POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_A_115A2_1
(HMG-COA REDUCTASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		9 / 9ARG A 590
MET A 657
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
RIE  A 876 (-2.9A)
RIE  A 876 (-4.1A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
0.37A95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		1ozn RETICULON 4 RECEPTOR
(Homo
sapiens)		4 / 8ASN A 260
LEU A 241
ALA A 245
LEU A 246
None
0.75A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens)		4 / 8GLU B  48
LEU B 160
ALA B 179
LEU B 177
None
0.92A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens)		4 / 8ASN A 232
LEU A 244
ALA A 247
LEU A 248
None
1.06A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens)		4 / 8GLU A  95
ASN A 217
LEU A 222
LEU A 226
None
0.87A22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		8 / 8GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
None
0.22A95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 8ASN A2175
LEU A2170
ALA A2192
LEU A2168
None
0.78A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		4 / 8ASN A 206
LEU A 231
ALA A 255
LEU A 228
None
0.84A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens)		4 / 8ASN A 372
LEU A 435
ALA A 438
LEU A 439
None
0.66A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens)		4 / 8GLU A 207
LEU A 258
ALA A 257
LEU A 266
None
0.92A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens)		4 / 8CYH B  76
LEU B  11
ALA B  14
LEU B  15
None
0.82A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens)		4 / 8GLU A 556
LEU A 639
ALA A 642
LEU A 643
None
0.90A22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		4b94 DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens)		4 / 8GLU A  63
ASN A 106
LEU A  98
ALA A  94
None
1.05A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens)		4 / 8CYH A1348
LEU A1392
ALA A1395
LEU A1396
None
0.78A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8ASN A 925
LEU A 937
ALA A 940
LEU A 941
None
0.87A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		4h7y DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens)		4 / 8GLU A  14
ASN A  57
LEU A  49
ALA A  45
None
1.05A17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens)		4 / 8GLU A 296
LEU A 202
ALA A 262
LEU A 265
None
1.01A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		4pw8 TRYPTOPHAN
2,3-DIOXYGENASE
(Homo
sapiens)		4 / 8HIS A 273
LEU A 289
ALA A 292
LEU A 293
None
0.69A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		4 / 8GLU A 366
LEU A 392
ALA A 349
LEU A 353
None
1.05A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 8GLU C1350
LEU C1050
ALA C1056
LEU C1048
None
0.97A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 8ASN A2175
LEU A2170
ALA A2192
LEU A2168
None
0.74A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens)		4 / 8ASN A 140
LEU A  57
ALA A  77
LEU A  67
IDV  A 401 ( 4.5A)
IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
1.05A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)		4 / 8ASN A 540
LEU A 408
ALA A 411
LEU A 412
None
1.04A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5lfn CHONDROADHERIN
(Homo
sapiens)		4 / 8ASN A 205
LEU A 186
ALA A 190
LEU A 191
None
0.95A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens)		4 / 8HIS A1286
LEU A1288
ALA A1172
LEU A1175
 U  H   4 ( 4.4A)
U  H   4 ( 4.5A)
None
None
1.06A23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5ykh PUMILIO HOMOLOG 1
(Homo
sapiens)		4 / 8HIS A 133
LEU A  99
ALA A 102
LEU A 103
None
1.01A9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens)		5 / 9CYH A  83
LEU A  75
ALA A  15
LEU A  17
LEU A 118
None
1.42A15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		1xkt FATTY ACID SYNTHASE
(Homo
sapiens)		5 / 9HIS A2498
LEU A2264
ALA A2261
LEU A2260
LEU A2246
None
1.08A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		5 / 9CYH A 432
LEU A 451
ALA A 272
LEU A 276
LEU A 309
9CR  A 801 ( 3.7A)
None
9CR  A 801 (-3.5A)
None
9CR  A 801 (-4.2A)
1.25A22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		8 / 9GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
None
0.20A95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2xmr PROTEIN NDRG2
(Homo
sapiens)		5 / 9ASN A 160
LEU A 229
ALA A 139
LEU A 143
LEU A 239
None
1.33A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens)		5 / 9ASN A 154
LEU A 148
ALA A 145
LEU A 144
LEU A 164
None
0.98A19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 9GLU A1480
LEU A1651
ALA A1653
LEU A1634
LEU A1619
None
1.46A16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens)		5 / 8ARG A 409
SER A 452
VAL A 169
ASN A 164
ASP A 162
None
1.48A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens)		4 / 8ARG A 175
SER A 171
VAL A 159
ASN A 107
None
1.07A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		4 / 8SER A 144
VAL A 314
SER A 313
LYS A 151
None
1.19A22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		8 / 8ARG A 590
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
RIE  A 876 (-2.9A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
0.36A95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		4 / 8SER A 192
VAL A 164
SER A 165
ASP A 110
ETQ  A1200 (-3.3A)
None
None
ETQ  A1200 (-3.5A)
1.01A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens)		4 / 8SER C 262
VAL C 266
SER C 267
ASN C 299
None
1.05A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		4uta BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8 HEAVY CHAIN
(Homo
sapiens)		4 / 8SER H   7
VAL H   5
SER H  23
ASN H  77
None
1.26A19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens)		4 / 8ARG A 239
VAL A 238
ASN A 214
LYS A 168
None
1.21A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		4yii ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens)		4 / 8ARG A 816
SER A 767
VAL A 814
SER A 811
None
1.22A9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens)		4 / 8ARG N 816
SER N 767
VAL N 814
SER N 811
None
1.22A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens)		4 / 8SER A 716
VAL A 436
SER A 435
ASN A 507
None
1.17A22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		1qdd LITHOSTATHINE
(Homo
sapiens)		4 / 7VAL A 116
SER A 117
ASN A  75
ASP A 134
None
1.32A15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		1s79 LUPUS LA PROTEIN
(Homo
sapiens)		4 / 7ARG A 111
VAL A 108
ASN A 139
ASP A 159
None
1.30A11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2odv PLECTIN 1
(Homo
sapiens)		4 / 7ARG A 365
ASN A 364
ASP A 362
LYS A 359
None
1.31A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2q9g CYTOCHROME P450 46A1
(Homo
sapiens)		4 / 7VAL A  85
SER A  84
ASP A 105
LYS A 107
None
1.35A23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		7 / 7ARG A 590
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
0.29A95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2vsz ENGULFMENT AND CELL
MOTILITY PROTEIN 1
(Homo
sapiens)		4 / 7VAL A 616
SER A 643
ASN A 653
LYS A 626
None
1.28A15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3s95 LIM DOMAIN KINASE 1
(Homo
sapiens)		4 / 7ARG A 608
VAL A 438
SER A 439
ASN A 473
None
1.21A22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens)		4 / 7ARG A 504
VAL A 417
ASN A 467
ASP A 465
None
1.30A19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1
(Homo
sapiens)		4 / 7ARG A 576
VAL A 575
ASP A 403
LYS A 341
None
1.37A20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6f9s CYTOKINESIS,
APOPTOSIS,
RNA-ASSOCIATED
PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Caenorhabditis
elegans;
Homo
sapiens)		4 / 7ARG A 331
SER A 330
ASN A 326
ASP B 189
None
1.29A10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN
(Homo
sapiens)		4 / 8HIS A 202
ASN A 231
ALA A 258
LEU A 253
None
0.92A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		1ozn RETICULON 4 RECEPTOR
(Homo
sapiens)		4 / 8ASN A 260
LEU A 241
ALA A 245
LEU A 246
None
0.74A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens)		4 / 8GLU B  48
LEU B 160
ALA B 179
LEU B 177
None
0.91A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		2mj7 AP-4 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens)		4 / 8GLU A 137
LEU A  59
ALA A  62
LEU A  63
None
0.90A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		2p4e PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		4 / 8GLU P 145
LEU P 131
ALA P 134
LEU P 135
None
0.94A23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens)		4 / 8GLU A  95
ASN A 217
LEU A 222
LEU A 226
None
0.92A22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		8 / 8GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
None
0.21A95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		2w2o PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		4 / 8GLU P 145
LEU P 131
ALA P 134
LEU P 135
None
0.89A12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 8ASN A2175
LEU A2170
ALA A2192
LEU A2168
None
0.78A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		4 / 8ASN A 206
LEU A 231
ALA A 255
LEU A 228
None
0.83A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens)		4 / 8ASN A 372
LEU A 435
ALA A 438
LEU A 439
None
0.68A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens)		4 / 8GLU A 207
LEU A 258
ALA A 257
LEU A 266
None
0.94A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens)		4 / 8CYH B  76
LEU B  11
ALA B  14
LEU B  15
None
0.79A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens)		4 / 8ASN A 154
LEU A 148
ALA A 145
LEU A 144
None
0.84A19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		3sqo PCSK9 PRODOMAIN
(Homo
sapiens)		4 / 8GLU P 145
LEU P 131
ALA P 134
LEU P 135
None
0.86A13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens)		4 / 8ASN A 372
LEU A 435
ALA A 438
LEU A 439
None
0.83A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens)		4 / 8GLU A 556
LEU A 639
ALA A 642
LEU A 643
None
0.89A22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens)		4 / 8CYH A1348
LEU A1392
ALA A1395
LEU A1396
None
0.76A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens)		4 / 8CYH A 215
LEU A 187
ALA A 190
LEU A 191
None
None
3AB  A 301 (-3.9A)
None
0.74A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8ASN A 925
LEU A 937
ALA A 940
LEU A 941
None
0.84A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		4 / 8GLU A 699
LEU A 718
ALA A 779
LEU A 780
None
0.93A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		4pw8 TRYPTOPHAN
2,3-DIOXYGENASE
(Homo
sapiens)		4 / 8HIS A 273
LEU A 289
ALA A 292
LEU A 293
None
0.66A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN
(Homo
sapiens)		4 / 8HIS A 132
ASN A 161
ALA A 188
LEU A 183
None
1.05A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN
(Homo
sapiens)		4 / 8HIS A 202
ASN A 231
ALA A 258
LEU A 253
None
0.92A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		1ozn RETICULON 4 RECEPTOR
(Homo
sapiens)		4 / 8ASN A 260
LEU A 241
ALA A 245
LEU A 246
None
0.74A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens)		4 / 8GLU B  48
LEU B 160
ALA B 179
LEU B 177
None
0.92A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens)		4 / 8ASN A 232
LEU A 244
ALA A 247
LEU A 248
None
1.06A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		2q12 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens)		4 / 8GLU A  95
ASN A 217
LEU A 222
LEU A 226
None
0.91A22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		8 / 8GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
None
0.20A95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 8ASN A2175
LEU A2170
ALA A2192
LEU A2168
None
0.78A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		4 / 8ASN A 206
LEU A 231
ALA A 255
LEU A 228
None
0.83A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens)		4 / 8ASN A 372
LEU A 435
ALA A 438
LEU A 439
None
0.67A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens)		4 / 8GLU A 207
LEU A 258
ALA A 257
LEU A 266
None
0.93A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens)		4 / 8CYH B  76
LEU B  11
ALA B  14
LEU B  15
None
0.80A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens)		4 / 8GLU A 556
LEU A 639
ALA A 642
LEU A 643
None
0.90A22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens)		4 / 8CYH A1348
LEU A1392
ALA A1395
LEU A1396
None
0.77A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8ASN A 925
LEU A 937
ALA A 940
LEU A 941
None
0.85A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN
(Homo
sapiens)		4 / 8GLU A 296
LEU A 202
ALA A 262
LEU A 265
None
1.00A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		4pw8 TRYPTOPHAN
2,3-DIOXYGENASE
(Homo
sapiens)		4 / 8HIS A 273
LEU A 289
ALA A 292
LEU A 293
None
0.65A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 8GLU C1350
LEU C1050
ALA C1056
LEU C1048
None
0.97A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens)		4 / 8ASN A2175
LEU A2170
ALA A2192
LEU A2168
None
0.74A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens)		4 / 8ASN A 140
LEU A  57
ALA A  77
LEU A  67
IDV  A 401 ( 4.5A)
IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
1.04A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)		4 / 8ASN A 540
LEU A 408
ALA A 411
LEU A 412
None
1.06A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5lfn CHONDROADHERIN
(Homo
sapiens)		4 / 8ASN A 205
LEU A 186
ALA A 190
LEU A 191
None
0.92A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens)		4 / 8HIS A1286
LEU A1288
ALA A1172
LEU A1175
 U  H   4 ( 4.4A)
U  H   4 ( 4.5A)
None
None
1.00A23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5ykh PUMILIO HOMOLOG 1
(Homo
sapiens)		4 / 8HIS A 133
LEU A  99
ALA A 102
LEU A 103
None
0.98A9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		1qdd LITHOSTATHINE
(Homo
sapiens)		4 / 7VAL A 116
SER A 117
ASN A  75
ASP A 134
None
1.32A15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		1s79 LUPUS LA PROTEIN
(Homo
sapiens)		4 / 7ARG A 111
VAL A 108
ASN A 139
ASP A 159
None
1.31A11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		2odv PLECTIN 1
(Homo
sapiens)		4 / 7ARG A 365
ASN A 364
ASP A 362
LYS A 359
None
1.31A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		2q9g CYTOCHROME P450 46A1
(Homo
sapiens)		4 / 7VAL A  85
SER A  84
ASP A 105
LYS A 107
None
1.35A23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		7 / 7ARG A 590
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
0.30A95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		2vsz ENGULFMENT AND CELL
MOTILITY PROTEIN 1
(Homo
sapiens)		4 / 7VAL A 616
SER A 643
ASN A 653
LYS A 626
None
1.28A15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		3s95 LIM DOMAIN KINASE 1
(Homo
sapiens)		4 / 7ARG A 608
VAL A 438
SER A 439
ASN A 473
None
1.21A22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens)		4 / 7ARG A 504
VAL A 417
ASN A 467
ASP A 465
None
1.30A19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1
(Homo
sapiens)		4 / 7ARG A 576
VAL A 575
ASP A 403
LYS A 341
None
1.37A20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6f9s CYTOKINESIS,
APOPTOSIS,
RNA-ASSOCIATED
PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Caenorhabditis
elegans;
Homo
sapiens)		4 / 7ARG A 331
SER A 330
ASN A 326
ASP B 189
None
1.30A10.90