homo
sapiens)		4 / 6LEU A 396
ALA A 392
LEU A 398
THR A 389
LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
0.95A14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1
(Homo
sapiens)		4 / 6LEU A 180
ALA A 176
LEU A 181
THR A 174
None
1.06A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN
(Homo
sapiens)		4 / 6LEU L 133
ALA L 131
LEU L 179
THR L 182
None
1.07A25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Homo
sapiens)		4 / 6LYS A 323
ALA A 168
SER A  92
THR A  94
None
0.86A17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens)		4 / 6LEU A 133
ALA A 131
LEU A 179
THR A 182
None
1.02A23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		4llu LIGHT CHAIN CLAMBDA
(Homo
sapiens)		4 / 6LEU B 133
ALA B 131
LEU B 179
THR B 182
None
1.06A25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens)		4 / 6LEU L 132
ALA L 130
LEU L 178
THR L 181
None
1.02A24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		2e7b OBSCURIN
(Homo
sapiens)		4 / 7LEU A  18
THR A  87
ALA A  89
LEU A  91
None
0.86A23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))
(Homo
sapiens)		4 / 7LEU L 135
THR L 172
SER L 162
THR L 164
None
0.84A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		4 / 7LYS A 295
LEU A 297
THR A 338
SER A 330
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
None
0.81A13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens)		4 / 7LEU B 363
THR B 415
ALA B 391
LEU B 367
None
0.83A18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens)		4 / 7LEU B 216
ALA B 209
LEU B 211
SER B 173
None
0.93A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER
(Homo
sapiens)		4 / 7LYS A  46
ALA A  44
LEU A  40
SER A  41
None
0.80A22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		3epd POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 7THR R  65
ALA R  67
SER R 120
THR R 122
None
0.90A22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		7 / 7LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.46A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		4 / 7LEU A 289
THR A 335
ALA A 314
THR A 385
None
1.03A13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 7THR A 548
ALA A 550
LEU A 552
SER A 483
None
0.81A8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		4 / 7THR A 457
ALA A 459
SER A 448
THR A 450
None
0.68A16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		4 / 7THR A 457
ALA A 459
SER A 448
THR A 450
None
0.72A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens)		4 / 7LYS A  69
LEU A  71
THR A 123
SER A 106
None
0.69A19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7LEU B 347
THR B 235
LEU B  91
SER B  90
None
0.98A13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		5c53 POL GAMMA B
(Homo
sapiens)		4 / 7LEU B 347
THR B 235
LEU B  91
SER B  90
None
1.01A9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF
(Homo
sapiens)		4 / 7LYS A 483
LEU A 485
THR A 529
LEU A 525
5XJ  A 801 (-3.8A)
None
5XJ  A 801 (-3.4A)
None
0.86A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		4 / 7LEU B 147
THR B 124
LEU B 128
THR B 119
None
0.78A20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		5te6 LIGHT CHAIN OF N6
(Homo
sapiens)		4 / 7LEU L 135
THR L 172
SER L 162
THR L 164
None
0.97A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
(Homo
sapiens)		4 / 7THR X 422
ALA X 418
LEU X 414
SER X 413
None
0.90Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		5yax SCFV1 ANTIBODY
(Homo
sapiens)		4 / 7THR A1092
ALA A1090
SER A1022
THR A1020
None
0.95A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens)		4 / 7LYS A 213
LEU A 215
LEU A 258
SER A 253
CJT  A 502 (-3.0A)
None
None
None
1.02A16.54