POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens)
5 / 12ASP L 330
HIS L 334
PHE L 328
ILE L 282
ALA L 269
None
1.31A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
5 / 12GLY A1053
PHE A1135
ALA A1061
GLN A1071
HIS A1057
None
1.35A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens)
5 / 12GLY A 202
ASP A 196
PHE A 476
ILE A 198
ALA A 470
None
1.41A15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
2rhp THROMBOSPONDIN-2
(Homo
sapiens)
5 / 12GLY A1073
PHE A1155
ALA A1081
GLN A1091
HIS A1077
None
1.30A12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
2yro GALECTIN-8
(Homo
sapiens)
5 / 12GLY A  28
ILE A 132
ALA A  59
PHE A 126
HIS A 124
None
1.09A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
3ouh EGL NINE HOMOLOG 1
(Homo
sapiens)
5 / 12GLY A 238
ASP A 237
ILE A 256
ALA A 301
PHE A 235
None
1.34A23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
3zyj NETRIN-G1
(Homo
sapiens)
5 / 12ASP B 237
PHE B 266
PHE B 267
ILE B 235
PHE B 233
None
1.37A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
4ydh FORMIN-LIKE PROTEIN
1
(Homo
sapiens)
5 / 12ASP A 287
HIS A 286
PHE A 329
ALA A 258
PHE A 293
None
1.37A15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens)
5 / 12GLY A 422
HIS A 426
PHE A 468
PHE A 329
GLN A 596
None
FZ4  A 801 ( 2.5A)
None
None
None
1.41Aundetectable