POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	10 / 12	GLU A 203 GLU A 204 TRP A 623 SER A 624 TYR A 625 VAL A 650 TYR A 656 TYR A 660 VAL A 705 HIS A 734	None	0.49A	53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	8 / 12	GLU A 203 GLU A 204 TYR A 541 SER A 624 TYR A 625 VAL A 650 TYR A 656 TYR A 660	None	0.75A	53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	7 / 12	PHE A 350 TRP A 623 SER A 624 TYR A 625 VAL A 650 TYR A 660 HIS A 734	None	0.94A	53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	6 / 12	PHE A 350 TYR A 541 SER A 624 TYR A 625 VAL A 650 TYR A 660	None	1.14A	53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	5 / 12	TRP A 623 TYR A 628 TYR A 656 VAL A 705 HIS A 734	None	1.13A	53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	2g5t	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	11 / 12	GLU A 205 GLU A 206 PHE A 357 TRP A 629 SER A 630 TYR A 631 VAL A 656 TYR A 662 TYR A 666 VAL A 711 HIS A 740	ACF  A 800 (-3.6A) ACF  A 800 (-3.2A) None None ACF  A 800 (-1.3A) None None ACF  A 800 (-4.1A) ACF  A 800 (-3.3A) None None	0.25A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	2g5t	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	11 / 12	GLU A 205 GLU A 206 PHE A 357 TYR A 547 TRP A 629 SER A 630 TYR A 631 VAL A 656 TYR A 662 TYR A 666 HIS A 740	ACF  A 800 (-3.6A) ACF  A 800 (-3.2A) None ACF  A 800 (-4.5A) None ACF  A 800 (-1.3A) None None ACF  A 800 (-4.1A) ACF  A 800 (-3.3A) None	0.49A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	2g5t	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	5 / 12	GLU A 206 SER A 630 VAL A 656 TYR A 662 VAL A 711	ACF  A 800 (-3.2A) ACF  A 800 (-1.3A) None ACF  A 800 (-4.1A) None	1.24A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	2g5t	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	5 / 12	GLU A 206 TYR A 547 SER A 630 VAL A 656 TYR A 662	ACF  A 800 (-3.2A) ACF  A 800 (-4.5A) ACF  A 800 (-1.3A) None ACF  A 800 (-4.1A)	1.35A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	4wjl	INACTIVE DIPEPTIDYL PEPTIDASE 10 (Homo sapiens)	6 / 12	GLU A 233 GLU A 234 TYR A 652 TYR A 683 VAL A 730 HIS A 759	None	0.68A	36.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	5vbb	RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 12	GLU A 109 SER A 162 VAL A 164 VAL A 150 HIS A 153	None	1.33A	18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	6eoq	DIPEPTIDYL PEPTIDASE 9 (Homo sapiens)	8 / 12	GLU A 249 SER A 730 TYR A 731 VAL A 756 TYR A 762 TYR A 766 VAL A 811 HIS A 840	None	0.58A	6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	6eoq	DIPEPTIDYL PEPTIDASE 9 (Homo sapiens)	5 / 12	GLU A 249 TYR A 644 TYR A 731 TYR A 762 TYR A 766	None	0.62A	6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	6eot	DIPEPTIDYL PEPTIDASE 8 (Homo sapiens)	10 / 12	GLU A 275 GLU A 276 TYR A 669 SER A 755 TYR A 756 VAL A 781 TYR A 787 TYR A 791 VAL A 836 HIS A 865	None	0.56A	8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	6eot	DIPEPTIDYL PEPTIDASE 8 (Homo sapiens)	6 / 12	GLU A 275 TYR A 669 SER A 755 VAL A 781 TYR A 787 VAL A 836	None	1.19A	8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_A_356A901_1 (DIPEPTIDYL PEPTIDASE 4)	6eot	DIPEPTIDYL PEPTIDASE 8 (Homo sapiens)	5 / 12	SER A 755 TYR A 759 TYR A 787 VAL A 836 HIS A 865	None	1.09A	8.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	10 / 11	GLU A 203 GLU A 204 TRP A 623 SER A 624 TYR A 625 VAL A 650 TYR A 656 TYR A 660 VAL A 705 HIS A 734	None	0.47A	53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	7 / 11	GLU A 203 GLU A 204 TYR A 541 TYR A 625 VAL A 650 TYR A 656 TYR A 660	None	0.75A	53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	5 / 11	TRP A 623 TYR A 628 TYR A 656 VAL A 705 HIS A 734	None	1.11A	53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	2g5t	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	11 / 11	GLU A 205 GLU A 206 TYR A 547 TRP A 629 SER A 630 TYR A 631 VAL A 656 TYR A 662 TYR A 666 VAL A 711 HIS A 740	ACF  A 800 (-3.6A) ACF  A 800 (-3.2A) ACF  A 800 (-4.5A) None ACF  A 800 (-1.3A) None None ACF  A 800 (-4.1A) ACF  A 800 (-3.3A) None None	0.47A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	2g5t	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	5 / 11	TRP A 629 TYR A 634 TYR A 662 VAL A 711 HIS A 740	None None ACF  A 800 (-4.1A) None None	1.11A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	4wjl	INACTIVE DIPEPTIDYL PEPTIDASE 10 (Homo sapiens)	5 / 11	GLU A 233 TYR A 652 TYR A 683 VAL A 730 HIS A 759	None	0.63A	36.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	4wjl	INACTIVE DIPEPTIDYL PEPTIDASE 10 (Homo sapiens)	5 / 11	GLU A 234 TYR A 652 TYR A 683 VAL A 730 HIS A 759	None	0.57A	36.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	5vbb	RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 11	GLU A 109 SER A 162 VAL A 164 VAL A 150 HIS A 153	None	1.32A	18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	6eoq	DIPEPTIDYL PEPTIDASE 9 (Homo sapiens)	8 / 11	GLU A 249 SER A 730 TYR A 731 VAL A 756 TYR A 762 TYR A 766 VAL A 811 HIS A 840	None	0.50A	6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	6eoq	DIPEPTIDYL PEPTIDASE 9 (Homo sapiens)	5 / 11	GLU A 249 TYR A 644 TYR A 731 TYR A 762 TYR A 766	None	0.60A	6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	6eot	DIPEPTIDYL PEPTIDASE 8 (Homo sapiens)	10 / 11	GLU A 275 GLU A 276 TYR A 669 SER A 755 TYR A 756 VAL A 781 TYR A 787 TYR A 791 VAL A 836 HIS A 865	None	0.54A	8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	6eot	DIPEPTIDYL PEPTIDASE 8 (Homo sapiens)	6 / 11	GLU A 275 TYR A 669 SER A 755 VAL A 781 TYR A 787 VAL A 836	None	1.18A	8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RGU_B_356B902_1 (DIPEPTIDYL PEPTIDASE 4)	6eot	DIPEPTIDYL PEPTIDASE 8 (Homo sapiens)	5 / 11	SER A 755 TYR A 759 TYR A 787 VAL A 836 HIS A 865	None	1.12A	8.24