POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		3 / 3GLN A  91
HIS A  95
ARG C 239
HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
0.37A38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		3 / 3GLN A  50
HIS A  78
ARG A  87
None
1.08A17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens)		3 / 3GLN A 383
HIS A 386
ARG A 381
None
1.27A19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens)		3 / 3GLN B 212
HIS B 211
ARG B 166
None
1.30A18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		3 / 3GLN A 632
HIS A 619
ARG A 622
None
1.06A22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		3hhr HUMAN GROWTH HORMONE
HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens)		3 / 3GLN A  22
HIS A  18
ARG B 217
None
1.20A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		3q06 CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens)		3 / 3GLN A 167
HIS A 168
ARG A 249
None
0.87A17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens)		3 / 3GLN A 168
HIS A 121
ARG A 120
None
0.71A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens)		3 / 3GLN A 397
HIS A 443
ARG A 446
None
1.24A22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME
(Homo
sapiens)		3 / 3GLN A 566
HIS A 545
ARG A 565
None
1.20A20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens)		3 / 3GLN A 443
HIS A 444
ARG A 410
None
0.89A9.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		3 / 3GLN A 257
HIS A 261
ARG A 405
HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
0.36A49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens)		3 / 3GLN C 737
HIS C 738
ARG C 702
None
1.16A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		3 / 3GLN A 257
HIS A 261
ARG A 405
None
0.50A11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens)		3 / 3GLN C 737
HIS C 738
ARG C 702
None
1.03A10.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		3 / 3GLN A  91
HIS A  95
ARG C 239
HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
0.31A38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		3 / 3GLN A  50
HIS A  78
ARG A  87
None
0.97A17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens)		3 / 3GLN A 383
HIS A 386
ARG A 381
None
1.18A19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		3 / 3GLN A 632
HIS A 619
ARG A 622
None
1.10A22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		3hhr HUMAN GROWTH HORMONE
HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens)		3 / 3GLN A  22
HIS A  18
ARG B 217
None
1.20A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		3q06 CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens)		3 / 3GLN A 167
HIS A 168
ARG A 249
None
0.88A17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens)		3 / 3GLN A 168
HIS A 121
ARG A 120
None
0.65A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens)		3 / 3GLN A 397
HIS A 443
ARG A 446
None
1.25A22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME
(Homo
sapiens)		3 / 3GLN A 566
HIS A 545
ARG A 565
None
1.18A20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens)		3 / 3GLN A 443
HIS A 444
ARG A 410
None
0.86A9.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		3 / 3GLN A 257
HIS A 261
ARG A 405
HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
0.30A49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens)		3 / 3GLN C 737
HIS C 738
ARG C 702
None
1.13A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		3 / 3GLN A 257
HIS A 261
ARG A 405
None
0.43A11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens)		3 / 3GLN C 737
HIS C 738
ARG C 702
None
0.98A10.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		6 / 6GLN A  91
ASP A  94
HIS A  95
ARG C 239
GLU C 242
ARG C 333
HEM  A 605 ( 3.4A)
HEM  A 605 (-2.1A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-2.9A)
0.40A38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		4 / 6GLN A 297
ASP A 349
ARG A 301
GLU A 298
None
1.22A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11
(Homo
sapiens)		4 / 6GLN A 202
ASP A 205
HIS A 142
ARG A 149
None
1.40A21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		5 / 6GLN A 257
ASP A 260
HIS A 261
ARG A 405
ARG A 499
HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
0.38A49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		5 / 6GLN A 257
ASP A 260
HIS A 261
GLU A 408
ARG A 499
HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-4.2A)
HEM  A 812 (-2.8A)
1.06A49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 6GLN A3667
ASP A3666
ARG A3620
GLU A3624
None
1.48A8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		5oym PC4 AND
SFRS1-INTERACTING
PROTEIN
(Homo
sapiens)		4 / 6GLN H 353
HIS H 393
GLU H 345
ARG H 351
None
0.93A9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		5 / 6GLN A 257
ASP A 260
HIS A 261
ARG A 405
ARG A 499
None
0.58A11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		5 / 6GLN A 257
ASP A 260
HIS A 261
GLU A 408
ARG A 499
None
1.09A11.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYQ_D_3CJD607_1
(LACTOPEROXIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		4 / 4GLN A  91
HIS A  95
ARG C 239
GLU C 242
HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
0.34A38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_D_3CJD607_1
(LACTOPEROXIDASE)		2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens)		4 / 4GLN A 479
HIS A 519
ARG A 521
GLU A 525
None
1.49A20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		5 / 5GLN A  91
HIS A  95
ARG C 239
GLU C 242
ARG C 333
HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-2.9A)
0.47A38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		4 / 5GLN A 257
HIS A 261
ARG A 405
ARG A 499
HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
0.38A49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		4 / 5GLN A 257
HIS A 261
GLU A 408
ARG A 499
HEM  A 812 (-3.3A)
None
HEM  A 812 (-4.2A)
HEM  A 812 (-2.8A)
1.09A49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		5oym PC4 AND
SFRS1-INTERACTING
PROTEIN
(Homo
sapiens)		4 / 5GLN H 353
HIS H 393
GLU H 345
ARG H 351
None
0.89A9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		4 / 5GLN A 257
HIS A 261
ARG A 405
ARG A 499
None
0.54A11.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_B_3CJB609_1
(LACTOPEROXIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		4 / 4GLN A  91
HIS A  95
ARG C 239
ARG C 333
HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.9A)
0.32A38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_B_3CJB609_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		4 / 4GLN A 257
HIS A 261
ARG A 405
ARG A 499
HEM  A 812 (-3.3A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
0.33A49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_B_3CJB609_1
(LACTOPEROXIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		4 / 4GLN A 257
HIS A 261
ARG A 405
ARG A 499
None
0.51A11.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		6 / 6GLN A  91
ASP A  94
HIS A  95
ARG C 239
GLU C 242
ARG C 333
HEM  A 605 ( 3.4A)
HEM  A 605 (-2.1A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-2.9A)
0.40A38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		4 / 6GLN A 297
ASP A 349
ARG A 301
GLU A 298
None
1.22A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11
(Homo
sapiens)		4 / 6GLN A 202
ASP A 205
HIS A 142
ARG A 149
None
1.40A21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		5 / 6GLN A 257
ASP A 260
HIS A 261
ARG A 405
ARG A 499
HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-3.7A)
HEM  A 812 (-2.8A)
0.38A49.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		5 / 6GLN A 257
ASP A 260
HIS A 261
GLU A 408
ARG A 499
HEM  A 812 (-3.3A)
HEM  A 812 (-1.1A)
None
HEM  A 812 (-4.2A)
HEM  A 812 (-2.8A)
1.06A49.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 6GLN A3667
ASP A3666
ARG A3620
GLU A3624
None
1.48A8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		5oym PC4 AND
SFRS1-INTERACTING
PROTEIN
(Homo
sapiens)		4 / 6GLN H 353
HIS H 393
GLU H 345
ARG H 351
None
0.93A9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		5 / 6GLN A 257
ASP A 260
HIS A 261
ARG A 405
ARG A 499
None
0.58A11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		5 / 6GLN A 257
ASP A 260
HIS A 261
GLU A 408
ARG A 499
None
1.09A11.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HPW_D_3CJD609_1
(LACTOPEROXIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		4 / 4GLN A  91
HIS A  95
ARG C 239
GLU C 242
HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
0.34A38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_D_3CJD609_1
(LACTOPEROXIDASE)		2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens)		4 / 4GLN A 479
HIS A 519
ARG A 521
GLU A 525
None
1.49A20.40