POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		1hlc HUMAN LECTIN
(Homo
sapiens)		6 / 6HIS A  45
ASN A  47
ARG A  49
ASN A  58
TRP A  65
GLU A  68
GAL  A 998 (-3.8A)
GAL  A 998 (-4.1A)
BGC  A 999 ( 2.7A)
GAL  A 998 (-3.6A)
GAL  A 998 (-3.7A)
BGC  A 999 ( 2.8A)
0.44A28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		1lpb LIPASE
(Homo
sapiens)		4 / 6ASN B 100
ARG B  68
ASN B  63
GLU B  44
None
1.06A15.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		2yro GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  61
ASN A  63
ASN A  74
TRP A  81
None
0.68A37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		2zhl GALECTIN-9
(Homo
sapiens)		4 / 6HIS A  61
ASN A  63
ARG A  44
TRP A  82
GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1491 (-4.6A)
GAL  A1493 (-3.7A)
1.10A38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		2zhl GALECTIN-9
(Homo
sapiens)		6 / 6HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1494 ( 2.8A)
GAL  A1493 (-3.9A)
GAL  A1493 (-3.7A)
NAG  A1494 ( 2.7A)
0.32A38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		3ayd GALECTIN-3
(Homo
sapiens)		6 / 6HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
GAL  A 253 (-3.7A)
GAL  A 253 (-4.1A)
A2G  A 252 ( 3.1A)
GAL  A 253 (-3.9A)
GAL  A 253 (-3.5A)
A2G  A 252 (-3.0A)
0.22A35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens)		6 / 6HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
GAL  A 501 (-3.9A)
GAL  A 501 (-3.8A)
NAG  A 502 ( 2.7A)
GAL  A 501 (-3.8A)
GAL  A 501 (-3.6A)
NAG  A 502 ( 2.7A)
0.20A38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		3ojb GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  53
ASN A  55
ASN A  66
GLU A  76
None
0.82A35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		3ojb GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  53
ASN A  55
ASN A  66
TRP A  73
None
0.40A35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		3wv6 GALECTIN-9
(Homo
sapiens)		4 / 6HIS A  61
ASN A  63
ARG A  44
TRP A  82
GAL  A 402 (-3.9A)
GAL  A 402 (-3.9A)
GAL  A 402 ( 4.9A)
GAL  A 402 (-3.7A)
1.09A23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		3wv6 GALECTIN-9
(Homo
sapiens)		6 / 6HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
GAL  A 402 (-3.9A)
GAL  A 402 (-3.9A)
BGC  A 403 (-2.7A)
GAL  A 402 (-4.0A)
GAL  A 402 (-3.7A)
BGC  A 403 (-2.9A)
0.20A23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		3wv6 GALECTIN-9
(Homo
sapiens)		6 / 6HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
GAL  A 404 (-4.0A)
GAL  A 404 (-4.1A)
GLC  A 405 (-2.7A)
GAL  A 404 (-3.7A)
GAL  A 404 ( 3.7A)
GLC  A 405 ( 2.8A)
0.20A23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		3zxe GALECTIN-7
(Homo
sapiens)		6 / 6HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
PGZ  A   1 (-3.9A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-3.6A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-4.0A)
PGZ  A   1 (-3.5A)
0.29A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		4bmb GALECTIN-8
(Homo
sapiens)		6 / 6HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
0.25A32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		4fqz GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  65
ASN A  67
ARG A  45
TRP A  86
GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
GAL  A 401 (-2.8A)
GAL  A 401 (-3.5A)
1.16A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		4fqz GALECTIN-8
(Homo
sapiens)		6 / 6HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
BGC  A 402 ( 2.5A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
BGC  A 402 ( 3.3A)
0.41A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		4fqz GALECTIN-8
(Homo
sapiens)		6 / 6HIS A 229
ASN A 231
ARG A 233
ASN A 242
TRP A 249
GLU A 252
None
0.38A20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		4xzp GALECTIN-4
(Homo
sapiens)		6 / 6HIS A  63
ASN A  65
ARG A  67
ASN A  77
TRP A  84
GLU A  87
None
0.51A33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		4y1y GALECTIN-1
(Homo
sapiens)		6 / 6HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
0.49A33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		4y26 GALECTIN-7
(Homo
sapiens)		6 / 6HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
GAL  A 201 (-3.9A)
GAL  A 201 (-4.1A)
6S2  A 202 (-2.9A)
GAL  A 201 (-3.7A)
GAL  A 201 (-3.5A)
6S2  A 202 (-2.8A)
0.21A88.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		4ym3 GALECTIN-4
(Homo
sapiens)		6 / 6HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
0.27A36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		4 / 6HIS A 210
ASN A 207
ARG A 206
GLU A 234
DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
1.18A16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		5dux GALECTIN-4
(Homo
sapiens)		6 / 6HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
0.25A36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		5gzg GALECTIN-8
(Homo
sapiens)		6 / 6HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
0.29A29.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		5h9p GALECTIN-3
(Homo
sapiens)		6 / 6HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
TD2  A 301 (-3.8A)
TD2  A 301 (-4.0A)
TD2  A 301 (-2.8A)
TD2  A 301 (-3.8A)
TD2  A 301 ( 3.7A)
TD2  A 301 (-2.9A)
0.19A35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		5nfb GALECTIN-3
(Homo
sapiens)		6 / 6HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
8VT  A 301 (-3.9A)
8VT  A 301 (-4.0A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.8A)
8VT  A 301 ( 3.7A)
8VT  A 301 (-2.7A)
0.21A29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens)		6 / 6HIS C 158
ASN C 160
ARG C 162
ASN C 174
TRP C 181
GLU C 184
LAT  C 301 (-3.8A)
LAT  C 301 (-4.1A)
LAT  C 301 (-2.7A)
LAT  C 301 (-3.8A)
LAT  C 301 (-3.8A)
LAT  C 301 ( 2.8A)
0.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		1hlc HUMAN LECTIN
(Homo
sapiens)		6 / 6HIS A  45
ASN A  47
ARG A  49
ASN A  58
TRP A  65
GLU A  68
GAL  A 998 (-3.8A)
GAL  A 998 (-4.1A)
BGC  A 999 ( 2.7A)
GAL  A 998 (-3.6A)
GAL  A 998 (-3.7A)
BGC  A 999 ( 2.8A)
0.39A28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1
(Homo
sapiens)		4 / 6ASN A  24
ARG A  21
TRP A  32
GLU A  25
None
1.45A16.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		2yro GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  61
ASN A  63
ASN A  74
TRP A  81
None
0.60A37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		2zhl GALECTIN-9
(Homo
sapiens)		6 / 6HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1494 ( 2.8A)
GAL  A1493 (-3.9A)
GAL  A1493 (-3.7A)
NAG  A1494 ( 2.7A)
0.34A38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		3ayd GALECTIN-3
(Homo
sapiens)		6 / 6HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
GAL  A 253 (-3.7A)
GAL  A 253 (-4.1A)
A2G  A 252 ( 3.1A)
GAL  A 253 (-3.9A)
GAL  A 253 (-3.5A)
A2G  A 252 (-3.0A)
0.34A35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens)		6 / 6HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
GAL  A 501 (-3.9A)
GAL  A 501 (-3.8A)
NAG  A 502 ( 2.7A)
GAL  A 501 (-3.8A)
GAL  A 501 (-3.6A)
NAG  A 502 ( 2.7A)
0.29A38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		3ojb GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  53
ASN A  55
ASN A  66
GLU A  76
None
0.81A35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		3ojb GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  53
ASN A  55
ASN A  66
TRP A  73
None
0.40A35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		3wv6 GALECTIN-9
(Homo
sapiens)		6 / 6HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
GAL  A 402 (-3.9A)
GAL  A 402 (-3.9A)
BGC  A 403 (-2.7A)
GAL  A 402 (-4.0A)
GAL  A 402 (-3.7A)
BGC  A 403 (-2.9A)
0.38A23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		3wv6 GALECTIN-9
(Homo
sapiens)		6 / 6HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
GAL  A 404 (-4.0A)
GAL  A 404 (-4.1A)
GLC  A 405 (-2.7A)
GAL  A 404 (-3.7A)
GAL  A 404 ( 3.7A)
GLC  A 405 ( 2.8A)
0.36A23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		3zxe GALECTIN-7
(Homo
sapiens)		6 / 6HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
PGZ  A   1 (-3.9A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-3.6A)
PGZ  A   1 (-3.8A)
PGZ  A   1 (-4.0A)
PGZ  A   1 (-3.5A)
0.32A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		4bmb GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  65
ASN A  67
ARG A  45
TRP A  86
LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.9A)
LAT  A1155 (-3.6A)
1.22A32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		4bmb GALECTIN-8
(Homo
sapiens)		6 / 6HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
LAT  A1155 (-3.9A)
LAT  A1155 (-3.9A)
LAT  A1155 (-2.7A)
LAT  A1155 (-3.9A)
LAT  A1155 (-3.6A)
LAT  A1155 (-3.0A)
0.35A32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		4fqz GALECTIN-8
(Homo
sapiens)		4 / 6HIS A  65
ASN A  67
ARG A  45
TRP A  86
GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
GAL  A 401 (-2.8A)
GAL  A 401 (-3.5A)
1.12A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		4fqz GALECTIN-8
(Homo
sapiens)		6 / 6HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
GAL  A 401 (-4.0A)
GAL  A 401 (-4.2A)
BGC  A 402 ( 2.5A)
GAL  A 401 (-3.8A)
GAL  A 401 (-3.5A)
BGC  A 402 ( 3.3A)
0.39A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		4fqz GALECTIN-8
(Homo
sapiens)		6 / 6HIS A 229
ASN A 231
ARG A 233
ASN A 242
TRP A 249
GLU A 252
None
0.44A20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		4xzp GALECTIN-4
(Homo
sapiens)		6 / 6HIS A  63
ASN A  65
ARG A  67
ASN A  77
TRP A  84
GLU A  87
None
0.46A33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		4y1y GALECTIN-1
(Homo
sapiens)		6 / 6HIS A  44
ASN A  46
ARG A  48
ASN A  61
TRP A  68
GLU A  71
GAL  A 201 (-3.9A)
GAL  A 201 (-4.4A)
6S2  A 202 (-2.8A)
GAL  A 201 (-3.8A)
GAL  A 201 ( 4.1A)
6S2  A 202 (-2.6A)
0.41A33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		4y26 GALECTIN-7
(Homo
sapiens)		6 / 6HIS A  49
ASN A  51
ARG A  53
ASN A  62
TRP A  69
GLU A  72
GAL  A 201 (-3.9A)
GAL  A 201 (-4.1A)
6S2  A 202 (-2.9A)
GAL  A 201 (-3.7A)
GAL  A 201 (-3.5A)
6S2  A 202 (-2.8A)
0.29A88.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		4ym3 GALECTIN-4
(Homo
sapiens)		6 / 6HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
0.30A36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		4 / 6HIS A 210
ASN A 207
ARG A 206
GLU A 234
DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
1.16A16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		5dux GALECTIN-4
(Homo
sapiens)		6 / 6HIS B  63
ASN B  65
ARG B  67
ASN B  77
TRP B  84
GLU B  87
LAT  B 201 (-3.9A)
LAT  B 201 (-3.8A)
LAT  B 201 (-2.6A)
LAT  B 201 (-3.9A)
LAT  B 201 ( 3.8A)
LAT  B 201 (-2.4A)
0.34A36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		5gzg GALECTIN-8
(Homo
sapiens)		5 / 6HIS A  65
ASN A  67
ARG A  45
ASN A  79
TRP A  86
LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.8A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
1.43A29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		5gzg GALECTIN-8
(Homo
sapiens)		6 / 6HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
0.37A29.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		5h9p GALECTIN-3
(Homo
sapiens)		6 / 6HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
TD2  A 301 (-3.8A)
TD2  A 301 (-4.0A)
TD2  A 301 (-2.8A)
TD2  A 301 (-3.8A)
TD2  A 301 ( 3.7A)
TD2  A 301 (-2.9A)
0.31A35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		5nfb GALECTIN-3
(Homo
sapiens)		6 / 6HIS A 158
ASN A 160
ARG A 162
ASN A 174
TRP A 181
GLU A 184
8VT  A 301 (-3.9A)
8VT  A 301 (-4.0A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.8A)
8VT  A 301 ( 3.7A)
8VT  A 301 (-2.7A)
0.29A29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		6fof GALECTIN-3,GALECTIN-
3
(Homo
sapiens)		6 / 6HIS C 158
ASN C 160
ARG C 162
ASN C 174
TRP C 181
GLU C 184
LAT  C 301 (-3.8A)
LAT  C 301 (-4.1A)
LAT  C 301 (-2.7A)
LAT  C 301 (-3.8A)
LAT  C 301 (-3.8A)
LAT  C 301 ( 2.8A)
0.42Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		1fh5 MONOCLONAL ANTIBODY
MAK33
(Homo
sapiens)		3 / 3THR H  25
SER H  28
TYR H  29
None
0.88A15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		1h0d ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.86A15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		1h6h NEUTROPHIL CYTOSOL
FACTOR 4
(Homo
sapiens)		3 / 3THR A  47
SER A  51
TYR A  53
None
0.79A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		2emp ZINC FINGER PROTEIN
347
(Homo
sapiens)		3 / 3THR A  29
SER A  26
TYR A  25
None
0.74A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.73A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		3 / 3THR A 527
SER A 529
TYR A 359
None
0.84A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  53
SER H  34
TYR H  33
None
0.87A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens)		3 / 3THR A 168
SER A 133
TYR A 135
None
0.75A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4a5w COMPLEMENT C5
(Homo
sapiens)		3 / 3THR A1511
SER A1510
TYR A1509
None
0.87A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens)		3 / 3THR B 740
SER B 741
TYR B 667
None
0.74A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H 153
SER H 156
TYR H 157
None
0.74A19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.73A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4lri MSL-109 HEAVY CHAIN
(Homo
sapiens)		3 / 3THR P  28
SER P  30
TYR P  32
None
0.75A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4odh CAP256-VRC26.UCA
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.76A15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens)		3 / 3THR L  91
SER L  90
TYR L  89
None
0.82A15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4wxu MYOCILIN
(Homo
sapiens)		3 / 3THR A 394
SER A 393
TYR A 392
None
0.70A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens)		3 / 3THR A 140
SER A 139
TYR A 121
None
0.84A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4zso ANTIBODY HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.82A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		3 / 3THR A 321
SER A 309
TYR A 308
None
0.79A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.70A15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.83A7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		5u68 MPE8
(Homo
sapiens)		3 / 3THR E  47
SER E  50
TYR E  51
None
0.80A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.86A8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		5xj3 IPILIMUMAB-VH
(Homo
sapiens)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.87A8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		6amj CAT192 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.84A7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		1b55 TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens)		3 / 3TYR A 106
TYR A  39
GLN A  15
None
4IP  A 171 (-4.6A)
4IP  A 171 (-4.6A)
1.17A11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		1lw3 MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens)		3 / 3TYR A 439
TYR A 215
GLN A 218
None
0.98A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens)		3 / 3TYR A 144
TYR A  29
GLN A 150
NHE  A 354 (-4.9A)
NHE  A 354 (-4.9A)
NHE  A 354 (-3.4A)
0.95A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens)		3 / 3TYR A  44
TYR A 159
GLN A 185
None
1.00A16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens)		3 / 3TYR A 159
TYR A  44
GLN A 165
None
None
PLO  A 401 (-4.1A)
0.82A16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens)		3 / 3TYR A 439
TYR A 215
GLN A 218
None
0.95A21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens)		3 / 3TYR B 404
TYR B 224
GLN B 220
None
1.04A15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens)		3 / 3TYR A1135
TYR A1400
GLN A1153
None
1.01A21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		2xst LIPOCALIN 15
(Homo
sapiens)		3 / 3TYR A 106
TYR A 139
GLN A 137
None
0.87A13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		3 / 3TYR A1551
TYR A1277
GLN A1247
None
0.82A21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		3 / 3TYR A1848
TYR A2064
GLN A2065
None
0.90A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		4iia RAS
GTPASE-ACTIVATING
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens)		3 / 3TYR A  20
TYR A  40
GLN A 110
None
1.11A11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens)		3 / 3TYR A 453
TYR A 155
GLN A 444
None
1.13A18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		3 / 3TYR A 706
TYR A 741
GLN A 755
None
0.92A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens)		3 / 3TYR B 216
TYR A 110
GLN A 119
None
1.14A10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		5c16 MYOTUBULARIN-RELATED
PROTEIN 1
(Homo
sapiens)		3 / 3TYR A 460
TYR A 236
GLN A 239
None
0.95A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		5drv RAS
GTPASE-ACTIVATING
PROTEIN-BINDING
PROTEIN 2
(Homo
sapiens)		3 / 3TYR A  20
TYR A  40
GLN A 110
None
1.12A10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
(Homo
sapiens)		3 / 3TYR A 209
TYR A  20
GLN A 113
None
0.97A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		5ir3 IG LAMBDA CHAIN V-VI
REGION AR
(Homo
sapiens)		3 / 3TYR A  94
TYR A  37
GLN A  35
ACT  A 201 (-4.2A)
None
None
1.07A11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens)		3 / 3TYR A 470
TYR A 359
GLN A 360
None
0.93A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens)		3 / 3TYR A 745
TYR A 628
GLN A 623
None
1.06A9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		5van BETA-KLOTHO
(Homo
sapiens)		3 / 3TYR A 622
TYR A 597
GLN A 585
None
0.97A8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE
(Homo
sapiens)		3 / 3TYR A 321
TYR A 197
GLN A 228
None
FAD  A 701 (-4.4A)
FAD  A 701 ( 4.5A)
0.99A7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		2pbh PROCATHEPSIN B
(Homo
sapiens)		3 / 3VAL A 208
GLU A 243
GLU A 157
None
0.78A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens)		3 / 3VAL A 296
GLU A 226
GLU A 194
None
0.63A22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3VAL A 108
GLU A 377
GLU A 373
None
0.85A19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens)		3 / 3VAL A 212
GLU A  90
GLU A  93
None
GOL  A 305 (-2.5A)
GOL  A 305 (-2.7A)
0.74A17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens)		3 / 3VAL A 782
GLU A 822
GLU A 818
None
0.88A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens)		3 / 3VAL f 450
GLU f 422
GLU f 465
None
0.73A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		1lw3 MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens)		3 / 3TYR A 439
TYR A 215
GLN A 218
None
0.98A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens)		3 / 3TYR A 144
TYR A  29
GLN A 150
NHE  A 354 (-4.9A)
NHE  A 354 (-4.9A)
NHE  A 354 (-3.4A)
0.94A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens)		3 / 3TYR A  44
TYR A 159
GLN A 185
None
1.01A16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens)		3 / 3TYR A 159
TYR A  44
GLN A 165
None
None
PLO  A 401 (-4.1A)
0.81A16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens)		3 / 3TYR A 439
TYR A 215
GLN A 218
None
0.95A21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens)		3 / 3TYR B 404
TYR B 224
GLN B 220
None
1.04A15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens)		3 / 3TYR A1135
TYR A1400
GLN A1153
None
1.02A21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		2xst LIPOCALIN 15
(Homo
sapiens)		3 / 3TYR A 106
TYR A 139
GLN A 137
None
0.88A13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		3 / 3TYR A1551
TYR A1277
GLN A1247
None
0.83A21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		3 / 3TYR A1848
TYR A2064
GLN A2065
None
0.91A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		4iia RAS
GTPASE-ACTIVATING
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens)		3 / 3TYR A  20
TYR A  40
GLN A 110
None
1.12A11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens)		3 / 3TYR A 453
TYR A 155
GLN A 444
None
1.13A18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		3 / 3TYR A 706
TYR A 741
GLN A 755
None
0.93A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens)		3 / 3TYR B 216
TYR A 110
GLN A 119
None
1.13A10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		5c16 MYOTUBULARIN-RELATED
PROTEIN 1
(Homo
sapiens)		3 / 3TYR A 460
TYR A 236
GLN A 239
None
0.96A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		5drv RAS
GTPASE-ACTIVATING
PROTEIN-BINDING
PROTEIN 2
(Homo
sapiens)		3 / 3TYR A  20
TYR A  40
GLN A 110
None
1.13A10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
(Homo
sapiens)		3 / 3TYR A 209
TYR A  20
GLN A 113
None
0.98A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		5ir3 IG LAMBDA CHAIN V-VI
REGION AR
(Homo
sapiens)		3 / 3TYR A  94
TYR A  37
GLN A  35
ACT  A 201 (-4.2A)
None
None
1.06A11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens)		3 / 3TYR A 470
TYR A 359
GLN A 360
None
0.93A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens)		3 / 3TYR A 745
TYR A 628
GLN A 623
None
1.06A9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		5van BETA-KLOTHO
(Homo
sapiens)		3 / 3TYR A 622
TYR A 597
GLN A 585
None
0.98A8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE
(Homo
sapiens)		3 / 3TYR A 321
TYR A 197
GLN A 228
None
FAD  A 701 (-4.4A)
FAD  A 701 ( 4.5A)
0.98A7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		1fh5 MONOCLONAL ANTIBODY
MAK33
(Homo
sapiens)		3 / 3THR H  25
SER H  28
TYR H  29
None
0.88A15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		1h0d ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.86A15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		1h6h NEUTROPHIL CYTOSOL
FACTOR 4
(Homo
sapiens)		3 / 3THR A  47
SER A  51
TYR A  53
None
0.79A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		2emp ZINC FINGER PROTEIN
347
(Homo
sapiens)		3 / 3THR A  29
SER A  26
TYR A  25
None
0.75A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.73A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		3 / 3THR A 527
SER A 529
TYR A 359
None
0.83A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  53
SER H  34
TYR H  33
None
0.88A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens)		3 / 3THR A 168
SER A 133
TYR A 135
None
0.75A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4a5w COMPLEMENT C5
(Homo
sapiens)		3 / 3THR A1511
SER A1510
TYR A1509
None
0.88A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens)		3 / 3THR B 740
SER B 741
TYR B 667
None
0.74A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H 153
SER H 156
TYR H 157
None
0.75A19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.73A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4lri MSL-109 HEAVY CHAIN
(Homo
sapiens)		3 / 3THR P  28
SER P  30
TYR P  32
None
0.75A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4odh CAP256-VRC26.UCA
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.77A15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens)		3 / 3THR L  91
SER L  90
TYR L  89
None
0.82A15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4wxu MYOCILIN
(Homo
sapiens)		3 / 3THR A 394
SER A 393
TYR A 392
None
0.71A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens)		3 / 3THR A 140
SER A 139
TYR A 121
None
0.85A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4zso ANTIBODY HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.82A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		3 / 3THR A 321
SER A 309
TYR A 308
None
0.79A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.70A15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.83A7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		5odb D10 FAB FRAGMENT -
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.89A8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		5u68 MPE8
(Homo
sapiens)		3 / 3THR E  47
SER E  50
TYR E  51
None
0.80A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.87A8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		5xj3 IPILIMUMAB-VH
(Homo
sapiens)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.87A8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		6amj CAT192 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.84A7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		1fh5 MONOCLONAL ANTIBODY
MAK33
(Homo
sapiens)		3 / 3THR H  25
SER H  28
TYR H  29
None
0.87A15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		1h0d ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.85A15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		1h6h NEUTROPHIL CYTOSOL
FACTOR 4
(Homo
sapiens)		3 / 3THR A  47
SER A  51
TYR A  53
None
0.79A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		2emp ZINC FINGER PROTEIN
347
(Homo
sapiens)		3 / 3THR A  29
SER A  26
TYR A  25
None
0.74A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.73A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		3 / 3THR A 527
SER A 529
TYR A 359
None
0.84A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  53
SER H  34
TYR H  33
None
0.88A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens)		3 / 3THR A 168
SER A 133
TYR A 135
None
0.75A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4a5w COMPLEMENT C5
(Homo
sapiens)		3 / 3THR A1511
SER A1510
TYR A1509
None
0.87A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens)		3 / 3THR B 740
SER B 741
TYR B 667
None
0.73A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H 153
SER H 156
TYR H 157
None
0.74A19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.74A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4lri MSL-109 HEAVY CHAIN
(Homo
sapiens)		3 / 3THR P  28
SER P  30
TYR P  32
None
0.75A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4odh CAP256-VRC26.UCA
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.77A15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens)		3 / 3THR L  91
SER L  90
TYR L  89
None
0.81A15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4wxu MYOCILIN
(Homo
sapiens)		3 / 3THR A 394
SER A 393
TYR A 392
None
0.70A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens)		3 / 3THR A 140
SER A 139
TYR A 121
None
0.84A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4zso ANTIBODY HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.82A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		3 / 3THR A 321
SER A 309
TYR A 308
None
0.79A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.69A15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.82A7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		5u68 MPE8
(Homo
sapiens)		3 / 3THR E  47
SER E  50
TYR E  51
None
0.80A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.86A8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		5xj3 IPILIMUMAB-VH
(Homo
sapiens)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.87A8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		6amj CAT192 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.83A7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		1h0d ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.87A15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		1h6h NEUTROPHIL CYTOSOL
FACTOR 4
(Homo
sapiens)		3 / 3THR A  47
SER A  51
TYR A  53
None
0.78A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		2dyb NEUTROPHIL CYTOSOL
FACTOR 4
(Homo
sapiens)		3 / 3THR A  47
SER A  51
TYR A  53
None
0.88A19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		2emp ZINC FINGER PROTEIN
347
(Homo
sapiens)		3 / 3THR A  29
SER A  26
TYR A  25
None
0.75A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.71A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		3 / 3THR A 527
SER A 529
TYR A 359
None
0.82A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  53
SER H  34
TYR H  33
None
0.88A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens)		3 / 3THR A 168
SER A 133
TYR A 135
None
0.76A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4a5w COMPLEMENT C5
(Homo
sapiens)		3 / 3THR A1511
SER A1510
TYR A1509
None
0.87A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens)		3 / 3THR B 740
SER B 741
TYR B 667
None
0.74A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H 153
SER H 156
TYR H 157
None
0.76A19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.72A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4lri MSL-109 HEAVY CHAIN
(Homo
sapiens)		3 / 3THR P  28
SER P  30
TYR P  32
None
0.75A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4odh CAP256-VRC26.UCA
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.78A15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens)		3 / 3THR L  91
SER L  90
TYR L  89
None
0.84A15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4wxu MYOCILIN
(Homo
sapiens)		3 / 3THR A 394
SER A 393
TYR A 392
None
0.71A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens)		3 / 3THR A 140
SER A 139
TYR A 121
None
0.83A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4zso ANTIBODY HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.83A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		3 / 3THR A 321
SER A 309
TYR A 308
None
0.81A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.71A15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.84A7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		5u68 MPE8
(Homo
sapiens)		3 / 3THR E  47
SER E  50
TYR E  51
None
0.82A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		5viy BG1 FAB LIGHT CHAIN
(Homo
sapiens)		3 / 3THR G  20
SER G  74
TYR G  65
None
0.88A15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.88A8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		5xj3 IPILIMUMAB-VH
(Homo
sapiens)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.89A8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		6amj CAT192 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.86A7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		1h0d ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.87A15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		1h6h NEUTROPHIL CYTOSOL
FACTOR 4
(Homo
sapiens)		3 / 3THR A  47
SER A  51
TYR A  53
None
0.79A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		2emp ZINC FINGER PROTEIN
347
(Homo
sapiens)		3 / 3THR A  29
SER A  26
TYR A  25
None
0.76A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.72A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		3 / 3THR A 527
SER A 529
TYR A 359
None
0.81A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  53
SER H  34
TYR H  33
None
0.86A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens)		3 / 3THR A 168
SER A 133
TYR A 135
None
0.77A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4a5w COMPLEMENT C5
(Homo
sapiens)		3 / 3THR A1511
SER A1510
TYR A1509
None
0.86A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens)		3 / 3THR B 740
SER B 741
TYR B 667
None
0.73A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H 153
SER H 156
TYR H 157
None
0.76A19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.73A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4lri MSL-109 HEAVY CHAIN
(Homo
sapiens)		3 / 3THR P  28
SER P  30
TYR P  32
None
0.77A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4odh CAP256-VRC26.UCA
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.79A15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens)		3 / 3THR L  91
SER L  90
TYR L  89
None
0.83A15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4wxu MYOCILIN
(Homo
sapiens)		3 / 3THR A 394
SER A 393
TYR A 392
None
0.70A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens)		3 / 3THR A 140
SER A 139
TYR A 121
None
0.83A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4zso ANTIBODY HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.83A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		3 / 3THR A 321
SER A 309
TYR A 308
None
0.82A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.71A15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.84A7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		5u68 MPE8
(Homo
sapiens)		3 / 3THR E  47
SER E  50
TYR E  51
None
0.81A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		5viy BG1 FAB LIGHT CHAIN
(Homo
sapiens)		3 / 3THR G  20
SER G  74
TYR G  65
None
0.88A15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.89A8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		6amj CAT192 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.85A7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		1h0d ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.87A15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		1h6h NEUTROPHIL CYTOSOL
FACTOR 4
(Homo
sapiens)		3 / 3THR A  47
SER A  51
TYR A  53
None
0.79A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		2emp ZINC FINGER PROTEIN
347
(Homo
sapiens)		3 / 3THR A  29
SER A  26
TYR A  25
None
0.75A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.73A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		3 / 3THR A 527
SER A 529
TYR A 359
None
0.82A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		2xa8 OMALIZUMAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  53
SER H  34
TYR H  33
None
0.87A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens)		3 / 3THR A 168
SER A 133
TYR A 135
None
0.77A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4a5w COMPLEMENT C5
(Homo
sapiens)		3 / 3THR A1511
SER A1510
TYR A1509
None
0.87A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens)		3 / 3THR B 740
SER B 741
TYR B 667
None
0.73A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H 153
SER H 156
TYR H 157
None
0.76A19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		3 / 3THR A 247
SER A 248
TYR A  90
None
0.73A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4lri MSL-109 HEAVY CHAIN
(Homo
sapiens)		3 / 3THR P  28
SER P  30
TYR P  32
None
0.77A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4odh CAP256-VRC26.UCA
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.79A15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens)		3 / 3THR L  91
SER L  90
TYR L  89
None
0.83A15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4wxu MYOCILIN
(Homo
sapiens)		3 / 3THR A 394
SER A 393
TYR A 392
None
0.70A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens)		3 / 3THR A 140
SER A 139
TYR A 121
None
0.84A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4zso ANTIBODY HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.83A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		3 / 3THR A 321
SER A 309
TYR A 308
None
0.81A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		5ifh HEAVY CHAIN OF THE
FAB FRAGMENT FROM
BCR DERIVED FROM THE
P11475 CLL CLONE
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.71A15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		5n2k BRIAKINUMAB FAB
HEAVY CHAIN
(Homo
sapiens)		3 / 3THR B  28
SER B  31
TYR B  32
None
0.84A7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		5u68 MPE8
(Homo
sapiens)		3 / 3THR E  47
SER E  50
TYR E  51
None
0.81A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		5viy BG1 FAB LIGHT CHAIN
(Homo
sapiens)		3 / 3THR G  20
SER G  74
TYR G  65
None
0.88A15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.88A8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		5xj3 IPILIMUMAB-VH
(Homo
sapiens)		3 / 3THR A  28
SER A  31
TYR A  32
None
0.88A8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		6amj CAT192 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H  28
SER H  31
TYR H  32
None
0.85A7.51