POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		1as4 ANTICHYMOTRYPSIN
(Homo
sapiens)		4 / 6GLY A 139
ASN A 116
LEU A 100
ASN A 104
None
1.02A23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		1mwp AMYLOID A4 PROTEIN
(Homo
sapiens)		4 / 6PRO A  56
GLY A  58
LEU A  41
ASN A  42
None
0.92A17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE
(Homo
sapiens)		4 / 6GLY A 230
LEU A 310
ASN A 307
GLU A 303
None
None
None
AOG  A 452 (-2.6A)
1.00A21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 6PRO A 723
GLY A 724
ASN A 727
LEU A 830
ASN A 833
None
1.00A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 6PRO A 723
GLY A 724
LEU A 830
ASN A 833
GLU A 837
None
0.55A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		2diw PUTATIVE RNA-BINDING
PROTEIN 16
(Homo
sapiens)		4 / 6PRO A  70
GLY A  71
LEU A 108
GLU A  66
None
1.02A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens)		4 / 6PRO B2171
LEU B2162
ASN B2163
GLU B2165
None
0.99A14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		2qdj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens)		4 / 6GLY A 100
LEU A 120
ASN A 123
GLU A 125
None
0.75A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		3be8 NEUROLIGIN-4,
X-LINKED
(Homo
sapiens)		4 / 6GLY A  68
LEU A  62
ASN A  64
GLU A  65
 NA  A 626 ( 4.8A)
None
None
None
0.96A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		3ejh COLLAGEN TYPE-I A1
CHAIN
FIBRONECTIN
(Homo
sapiens)		4 / 6PRO E 964
GLY E 965
LEU A 541
GLU A 537
None
0.88A7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens)		4 / 6PRO A 489
LEU A 508
ASN A 486
GLU A 485
None
0.83A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		3ktm AMYLOID BETA A4
PROTEIN
(Homo
sapiens)		4 / 6PRO A  56
GLY A  58
LEU A  41
ASN A  42
None
0.99A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		3p8c ABL INTERACTOR 2
(Homo
sapiens)		4 / 6PRO F  13
GLY F  15
LEU F  68
ASN F  71
None
0.86A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens)		4 / 6GLY A  82
ASN A 119
LEU A  85
GLU A   8
None
0.90A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens)		4 / 6GLY A  82
ASN A 119
LEU A  85
GLU A   8
None
0.95A15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		4dhx ENHANCER OF YELLOW 2
TRANSCRIPTION FACTOR
HOMOLOG
(Homo
sapiens)		4 / 6PRO B  73
GLY B  75
LEU B  46
GLU B  70
None
0.97A18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens)		4 / 6GLY A 100
LEU A 120
ASN A 123
GLU A 125
None
0.89A17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		4jfn AMYLOID BETA A4
PROTEIN
(Homo
sapiens)		4 / 6PRO A  56
GLY A  58
LEU A  41
ASN A  42
None
0.94A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens)		4 / 6GLY A 173
LEU A 176
ASN A 179
GLU A 169
None
0.99A23.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		4 / 6PRO A 788
GLY A 789
ASN A 898
GLU A 902
None
0.56A49.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens)		4 / 6GLY A 230
LEU A 310
ASN A 307
GLU A 303
None
None
None
BHE  A 401 (-2.6A)
0.99A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 6PRO A 788
GLY A 789
ASN A 792
ASN A 898
GLU A 902
None
1.07A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33
(Homo
sapiens)		4 / 6PRO A 228
GLY A 229
ASN B 405
ASN B 104
None
0.91A14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens)		5 / 6LYS A 496
LEU A 492
THR A 499
ALA A 495
LEU A 322
None
1.45A14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		1wha KIAA0147 PROTEIN
(Homo
sapiens)		4 / 6THR A  89
ALA A  91
LEU A  93
SER A  65
THR  A  89 ( 0.8A)
ALA  A  91 ( 0.0A)
LEU  A  93 ( 0.6A)
SER  A  65 ( 0.0A)
0.76A29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		2e7b OBSCURIN
(Homo
sapiens)		4 / 6LEU A  18
THR A  87
ALA A  89
LEU A  91
None
0.91A23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		4 / 6LYS A 295
LEU A 297
THR A 338
SER A 330
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
None
0.84A15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens)		4 / 6LEU A 305
THR A  31
ALA A 335
LEU A 337
None
1.03A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens)		4 / 6LEU B 363
THR B 415
ALA B 391
LEU B 367
None
0.89A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens)		4 / 6LEU A 269
THR A 293
ALA A 291
LEU A 289
None
0.95A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens)		4 / 6LEU B 216
ALA B 209
LEU B 211
SER B 173
None
0.97A21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER
(Homo
sapiens)		4 / 6LYS A  46
ALA A  44
LEU A  40
SER A  41
None
0.78A22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		6 / 6LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.66A99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		4 / 6LEU A 621
THR A 589
LEU A 624
SER A 625
None
0.96A11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6THR A 548
ALA A 550
LEU A 552
SER A 483
None
0.84A9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens)		4 / 6LYS A  69
LEU A  71
THR A 123
SER A 106
None
0.78A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		4zey NUCLEAR
RECEPTOR-BINDING
FACTOR 2
(Homo
sapiens)		4 / 6LYS A  35
LEU A  68
ALA A  38
SER A  63
None
1.05A19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		1jmy BILE-SALT-ACTIVATED
LIPASE
(Homo
sapiens)		4 / 7LYS A 361
LEU A 357
ALA A 360
THR A 352
None
0.94A14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		2e7b OBSCURIN
(Homo
sapiens)		4 / 7LEU A  18
THR A  87
ALA A  89
LEU A  91
None
0.89A23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens)		4 / 7LEU B 363
THR B 415
ALA B 391
LEU B 367
None
0.84A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens)		4 / 7LEU A 269
THR A 293
ALA A 291
LEU A 289
None
0.89A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens)		4 / 7LEU A 482
ALA A 503
SER A 527
THR A 529
None
0.75A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens)		4 / 7LEU B 216
ALA B 209
LEU B 211
SER B 173
None
0.97A21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER
(Homo
sapiens)		4 / 7LYS A  46
ALA A  44
LEU A  40
SER A  41
None
0.74A22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		6 / 7LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.38A99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		6 / 7LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.70A99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		4 / 7LEU A 289
THR A 335
ALA A 314
THR A 385
None
1.04A15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		3nps S4 FAB LIGHT CHAIN
(Homo
sapiens)		4 / 7THR C  76
ALA C  74
SER C  22
THR C  20
None
0.74A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 7THR A 548
ALA A 550
LEU A 552
SER A 483
None
0.81A9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		4 / 7THR A 457
ALA A 459
SER A 448
THR A 450
None
0.56A18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		4 / 7THR A 457
ALA A 459
SER A 448
THR A 450
None
0.65A18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens)		4 / 7LYS A  69
LEU A  71
THR A 123
SER A 106
None
0.78A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens)		4 / 7LEU L 135
THR L 172
SER L 162
THR L 164
None
0.90A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7LEU B 347
THR B 235
LEU B  91
SER B  90
None
1.03A16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		4 / 7LEU B 147
THR B 124
LEU B 128
THR B 119
None
0.80A15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		5u68 MPE8
(Homo
sapiens)		4 / 7THR E 241
ALA E 239
SER E 184
THR E 182
None
0.75A19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
(Homo
sapiens)		4 / 7THR X 422
ALA X 418
LEU X 414
SER X 413
None
0.86Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		5yax SCFV1 ANTIBODY
(Homo
sapiens)		4 / 7THR A1092
ALA A1090
SER A1022
THR A1020
None
0.94A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		6f1d COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		4 / 7LYS A 218
LEU A 220
THR A 286
SER A 189
None
0.97A19.25