POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	1aye	PROCARBOXYPEPTIDASE A2 (Homo sapiens)	4 / 5	LEU A 195 LEU A  64 MET A 301 THR A  82	None	1.11A	20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	1dtd	CARBOXYPEPTIDASE A2 (Homo sapiens)	4 / 5	LEU A 551 LEU A 419 MET A 657 THR A 437	None	1.09A	18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	1qh5	PROTEIN (HYDROXYACYLGLUTATHI ONE HYDROLASE) (Homo sapiens)	4 / 5	LEU A 163 LEU A 215 MET A 225 THR A 132	None	1.39A	19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	2a98	INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE C (Homo sapiens)	4 / 5	LEU A 441 LEU A 444 MET A 636 THR A 642	None	1.26A	19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	2pcu	CARBOXYPEPTIDASE A4 (Homo sapiens)	4 / 5	LEU A 195 LEU A  64 MET A 301 THR A  82	None	1.30A	18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	2wd9	ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL (Homo sapiens)	4 / 5	LEU A 297 LEU A 318 MET A 308 THR A 353	None	1.27A	22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	3hw2	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2 (Homo sapiens)	4 / 5	LEU B 818 LEU B 852 MET B 822 TRP B 865	None	1.41A	13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	3pk1	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 (Homo sapiens)	4 / 5	LEU A 267 LEU A 298 THR A 259 TRP A 305	None	1.42A	16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	4akm	LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 3 (Homo sapiens)	4 / 5	LEU A 360 LEU A 292 MET A 328 THR A 355	None	1.32A	15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	5jsb	INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 (Homo sapiens)	4 / 5	LEU A 267 LEU A 298 THR A 259 TRP A 305	None	1.50A	16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	1aye	PROCARBOXYPEPTIDASE A2 (Homo sapiens)	5 / 6	LEU A 195 LEU A  64 ILE A 105 MET A 301 THR A  82	None	1.28A	20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	1dtd	CARBOXYPEPTIDASE A2 (Homo sapiens)	5 / 6	LEU A 551 LEU A 419 ILE A 460 MET A 657 THR A 437	None	1.28A	18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	1t5c	CENTROMERIC PROTEIN E (Homo sapiens)	4 / 6	LEU A 292 LEU A 296 ILE A 269 THR A 302	None	0.94A	20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	1xwd	FOLLICLE STIMULATING HORMONE RECEPTOR (Homo sapiens)	4 / 6	LEU C 233 LEU C 209 ILE C 185 THR C 228	None	0.91A	18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	2l54	DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE (Homo sapiens)	4 / 6	LEU A  55 LEU A  46 ILE A  42 THR A  26	None	0.97A	9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	3b2d	CD180 ANTIGEN (Homo sapiens)	4 / 6	LEU A 106 LEU A 130 ILE A 143 MET A 116	None	0.97A	22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	3c5w	PP2A-SPECIFIC METHYLESTERASE PME-1 (Homo sapiens)	4 / 6	LEU P 110 LEU P  80 ILE P 150 THR P 165	None	0.92A	20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	3wsy	SORTILIN-RELATED RECEPTOR (Homo sapiens)	4 / 6	LEU A 644 ILE A 374 THR A 443 TRP A 450	None	0.98A	20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	4ay9	FOLLICLE-STIMULATING HORMONE RECEPTOR (Homo sapiens)	4 / 6	LEU X 233 LEU X 209 ILE X 185 THR X 228	None	0.93A	22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	4oli	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	4 / 6	LEU A 699 LEU A 695 ILE A 755 THR A 803	None	0.97A	24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	4wov	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	4 / 6	LEU A 699 LEU A 695 ILE A 755 THR A 803	None	0.95A	22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	4wyk	NUCLEAR RNA EXPORT FACTOR 1 (Homo sapiens)	4 / 6	LEU A 270 LEU A 296 ILE A 312 MET A 283	None	1.01A	22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	4zk3	SERPIN B3 (Homo sapiens)	4 / 6	LEU A 241 LEU A 382 ILE A  32 THR A 378	None	0.89A	21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	5gje	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 (Homo sapiens)	4 / 6	LEU A 585 LEU A 421 ILE A 420 TRP A 400	None	0.77A	24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	5gs0	TOLL-LIKE RECEPTOR 3 (Homo sapiens)	4 / 6	LEU A 202 LEU A 204 ILE A 209 THR A 162	None	0.99A	23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	5lgd	PLATELET GLYCOPROTEIN 4 (Homo sapiens)	4 / 6	LEU A 416 LEU A 387 ILE A 271 THR A 369	None PLM  A 513 ( 4.4A) PLM  A 513 ( 4.6A) PLM  A 513 (-3.9A)	0.91A	22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	5m7r	PROTEIN O-GLCNACASE (Homo sapiens)	4 / 6	LEU A 158 LEU A 154 ILE A 143 THR A 199	None	0.93A	21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	5obn	RNA-BINDING PROTEIN 40 (Homo sapiens)	4 / 6	LEU A 459 LEU A 436 ILE A 439 MET A 496	None	0.84A	8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	5uhk	O-GLCNACASE TIM-BARREL DOMAIN (Homo sapiens)	4 / 6	LEU A 158 LEU A 154 ILE A 143 THR A 199	None	0.98A	18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_B_0LAB602_1 (FATTY-ACID AMIDE HYDROLASE 1)	5uhp	O-GLCNACASE TIM-BARREL DOMAIN (Homo sapiens)	4 / 6	LEU A 158 LEU A 154 ILE A 143 THR A 199	None	0.94A	19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MJR_A_0LAA404_1 (DNA POLYMERASE III SUBUNIT BETA)	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	5 / 9	TYR A 276 GLY A 250 LEU A 255 PRO A 262 VAL A 176	None	1.46A	22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	1q20	SULFOTRANSFERASE FAMILY, CYTOSOLIC, 2B, MEMBER 1 ISOFORM B (Homo sapiens)	4 / 7	LEU A 121 ILE A 224 LEU A 206 MET A 145	None	0.91A	21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	1q5h	DUTP PYROPHOSPHATASE (Homo sapiens)	4 / 7	LEU A  27 THR A  45 PRO A  15 LEU A   8	None	1.04A	14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	2awg	38 KDA FK-506 BINDING PROTEIN (Homo sapiens)	4 / 7	LEU A 127 THR A 129 ILE A 188 LEU A 131	None	1.04A	20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	2jam	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE 1G (Homo sapiens)	4 / 7	LEU A 259 PRO A 219 ILE A 212 LEU A 213	None	1.00A	24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	3ehw	DUTP PYROPHOSPHATASE (Homo sapiens)	4 / 7	LEU A  50 THR A  68 PRO A  38 LEU A  31	None	0.99A	16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	3she	MAP KINASE-ACTIVATED PROTEIN KINASE 3 (Homo sapiens)	4 / 7	LEU A 285 PRO A 241 ILE A 234 LEU A 235	None	0.97A	21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	4d1e	ALPHA-ACTININ-2 (Homo sapiens)	4 / 7	PRO A 240 ILE A 245 LEU A 186 MET A 216	MLZ  A 239 ( 2.6A) None None None	1.05A	16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	4xgm	MITOCHONDRIAL RIBONUCLEASE P PROTEIN 3 (Homo sapiens)	4 / 7	LEU A 233 PRO A 242 ILE A 275 LEU A 271	None	0.92A	23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	5wvo	DNA (CYTOSINE-5)-METHYLT RANSFERASE 1 (Homo sapiens)	4 / 7	LEU C 426 THR C 424 ILE C 498 LEU C 501	None	1.03A	22.45