POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		1elv COMPLEMENT C1S
COMPONENT
(Homo
sapiens)		5 / 12HIS A 460
ASP A 514
LYS A 614
GLY A 615
SER A 617
SO4  A2001 ( 3.9A)
None
SO4  A2001 (-2.9A)
SO4  A2001 (-4.1A)
SO4  A2001 ( 2.7A)
0.90A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		2qz4 PARAPLEGIN
(Homo
sapiens)		5 / 12GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
None
ADP  A 700 (-3.4A)
None
None
None
0.88A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		5f8z PLASMA KALLIKREIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.90A27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens)		5 / 12HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
0.75A18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
None
0.93A17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		6coy CHLORIDE CHANNEL
PROTEIN 1
(Homo
sapiens)		5 / 12GLY A 226
GLY A 230
ALA A 221
ALA A 218
CYH A 179
None
CL  A1001 (-3.2A)
None
None
None
1.12A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens)		5 / 12GLY H  54
SER H  30
ARG H 102
ALA H 101
ASP H 100
None
1.07A16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_2
(GENOME POLYPROTEIN)		4ll9 LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens)		4 / 4GLN A  47
PHE A  62
TYR A  38
VAL A  16
None
1.32A22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens)		5 / 12GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
1.08A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		1elv COMPLEMENT C1S
COMPONENT
(Homo
sapiens)		5 / 12HIS A 460
ASP A 514
LYS A 614
GLY A 615
SER A 617
SO4  A2001 ( 3.9A)
None
SO4  A2001 (-2.9A)
SO4  A2001 (-4.1A)
SO4  A2001 ( 2.7A)
0.89A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		1hlg LIPASE, GASTRIC
(Homo
sapiens)		6 / 12HIS A 353
ASP A 324
VAL A 150
GLY A  66
SER A 153
ALA A 178
None
1.45A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		2qz4 PARAPLEGIN
(Homo
sapiens)		5 / 12GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
None
ADP  A 700 (-3.4A)
None
None
None
0.88A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12VAL A 225
GLY A 222
ARG A 111
ALA A 108
ALA A 105
None
1.10A16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
None
1.04A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
None
0.94A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6
(Homo
sapiens)		5 / 12GLN A 131
GLY A 128
SER A 172
ARG A 168
ALA A 333
None
None
None
MLA  A 501 (-3.7A)
None
1.09A19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
None
0.99A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
None
0.93A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens)		5 / 12HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
0.76A18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
None
0.95A17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
None
0.87A17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		1f6l ANTI-FERRITIN
IMMUNOGLOBULIN LIGHT
CHAIN
(Homo
sapiens)		3 / 3PHE L  71
TYR L  92
LEU L  47
None
0.67A23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		1qac IMMUNOGLOBULIN LIGHT
CHAIN VARIABLE
DOMAIN
(Homo
sapiens)		3 / 3PHE A  71
TYR A  92
LEU A  47
None
0.75A19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		2cuh TENASCIN-X
(Homo
sapiens)		3 / 3PHE A  23
TYR A  61
LEU A  96
None
0.72A24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4
(Homo
sapiens)		3 / 3PHE D 119
TYR D 147
LEU D 111
None
0.49A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)		3 / 3PHE A 147
TYR A  36
LEU A 119
None
0.72A21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		3auv SC-DSFV DERIVED FROM
THE G6-FAB
(Homo
sapiens)		3 / 3PHE A  82
TYR A 103
LEU A  58
None
0.72A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus)		3 / 3PHE A  71
TYR A  92
LEU A  47
None
0.68A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		3ntc FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus)		3 / 3PHE L  71
TYR L  92
LEU L  47
None
0.70A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens)		3 / 3PHE L  71
TYR L  92
LEU L  47
None
0.80A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)		3 / 3PHE A 147
TYR A  36
LEU A 119
None
0.73A15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		4x4y HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN
(Homo
sapiens)		3 / 3PHE B  71
TYR B  92
LEU B  47
None
0.63A20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		5drz HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens)		3 / 3PHE L  71
TYR L  92
LEU L  47
None
0.71A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		5f72 SINGLE CHAIN FV FROM
A FAB
(Homo
sapiens)		3 / 3PHE T 212
TYR T 233
LEU T 188
None
0.75A22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens)		3 / 3PHE A 584
TYR A 587
LEU A 540
None
0.76A19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens)		3 / 3PHE A 584
TYR A 587
LEU A 540
None
0.75A18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		3 / 3PHE A  73
TYR A  96
LEU A  76
None
0.71A18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM
(Homo
sapiens)		3 / 3PHE A 550
TYR A 557
LEU A 570
None
0.78A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		5xs2 CYCLIN-C
(Homo
sapiens)		3 / 3PHE B 195
TYR B 192
LEU B 160
None
0.74A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		3 / 3PHE C1978
TYR C2030
LEU C1934
None
0.66A3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens)		3 / 3PHE D 278
TYR D 191
LEU D 270
None
0.76A16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE
(Homo
sapiens)		5 / 12GLY A 274
VAL A 222
GLY A 237
ALA A 257
ASP A 259
None
None
NDP  A 302 (-3.5A)
None
None
1.01A21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		1elv COMPLEMENT C1S
COMPONENT
(Homo
sapiens)		5 / 12HIS A 460
ASP A 514
LYS A 614
GLY A 615
SER A 617
SO4  A2001 ( 3.9A)
None
SO4  A2001 (-2.9A)
SO4  A2001 (-4.1A)
SO4  A2001 ( 2.7A)
0.90A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		2qz4 PARAPLEGIN
(Homo
sapiens)		5 / 12GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
None
ADP  A 700 (-3.4A)
None
None
None
0.80A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		3mos TRANSKETOLASE
(Homo
sapiens)		5 / 12ASP A 561
GLY A 425
ALA A 430
ALA A 391
ASP A 433
None
1.00A14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		5f8z PLASMA KALLIKREIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.88A27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens)		5 / 12HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
0.79A18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens)		5 / 12GLY H  54
SER H  30
ARG H 102
ALA H 101
ASP H 100
None
0.99A16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		4 / 4GLN A 433
PHE A 355
TYR A 325
LEU A 440
None
1.45A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		4 / 4GLN B 433
PHE B 355
TYR B 325
LEU B 440
None
None
None
PG4  B 503 ( 4.7A)
1.43A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		4 / 4GLN A 433
PHE A 355
TYR A 325
LEU A 440
None
1.40A17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens)		5 / 12GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
1.04A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		2odp COMPLEMENT C2
(Homo
sapiens)		5 / 12HIS A 487
ASP A 541
LYS A 656
GLY A 657
SER A 659
None
1.05A17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		2qz4 PARAPLEGIN
(Homo
sapiens)		5 / 12GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
None
ADP  A 700 (-3.4A)
None
None
None
0.81A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
None
1.10A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
None
0.96A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
None
1.05A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
None
0.94A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		4ylq COAGULATION FACTOR
VII
(Homo
sapiens)		5 / 12HIS H  57
ASP H 102
LYS H 192
GLY H 193
SER H 195
0Z7  H 501 (-2.6A)
0Z7  H 501 (-3.3A)
0Z7  H 501 (-2.9A)
0Z7  H 501 (-3.2A)
0Z7  H 501 (-1.4A)
1.13A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		5f8z PLASMA KALLIKREIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.71A27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens)		5 / 12HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
0.75A18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		6 / 12GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
None
1.14A17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens)		5 / 12GLY H  54
SER H  30
ARG H 102
ALA H 101
ASP H 100
None
1.03A16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		1ux6 THROMBOSPONDIN-1
(Homo
sapiens)		4 / 4PHE A1007
TYR A1108
VAL A 969
LEU A 968
None
1.27A18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM
(Homo
sapiens)		4 / 4PHE A 192
TYR A 169
VAL A 220
LEU A 223
None
1.38A16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		2pqf POLY [ADP-RIBOSE]
POLYMERASE 12
(Homo
sapiens)		4 / 4PHE A 664
TYR A 591
VAL A 557
LEU A 623
None
1.44A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		5drz HIV ANTIBODY F240
LIGHT CHAIN
(Homo
sapiens)		4 / 4PHE L  71
TYR L  92
VAL L  55
LEU L  47
None
1.17A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		5mv9 UNCONVENTIONAL
MYOSIN-VIIA
(Homo
sapiens)		4 / 4PHE A2085
TYR A2052
VAL A2034
LEU A2037
None
1.44A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		5ola TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens)		4 / 4PHE A 350
TYR A 229
VAL A 300
LEU A 345
None
1.33A22.18