POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		1fq9 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens)		5 / 9ASP C 335
VAL C 267
ALA C 268
GLY C 337
SER C 332
None
1.42A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens)		5 / 9ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
None
0.85A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		1n76 LACTOFERRIN
(Homo
sapiens)		5 / 9VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
None
1.27A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		1tki TITIN
(Homo
sapiens)		5 / 9ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
None
1.25A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		2dne DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens)		5 / 9ASP A  72
VAL A  66
ALA A  67
GLY A  22
GLY A  69
None
1.23A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens)		5 / 9ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
None
1.28A14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1
MUS81 PROTEIN
(Danio
rerio;
Homo
sapiens)		5 / 9ASP B 464
ALA A 537
GLY B 468
SER B 463
GLY A 548
None
1.42A21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		3bvh FIBRINOGEN BETA
CHAIN
(Homo
sapiens)		5 / 9ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.23A20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		3fd5 SELENIDE, WATER
DIKINASE 1
(Homo
sapiens)		5 / 9VAL A 302
ALA A 305
GLY A  28
PHE A 310
GLY A 307
None
1.21A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 9ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
None
1.02A18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MME_A_29QA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 9TYR A  95
ASP A  98
ALA A 169
GLY A 338
SER A 438
GLY A 442
None
1.40A31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MME_A_29QA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		7 / 9TYR A  95
ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.70A31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens)		5 / 9ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
None
1.33A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		1n76 LACTOFERRIN
(Homo
sapiens)		5 / 9VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
None
1.26A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		1tki TITIN
(Homo
sapiens)		5 / 9ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
None
1.29A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		2dne DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens)		5 / 9ASP A  72
VAL A  66
ALA A  67
GLY A  22
GLY A  69
None
1.24A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens)		5 / 9ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
None
1.29A14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		3bvh FIBRINOGEN BETA
CHAIN
(Homo
sapiens)		5 / 9ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.22A20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens)		5 / 9VAL A 457
ALA A 458
PHE A 488
SER A 485
GLY A 470
None
1.30A19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens)		5 / 9TYR A 136
VAL A 155
ALA A 154
GLY A 141
PHE A 125
None
1.19A13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 9ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
None
1.03A18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MME_B_29QB603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 9TYR A  95
ASP A  98
ALA A 169
GLY A 338
SER A 438
GLY A 442
None
1.40A31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MME_B_29QB603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		7 / 9TYR A  95
ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.71A31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens)		5 / 9ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
None
1.33A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens)		5 / 9TYR A 394
ASP A 473
VAL A 404
PHE A 391
GLY A 393
836  A1201 (-4.6A)
836  A1201 ( 4.9A)
None
836  A1201 (-3.5A)
None
1.24A22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		6f39 COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		5 / 9ASP A 226
TYR A 197
GLY A 252
PHE A 223
SER A 278
 CA  A 303 (-3.2A)
None
None
None
CA  A 303 ( 3.8A)
1.14A9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens)		5 / 9ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
None
0.87A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		1lgb LACTOTRANSFERRIN (N2
FRAGMENT)
(Homo
sapiens)		5 / 9VAL C 206
ALA C 207
GLY C 111
SER C 156
GLY C 204
None
1.24A16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		1n76 LACTOFERRIN
(Homo
sapiens)		5 / 9VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
None
1.20A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		1tki TITIN
(Homo
sapiens)		5 / 9ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
None
1.26A19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens)		5 / 9VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
None
BI1  A1000 (-3.4A)
None
None
None
1.25A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		2hau SEROTRANSFERRIN
(Homo
sapiens)		5 / 9VAL A 202
ALA A 203
GLY A 114
SER A 157
GLY A 200
None
1.20A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens)		5 / 9ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
None
1.31A14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		3bvh FIBRINOGEN BETA
CHAIN
(Homo
sapiens)		5 / 9ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.27A20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA
(Escherichia
coli;
Homo
sapiens)		5 / 9ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
None
1.38A22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens)		5 / 9ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
None
PE5  A1216 (-4.7A)
None
None
None
1.37A23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 9ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
None
1.02A18.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMF_A_29QA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 9TYR A  95
ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
None
0.85A30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMF_A_29QA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 9TYR A  95
ASP A  98
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.68A30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens)		5 / 9ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
None
0.87A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		1n76 LACTOFERRIN
(Homo
sapiens)		5 / 9VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
None
1.21A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		1tki TITIN
(Homo
sapiens)		5 / 9ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
None
1.30A19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens)		5 / 9VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
None
BI1  A1000 (-3.4A)
None
None
None
1.21A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		2dne DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX
(Homo
sapiens)		5 / 9ASP A  72
VAL A  66
ALA A  67
GLY A  22
GLY A  69
None
1.25A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		2hau SEROTRANSFERRIN
(Homo
sapiens)		5 / 9VAL A 202
ALA A 203
GLY A 114
SER A 157
GLY A 200
None
1.22A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens)		5 / 9ASP A 435
VAL A 413
ALA A 412
SER A 437
GLY A 410
None
1.29A14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		3bvh FIBRINOGEN BETA
CHAIN
(Homo
sapiens)		5 / 9ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.22A20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens)		5 / 9ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
None
PE5  A1216 (-4.7A)
None
None
None
1.40A23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 9ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
None
1.03A18.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMF_B_29QB603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 9TYR A  95
ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
None
0.82A30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMF_B_29QB603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 9TYR A  95
ASP A  98
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.66A30.92