POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		5 / 10ALA A 155
HIS A 268
GLU A 110
HIS A 278
HIS A 266
None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
1.19A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		5 / 10HIS A 268
GLU A 110
HIS A 278
HIS A 266
ALA A 158
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
None
0.99A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		2fv5 ADAM 17
(Homo
sapiens)		5 / 10THR A 347
HIS A 405
GLU A 406
HIS A 409
ALA A 439
541  A   1 (-3.6A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
541  A   1 (-3.9A)
1.04A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		2fv5 ADAM 17
(Homo
sapiens)		5 / 10THR A 347
HIS A 405
GLU A 406
HIS A 409
HIS A 415
541  A   1 (-3.6A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens)		5 / 10ALA A 280
VAL A 393
HIS A 348
HIS A 385
THR A 383
None
1.05A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens)		5 / 10ALA A 281
THR A 379
HIS A 348
HIS A 385
THR A 383
None
1.22A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 10THR A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.8A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.88A23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		2rjq ADAMTS-5
(Homo
sapiens)		6 / 10THR A 378
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
BAT  A 559 ( 4.1A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.46A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens)		5 / 10ALA A 224
HIS A 248
HIS A 192
ALA A 229
THR A 230
None
ZN  A1495 (-3.4A)
ZN  A1495 (-3.7A)
None
None
1.09A16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 10THR A 180
HIS A 219
GLU A 220
HIS A 223
HIS A 229
TQI  A1269 (-4.2A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.53A25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		6 / 10THR A 378
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
294  A 801 ( 3.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.33A30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 10THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.67A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		6 / 10THR A 117
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
QHF  A   1 ( 4.0A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.29A24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		7 / 10THR A 300
VAL A 301
THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
BAT  A1000 (-3.2A)
BAT  A1000 (-3.8A)
BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.32A43.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		4dkk DOUBLE-STRANDED
RNA-BINDING PROTEIN
STAUFEN HOMOLOG 1
(Homo
sapiens)		5 / 10ALA A 368
THR A 369
VAL A 370
THR A 386
ALA A 375
None
1.11A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens)		5 / 10ALA B 259
THR B 260
VAL B 267
ALA B 293
THR B 305
None
1.24A18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 10THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.43A25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 10THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.48A15.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		6 / 10THR A 329
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
3PQ  A 505 ( 4.6A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.39A30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		5 / 10THR A 380
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.72A15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.40A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		6 / 9LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
MET A 422
None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
None
0.47A22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.29A18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		1r55 ADAM 33
(Homo
sapiens)		5 / 9THR A 342
HIS A 345
GLU A 346
HIS A 349
HIS A 355
097  A 518 (-3.5A)
ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.28A24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 9LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.30A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.40A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		2fv5 ADAM 17
(Homo
sapiens)		5 / 9LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.29A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 9LEU A 189
HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 (-4.1A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.70A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 160
HIS A 197
GLU A 198
HIS A 201
HIS A 207
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.30A21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		2rjq ADAMTS-5
(Homo
sapiens)		6 / 9ASP A 377
LEU A 379
THR A 407
GLU A 411
HIS A 414
LEU A 443
BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
1.01A48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		2rjq ADAMTS-5
(Homo
sapiens)		7 / 9LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
0.75A48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 9LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.46A19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		3b2z ADAMTS-4
(Homo
sapiens)		5 / 9LEU A 330
THR A 358
HIS A 361
HIS A 365
HIS A 371
None
None
ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
0.48A59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		7 / 9ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
None
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.34A58.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		7 / 9LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
294  A 801 (-4.1A)
0.64A58.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 9LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.79A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 9LEU A1185
HIS A1222
GLU A1223
HIS A1226
HIS A1232
3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.40A20.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		8 / 9ASP A 116
LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
MET A 181
None
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
None
0.77A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		8 / 9LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
MET A 181
LEU A 182
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
None
QHF  A   1 (-4.7A)
0.76A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.32A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 9LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.38A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		5 / 9THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.36A28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 9LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.48A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 9THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.41A20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		7 / 9ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.37A53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 9HIS A 226
GLU A 227
HIS A 230
HIS A 236
MET A 247
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
None
0.52A19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 9LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.43A19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 9LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.40A22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		6 / 9LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
MET A 422
None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
None
0.49A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		5 / 9ASP A 325
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.77A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		6 / 9LEU A 328
THR A 380
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.69A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 8LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.40A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 8LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.36A22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 8LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.33A18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		1r55 ADAM 33
(Homo
sapiens)		5 / 8THR A 342
HIS A 345
GLU A 346
HIS A 349
HIS A 355
097  A 518 (-3.5A)
ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.29A24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 8LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.28A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 8LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.38A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 8LEU A 181
HIS A 218
HIS A 222
HIS A 228
None
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
0.33A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		2fv5 ADAM 17
(Homo
sapiens)		5 / 8LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.23A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8THR A 470
HIS A 473
GLU A 474
HIS A 477
None
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
0.30A18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 8LEU A 160
HIS A 197
GLU A 198
HIS A 201
HIS A 207
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.33A21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		2rjq ADAMTS-5
(Homo
sapiens)		6 / 8LEU A 379
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
BAT  A 559 (-4.0A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
0.57A48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		2rjq ADAMTS-5
(Homo
sapiens)		6 / 8LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.26A48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8THR A 358
HIS A 361
GLU A 362
HIS A 365
3ES  A1611 (-3.6A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
0.23A19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 8HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.21A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 8THR A 350
HIS A 353
GLU A 354
HIS A 357
BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
0.23A15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		3b2z ADAMTS-4
(Homo
sapiens)		4 / 8THR A 358
HIS A 361
HIS A 365
HIS A 371
None
ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
0.25A59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		7 / 8ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
None
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.44A58.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		5 / 8THR A 407
GLU A 411
HIS A 414
HIS A 420
LEU A 443
294  A 801 ( 3.8A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
294  A 801 (-4.1A)
0.94A58.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 8LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.79A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 8HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.27A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		4 / 8THR A 371
HIS A 374
GLU A 375
HIS A 378
None
0.36A17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 8LEU A1185
HIS A1222
GLU A1223
HIS A1226
HIS A1232
3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.33A20.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		7 / 8ASP A 116
LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
None
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.36A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		7 / 8LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
LEU A 182
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
QHF  A   1 (-4.7A)
0.51A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 8LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.33A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 8LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.45A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 8LEU A 162
HIS A 199
HIS A 203
HIS A 209
None
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
0.29A20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		5 / 8THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.38A28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		4fvl COLLAGENASE 3
(Homo
sapiens)		4 / 8LEU A 185
HIS A 222
HIS A 226
HIS A 232
None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
0.39A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 8LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.49A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 8THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.39A20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		7 / 8ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.51A53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 8LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.35A19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 8LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.38A22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 8LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.34A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		5 / 8ASP A 325
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.71A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		5 / 8LEU A 328
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.65A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		5 / 8LEU A 328
THR A 380
HIS A 383
HIS A 387
HIS A 393
None
None
ZN  A 705 (-3.3A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.62A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 191
HIS A 403
HIS A 407
HIS A 413
ILE A 424
None
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
None
0.90A19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.40A23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 9LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.38A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 9HIS A 201
GLU A 202
HIS A 205
HIS A 211
ILE A 222
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
None
0.76A19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.35A19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1r55 ADAM 33
(Homo
sapiens)		5 / 9THR A 342
HIS A 345
GLU A 346
HIS A 349
HIS A 355
097  A 518 (-3.5A)
ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.24A30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 9LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.34A26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.40A24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2fv5 ADAM 17
(Homo
sapiens)		6 / 9LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
ILE A 438
541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
None
0.43A23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 9LEU A 189
HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 (-4.1A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.67A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 160
HIS A 197
GLU A 198
HIS A 201
HIS A 207
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.33A21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2rjq ADAMTS-5
(Homo
sapiens)		6 / 9ASP A 377
LEU A 379
THR A 407
GLU A 411
HIS A 414
HIS A 420
BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.69A99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2rjq ADAMTS-5
(Homo
sapiens)		7 / 9LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.3A)
0.46A99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 9LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.46A23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3b2z ADAMTS-4
(Homo
sapiens)		5 / 9LEU A 330
THR A 358
HIS A 361
HIS A 365
HIS A 371
None
None
ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
0.46A36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		8 / 9ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
None
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
None
0.52A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		7 / 9LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
ILE A 442
LEU A 443
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
None
294  A 801 (-4.1A)
0.91A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 9LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.77A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 9LEU A1185
HIS A1222
GLU A1223
HIS A1226
HIS A1232
3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.40A25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 9LEU A1185
HIS A1222
GLU A1223
HIS A1226
ILE A1243
3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
None
0.73A25.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		8 / 9ASP A 116
LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
LEU A 182
None
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
QHF  A   1 (-4.7A)
0.48A57.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.35A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 9LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.36A24.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		5 / 9THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.37A30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 9LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.45A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 9THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.34A17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		7 / 9ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.30A47.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 9LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.47A23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens)		5 / 9LEU A 356
HIS A 360
HIS A  43
ILE A  47
LEU A  48
None
1.35A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 9LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.43A25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 9LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.36A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		5 / 9ASP A 325
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.73A15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		6 / 9LEU A 328
THR A 380
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.65A15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS
(Homo
sapiens)		5 / 9LEU A1092
HIS A1015
GLU A1091
HIS A1051
ILE A1045
None
1.23A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		5 / 9LEU A 191
HIS A 403
HIS A 407
HIS A 413
ILE A 424
None
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
None
0.54A16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 191
HIS A 403
HIS A 407
HIS A 413
ILE A 424
None
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
None
0.60A19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
L04  A 256 ( 3.7A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.35A23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 9LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
None
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.34A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		6 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
ILE A 222
None
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
None
0.54A19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1r55 ADAM 33
(Homo
sapiens)		5 / 9THR A 342
HIS A 345
GLU A 346
HIS A 349
HIS A 355
097  A 518 (-3.5A)
ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.25A30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 9LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.29A26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 9LEU A 164
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.35A24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2fv5 ADAM 17
(Homo
sapiens)		6 / 9LEU A 348
HIS A 405
GLU A 406
HIS A 409
HIS A 415
ILE A 438
541  A   1 (-4.4A)
ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
None
0.37A23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 9LEU A 189
HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 (-4.1A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.64A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 160
HIS A 197
GLU A 198
HIS A 201
HIS A 207
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.29A21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2rjq ADAMTS-5
(Homo
sapiens)		8 / 9ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
0.75A99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2rjq ADAMTS-5
(Homo
sapiens)		8 / 9LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
LEU A 443
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.3A)
BAT  A 559 (-4.2A)
0.64A99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 9LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
TQI  A1269 ( 3.8A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.44A23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3b2z ADAMTS-4
(Homo
sapiens)		5 / 9LEU A 330
THR A 358
HIS A 361
HIS A 365
HIS A 371
None
None
ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
0.54A36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		8 / 9ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
None
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
None
0.49A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		8 / 9LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
LEU A 443
294  A 801 (-4.8A)
294  A 801 ( 3.8A)
ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
None
294  A 801 (-4.1A)
0.87A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 9LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.76A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3o2x COLLAGENASE 3
(Homo
sapiens)		6 / 9LEU A1185
HIS A1222
GLU A1223
HIS A1226
HIS A1232
ILE A1243
3O2  A1801 (-4.0A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
None
0.54A25.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		8 / 9ASP A 116
LEU A 118
THR A 146
HIS A 149
GLU A 150
HIS A 153
HIS A 159
LEU A 182
None
QHF  A   1 (-4.5A)
QHF  A   1 (-4.4A)
ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
QHF  A   1 (-4.7A)
0.59A57.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 9LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.32A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 9LEU B 180
HIS B 217
GLU B 218
HIS B 221
HIS B 227
None
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.37A24.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		5 / 9THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.38A30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4fvl COLLAGENASE 3
(Homo
sapiens)		5 / 9LEU A 185
HIS A 222
HIS A 226
HIS A 232
ILE A 243
None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
None
0.50A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 9LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.43A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 9THR A 149
HIS A 152
GLU A 153
HIS A 156
HIS A 162
None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.36A17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		7 / 9ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.30A47.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 9LEU A 188
HIS A 226
GLU A 227
HIS A 230
HIS A 236
N73  A 301 (-4.4A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.38A23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		5eh1 INTERFERON GAMMA
RECEPTOR 2
(Homo
sapiens)		5 / 9ASP A 200
LEU A 202
THR A 237
ILE A 156
LEU A 155
None
1.07A18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 9LEU A 199
HIS A 239
GLU A 240
HIS A 243
HIS A 249
GOL  A 312 (-4.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.39A25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 9LEU A 188
HIS A 401
GLU A 402
HIS A 405
HIS A 411
None
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.31A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		5 / 9ASP A 325
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.79A15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		6 / 9LEU A 328
THR A 380
HIS A 383
GLU A 384
HIS A 387
HIS A 393
None
None
ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.70A15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS
(Homo
sapiens)		5 / 9LEU A1092
HIS A1015
GLU A1091
HIS A1051
ILE A1045
None
1.23A18.62