POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	1h4w	TRYPSIN IVA (Homo sapiens)	5 / 12	HIS A  57 LEU A  99 ASP A 189 GLY A 216 GLY A 226	None None BEN  A 250 (-2.9A) BEN  A 250 (-3.9A) BEN  A 250 (-3.3A)	0.31A	36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	1riw	THROMBIN HEAVY CHAIN, B (Homo sapiens)	5 / 12	HIS B  79 TYR B  83 TRP B  86 LYS B  88 LEU B 132	None	0.56A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	2mqs	MATRIX METALLOPROTEINASE-14 THP_L_AND_M_CHAIN (; Homo sapiens)	5 / 12	TRP A 361 ALA A 393 ILE B  13 GLU A 392 GLY B  15	None	1.24A	22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	5 / 12	ILE C 209 ASP C 229 GLU C 232 GLY C 258 GLY C 268	G44  C 101 (-3.9A) G44  C 101 (-2.6A) None G44  C 101 (-3.3A) G44  C 101 (-3.0A)	0.69A	99.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	5 / 12	HIS H  57 ASP H 189 GLU H 192 GLY H 216 GLY H 226	0G6  H   1 (-3.2A) 0G6  H   1 (-2.8A) 0G6  H   1 ( 4.0A) 0G6  H   1 (-3.8A) 0G6  H   1 ( 3.9A)	0.63A	39.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3nks	PROTOPORPHYRINOGEN OXIDASE (Homo sapiens)	5 / 12	LEU A 240 ALA A 467 ILE A  12 GLY A  14 GLY A   9	None None None None FAD  A 479 (-3.3A)	1.18A	20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	3nxp	PRETHROMBIN-1 (Homo sapiens)	5 / 12	HIS A 457 TYR A 460 TRP A 460 LEU A 499 GLY A 616	None	1.16A	99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	3nxp	PRETHROMBIN-1 (Homo sapiens)	6 / 12	HIS A 457 TYR A 460 TRP A 460 LEU A 499 ILE A 574 GLY A 626	None	1.05A	99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	8 / 12	HIS B  57 TYR B  60 LEU B  99 ILE B 174 ASP B 189 GLU B 192 GLY B 216 GLY B 226	None	0.74A	97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	5 / 12	LYS B  60 ASP B 189 GLU B 192 GLY B 216 GLY B 226	None	0.96A	97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	4hzh	PROTHROMBIN (Homo sapiens)	6 / 12	HIS A 363 TYR A 367 TRP A 370 LYS A 372 LEU A 416 GLY A 558	None	0.96A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	5l2q	SERINE/THREONINE-PRO TEIN KINASE 40 (Homo sapiens)	5 / 12	TYR C 239 LEU C 200 ILE C 164 ASP C 296 GLY C 270	None	1.25A	23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	5m32	PROTEASOME SUBUNIT ALPHA TYPE-7 (Homo sapiens)	5 / 12	LEU C 144 ALA C 209 ILE C 133 ASP C 214 GLY C 135	None	1.15A	22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	5 / 12	HIS B  58 LYS B  67 ASP B 214 GLY B 243 GLY B 253	0G6  B 501 (-2.5A) None 0G6  B 501 (-2.9A) 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A)	0.81A	88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	7 / 12	HIS B  58 TYR B  62 LEU B 111 ILE B 194 ASP B 214 GLY B 243 GLY B 253	0G6  B 501 (-2.5A) 0G6  B 501 (-3.7A) 0G6  B 501 ( 3.8A) None 0G6  B 501 (-2.9A) 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A)	0.39A	88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_B_15UB402_1 (PROTHROMBIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	6 / 12	TYR B  62 TRP B  65 LEU B 111 ILE B 194 GLY B 243 GLY B 253	0G6  B 501 (-3.7A) 0G6  B 501 (-4.8A) 0G6  B 501 ( 3.8A) None 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A)	0.83A	88.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	1elv	COMPLEMENT C1S COMPONENT (Homo sapiens)	5 / 12	HIS A 460 ASP A 611 VAL A 638 TRP A 640 GLY A 648	SO4  A2001 ( 3.9A) None None None None	0.33A	28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	1fxy	COAGULATION FACTOR XA-TRYPSIN CHIMERA (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	0G6  A   1 (-2.7A) 0G6  A   1 (-2.8A) None None 0G6  A   1 (-3.3A)	0.35A	36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	1h4w	TRYPSIN IVA (Homo sapiens)	6 / 12	HIS A  57 LEU A  99 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None None BEN  A 250 (-2.9A) None None BEN  A 250 (-3.3A)	0.34A	36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	6 / 12	HIS H  57 ASP H 189 ALA H 190 VAL H 213 TRP H 215 GLY H 226	CR9  H 256 (-3.9A) CR9  H 256 (-2.4A) CR9  H 256 (-2.9A) CR9  H 256 (-4.3A) None CR9  H 256 (-3.0A)	0.36A	39.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	1q3x	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	5 / 12	HIS A 483 ASP A 627 VAL A 653 TRP A 655 GLY A 667	None NA  A 800 ( 4.6A) GOL  A 701 (-4.9A) None GOL  A 701 ( 4.0A)	0.23A	28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	1zlr	COAGULATION FACTOR XI (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 ALA A 190 TRP A 215 GLY A 226	368  A 901 (-4.0A) 368  A 901 (-2.8A) 368  A 901 (-3.7A) None 368  A 901 (-3.5A)	0.22A	36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	6 / 12	HIS A  57 ASP A 189 ALA A 190 VAL A 213 TRP A 215 GLY A 226	None DT8  A 700 (-3.5A) DT8  A 700 (-3.6A) DT8  A 700 ( 4.1A) DT8  A 700 (-3.9A) DT8  A 700 (-3.5A)	0.42A	40.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	2oq5	TRANSMEMBRANE PROTEASE, SERINE 11E (Homo sapiens)	6 / 12	HIS A  57 ASP A 189 ALA A 190 VAL A 213 TRP A 215 GLY A 226	None BEN  A 245 (-3.0A) BEN  A 245 (-3.9A) None None BEN  A 245 (-3.4A)	0.28A	36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	7 / 12	ILE C 209 ASP C 229 ALA C 230 GLU C 232 VAL C 255 TRP C 257 GLY C 268	G44  C 101 (-3.9A) G44  C 101 (-2.6A) G44  C 101 (-3.8A) None None G44  C 101 (-4.1A) G44  C 101 (-3.0A)	0.65A	99.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	2psy	KALLIKREIN-5 (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None	0.45A	34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	2qy0	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	6 / 12	HIS B 485 ASP B 631 ALA B 632 VAL B 657 TRP B 659 GLY B 668	None	0.32A	37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	2r0l	HEPATOCYTE GROWTH FACTOR ACTIVATOR (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 ALA A 190 TRP A 215 GLY A 226	None	0.27A	34.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	5 / 12	HIS U  57 ASP U 189 VAL U 213 TRP U 215 GLY U 226	4PG  U 300 (-3.9A) 4PG  U 300 (-2.8A) None None 4PG  U 300 (-3.2A)	0.42A	31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	2zec	TRYPTASE BETA 2 (Homo sapiens)	5 / 12	HIS A  59 ASP A 203 VAL A 227 TRP A 229 GLY A 240	None 11N  A   1 (-2.6A) None None 11N  A   1 (-3.6A)	0.37A	35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	6 / 12	ASP H 189 ALA H 190 GLU H 192 VAL H 213 TRP H 215 GLY H 226	0G6  H   1 (-2.8A) 0G6  H   1 (-3.4A) 0G6  H   1 ( 4.0A) None 0G6  H   1 (-4.1A) 0G6  H   1 ( 3.9A)	0.74A	39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	6 / 12	HIS H  57 ASP H 189 ALA H 190 VAL H 213 TRP H 215 GLY H 226	0G6  H   1 (-3.2A) 0G6  H   1 (-2.8A) 0G6  H   1 (-3.4A) None 0G6  H   1 (-4.1A) 0G6  H   1 ( 3.9A)	0.38A	39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	3gov	MASP-1 (Homo sapiens)	6 / 12	HIS B 490 ASP B 640 ALA B 641 VAL B 666 TRP B 668 GLY B 679	None	0.30A	36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	3gym	PROSTASIN (Homo sapiens)	6 / 12	HIS A  57 ASP A 189 ALA A 190 VAL A 213 TRP A 215 GLY A 226	None	0.40A	36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	3kzz	SNAP-TAG (Homo sapiens)	5 / 12	LEU A 168 GLU A 159 ALA A 145 VAL A 148 GLY A 156	None OBG  A 181 (-3.7A) OBG  A 181 (-3.4A) OBG  A 181 (-4.3A) None	1.14A	23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	3nxp	PRETHROMBIN-1 (Homo sapiens)	7 / 12	HIS A 457 TYR A 460 TRP A 460 LEU A 499 ILE A 574 VAL A 613 GLY A 626	None	0.73A	99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	9 / 12	HIS B  57 TYR B  60 LEU B  99 ILE B 174 ALA B 190 GLU B 192 VAL B 213 TRP B 215 GLY B 226	None	0.80A	97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	10 / 12	HIS B  57 TYR B  60 TRP B  60 LEU B  99 ILE B 174 ASP B 189 ALA B 190 VAL B 213 TRP B 215 GLY B 226	None	0.57A	97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	4fxg	MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN (Homo sapiens)	6 / 12	HIS H 483 ASP H 627 ALA H 633 VAL H 653 TRP H 655 GLY H 667	None	0.54A	35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	4hzh	PROTHROMBIN (Homo sapiens)	6 / 12	HIS A 363 TYR A 367 LEU A 416 ILE A 499 VAL A 545 GLY A 558	None	0.86A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	4hzh	PROTHROMBIN (Homo sapiens)	7 / 12	HIS A 363 TYR A 367 TRP A 370 LEU A 416 ALA A 525 VAL A 545 GLY A 558	None	0.79A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	5 / 12	HIS E 478 ASP E 639 VAL E 665 TRP E 667 GLY E 680	None	0.59A	34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	4r0i	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 VAL A 213 TRP A 215 GLY A 226	3KM  A 900 ( 4.4A) 3KM  A 900 (-2.9A) None None 3KM  A 900 (-3.2A)	0.36A	35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	4wwy	TRYPSIN-1 (Homo sapiens)	6 / 12	HIS A  57 LEU A  99 ASP A 189 VAL A 213 TRP A 215 GLY A 226	None	0.62A	36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	4ylq	COAGULATION FACTOR VII (Homo sapiens)	5 / 12	HIS H  57 ASP H 189 VAL H 213 TRP H 215 GLY H 226	0Z7  H 501 (-2.6A) 0Z7  H 501 (-2.3A) 0Z7  H 501 ( 4.7A) TMA  H 508 ( 3.9A) 0Z7  H 501 (-3.0A)	0.26A	35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	5brr	TISSUE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens)	6 / 12	HIS E  57 ASP E 189 ALA E 190 ALA E 195 TRP E 215 GLY E 226	None	0.46A	32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	5f8z	PLASMA KALLIKREIN LIGHT CHAIN (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 ALA A 190 TRP A 215 GLY A 226	None	0.22A	39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	5o32	COMPLEMENT FACTOR I (Homo sapiens)	5 / 12	ASP I 519 ALA I 520 VAL I 544 TRP I 546 GLY I 557	None	0.83A	32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	8 / 12	HIS B  58 TYR B  62 LEU B 111 ILE B 194 ASP B 214 ALA B 215 VAL B 240 GLY B 253	0G6  B 501 (-2.5A) 0G6  B 501 (-3.7A) 0G6  B 501 ( 3.8A) None 0G6  B 501 (-2.9A) 0G6  B 501 (-3.4A) None 0G6  B 501 (-3.6A)	0.40A	88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	6 / 12	TYR B  62 LEU B 111 ILE B 194 ALA B 215 GLU B 217 VAL B 240	0G6  B 501 (-3.7A) 0G6  B 501 ( 3.8A) None 0G6  B 501 (-3.4A) 0G6  B 501 (-3.8A) None	1.37A	88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	8 / 12	TYR B  62 TRP B  65 LEU B 111 ILE B 194 ASP B 214 ALA B 215 VAL B 240 GLY B 253	0G6  B 501 (-3.7A) 0G6  B 501 (-4.8A) 0G6  B 501 ( 3.8A) None 0G6  B 501 (-2.9A) 0G6  B 501 (-3.4A) None 0G6  B 501 (-3.6A)	0.52A	88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	5ubm	COMPLEMENT C1S SUBCOMPONENT (Homo sapiens)	5 / 12	HIS A 475 ASP A 626 VAL A 653 TRP A 655 GLY A 663	None	0.48A	35.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6b74	COAGULATION FACTOR XII (Homo sapiens)	5 / 12	HIS B  57 ASP B 189 ALA B 190 TRP B 215 GLY B 226	SO4  B 304 (-3.8A) BEN  B 301 (-2.7A) BEN  B 301 (-4.1A) None BEN  B 301 (-3.1A)	0.44A	16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	1rz8	FAB 17B HEAVY CHAIN (Homo sapiens)	5 / 10	TYR B  90 LEU B  80 LEU B 100 ALA B  93 GLY B  49	None	0.99A	22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	2x47	MACRO DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 10	LEU A 194 TRP A  95 ALA A 191 ALA A  98 GLY A 214	None	1.33A	22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	5 / 10	HIS B  57 TYR B  60 LEU B  99 TRP B 215 GLY B 216	None	0.54A	97.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	4jpz	SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA (Homo sapiens)	5 / 10	TRP B1802 LEU B1825 LEU B1844 ALA B1841 ALA B1860	None	1.46A	19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	5gvb	WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1 (Homo sapiens)	5 / 10	TYR A 640 TRP A 658 LEU A 627 ALA A 548 ALA A 577	None	1.18A	22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	5ogs	WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1 (Homo sapiens)	5 / 10	TYR A 640 TRP A 658 LEU A 627 ALA A 548 ALA A 577	None	1.16A	21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	5u09	CANNABINOID RECEPTOR 1,GLGA GLYCOGEN SYNTHASE (Homo sapiens; Pyrococcus abyssi)	5 / 10	TRP A 356 LEU A 165 TRP A 279 ALA A 244 GLY A 194	None PEG  A1206 ( 4.9A) None None None	1.29A	19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	5w4x	UDP-GLUCOSE 6-DEHYDROGENASE (Homo sapiens)	5 / 10	TYR A 199 LEU A 172 LEU A  69 ALA A  24 GLY A  17	None	1.49A	20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1elv	COMPLEMENT C1S COMPONENT (Homo sapiens)	5 / 12	HIS A 460 VAL A 638 TRP A 640 GLY A 641 GLY A 648	SO4  A2001 ( 3.9A) None None None None	0.50A	30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1fxy	COAGULATION FACTOR XA-TRYPSIN CHIMERA (Homo sapiens)	5 / 12	HIS A  57 VAL A 213 TRP A 215 GLY A 216 GLY A 226	0G6  A   1 (-2.7A) None None 0G6  A   1 (-3.9A) 0G6  A   1 (-3.3A)	0.36A	36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1gvl	KALLIKREIN 6 (Homo sapiens)	5 / 12	HIS A  57 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None	0.52A	34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1h4w	TRYPSIN IVA (Homo sapiens)	6 / 12	HIS A  57 LEU A  99 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None None None None BEN  A 250 (-3.9A) BEN  A 250 (-3.3A)	0.34A	36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	6 / 12	HIS H  57 ALA H 190 VAL H 213 TRP H 215 GLY H 216 GLY H 226	CR9  H 256 (-3.9A) CR9  H 256 (-2.9A) CR9  H 256 (-4.3A) None CR9  H 256 ( 3.8A) CR9  H 256 (-3.0A)	0.66A	39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1q3x	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	5 / 12	HIS A 483 VAL A 653 TRP A 655 GLY A 656 GLY A 667	None GOL  A 701 (-4.9A) None GOL  A 701 ( 4.1A) GOL  A 701 ( 4.0A)	0.41A	34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1zjk	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	5 / 12	HIS A 483 VAL A 653 TRP A 655 GLY A 656 GLY A 667	None	0.34A	25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1zlr	COAGULATION FACTOR XI (Homo sapiens)	5 / 12	HIS A  57 ALA A 190 TRP A 215 GLY A 216 GLY A 226	368  A 901 (-4.0A) 368  A 901 (-3.7A) None 368  A 901 (-3.6A) 368  A 901 (-3.5A)	0.93A	36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	6 / 12	HIS A  57 ALA A 190 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None DT8  A 700 (-3.6A) DT8  A 700 ( 4.1A) DT8  A 700 (-3.9A) DT8  A 700 (-3.5A) DT8  A 700 (-3.5A)	0.63A	40.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2gk1	BETA-HEXOSAMINIDASE SUBUNIT BETA CHAIN A BETA-HEXOSAMINIDASE SUBUNIT BETA CHAIN B (Homo sapiens)	5 / 12	LEU N 451 ALA N 506 VAL N 509 GLY M 204 GLY N 484	None	1.02A	20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2oq5	TRANSMEMBRANE PROTEASE, SERINE 11E (Homo sapiens)	6 / 12	HIS A  57 ALA A 190 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None BEN  A 245 (-3.9A) None None BEN  A 245 ( 3.8A) BEN  A 245 (-3.4A)	0.84A	36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	5 / 12	ALA C 230 VAL C 255 TRP C 257 GLY C 258 GLY C 268	G44  C 101 (-3.8A) None G44  C 101 (-4.1A) G44  C 101 (-3.3A) G44  C 101 (-3.0A)	0.75A	99.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2psy	KALLIKREIN-5 (Homo sapiens)	5 / 12	HIS A  57 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None	0.52A	34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2qy0	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	5 / 12	HIS B 485 VAL B 657 TRP B 659 GLY B 660 GLY B 668	None	0.29A	37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	5 / 12	HIS U  57 VAL U 213 TRP U 215 GLY U 216 GLY U 226	4PG  U 300 (-3.9A) None None 4PG  U 300 (-3.3A) 4PG  U 300 (-3.2A)	0.32A	29.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2zec	TRYPTASE BETA 2 (Homo sapiens)	5 / 12	HIS A  59 VAL A 227 TRP A 229 GLY A 230 GLY A 240	None None None 11N  A   1 (-3.9A) 11N  A   1 (-3.6A)	0.48A	35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	6 / 12	HIS H  57 ALA H 190 VAL H 213 TRP H 215 GLY H 216 GLY H 226	0G6  H   1 (-3.2A) 0G6  H   1 (-3.4A) None 0G6  H   1 (-4.1A) 0G6  H   1 (-3.8A) 0G6  H   1 ( 3.9A)	0.91A	36.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3fht	ATP-DEPENDENT RNA HELICASE DDX19B (Homo sapiens)	5 / 12	LEU A  99 ALA A 146 VAL A 149 GLY A 106 GLY A 186	None ANP  A 480 ( 4.6A) None None None	0.78A	23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3gov	MASP-1 (Homo sapiens)	5 / 12	HIS B 490 ALA B 641 VAL B 666 TRP B 668 GLY B 669	None	0.85A	36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3gov	MASP-1 (Homo sapiens)	5 / 12	HIS B 490 VAL B 666 TRP B 668 GLY B 669 GLY B 679	None	0.44A	36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3gym	PROSTASIN (Homo sapiens)	6 / 12	HIS A  57 ALA A 190 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None	0.79A	36.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3nxp	PRETHROMBIN-1 (Homo sapiens)	5 / 12	HIS A 457 TYR A 460 LEU A 499 VAL A 613 GLY A 626	None	0.50A	99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3nxp	PRETHROMBIN-1 (Homo sapiens)	5 / 12	HIS A 457 TYR A 460 TRP A 460 LEU A 499 GLY A 626	None	0.88A	99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	8 / 12	HIS B  57 TYR B  60 LEU B  99 ALA B 190 VAL B 213 TRP B 215 GLY B 216 GLY B 226	None	0.77A	97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	6 / 12	TYR B  60 TRP B  60 LEU B  99 TRP B 215 GLY B 216 GLY B 226	None	0.78A	97.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4fxg	MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN (Homo sapiens)	6 / 12	HIS H 483 ALA H 633 VAL H 653 TRP H 655 GLY H 656 GLY H 667	None	0.58A	35.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4h4f	CHYMOTRYPSIN-C (Homo sapiens)	5 / 12	HIS A  57 LEU A  99 ALA A 190 VAL A 213 GLY A 216	None	0.72A	30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4hzh	PROTHROMBIN (Homo sapiens)	7 / 12	HIS A 363 TYR A 367 TRP A 370 ALA A 525 VAL A 545 GLY A 548 GLY A 558	None	1.04A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4hzh	PROTHROMBIN (Homo sapiens)	7 / 12	HIS A 363 TYR A 367 TRP A 370 LEU A 416 ALA A 525 VAL A 545 GLY A 558	None	0.73A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	5 / 12	HIS E 478 VAL E 665 TRP E 667 GLY E 668 GLY E 680	None	0.34A	31.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4kkd	MANNAN-BINDING LECTIN SERINE PROTEASE 1 (Homo sapiens)	5 / 12	HIS A 497 VAL A 684 TRP A 686 GLY A 687 GLY A 699	None	0.49A	26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4r0i	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN (Homo sapiens)	5 / 12	HIS A  57 VAL A 213 TRP A 215 GLY A 216 GLY A 226	3KM  A 900 ( 4.4A) None None 3KM  A 900 (-3.4A) 3KM  A 900 (-3.2A)	0.35A	31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4wwy	TRYPSIN-1 (Homo sapiens)	6 / 12	HIS A  57 LEU A  99 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None	0.63A	36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	4ylq	COAGULATION FACTOR VII (Homo sapiens)	5 / 12	HIS H  57 VAL H 213 TRP H 215 GLY H 216 GLY H 226	0Z7  H 501 (-2.6A) 0Z7  H 501 ( 4.7A) TMA  H 508 ( 3.9A) 0Z7  H 501 (-3.4A) 0Z7  H 501 (-3.0A)	0.33A	35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5brr	TISSUE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens)	5 / 12	HIS E  57 ALA E 190 ALA E 195 TRP E 215 GLY E 216	None	0.98A	32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5brr	TISSUE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens)	5 / 12	HIS E  57 ALA E 195 TRP E 215 GLY E 216 GLY E 226	None	0.52A	32.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5d68	KREV INTERACTION TRAPPED PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 411 ALA A 407 VAL A 371 GLY A 364 GLY A 366	None	0.98A	21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5do7	ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5 (Homo sapiens)	5 / 12	LEU A 518 ALA A 438 ALA A 468 GLY A 513 GLY A 434	None	1.02A	17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5fah	KALLIKREIN-7 (Homo sapiens)	5 / 12	ALA A 190 VAL A 213 TRP A 215 GLY A 216 GLY A 226	5VT  A 302 (-3.8A) None None 5VT  A 302 (-3.4A) 5VT  A 302 ( 4.3A)	0.90A	30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5o32	COMPLEMENT FACTOR I (Homo sapiens)	6 / 12	HIS I 380 ALA I 520 VAL I 544 TRP I 546 GLY I 547 GLY I 557	None	0.74A	32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	6 / 12	HIS B  58 LEU B 111 ALA B 215 VAL B 240 GLY B 243 GLY B 253	0G6  B 501 (-2.5A) 0G6  B 501 ( 3.8A) 0G6  B 501 (-3.4A) None 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A)	0.76A	88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	6 / 12	HIS B  58 TYR B  62 LEU B 111 VAL B 240 GLY B 243 GLY B 253	0G6  B 501 (-2.5A) 0G6  B 501 (-3.7A) 0G6  B 501 ( 3.8A) None 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A)	0.35A	88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5ubm	COMPLEMENT C1S SUBCOMPONENT (Homo sapiens)	5 / 12	HIS A 475 VAL A 653 TRP A 655 GLY A 656 GLY A 663	None	0.48A	35.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6b74	COAGULATION FACTOR XII (Homo sapiens)	5 / 12	HIS B  57 ALA B 190 TRP B 215 GLY B 216 GLY B 226	SO4  B 304 (-3.8A) BEN  B 301 (-4.1A) None BEN  B 301 (-3.3A) BEN  B 301 (-3.1A)	0.71A	15.00