POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1ni6 HEME OXYGENASE 1
(Homo
sapiens)		4 / 5GLU A  66
GLU A  62
TYR A 137
TYR A  78
None
1.14A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens)		4 / 5GLU A 107
GLU A 147
TYR A  54
TYR A  34
None
1.41A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens)		4 / 5GLU A 147
GLU A 107
TYR A  34
TYR A  54
None
1.31A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2bzn GMP REDUCTASE 2
(Homo
sapiens)		4 / 5GLU A 204
GLU A 163
TYR A 134
TYR A 196
None
1.33A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens)		4 / 5GLU A 220
GLU A 330
TYR A 299
PHE A 336
None
1.36A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens)		4 / 5GLU A 302
TYR A 325
PHE A 230
TYR A 336
None
1.25A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens)		4 / 5GLU A  39
TYR A 199
PHE A 275
TYR A 303
None
1.46A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens)		4 / 5GLU A  36
TYR A 196
PHE A 272
TYR A 300
None
1.50A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1tnn TITIN MODULE M5
(Homo
sapiens)		5 / 9ALA A  44
SER A  41
ALA A  64
SER A  65
SER A  61
None
1.18A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1tnn TITIN MODULE M5
(Homo
sapiens)		5 / 9SER A  61
ALA A  44
SER A  41
ALA A  64
SER A  65
None
1.18A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2nn6 EXOSOME COMPONENT 6
(Homo
sapiens)		5 / 9ALA F 157
SER F 156
ALA F 161
ALA F 164
ALA F  57
None
1.32A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3h1v GLUCOKINASE
(Homo
sapiens)		5 / 9ALA X 201
ALA X 456
ALA X 454
ALA X 449
SER X  76
None
TK1  X 501 ( 4.5A)
None
None
None
1.21A18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3j7y MS30
(Homo
sapiens)		5 / 9ALA s 330
ALA s 328
ALA s 359
SER s 357
ALA s 334
None
1.12A21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5jhw FOLLISTATIN
(Homo
sapiens)		5 / 9ALA C 256
SER C 257
ALA C 260
ALA C 271
SER C 275
None
1.34A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens)		5 / 9ALA A 333
ALA A  87
ALA A  83
SER A  81
ALA A 336
None
1.30A19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens)		4 / 5TYR A  34
GLU A 107
GLU A 147
TYR A  54
None
1.48A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens)		4 / 5TYR A  54
GLU A 147
GLU A 107
TYR A  34
None
1.33A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2bzn GMP REDUCTASE 2
(Homo
sapiens)		4 / 5TYR A 196
GLU A 204
GLU A 163
TYR A 134
None
1.38A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens)		4 / 5GLU A 220
GLU A 330
TYR A 299
PHE A 336
None
1.31A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens)		4 / 5TYR A 303
GLU A  39
TYR A 199
PHE A 275
None
1.48A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5y6o DEATH
DOMAIN-ASSOCIATED
PROTEIN
6,TRANSCRIPTIONAL
REGULATOR ATRX
(Homo
sapiens)		4 / 5GLU A  72
GLU A  68
TYR A  89
PHE A  67
None
1.27A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens)		4 / 6TYR A2316
GLU A2324
TYR A2275
LEU A2292
None
1.32A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2cq4 RNA BINDING MOTIF
PROTEIN 23
(Homo
sapiens)		4 / 6ASN A 186
GLU A 228
TYR A 195
PHE A 153
None
1.19A16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 6ASN A2470
GLU A2243
TYR A2348
PHE A2242
None
1.18A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3k9b LIVER
CARBOXYLESTERASE 1
(Homo
sapiens)		4 / 6TYR A1152
ASN A1103
GLU A1246
LEU A1157
None
1.01A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 6TYR A 140
TYR A 132
LEU A 133
PHE A 102
None
1.07A22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 6GLU A 428
TYR A 568
LEU A 572
PHE A 474
None
0.98A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 6GLU A 428
TYR A 568
LEU A 572
PHE A 474
None
0.99A20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN
(Escherichia
virus
T4;
Homo
sapiens)		4 / 6TYR A 403
ASN A 404
TYR A 104
PHE A 181
QNB  A1162 (-3.9A)
QNB  A1162 (-2.9A)
QNB  A1162 (-4.0A)
QNB  A1162 (-4.4A)
1.26A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ASN A 421
GLU A 414
TYR A 441
LEU A 442
None
1.30A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		4 / 6TYR A 149
TYR A 141
LEU A 142
PHE A 111
None
1.05A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 6GLU A 663
TYR A 592
LEU A 596
PHE A 666
None
1.28A16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens)		4 / 6ASN A 639
GLU A 419
TYR A 594
LEU A 697
None
1.31A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		4 / 6TYR A 469
TYR A 525
LEU A 476
PHE A 593
None
1.20A20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens)		4 / 6ASN B4102
TYR B4078
LEU B4080
PHE B4027
None
1.29A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens)		4 / 6GLU C 277
TYR C 296
LEU C 317
PHE C 289
None
1.14A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens)		4 / 6TYR A 438
TYR A 494
LEU A 445
PHE A 562
None
1.23A13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens)		4 / 6TYR A 454
TYR A 510
LEU A 461
PHE A 578
None
1.18A11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3nr5 REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION MAF1
HOMOLOG
(Homo
sapiens)		4 / 5ASN A  54
GLU A  70
TYR A 121
PHE A  71
None
1.48A18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN
(Escherichia
virus
T4;
Homo
sapiens)		4 / 5TYR A 403
ASN A 404
TYR A 104
PHE A 181
QNB  A1162 (-3.9A)
QNB  A1162 (-2.9A)
QNB  A1162 (-4.0A)
QNB  A1162 (-4.4A)
1.31A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens)		4 / 5TYR A 303
GLU A  39
TYR A 199
PHE A 275
None
1.43A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens)		4 / 5TYR A 300
GLU A  36
TYR A 196
PHE A 272
None
1.46A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 5ASN A2470
GLU A2243
TYR A2348
PHE A2242
None
1.08A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1itu RENAL DIPEPTIDASE
(Homo
sapiens)		4 / 6TYR A 141
GLU A 338
LEU A 121
PHE A 334
None
1.30A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens)		4 / 6TYR A2316
GLU A2324
TYR A2275
LEU A2292
None
1.30A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens)		4 / 6TYR A 330
TYR A 115
LEU A 120
PHE A 170
None
1.19A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)		4 / 6TYR A 903
ASN A 906
GLU A 922
TYR A1197
None
1.23A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2cq4 RNA BINDING MOTIF
PROTEIN 23
(Homo
sapiens)		4 / 6ASN A 186
GLU A 228
TYR A 195
PHE A 153
None
1.20A16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 6ASN A2470
GLU A2243
TYR A2348
PHE A2242
None
1.14A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3k9b LIVER
CARBOXYLESTERASE 1
(Homo
sapiens)		4 / 6TYR A1152
ASN A1103
GLU A1246
LEU A1157
None
0.98A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 6TYR A 140
TYR A 132
LEU A 133
PHE A 102
None
1.02A22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 6GLU A 428
TYR A 568
LEU A 572
PHE A 474
None
1.06A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 6GLU A 428
TYR A 568
LEU A 572
PHE A 474
None
1.06A20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ASN A 421
GLU A 414
TYR A 441
LEU A 442
None
1.25A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		4 / 6TYR A 149
TYR A 141
LEU A 142
PHE A 111
None
1.00A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 6GLU A 663
TYR A 592
LEU A 596
PHE A 666
None
1.26A16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		4 / 6TYR A 469
TYR A 525
LEU A 476
PHE A 593
None
1.13A20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 6ASN A2470
GLU A2243
TYR A2348
PHE A2242
None
1.13A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens)		4 / 6ASN B4102
TYR B4078
LEU B4080
PHE B4027
None
1.27A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens)		4 / 6GLU C 277
TYR C 296
LEU C 317
PHE C 289
None
1.15A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		4 / 6TYR A 438
TYR A 494
LEU A 445
PHE A 562
None
1.20A16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens)		4 / 6TYR A 438
TYR A 494
LEU A 445
PHE A 562
None
1.17A13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens)		4 / 6TYR A 454
TYR A 510
LEU A 461
PHE A 578
None
1.12A11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE
(Homo
sapiens)		4 / 6ASN A 624
GLU A 533
TYR A 538
LEU A 621
None
1.00A12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens)		4 / 7GLU A  24
TYR A  77
LEU A  16
ARG A  46
None
1.15A16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens)		4 / 7GLU A2324
TYR A2275
LEU A2292
TYR A2316
None
1.19A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6A
(Homo
sapiens)		4 / 7GLU B  61
GLU B  62
TYR B  93
LEU B  85
None
1.15A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3b6u KINESIN-LIKE PROTEIN
KIF3B
(Homo
sapiens)		4 / 7GLU A 107
TYR A 144
LEU A 156
PHE A 219
None
1.20A24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens)		4 / 7GLU A 302
TYR A 325
PHE A 230
TYR A 336
None
1.20A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 7TYR A 132
LEU A 133
PHE A 102
TYR A 140
None
1.15A22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 7GLU A 428
TYR A 568
LEU A 572
PHE A 474
None
1.13A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 7GLU A 428
TYR A 568
LEU A 572
PHE A 474
None
1.11A20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4o27 CALCIUM-BINDING
PROTEIN 39
SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens)		4 / 7GLU B  61
GLU B  58
TYR A 223
LEU B  90
None
1.10A19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		4 / 7TYR A 141
LEU A 142
PHE A 111
TYR A 149
None
1.13A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4zcv CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
SCAMC-1
(Homo
sapiens)		4 / 7GLU A  88
LEU A  31
PHE A 153
TYR A  24
None
1.08A18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		4 / 7TYR A 525
LEU A 476
PHE A 593
TYR A 469
None
1.16A20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 7GLU A 394
GLU A 393
TYR A 372
LEU A 376
None
1.13A17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens)		4 / 7GLU A 654
TYR A 660
LEU B  73
PHE A 608
None
1.18A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens)		4 / 7GLU C 277
TYR C 296
LEU C 317
PHE C 289
None
1.10A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		4 / 7TYR A 494
LEU A 445
PHE A 562
TYR A 438
None
1.20A16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens)		4 / 7TYR A 494
LEU A 445
PHE A 562
TYR A 438
None
1.18A13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens)		4 / 7TYR A 510
LEU A 461
PHE A 578
TYR A 454
None
1.18A11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1as4 ANTICHYMOTRYPSIN
(Homo
sapiens)		4 / 8ALA A 117
ALA A 350
SER A  56
ALA A 352
None
0.79A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens)		4 / 8ALA A 224
SER A 257
ALA A 111
SER A 105
None
0.76A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens)		4 / 8ALA B  93
ALA B  89
ALA B 127
ALA B 124
None
0.72A12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens)		4 / 8ALA B 127
ALA B 124
ALA B  93
ALA B  89
None
0.77A12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens)		5 / 8ALA B 128
ALA B 124
ALA B  93
ALA B  89
ALA B  87
None
1.32A12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens)		4 / 6ARG A  46
GLU A  24
TYR A  77
LEU A  16
None
1.09A16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens)		4 / 6TYR A 144
TYR A 163
LEU A 118
PHE A 124
None
1.35A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1itu RENAL DIPEPTIDASE
(Homo
sapiens)		4 / 6TYR A 141
GLU A 338
LEU A 121
PHE A 334
None
1.28A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens)		4 / 6TYR A2316
GLU A2324
TYR A2275
LEU A2292
None
1.12A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 6TYR A 140
TYR A 132
LEU A 133
PHE A 102
None
1.10A22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens)		4 / 6TYR B  30
ARG B 269
TYR B 279
LEU B 282
None
1.27A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3qfv CDC42BPB PROTEIN
(Homo
sapiens)		4 / 6ARG A 412
GLU A 406
TYR A 141
LEU A 139
None
1.35A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4cak INTEGRIN BETA-3
(Homo
sapiens)		4 / 6TYR B 289
TYR B 321
LEU B 292
PHE B 308
None
1.35A18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4ij3 SULFHYDRYL OXIDASE 1
(Homo
sapiens)		4 / 6GLU A  64
TYR A  36
LEU A  44
PHE A  66
None
1.35A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 6GLU A 888
TYR A 895
LEU A 900
PHE A 892
None
1.35A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		4 / 6TYR A 149
TYR A 141
LEU A 142
PHE A 111
None
1.08A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6ARG A  87
TYR A 216
LEU A 211
PHE A  80
None
1.27A24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 6GLU A 663
TYR A 592
LEU A 596
PHE A 666
None
1.32A16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		4 / 6TYR A 469
TYR A 525
LEU A 476
PHE A 593
None
1.16A20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens)		4 / 6GLU A 654
TYR A 660
LEU B  73
PHE A 608
None
1.15A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens)		4 / 6GLU C 277
TYR C 296
LEU C 317
PHE C 289
None
1.08A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		4 / 6TYR A 438
TYR A 494
LEU A 445
PHE A 562
None
1.22A16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens)		4 / 6TYR A 438
TYR A 494
LEU A 445
PHE A 562
None
1.20A13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens)		4 / 6TYR A 454
TYR A 510
LEU A 461
PHE A 578
None
1.18A11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens)		4 / 6TYR A  34
GLU A 107
GLU A 147
TYR A  54
None
1.46A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1r03 MITOCHONDRIAL
FERRITIN
(Homo
sapiens)		4 / 6TYR A  54
GLU A 147
GLU A 107
TYR A  34
None
1.33A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2bzn GMP REDUCTASE 2
(Homo
sapiens)		4 / 6TYR A 134
GLU A 163
GLU A 204
TYR A 196
None
1.49A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2bzn GMP REDUCTASE 2
(Homo
sapiens)		4 / 6TYR A 196
GLU A 204
GLU A 163
TYR A 134
None
1.36A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens)		4 / 6GLU A 220
GLU A 330
TYR A 299
PHE A 336
None
1.32A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 6ASN A2470
GLU A2243
TYR A2348
PHE A2242
None
1.18A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3nr5 REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION MAF1
HOMOLOG
(Homo
sapiens)		4 / 6ASN A  54
GLU A  70
TYR A 121
PHE A  71
None
1.46A18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN
(Escherichia
virus
T4;
Homo
sapiens)		4 / 6TYR A 403
ASN A 404
TYR A 104
PHE A 181
QNB  A1162 (-3.9A)
QNB  A1162 (-2.9A)
QNB  A1162 (-4.0A)
QNB  A1162 (-4.4A)
1.32A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 6ASN A2470
GLU A2243
TYR A2348
PHE A2242
None
1.17A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5jk7 PROTEIN VPRBP
URACIL-DNA
GLYCOSYLASE
(Homo
sapiens)		4 / 6TYR C1131
ASN C1132
GLU C1127
TYR D 116
None
1.45A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5y6o DEATH
DOMAIN-ASSOCIATED
PROTEIN
6,TRANSCRIPTIONAL
REGULATOR ATRX
(Homo
sapiens)		4 / 6GLU A  72
GLU A  68
TYR A  89
PHE A  67
None
1.23A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1ebp EPO RECEPTOR
(Homo
sapiens)		4 / 5TYR A 109
GLU A  24
GLU A  42
TYR A  53
None
1.34A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2bzn GMP REDUCTASE 2
(Homo
sapiens)		4 / 5TYR A 196
GLU A 204
GLU A 163
TYR A 134
None
1.33A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens)		4 / 5GLU A 220
GLU A 330
TYR A 299
PHE A 336
None
1.31A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens)		4 / 5TYR A 303
GLU A  39
TYR A 199
PHE A 275
None
1.46A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens)		4 / 5TYR A 300
GLU A  36
TYR A 196
PHE A 272
None
1.49A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1d5v S12 TRANSCRIPTION
FACTOR (FKH-14)
(Homo
sapiens)		4 / 6ASN A  19
TYR A   7
LEU A  12
PHE A  38
None
1.31A16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens)		4 / 6TYR A 330
TYR A 115
LEU A 120
PHE A 170
None
0.98A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3k9b LIVER
CARBOXYLESTERASE 1
(Homo
sapiens)		4 / 6TYR A1152
ASN A1103
GLU A1246
LEU A1157
None
0.93A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 6TYR A 140
TYR A 132
LEU A 133
PHE A 102
None
1.15A22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN
(Escherichia
virus
T4;
Homo
sapiens)		4 / 6TYR A 403
ASN A 404
TYR A 104
PHE A 181
QNB  A1162 (-3.9A)
QNB  A1162 (-2.9A)
QNB  A1162 (-4.0A)
QNB  A1162 (-4.4A)
1.31A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens)		4 / 6TYR A 401
TYR A 192
LEU A 197
PHE A 247
None
1.07A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 6GLU A 888
TYR A 895
LEU A 900
PHE A 892
None
1.27A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ASN A 421
GLU A 414
TYR A 441
LEU A 442
None
1.13A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens)		4 / 6ASN A 867
GLU A 929
LEU A 872
PHE A 932
None
1.31A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		4 / 6TYR A 149
TYR A 141
LEU A 142
PHE A 111
None
1.13A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 6GLU A 663
TYR A 592
LEU A 596
PHE A 666
None
1.26A16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens)		4 / 6ASN A 639
GLU A 419
TYR A 594
LEU A 697
None
1.31A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL
(Escherichia
virus
T4;
Homo
sapiens)		4 / 6ASN A   2
GLU A  64
LEU A   7
PHE A  67
None
1.27A24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		4 / 6TYR A 469
TYR A 525
LEU A 476
PHE A 593
None
1.16A20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens)		4 / 6GLU A 654
TYR A 660
LEU B  73
PHE A 608
None
1.10A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens)		4 / 6GLU A 342
TYR A 338
LEU A 362
PHE A 356
None
1.25A13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		4 / 6GLU A 150
TYR A  70
LEU A 443
PHE A 155
None
1.03A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens)		4 / 6GLU C 277
TYR C 296
LEU C 317
PHE C 289
None
1.14A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		4 / 6TYR A 438
TYR A 494
LEU A 445
PHE A 562
None
1.20A16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens)		4 / 6TYR A 438
TYR A 494
LEU A 445
PHE A 562
None
1.19A13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens)		4 / 6TYR A 454
TYR A 510
LEU A 461
PHE A 578
None
1.20A11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE
(Homo
sapiens)		4 / 6ASN A 624
GLU A 533
TYR A 538
LEU A 621
None
1.04A12.97