POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens)
5 / 12MET A  93
GLN A  83
VAL A  82
LEU A   4
GLN A 120
None
1.16A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
1pcg ESTROGEN RECEPTOR
(Homo
sapiens)
5 / 12MET A 343
LEU A 346
LEU A 391
ARG A 394
LEU A 384
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
None
1.22A28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
5 / 12GLY A 708
GLN A 711
MET A 745
ARG A 752
LEU A 873
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.74A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
7 / 12LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 745
ARG A 752
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
1.00A46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2gyt DELETED IN LIVER
CANCER 1 PROTEIN,
ISOFORM 2
(Homo
sapiens)
5 / 12LEU A  66
ASN A  67
VAL A  74
LEU A  34
LEU A  46
None
1.29A13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens)
5 / 12LEU B1161
GLY B1192
LEU B1199
MET B1205
LEU B1152
None
1.30A15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens)
5 / 12LEU B1161
VAL B1358
LEU B1199
MET B1205
LEU B1152
None
1.38A15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2ocf ESTROGEN RECEPTOR
(Homo
sapiens)
5 / 12MET A 343
LEU A 346
LEU A 391
ARG A 394
LEU A 384
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
None
1.14A26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2oj4 REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens)
5 / 12LEU A  22
GLY A  21
LEU A  12
MET A 109
LEU A  29
None
1.28A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2wl8 PEROXISOMAL
BIOGENESIS FACTOR 19
(Homo
sapiens)
5 / 12LEU A 268
GLY A 270
GLN A 221
MET A 225
LEU A 258
None
1.36A17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
2y05 PROSTAGLANDIN
REDUCTASE 1
(Homo
sapiens)
5 / 12LEU A 322
ASN A 321
GLY A 152
VAL A 154
LEU A 185
None
NAP  A 701 (-3.1A)
NAP  A 701 (-3.1A)
NAP  A 701 (-3.7A)
None
1.29A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP
(Escherichia
coli;
Homo
sapiens)
5 / 12LEU A-189
VAL A   8
LEU A-151
MET A-145
LEU A-198
None
1.44A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens)
5 / 12LEU A 286
GLY A 288
VAL A 186
MET A 191
LEU A 259
None
1.40A19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
3j9p MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY A
MEMBER 1 CHIMERA
(Escherichia
coli;
Homo
sapiens)
5 / 12LEU D 955
ASN D 954
GLY D 958
VAL D 961
LEU D 870
None
1.36A11.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 12ASN A 719
GLY A 722
GLN A 725
MET A 759
ARG A 766
LEU A 887
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
1.21A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
8 / 12LEU A 718
ASN A 719
GLY A 722
MET A 759
LEU A 763
ARG A 766
MET A 801
LEU A 887
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
0.95A49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens)
5 / 12LEU A 196
GLY A 194
VAL A 283
GLN A 186
LEU A 187
None
1.33A18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
3zhp CALCIUM-BINDING
PROTEIN 39-LIKE
(Homo
sapiens)
5 / 12MET A 258
LEU A 262
ASN A 260
LEU A 305
LEU A 294
None
1.40A22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 563
ASN A 564
GLY A 567
GLN A 570
VAL A 571
MET A 604
ARG A 611
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
None
MOF  A 801 (-4.2A)
1.01A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
9 / 12LEU A 563
GLY A 567
GLN A 570
VAL A 571
MET A 604
LEU A 608
ARG A 611
MET A 646
LEU A 732
MOF  A 801 (-3.9A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
0.61A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 769
GLN A 776
LEU A 814
ARG A 817
MET A 852
LEU A 938
CV7  A1987 (-4.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
0.61A51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
4wmh HEME OXYGENASE 2
(Homo
sapiens)
5 / 12MET A 158
LEU A 161
GLY A 164
GLN A 165
VAL A 166
None
1.07A22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
5iry DESMOCOLLIN-1
(Homo
sapiens)
5 / 12LEU A   9
LEU A  50
ARG A  64
GLN A  22
LEU A  76
None
1.44A18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12ASN A 770
GLN A 776
LEU A 814
ARG A 817
MET A 852
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.34A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLN A 776
LEU A 814
ARG A 817
MET A 852
LEU A 938
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
1.30A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12LEU A 769
GLN A 776
LEU A 814
ARG A 817
LEU A 938
ECV  A1101 (-4.7A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
0.51A41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
5xct VL-SARAH(S37C)CHIMER
A
(Homo
sapiens;
Mus
musculus)
5 / 12ASN B  34
GLY B  46
VAL B  58
GLN B   6
LEU B  21
None
1.41A21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
4 / 4TRP A 600
MET A 601
PHE A 623
TYR A 735
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.8A)
1.16A96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
1d9n METHYL-CPG-BINDING
PROTEIN MBD1
(Homo
sapiens)
5 / 12LEU A  49
GLY A  14
PHE A  62
LEU A  69
CYH A  57
None
1.30A16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
1x40 ARAP2
(Homo
sapiens)
5 / 12LEU A  68
LEU A  27
LEU A  52
CYH A  45
VAL A  16
None
1.35A17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
1xb7 STEROID HORMONE
RECEPTOR ERR1
(Homo
sapiens)
5 / 12LEU A 327
TRP A 361
MET A 362
ARG A 372
LEU A 401
None
0.75A27.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
5 / 12LEU A 700
LEU A 707
GLY A 708
GLN A 711
ARG A 752
None
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
1.38A53.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
7 / 12LEU A 701
LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
ARG A 752
None
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
0.55A53.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens)
5 / 12LEU A 181
GLN A  93
PHE A 200
LEU A 203
VAL A 120
None
None
None
MLY  A 202 ( 4.2A)
None
1.44A21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)
6 / 12LEU A 265
LEU A 271
TRP A 305
MET A 306
ARG A 316
LEU A 345
None
OHT  A 500 ( 4.4A)
None
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
OHT  A 500 (-4.3A)
0.74A28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens)
5 / 12LEU A 209
LEU A 172
GLY A  95
TRP A 104
VAL A 105
None
1.39A18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
10 / 12LEU A 715
LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
ARG A 766
PHE A 794
CYH A 891
VAL A 912
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.4A)
WOW  A   1 (-3.5A)
None
0.69A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 715
MET A 756
MET A 759
PHE A 794
LEU A 797
CYH A 891
VAL A 912
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.4A)
WOW  A   1 ( 4.5A)
WOW  A   1 (-3.5A)
None
0.97A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
5 / 12LEU A 715
TRP A 755
MET A 756
PHE A 794
CYH A 891
WOW  A   1 (-3.9A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.4A)
WOW  A   1 (-3.5A)
1.05A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens)
5 / 12LEU A 123
LEU A 129
GLN A 133
PHE A  95
CYH A 153
None
1.06A20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
4a69 HISTONE DEACETYLASE
3,
(Homo
sapiens)
5 / 12LEU A 133
GLY A 132
ARG A  28
PHE A 200
VAL A 253
None
1.39A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
4bkx HISTONE DEACETYLASE
1
(Homo
sapiens)
5 / 12LEU B 139
GLY B 138
ARG B  34
PHE B 205
VAL B 258
None
1.36A19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLY A 568
GLN A 570
TRP A 600
MET A 601
CYH A 736
None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
1.12A53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 566
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
CYH A 736
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
0.48A53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 566
GLY A 567
GLN A 570
TRP A 600
MET A 601
MET A 604
ARG A 611
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
0.78A53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 766
LEU A 772
GLN A 776
TRP A 806
MET A 807
ARG A 817
CYH A 942
CV7  A1987 (-3.6A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.0A)
0.50A52.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 766
TRP A 806
MET A 807
ARG A 817
LEU A 848
CYH A 942
CV7  A1987 (-3.6A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.0A)
0.79A52.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 766
GLN A 776
TRP A 806
MET A 807
ARG A 817
LEU A 848
CYH A 942
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
None
ECV  A1101 (-4.0A)
0.95A40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 766
LEU A 772
GLN A 776
TRP A 806
MET A 807
ARG A 817
CYH A 942
ECV  A1101 ( 3.9A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
0.61A40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens)
5 / 12LEU f 445
LEU f 487
GLY f 486
CYH f 459
VAL f 497
None
1.42A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens)
4 / 7GLU A 501
LEU A 505
MET A 312
TYR A 464
None
1.03A18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
4 / 7LEU A 704
ASN A 705
GLU A 709
LEU A 712
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
None
None
0.53A53.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens)
4 / 7LEU A 174
GLU A 177
LEU A 179
TYR A 160
None
1.11A23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens)
4 / 7LEU A1089
ASN A1087
LEU A1116
MET A1076
None
1.26A16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
3c5w PP2A A SUBUNIT
(Homo
sapiens)
4 / 7LEU A  29
ASN A  30
GLU A  19
LEU A  16
None
1.13A26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens)
4 / 7ASN A 489
GLU A 490
LEU A 494
TYR A  79
None
None
None
EDO  A 704 (-4.6A)
1.22A19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens)
4 / 7LEU A 847
ASN A 850
GLU A 852
LEU A 854
None
1.24A20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 7LEU A 718
ASN A 719
GLU A 723
LEU A 726
MET A 801
TYR A 890
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
None
None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
0.33A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 7LEU A 718
ASN A 719
LEU A 726
MET A 801
TYR A 890
MET A 909
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
None
0.87A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
3nuu PKB-LIKE
(Homo
sapiens)
4 / 7LEU A 206
ASN A 210
GLU A 166
LEU A 168
None
1.17A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2
(Homo
sapiens)
4 / 7LEU A 494
GLU A 444
LEU A 445
MET A 457
None
1.22A23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens)
4 / 7LEU A1089
ASN A1087
LEU A1116
MET A1076
None
1.25A20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens)
4 / 7LEU A 204
LEU A 273
TYR A 177
MET A 274
None
1.20A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
4c9y SPINDLE AND
KINETOCHORE-ASSOCIAT
ED PROTEIN 1
(Homo
sapiens)
4 / 7LEU A 101
ASN A 102
MET A   6
MET A  21
None
1.13A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens)
4 / 7ASN A  68
LEU A  75
MET A  32
MET A 104
None
1.17A23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
4n9j SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens)
4 / 7LEU A 637
GLU A 618
LEU A 614
TYR A 650
None
1.15A21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
4nqj E3 UBIQUITIN-PROTEIN
LIGASE TRIM69
(Homo
sapiens)
4 / 7LEU A 240
ASN A 239
GLU A 235
LEU A 232
None
0.90A23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens)
4 / 7LEU A 227
ASN A 226
GLU A 123
LEU A 143
None
1.23A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens)
4 / 7LEU A1642
LEU A1596
MET A1529
MET A1595
None
1.18A7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens)
4 / 7LEU A  69
ASN A  68
GLU A  64
LEU A  61
None
1.15A17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1
(Escherichia
virus
T4;
Homo
sapiens)
4 / 7LEU A1093
LEU A1103
MET A1126
TYR A1072
None
1.13A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens)
4 / 7LEU A 296
GLU A 173
LEU A 170
MET A 143
None
1.14A23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
6b5q DCN1-LIKE PROTEIN 1
(Homo
sapiens)
4 / 7LEU A  93
LEU A 103
MET A 126
TYR A  72
None
1.07A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens)
4 / 7LEU A1133
ASN A1132
GLU A1128
MET A1102
None
1.23A12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens)
5 / 12LEU B  38
GLY B  40
VAL B  15
LEU B  32
ILE B  44
None
1.43A16.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
LEU A 873
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.69A48.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
LEU A 873
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
1.12A48.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
0.68A48.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 704
GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
1.00A48.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)
5 / 12MET A 428
LEU A 402
GLY A 406
MET A 438
LEU A 459
None
1.21A19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 12ASN A 719
GLY A 722
GLN A 725
MET A 756
ARG A 766
LEU A 887
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
0.84A53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 718
ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
LEU A 887
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
0.69A53.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens)
5 / 12LEU A 301
GLY A 299
VAL A 452
LEU A 285
ILE A 254
None
1.41A17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
9 / 12LEU A 563
ASN A 564
GLY A 567
GLN A 570
VAL A 571
MET A 601
ARG A 611
MET A 646
LEU A 732
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
0.61A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12MET A 560
ASN A 564
VAL A 571
MET A 601
ARG A 611
MET A 646
LEU A 732
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
0.87A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 769
ASN A 770
GLN A 776
ARG A 817
MET A 852
LEU A 938
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
0.82A55.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 769
GLN A 776
MET A 807
ARG A 817
MET A 852
LEU A 938
CV7  A1987 (-4.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
0.74A55.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLN A 776
MET A 807
ARG A 817
MET A 852
LEU A 938
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
1.35A53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 769
ASN A 770
GLN A 776
MET A 807
ARG A 817
LEU A 938
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
0.73A53.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens)
5 / 12LEU A1614
ASN A1611
GLN A 602
VAL A 617
ARG A 606
None
1.30A7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
6avo PROTEASOME SUBUNIT
BETA TYPE-9
(Homo
sapiens)
5 / 12LEU A 115
GLY A 113
GLN A 122
VAL A 111
ILE A   3
None
1.21A14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)
3k9b LIVER
CARBOXYLESTERASE 1
(Homo
sapiens)
5 / 10ASN A1351
TRP A1500
GLN A1528
LEU A1527
TYR A1526
None
1.31A21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
5 / 10LEU A 718
MET A 756
MET A 759
LEU A 887
TYR A 890
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.9A)
0.60A53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 10LEU A 563
TRP A 600
MET A 601
LEU A 732
TYR A 735
MOF  A 801 (-3.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-4.8A)
0.66A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 10LEU A 563
TRP A 600
MET A 601
MET A 604
LEU A 732
MOF  A 801 (-3.9A)
None
MOF  A 801 (-3.7A)
None
MOF  A 801 ( 4.2A)
0.76A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 10TRP A 600
MET A 601
GLN A 642
LEU A 732
TYR A 735
None
MOF  A 801 (-3.7A)
None
MOF  A 801 ( 4.2A)
MOF  A 801 (-4.8A)
1.23A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 10LEU A 772
TRP A 806
MET A 807
MET A 959
LEU A 960
CV7  A1987 ( 4.5A)
None
CV7  A1987 ( 3.9A)
None
None
1.41A55.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 10LEU A 772
TRP A 806
MET A 807
MET A 959
LEU A 960
ECV  A1101 ( 3.9A)
None
ECV  A1101 (-3.6A)
None
None
1.22A53.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)
5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)
5 / 10ASN A1132
TRP A1138
MET A1102
LEU A1099
LEU A1133
None
1.49A18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
1kcw CERULOPLASMIN
(Homo
sapiens)
5 / 12MET A 617
GLY A 614
GLN A 612
LEU A 561
MET A 668
None
1.25A12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
1lar PROTEIN (LAR)
(Homo
sapiens)
5 / 12GLY A1527
GLY A1530
GLN A1566
VAL A1565
ILE A1574
None
1.21A16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12GLY A 708
GLN A 711
ARG A 752
CYH A 784
MET A 787
ILE A 898
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
None
0.89A48.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6
(Homo
sapiens)
5 / 12GLY A 458
GLY A 461
GLN A 500
VAL A 499
ILE A 508
None
1.26A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens)
5 / 12GLY A 175
GLN A 179
VAL A 180
MET A 488
ILE A 616
None
1.28A14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens)
5 / 12GLY A1088
GLY A1091
GLN A1127
VAL A1126
ILE A1135
ACT  A2156 (-3.6A)
None
ACT  A2156 (-3.4A)
None
None
1.06A18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens)
5 / 12GLY A  70
GLY A  71
GLN A 150
VAL A 149
ILE A  81
U  B   2 ( 3.9A)
C  B   1 ( 2.7A)
U  B   2 ( 2.8A)
None
None
1.09A21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 12GLY A 722
LEU A 763
ARG A 766
CYH A 798
MET A 801
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
0.87A53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
9 / 12GLY A 567
GLY A 568
GLN A 570
VAL A 571
LEU A 608
ARG A 611
MET A 639
CYH A 643
MET A 646
MOF  A 801 (-3.4A)
None
MOF  A 801 (-2.9A)
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
0.68A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
10 / 12GLY A 567
GLY A 568
GLN A 570
VAL A 571
LEU A 608
ARG A 611
MET A 639
MET A 646
CYH A 736
ILE A 756
MOF  A 801 (-3.4A)
None
MOF  A 801 (-2.9A)
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
None
0.72A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12GLY A 567
LEU A 608
ARG A 611
CYH A 643
MET A 646
ILE A 757
MOF  A 801 (-3.4A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
None
1.32A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLY A 568
GLN A 570
VAL A 571
CYH A 736
ILE A 756
None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
None
1.09A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
8 / 12MET A 560
GLY A 568
VAL A 571
LEU A 608
ARG A 611
MET A 639
CYH A 643
MET A 646
MOF  A 801 (-3.9A)
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
0.87A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
9 / 12MET A 560
GLY A 568
VAL A 571
LEU A 608
ARG A 611
MET A 639
MET A 646
CYH A 736
ILE A 756
MOF  A 801 (-3.9A)
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
None
0.93A94.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)
5 / 12GLY A 464
GLY A 467
GLN A 506
VAL A 505
ILE A 514
2WT  A 601 ( 3.9A)
None
2WT  A 601 (-3.4A)
None
None
1.14A17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLN A 776
LEU A 814
ARG A 817
CYH A 849
MET A 852
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
0.79A55.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12GLY A 774
GLN A 776
LEU A 814
ARG A 817
MET A 852
CYH A 942
ILE A 963
None
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
None
0.89A55.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12LEU A 814
ARG A 817
CYH A 849
MET A 852
ILE A 964
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
None
0.94A55.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)
5 / 12GLY A 464
GLY A 467
GLN A 506
VAL A 505
ILE A 514
None
1.23A17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)
5 / 12GLY Q 376
GLY Q 375
GLN Q 401
VAL Q 402
ILE Q 382
None
1.28A20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)
5 / 12GLY R 376
GLY R 375
GLN R 401
VAL R 402
ILE R 382
None
1.28A18.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLN A 776
LEU A 814
ARG A 817
CYH A 849
ILE A 964
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
None
1.07A53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12GLY A 774
GLN A 776
LEU A 814
ARG A 817
CYH A 849
CYH A 942
ILE A 963
None
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
ECV  A1101 (-4.0A)
None
0.92A53.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5o32 COMPLEMENT FACTOR I
(Homo
sapiens)
5 / 12GLY I 343
GLY I 342
GLN I 485
VAL I 341
LEU I 484
None
1.21A17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens)
5 / 12GLY f 201
GLY f 200
GLN f 205
MET f 162
ILE f 189
None
1.20A15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X
(Homo
sapiens)
5 / 12GLY A1867
VAL A1866
LEU A1822
MET A1824
ILE A1578
None
1.04A14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 764
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
0.92A48.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 704
GLY A 708
GLN A 711
ARG A 752
PHE A 764
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
0.81A48.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 12GLY A 722
MET A 756
LEU A 763
ARG A 766
PHE A 778
MET A 801
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
0.81A53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 718
GLY A 722
LEU A 763
ARG A 766
PHE A 778
MET A 801
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
0.97A53.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
3p0f URIDINE
PHOSPHORYLASE 2
(Homo
sapiens)
5 / 12LEU A  52
VAL A  25
LEU A 110
PHE A  56
MET A 103
None
1.33A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)
5 / 12LEU A 422
GLY A 430
VAL A 428
LEU A 390
MET A 398
None
1.43A19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
9 / 12GLY A 567
GLN A 570
VAL A 571
TRP A 600
MET A 601
LEU A 608
ARG A 611
PHE A 623
MET A 646
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.4A)
0.66A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLY A 568
GLN A 570
VAL A 571
TRP A 600
MET A 601
None
MOF  A 801 (-2.9A)
None
None
MOF  A 801 (-3.7A)
1.02A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 563
GLY A 567
GLN A 570
VAL A 571
TRP A 600
MET A 601
PHE A 623
MOF  A 801 (-3.9A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.7A)
0.99A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12LEU A 627
GLN A 570
LEU A 608
PHE A 623
MET A 646
None
MOF  A 801 (-2.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.4A)
1.33A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
PHE A 829
MET A 852
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
0.62A55.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12LEU A 769
GLN A 776
TRP A 806
PHE A 829
MET A 852
CV7  A1987 (-4.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
1.00A55.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens)
5 / 12LEU A 193
GLY A 195
LEU A 284
MET A 186
MET A 241
None
1.33A23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
5kem BDBV91 VARIABLE FAB
DOMAIN HEAVY CHAIN
(Homo
sapiens)
5 / 12GLY B  49
GLN B  61
VAL B  37
ARG B  64
PHE B  63
None
1.13A19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
MET A 852
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.22A53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
PHE A 829
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
0.61A53.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)
5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)
5 / 12LEU A 298
TRP A 335
LEU A 343
ARG A 346
PHE A 356
EST  A 601 (-4.1A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.9A)
0.98A29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
1r79 DIACYLGLYCEROL
KINASE, DELTA
(Homo
sapiens)
3 / 3MET A  26
CYH A  59
PRO A  81
None
ZN  A 201 (-2.3A)
None
1.22A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
2cpr EXOSOME COMPONENT 10
(Homo
sapiens)
3 / 3MET A 569
CYH A 554
PRO A 559
None
1.15A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
3c6g CYTOCHROME P450 2R1
(Homo
sapiens)
3 / 3MET A 458
CYH A 448
PRO A 440
HEM  A 601 ( 4.3A)
HEM  A 601 (-2.1A)
None
1.32A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
3fd5 SELENIDE, WATER
DIKINASE 1
(Homo
sapiens)
3 / 3MET A 187
CYH A 180
PRO A  74
None
1.29A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens)
3 / 3MET A 268
CYH A 319
PRO A 294
None
1.26A13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
4kq8 CYTOCHROME P450 19A1
(Homo
sapiens)
3 / 3MET A 444
CYH A 437
PRO A 429
None
HEM  A 601 (-2.3A)
None
1.14A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)
3 / 3MET A 345
CYH A 243
PRO A 267
None
1.17A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
5il0 METTL3
(Homo
sapiens)
3 / 3MET A 520
CYH A 483
PRO A 514
None
0.51A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
5tey N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
(Homo
sapiens)
3 / 3MET A 520
CYH A 483
PRO A 514
None
0.62A18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)
3 / 3MET A 348
CYH A 244
PRO A 268
None
1.22A19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
6flk CEP120
(Homo
sapiens)
3 / 3MET A 501
CYH A 474
PRO A 471
None
1.15A14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
1hci ALPHA-ACTININ 2
(Homo
sapiens)
5 / 12GLY A 373
LEU A 294
ARG A 298
MET A 361
LEU A 341
None
1.16A22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
1kcw CERULOPLASMIN
(Homo
sapiens)
5 / 12MET A 617
GLY A 614
GLN A 612
LEU A 561
MET A 668
None
1.38A12.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
LEU A 873
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.67A48.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
1.07A48.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
2oby PUTATIVE QUINONE
OXIDOREDUCTASE
(Homo
sapiens)
5 / 12GLY A  62
GLN A  95
LEU A  39
MET A 317
LEU A  44
None
None
None
NAP  A1400 (-3.6A)
None
1.48A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)
5 / 12MET A 382
GLY A 377
LEU A 478
MET A 482
LEU A 448
None
1.35A13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
5 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-3.5A)
1.13A53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
5 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
LEU A 887
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
0.98A53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
5 / 12GLY A 722
MET A 756
ARG A 766
MET A 801
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
1.09A53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 12GLY A 722
MET A 756
LEU A 763
ARG A 766
MET A 801
LEU A 887
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
0.79A53.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
4jgh CULLIN-5
(Homo
sapiens)
5 / 12MET D 310
GLY D 283
MET D 300
MET D 231
LEU D 295
None
1.24A22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
9 / 12GLY A 567
GLN A 570
VAL A 571
MET A 601
LEU A 608
ARG A 611
MET A 639
MET A 646
LEU A 732
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
0.63A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
9 / 12GLY A 567
GLN A 570
VAL A 571
MET A 601
LEU A 608
ARG A 611
MET A 646
LEU A 732
CYH A 736
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
0.67A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLY A 568
GLN A 570
VAL A 571
MET A 601
CYH A 736
None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
1.27A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
8 / 12MET A 560
VAL A 571
MET A 601
LEU A 608
ARG A 611
MET A 639
MET A 646
LEU A 732
MOF  A 801 (-3.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
0.86A94.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12GLN A 776
MET A 807
LEU A 814
ARG A 817
LEU A 938
CYH A 942
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
0.81A55.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
LEU A 938
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
0.68A55.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12GLN A 776
MET A 807
LEU A 814
ARG A 817
LEU A 938
CYH A 942
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
0.79A53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
LEU A 938
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
1.33A53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12LEU A 814
ARG A 817
MET A 845
MET A 852
LEU A 934
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
None
1.32A53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_2
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
4 / 5LEU A 718
ASN A 719
MET A 759
TYR A 890
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.9A)
0.86A53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)
5 / 12CYH A 276
LEU A 321
ILE A 339
LYS A 358
HIS A 440
735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
None
735  A 469 (-4.0A)
1.45A61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B
(Homo
sapiens)
5 / 12CYH A1202
LEU A1458
ILE A1185
PHE A1350
MET A1351
None
None
EDO  A2496 (-3.5A)
None
None
1.50A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)
5 / 12SER A 108
TYR A 136
LEU A 112
ILE A  67
PHE A 120
None
1.39A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)
5 / 12SER A 108
TYR A 136
LEU A 112
ILE A  67
PHE A 120
None
1.48A23.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)
10 / 12ARG A 288
ALA A 292
TYR A 327
LEU A 330
ILE A 341
MET A 348
PHE A 363
MET A 364
LYS A 367
HIS A 449
None
None
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
None
MC5  A   1 (-3.7A)
None
MC5  A   1 (-3.9A)
0.72A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)
10 / 12CYH A 285
ARG A 288
ALA A 292
TYR A 327
LEU A 330
ILE A 341
MET A 348
PHE A 363
LYS A 367
HIS A 449
MC5  A   1 (-3.6A)
None
None
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
None
None
MC5  A   1 (-3.9A)
0.61A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)
10 / 12CYH A 285
ARG A 288
SER A 289
ALA A 292
LEU A 330
ILE A 341
MET A 348
PHE A 363
LYS A 367
HIS A 449
MC5  A   1 (-3.6A)
None
MC5  A   1 (-2.6A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
None
None
MC5  A   1 (-3.9A)
0.77A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3b2d CD180 ANTIGEN
(Homo
sapiens)
5 / 12SER A 528
ALA A 551
TYR A 547
LEU A 548
ILE A 511
None
1.36A19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)
6 / 12ALA D 292
LEU D 330
ILE D 341
MET D 348
MET D 364
HIS D 449
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
1.10A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)
6 / 12ALA D 292
TYR D 327
LEU D 330
ILE D 341
MET D 364
HIS D 449
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
None
1.16A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)
6 / 12CYH D 285
ALA D 292
TYR D 327
LEU D 330
ILE D 341
HIS D 449
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
None
1.12A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)
5 / 12SER D 289
ALA D 292
ILE D 341
MET D 348
HIS D 449
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
0.87A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)
5 / 12SER D 289
ALA D 292
TYR D 327
ILE D 341
HIS D 449
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
None
0.97A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4f9o HEXOKINASE-1
(Homo
sapiens)
5 / 12CYH A 823
SER A 827
ALA A 830
ILE A 757
PHE A 786
None
1.04A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens)
5 / 12CYH A1580
ARG A1625
SER A1624
LEU A1475
HIS A1549
None
0UM  A1804 (-4.9A)
None
None
None
1.48A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens)
5 / 12ALA A 622
LEU A 639
ILE A 601
PHE A 563
MET A 608
None
None
CL  A 905 (-4.6A)
None
None
1.46A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens)
4 / 4LYS A 216
GLN A 208
ILE A  19
LEU A   7
None
1.17A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2pg6 CYTOCHROME P450 2A6
(Homo
sapiens)
4 / 4LYS A 250
GLN A 242
ILE A 208
LEU A 202
None
0.96A18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens)
4 / 4LYS B 318
GLN B 311
ILE B 564
LEU B 267
None
1.30A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3vi3 INTEGRIN ALPHA-5
(Homo
sapiens)
4 / 4LYS A 559
GLN A 599
ILE A 565
LEU A 520
None
1.21A18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B
(Homo
sapiens)
4 / 4LYS A 690
GLN A 534
ILE A 468
LEU A 737
None
1.30A18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5u03 CTP SYNTHASE 1
(Homo
sapiens)
4 / 4LYS A 284
GLN A 277
ILE A 274
LEU A  27
None
1.41A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens)
4 / 4LYS A 861
GLN A 937
ILE A 948
LEU A 906
None
1.21A14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
1jmo HEPARIN COFACTOR II
(Homo
sapiens)
5 / 12LEU A 386
LEU A 457
MET A 471
ILE A 134
ILE A 139
None
1.09A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)
5 / 12LEU A 166
ILE A 157
GLU A 172
ILE A 173
ALA A 176
None
0.93A14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens)
5 / 12LEU A1153
VAL A1084
LEU A1100
ILE A1106
ILE A1110
None
SO4  A 301 ( 4.6A)
None
None
None
0.87A23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
1xb7 STEROID HORMONE
RECEPTOR ERR1
(Homo
sapiens)
6 / 12LEU A 509
LEU A 350
GLN A 353
MET A 354
GLN A 358
ALA A 516
None
1.43A25.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 712
VAL A 716
GLN A 733
ILE A 737
MET A 894
GLU A 897
None
0.87A60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 712
VAL A 716
GLN A 733
MET A 894
GLU A 897
ILE A 898
None
1.11A60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 712
VAL A 716
LYS A 720
ILE A 737
MET A 894
GLU A 897
None
1.18A60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 712
VAL A 716
LYS A 720
MET A 894
GLU A 897
ILE A 898
None
1.27A60.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6
(Homo
sapiens)
5 / 12VAL A 465
LEU A 251
ILE A 508
ILE A 512
ALA A 221
None
1.03A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)
5 / 12LEU A 276
LEU A 294
GLN A 297
MET A 298
GLN A 302
OHT  A 500 (-4.9A)
None
None
None
None
0.70A27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
3fd5 SELENIDE, WATER
DIKINASE 1
(Homo
sapiens)
5 / 12LEU A 203
LEU A 328
ILE A 354
ILE A 271
ALA A 275
None
0.92A21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 726
VAL A 730
GLN A 747
ILE A 751
MET A 908
ALA A 915
None
0.69A66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
5 / 12VAL A 730
GLN A 747
ILE A 751
GLN A 752
ALA A 915
None
0.90A66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
3tx7 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2
(Homo
sapiens)
6 / 12LEU B 353
VAL B 357
GLN B 374
GLN B 379
GLU B 534
ALA B 538
None
0.52A24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens)
6 / 12LEU A 134
VAL A  50
LEU A 167
ILE A 154
ILE A 222
ALA A 179
None
1.25A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)
5 / 12LEU A 804
VAL A 806
LEU A 930
ILE A 941
ALA A 940
None
1.08A19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12VAL A 575
LEU A 589
GLN A 592
MET A 593
GLN A 597
GLU A 755
ILE A 756
None
0.75A62.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens)
5 / 12LEU A 110
LEU A 145
ILE A 179
ILE A  70
ALA A  69
OGA  A 301 ( 4.6A)
None
None
None
None
1.09A23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12VAL A 781
GLN A 798
ILE A 802
GLN A 803
GLU A 962
ILE A 963
None
0.50A65.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12VAL A 781
LEU A 795
GLN A 798
ILE A 802
GLN A 803
None
0.73A65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)
5 / 12LEU A1265
MET A1169
GLU A1168
ILE A1167
ALA A1166
None
SAH  A1706 (-3.9A)
SAH  A1706 (-2.8A)
None
None
1.08A11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens)
6 / 12VAL A 249
LEU A 273
ILE A 181
GLN A 182
ILE A 190
ALA A 191
None
None
None
None
None
499  A 401 ( 4.6A)
1.35A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
5aek SENTRIN-SPECIFIC
PROTEASE 2
(Homo
sapiens)
6 / 12LEU A 368
LEU A 422
MET A 372
GLU A 375
ILE A 376
ALA A 379
None
1.04A22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens)
5 / 12LEU A 579
GLN A 603
ILE A 604
ILE A 633
ALA A 632
None
1.02A15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
5dkc PROBABLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2
(Homo
sapiens)
5 / 12LEU A1383
GLN A1386
MET A1387
ILE A1390
MET A1454
None
1.03A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)
5 / 12LEU C 708
VAL C 712
ILE C 755
ILE C 752
ALA C 541
None
0.98A12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)
5 / 12LEU A 708
VAL A 712
ILE A 755
ILE A 752
ALA A 541
None
1.01A13.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12VAL A 781
LEU A 795
GLN A 798
ILE A 802
GLN A 803
ILE A 963
None
0.79A47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
2bzn GMP REDUCTASE 2
(Homo
sapiens)
5 / 9THR A  74
LEU A  99
ALA A  64
GLN A  91
PHE A  88
None
1.27A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
2d68 FOP
(Homo
sapiens)
5 / 9ALA A  75
LEU A  82
PHE A  94
THR A  98
LEU A  62
None
1.36A15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
2dam ETEA PROTEIN
(Homo
sapiens)
5 / 9ALA A  51
GLN A  24
PHE A  25
THR A  29
LEU A  56
None
1.43A16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
2jr7 DPH3 HOMOLOG
(Homo
sapiens)
5 / 9ALA A  46
GLN A  14
PHE A  13
TYR A  22
LEU A  39
None
1.32A16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
3b2d CD180 ANTIGEN
(Homo
sapiens)
5 / 9THR A 308
LEU A 305
GLN A 295
PHE A 294
LEU A 281
None
1.28A19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
3cjw COUP TRANSCRIPTION
FACTOR 2
(Homo
sapiens)
5 / 9LEU A 245
ALA A 227
LEU A 236
THR A 248
LEU A 252
None
1.38A26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
4gul PIRIN
(Homo
sapiens)
5 / 9LEU A 116
LEU A  36
PHE A 193
TYR A 195
LEU A 114
None
1.41A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens)
5 / 9THR G  73
LEU G  83
LEU G  66
GLN G  48
TYR G  39
None
1.44A18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 9LEU A 766
LEU A 848
PHE A 941
TYR A 944
THR A 945
LEU A 952
CV7  A1987 (-3.6A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.6A)
None
CV7  A1987 (-3.1A)
None
0.51A65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens)
5 / 9THR X   9
LEU X   7
ALA X 156
GLN X 184
THR X 206
None
None
MLZ  X 155 ( 3.0A)
NAP  X 401 (-3.8A)
EDO  X 403 (-4.6A)
1.27A21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 9LEU A 766
ALA A 844
LEU A 848
PHE A 941
TYR A 944
THR A 945
LEU A 952
ECV  A1101 ( 3.9A)
None
None
ECV  A1101 (-4.3A)
None
ECV  A1101 (-3.2A)
None
0.47A47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
7 / 12LEU A 704
GLY A 708
GLN A 711
MET A 745
ARG A 752
CYH A 784
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
0.95A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
7 / 12LEU A 704
LEU A 707
GLY A 708
GLN A 711
ARG A 752
CYH A 784
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
0.73A50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
2ocf ESTROGEN RECEPTOR
(Homo
sapiens)
5 / 12LEU A 346
LEU A 349
TRP A 383
LEU A 391
ARG A 394
EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
0.78A15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)
5 / 12LEU A 705
LEU A 708
GLY A 709
GLN A 712
VAL A 713
None
0.38A8.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 718
GLY A 722
MET A 759
LEU A 763
ARG A 766
CYH A 798
MET A 801
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
0.89A56.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 718
LEU A 721
GLY A 722
LEU A 763
ARG A 766
CYH A 798
MET A 801
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
0.67A56.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens)
5 / 12LEU A 302
LEU A 350
GLY A 351
GLY A 352
VAL A 455
None
1.11A7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens)
5 / 12LEU A 298
GLY A 168
GLY A 167
LEU A 112
CYH A 134
None
1.12A16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens)
5 / 12LEU A 205
GLY A 332
GLY A 330
VAL A 149
CYH A 268
None
None
None
DLY  A 403 (-4.4A)
None
1.15A14.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
11 / 12LEU A 563
LEU A 566
GLY A 567
GLY A 568
GLN A 570
VAL A 571
MET A 604
LEU A 608
ARG A 611
CYH A 643
MET A 646
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
None
MOF  A 801 (-2.9A)
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
0.83A96.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
11 / 12LEU A 566
GLY A 567
GLY A 568
GLN A 570
VAL A 571
TRP A 600
MET A 604
LEU A 608
ARG A 611
CYH A 643
MET A 646
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
None
MOF  A 801 (-2.9A)
None
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
0.93A96.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 769
LEU A 772
GLN A 776
LEU A 814
ARG A 817
CYH A 849
MET A 852
CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
0.72A47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 769
LEU A 772
GLY A 774
GLN A 776
LEU A 814
ARG A 817
MET A 852
CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
None
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
0.71A47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 772
GLN A 776
TRP A 806
LEU A 814
ARG A 817
CYH A 849
MET A 852
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
0.68A47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 772
GLY A 774
GLN A 776
TRP A 806
LEU A 814
ARG A 817
MET A 852
CV7  A1987 ( 4.5A)
None
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
0.87A47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 769
LEU A 772
GLY A 774
GLN A 776
LEU A 814
ARG A 817
CYH A 849
ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
0.81A43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 772
GLN A 776
LEU A 814
ARG A 817
CYH A 849
MET A 852
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.7A)
1.00A43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 772
GLN A 776
TRP A 806
LEU A 814
ARG A 817
MET A 852
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.22A43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 772
GLY A 774
GLN A 776
TRP A 806
LEU A 814
ARG A 817
ECV  A1101 ( 3.9A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
0.80A43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)
5 / 12LEU A 412
LEU A 409
GLY A 603
GLY A 602
LEU A 424
None
0.97A21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
1hcf BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens)
3 / 3TRP X 301
MET X 379
ASN X 356
None
1.19A17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
1uwy CARBOXYPEPTIDASE M
(Homo
sapiens)
3 / 3TRP A 241
MET A 229
ASN A 230
None
1.41A10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
2c6a UBIQUITIN-PROTEIN
LIGASE E3 MDM2
(Homo
sapiens)
3 / 3TRP A 303
MET A 311
ASN A 309
None
1.34A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens)
3 / 3TRP A 299
MET A 379
ASN A 356
None
1.06A12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)
3 / 3TRP A 423
MET A 388
ASN A 419
None
1.31A6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
3f1s VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens)
3 / 3TRP B 354
MET B 211
ASN B 220
None
1.37A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
3h5c VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens)
3 / 3TRP B 354
MET B 211
ASN B 220
None
1.33A14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)
3 / 3TRP C2245
MET C2220
ASN C2217
None
1.45A1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
1hcf BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens)
3 / 3TRP X 301
MET X 379
ASN X 356
None
1.16A17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
1kcw CERULOPLASMIN
(Homo
sapiens)
3 / 3TRP A 364
MET A 608
ASN A 611
None
1.02A6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
1uwy CARBOXYPEPTIDASE M
(Homo
sapiens)
3 / 3TRP A 241
MET A 229
ASN A 230
None
1.46A10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
2c6a UBIQUITIN-PROTEIN
LIGASE E3 MDM2
(Homo
sapiens)
3 / 3TRP A 303
MET A 311
ASN A 309
None
1.27A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens)
3 / 3TRP A 299
MET A 379
ASN A 356
None
1.02A12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)
3 / 3TRP A 423
MET A 388
ASN A 419
None
1.37A6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
3f1s VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens)
3 / 3TRP B 354
MET B 211
ASN B 220
None
1.39A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
3h5c VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens)
3 / 3TRP B 354
MET B 211
ASN B 220
None
1.34A14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
4f02 POLYADENYLATE-BINDIN
G PROTEIN 1
(Homo
sapiens)
3 / 3TRP A  86
MET A  85
ASN A  73
None
A  B   6 (-3.3A)
None
1.22A16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)
3 / 3TRP C2245
MET C2220
ASN C2217
None
1.45A1.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 745
ARG A 752
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
0.86A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 704
ASN A 705
LEU A 707
GLY A 708
GLN A 711
ARG A 752
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
0.64A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
7 / 12LEU A 704
GLY A 708
GLN A 711
MET A 745
ARG A 752
CYH A 784
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
0.96A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
7 / 12LEU A 704
LEU A 707
GLY A 708
GLN A 711
ARG A 752
CYH A 784
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
0.75A50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)
5 / 12LEU A 705
LEU A 708
GLY A 709
GLN A 712
VAL A 713
None
0.36A8.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
5 / 12ASN A 719
LEU A 721
GLY A 722
GLN A 725
ARG A 766
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
0.84A56.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
8 / 12LEU A 718
ASN A 719
LEU A 721
GLY A 722
LEU A 763
ARG A 766
CYH A 798
MET A 801
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
0.77A56.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 718
GLY A 722
MET A 759
LEU A 763
ARG A 766
CYH A 798
MET A 801
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
0.90A56.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
3t5o COMPLEMENT COMPONENT
C6
(Homo
sapiens)
5 / 12LEU A 302
LEU A 350
GLY A 351
GLY A 352
VAL A 455
None
1.16A7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
4b94 DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens)
5 / 12LEU A  84
ASN A  85
LEU A  87
GLY A  89
ARG A 115
None
0.99A19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
4h7y DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens)
5 / 12LEU A  35
ASN A  36
LEU A  38
GLY A  40
ARG A  66
None
0.82A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens)
5 / 12LEU A 298
GLY A 168
GLY A 167
LEU A 112
CYH A 134
None
1.09A16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens)
5 / 12LEU A 205
GLY A 332
GLY A 330
VAL A 149
CYH A 268
None
None
None
DLY  A 403 (-4.4A)
None
1.13A14.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
12 / 12LEU A 563
ASN A 564
LEU A 566
GLY A 567
GLY A 568
GLN A 570
VAL A 571
MET A 604
LEU A 608
ARG A 611
CYH A 643
MET A 646
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
None
MOF  A 801 (-2.9A)
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
0.87A96.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
8 / 12LEU A 769
ASN A 770
LEU A 772
GLY A 774
GLN A 776
LEU A 814
ARG A 817
MET A 852
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
None
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
0.77A47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 769
LEU A 772
GLN A 776
LEU A 814
ARG A 817
CYH A 849
MET A 852
CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
0.73A47.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens)
5 / 12LEU Q  63
ASN Q  64
LEU Q  66
GLY Q  68
LEU Q  37
None
1.12A9.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
8 / 12LEU A 769
ASN A 770
LEU A 772
GLY A 774
GLN A 776
LEU A 814
ARG A 817
CYH A 849
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
0.84A43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12LEU A 772
GLN A 776
LEU A 814
ARG A 817
CYH A 849
MET A 852
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.7A)
0.98A43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)
5 / 12LEU A 412
LEU A 409
GLY A 603
GLY A 602
LEU A 424
None
0.96A21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
7 / 12ASN A 705
GLY A 708
GLN A 711
MET A 745
ARG A 752
PHE A 764
LEU A 873
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-4.4A)
0.75A51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12GLY A 708
GLN A 711
MET A 745
ARG A 752
PHE A 764
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
0.72A51.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
2ocf ESTROGEN RECEPTOR
(Homo
sapiens)
5 / 12MET A 343
ARG A 394
PHE A 404
MET A 421
LEU A 384
EST  A 596 (-4.8A)
EST  A 596 (-4.0A)
None
EST  A 596 (-4.5A)
None
1.26A15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
7 / 12ASN A 719
GLY A 722
GLN A 725
MET A 759
ARG A 766
MET A 801
LEU A 887
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
0.85A53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
8 / 12ASN A 719
GLY A 722
MET A 759
ARG A 766
PHE A 778
MET A 801
LEU A 887
CYH A 891
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
0.70A53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
9 / 12ASN A 564
GLY A 567
GLN A 570
MET A 604
ARG A 611
PHE A 623
MET A 639
MET A 646
LEU A 732
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
0.69A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
10 / 12ASN A 564
GLY A 567
GLN A 570
TRP A 600
ARG A 611
PHE A 623
MET A 639
MET A 646
LEU A 732
CYH A 736
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
0.70A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12MET A 560
ASN A 564
TRP A 600
MET A 646
LEU A 732
CYH A 736
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
1.00A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
8 / 12ASN A 770
GLN A 776
TRP A 806
ARG A 817
PHE A 829
MET A 852
LEU A 938
CYH A 942
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
0.72A48.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12ASN A 770
GLN A 776
TRP A 806
ARG A 817
PHE A 829
LEU A 938
CYH A 942
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
0.70A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLN A 776
TRP A 806
ARG A 817
MET A 852
LEU A 938
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
1.27A45.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
1uwy CARBOXYPEPTIDASE M
(Homo
sapiens)
4 / 5LEU A 263
LEU A 265
MET A  65
GLN A 249
None
1.22A9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens)
4 / 5LEU A 208
LEU A 224
MET A 139
TYR A 204
LEU  A 208 ( 0.6A)
LEU  A 224 ( 0.6A)
MET  A 139 ( 0.0A)
TYR  A 204 ( 1.3A)
1.44A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens)
4 / 5LEU A 402
LEU A 420
MET A 426
TYR A 394
None
1.42A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens)
4 / 5LEU A 287
LEU A 289
MET A  65
GLN A 273
None
1.24A11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens)
4 / 5LEU A  72
LEU A  76
MET A  97
TYR A  39
None
None
UNX  A 300 (-3.5A)
None
1.35A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)
4 / 5LEU A1027
LEU A1026
MET A1034
TYR A1050
None
1.42A6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens)
4 / 5LEU A 446
LEU A 438
MET A 279
GLN A  65
None
1.34A9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
4akv SORTING NEXIN-33
(Homo
sapiens)
4 / 5LEU A 469
LEU A 465
MET A 545
GLN A 476
None
1.40A12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
4bsn EXPORTIN-1
(Homo
sapiens)
4 / 5LEU A 233
LEU A 230
MET A 213
TYR A 240
None
1.43A6.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
4 / 5LEU A 563
LEU A 566
MET A 601
TYR A 735
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.8A)
1.01A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)
4 / 5LEU A1609
LEU A1612
MET A1373
TYR A1589
None
1.17A4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens)
4 / 5LEU B  51
LEU B  88
MET B 632
GLN B 610
None
1.28A8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)
4 / 5LEU A1609
LEU A1612
MET A1373
TYR A1589
None
1.18A3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
5lub LEGUMAIN
(Homo
sapiens)
4 / 5LEU B 161
LEU B 154
MET B  69
GLN B 111
None
1.20A15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
5vk1 PROTEIN MDM4
(Homo
sapiens)
4 / 5LEU A  85
LEU A  81
MET A  53
TYR A  99
None
1.40A22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens)
4 / 5LEU A 314
LEU A 318
MET A  42
TYR A 178
None
1.34A11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN
(Homo
sapiens)
4 / 5LEU A 161
LEU A 192
MET A 183
TYR A 148
None
1.34A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2
(Homo
sapiens)
4 / 5LEU E 246
LEU E 250
MET E 276
TYR E 241
None
1.46A22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
5 / 12GLY A 708
GLN A 711
ARG A 752
PHE A 764
LEU A 873
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-4.4A)
0.69A51.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)
6 / 12LEU A 704
GLY A 708
GLN A 711
ARG A 752
PHE A 764
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
0.70A51.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
2ebz REGULATOR OF
G-PROTEIN SIGNALING
12
(Homo
sapiens)
5 / 12LEU A  23
GLY A  28
PHE A  19
MET A 117
LEU A  36
None
1.27A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
2ocf ESTROGEN RECEPTOR
(Homo
sapiens)
5 / 12MET A 343
LEU A 346
ARG A 394
PHE A 404
LEU A 384
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 (-4.0A)
None
None
1.11A15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
2ocf ESTROGEN RECEPTOR
(Homo
sapiens)
5 / 12MET A 343
LEU A 346
TRP A 383
ARG A 394
PHE A 404
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
EST  A 596 (-4.0A)
None
0.81A15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
2wl8 PEROXISOMAL
BIOGENESIS FACTOR 19
(Homo
sapiens)
5 / 12LEU A 268
GLY A 270
GLN A 221
MET A 225
LEU A 258
None
1.26A23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
3d8b FIDGETIN-LIKE
PROTEIN 1
(Homo
sapiens)
5 / 12MET A 608
LEU A 611
ARG A 649
PHE A 648
LEU A 588
None
1.43A14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
3gf9 INTERSECTIN 2
(Homo
sapiens)
5 / 12LEU A1319
GLY A1283
PHE A1226
MET A1211
LEU A1301
UNX  A   3 (-4.5A)
UNX  A   3 (-3.4A)
None
None
None
1.29A17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
6 / 12GLY A 722
GLN A 725
ARG A 766
PHE A 778
MET A 801
LEU A 887
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
0.68A53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 718
GLY A 722
ARG A 766
PHE A 778
MET A 801
LEU A 887
CYH A 891
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
0.52A53.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)
5 / 12GLY A 377
GLN A 380
PHE A 314
GLN A 526
LEU A 529
None
1.49A9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2
(Homo
sapiens)
5 / 12MET B 218
LEU B 215
GLY B 213
ARG A 407
PHE B 245
None
1.49A8.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
10 / 12LEU A 563
GLY A 567
GLN A 570
VAL A 571
TRP A 600
ARG A 611
PHE A 623
MET A 646
LEU A 732
CYH A 736
MOF  A 801 (-3.9A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
0.63A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
6 / 12MET A 560
VAL A 571
TRP A 600
MET A 646
LEU A 732
CYH A 736
MOF  A 801 (-3.9A)
None
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
0.92A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12TRP A 600
GLN A 642
MET A 646
LEU A 732
CYH A 736
None
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
0.99A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
8 / 12LEU A 769
GLN A 776
TRP A 806
ARG A 817
PHE A 829
MET A 852
LEU A 938
CYH A 942
CV7  A1987 (-4.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
0.58A48.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
4wmh HEME OXYGENASE 2
(Homo
sapiens)
5 / 12MET A 158
LEU A 161
GLY A 164
GLN A 165
VAL A 166
None
1.17A15.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
5 / 12GLN A 776
TRP A 806
ARG A 817
MET A 852
LEU A 938
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
1.25A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)
7 / 12LEU A 769
GLN A 776
TRP A 806
ARG A 817
PHE A 829
LEU A 938
CYH A 942
ECV  A1101 (-4.7A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
0.60A45.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens)
5 / 12LEU A 191
GLY A 308
GLN A 363
PHE A 206
LEU A 301
None
1.34A11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
4igg CATENIN ALPHA-1
(Homo
sapiens)
4 / 4ASN A 791
MET A 723
MET A 726
TYR A 786
None
0.94A7.21