POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1x3c ZINC FINGER PROTEIN
292
(Homo
sapiens)		4 / 7PHE A  60
TYR A  49
PRO A  58
HIS A  32
None
ZN  A 201 ( 4.8A)
None
None
1.03A11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens)		4 / 7TYR A  70
HIS A  74
ILE A 113
TYR A 116
None
1.14A21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens)		4 / 7TYR A 807
HIS A 811
ILE A 815
PRO A 854
None
0.54A73.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		3bpo INTERLEUKIN-13
RECEPTOR ALPHA-1
CHAIN
(Homo
sapiens)		4 / 7PHE C 183
TYR C 158
ILE C 213
PRO C 148
PHE  C 183 ( 1.3A)
TYR  C 158 ( 1.3A)
ILE  C 213 ( 0.6A)
PRO  C 148 ( 1.1A)
0.78A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		3j7y UL16
(Homo
sapiens)		4 / 7PHE N 128
ILE N 131
TYR N  96
PRO N 153
None
None
A  A2110 ( 4.5A)
None
1.11A21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens)		4 / 7PHE B 282
TYR B  96
TYR B 335
PRO B  94
None
0.86A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 7PHE A 444
TYR A 529
ILE A 511
PRO A 442
None
1.14A16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		6 / 7PHE A 771
TYR A 777
HIS A 781
ILE A 785
TYR A 789
PRO A 824
None
0.48A86.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)		4 / 7PHE A 921
TYR A 927
TYR A1008
HIS A1004
None
1.20A30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens)		4 / 7TYR D 225
HIS D 163
ILE D 196
TYR D 147
None
1.12A22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens)		4 / 7PHE A 299
TYR A 252
TYR A 191
PRO A 304
None
1.09A23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens)		4 / 7PHE D  38
TYR D  40
TYR G  39
HIS G  37
None
1.01A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens)		4 / 7PHE A  21
TYR A  16
ILE A 353
PRO A  22
None
1.13A22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens)		4 / 7PHE A 184
TYR A 176
HIS A 411
HIS A 378
None
None
None
C8E  A 702 ( 2.6A)
1.08A18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens)		4 / 7PHE B 333
ILE B  97
TYR B  95
HIS B 344
None
1.19A21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens)		4 / 7ILE C 121
TYR C 274
PRO C 272
HIS C 128
None
1.15A23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		4 / 7PHE A 407
TYR A 232
ILE A 239
PRO A 403
None
0.91A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7HIS A 421
ILE A 423
TYR A 313
PRO A 371
None
1.16A19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		6 / 7PHE A 795
TYR A 801
HIS A 805
ILE A 809
TYR A 813
PRO A 848
None
0.50A98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		4 / 7PHE A 490
TYR A 575
ILE A 557
PRO A 488
None
1.17A16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20
(Homo
sapiens)		4 / 7ILE A  37
TYR A  38
PRO A  31
HIS A 131
CME  A  52 ( 3.6A)
None
None
None
1.06A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2ct0 NON-SMC ELEMENT 1
HOMOLOG
(Homo
sapiens)		4 / 5ASN A  19
MET A  38
HIS A  39
LEU A  40
None
None
ZN  A 201 (-3.4A)
None
1.37A12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		4l01 TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens)		4 / 5ASN A 789
MET A 679
HIS A 680
LEU A 677
None
1.21A26.76