POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	2do7	CULLIN-4B (Homo sapiens)	5 / 12	TYR A 856 LEU A 859 PHE A 861 VAL A 863 ALA A 835	None	1.30A	13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	2ibu	ACETYL-COA ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 309 ALA A  79 GLU A 234 ALA A  47 THR A  48	None	1.29A	23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	2q9g	CYTOCHROME P450 46A1 (Homo sapiens)	9 / 12	PHE A  80 TYR A 109 LEU A 112 PHE A 121 VAL A 126 ALA A 302 THR A 306 ALA A 474 THR A 475	None None None None HEM  A 505 ( 3.8A) HEM  A 505 (-3.7A) HEM  A 505 (-3.7A) None None	0.87A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	2q9g	CYTOCHROME P450 46A1 (Homo sapiens)	7 / 12	PHE A  80 TYR A 109 VAL A 126 THR A 306 GLU A 472 ALA A 474 THR A 475	None None HEM  A 505 ( 3.8A) HEM  A 505 (-3.7A) None None None	0.86A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	2q9g	CYTOCHROME P450 46A1 (Homo sapiens)	9 / 12	TYR A 109 LEU A 112 PHE A 121 VAL A 126 ALA A 302 THR A 306 TRP A 368 ALA A 474 THR A 475	None None None HEM  A 505 ( 3.8A) HEM  A 505 (-3.7A) HEM  A 505 (-3.7A) None None None	0.67A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	2q9g	CYTOCHROME P450 46A1 (Homo sapiens)	7 / 12	TYR A 109 VAL A 126 THR A 306 TRP A 368 GLU A 472 ALA A 474 THR A 475	None HEM  A 505 ( 3.8A) HEM  A 505 (-3.7A) None None None None	0.77A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	3eap	RHO GTPASE-ACTIVATING PROTEIN 11A (Homo sapiens)	5 / 12	LEU A  15 VAL A  23 ALA A 140 ALA A 155 THR A 156	None	1.10A	20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	3eap	RHO GTPASE-ACTIVATING PROTEIN 11A (Homo sapiens)	5 / 12	PHE A 244 LEU A  15 ALA A 140 ALA A 155 THR A 156	None	1.23A	20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	3l8j	PROGRAMMED CELL DEATH PROTEIN 10 (Homo sapiens)	5 / 12	TYR A 181 LEU A 178 PHE A 174 VAL A 190 THR A 130	None	1.25A	19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	3pm0	CYTOCHROME P450 1B1 (Homo sapiens)	5 / 12	PHE A 268 PHE A 134 VAL A 235 ALA A 330 THR A 334	BHF  A 800 ( 3.8A) BHF  A 800 (-4.8A) None HEM  A 900 ( 3.4A) HEM  A 900 ( 3.2A)	1.28A	25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	5dzz	DESMOPLAKIN (Homo sapiens)	5 / 12	PHE A2415 ALA A2294 THR A2298 ALA A2373 THR A2374	None	0.91A	23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	5g1n	CAD PROTEIN (Homo sapiens)	5 / 12	LEU A2142 VAL A2078 ARG A2200 ALA A2135 ALA A2175	None	1.24A	20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	5mwa	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	5 / 12	PHE A  86 LEU A  23 VAL A  19 THR A  50 ALA A  40	None None 8S9  A 302 (-3.8A) 8S9  A 302 ( 4.8A) None	1.29A	10.75