POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens)		5 / 11ILE A 166
ILE A 191
ILE A 150
VAL A 188
PRO A 286
None
0.97A19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens)		5 / 11ILE A 980
ILE A1005
ILE A 963
VAL A1002
PRO A1116
None
0.97A20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens)		5 / 11ILE A1773
ILE A1798
ILE A1758
VAL A1795
PRO A1899
None
0.99A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens)		5 / 11ILE A 373
ILE A 398
ILE A 358
VAL A 395
PRO A 510
None
0.94A21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		3fht ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens)		5 / 11PHE A 239
ILE A 258
ALA A 244
VAL A 289
PRO A 290
None
1.08A23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)		5 / 11PHE C 260
ALA C 235
THR C 232
VAL C 243
VAL C 245
None
PLR  C 500 (-3.5A)
None
None
None
1.07A22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens)		5 / 11ILE A 100
ILE A 125
ILE A  85
VAL A 122
PRO A 222
None
0.97A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		3rru TOM1L1 PROTEIN
(Homo
sapiens)		5 / 11ILE A 119
ILE A  76
PHE A 122
ILE A 115
THR A  23
None
1.08A14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18
(Homo
sapiens)		5 / 11ILE A 102
ILE A 127
ILE A  87
VAL A 124
PRO A 224
None
1.00A21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		5 / 11ILE A1798
ILE A1823
ILE A1783
VAL A1820
PRO A1928
None
0.92A20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		6 / 11ILE A 101
ILE A 114
ILE A 209
ALA A 298
VAL A 367
PRO A 368
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 4.2A)
None
0.92A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		6 / 11ILE A 101
ILE A 114
ILE A 209
THR A 302
VAL A 367
PRO A 368
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
0.99A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 11ILE A 114
ALA A 298
VAL A 367
PRO A 368
VAL A 477
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 4.2A)
None
None
0.86A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 11ILE A 114
THR A 302
VAL A 367
PRO A 368
VAL A 477
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
None
0.83A86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6b0t FASCIN
(Homo
sapiens)		5 / 11ILE A 144
PHE A 254
ALA A 153
GLU A 162
VAL A 188
None
1.04A9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6gmb HYDROXYACID OXIDASE
1
(Homo
sapiens)		5 / 11ILE A 233
ILE A 255
ILE A 222
ALA A 244
GLU A 246
None
1.05A10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		1qql FIBROBLAST GROWTH
FACTOR 7/1 CHIMERA
(Homo
sapiens;
Rattus
norvegicus)		5 / 9LEU A  65
LEU A  23
ILE A  10
PHE A  85
VAL A  54
None
1.47A15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2dmm PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens)		5 / 9LEU A 131
LEU A  70
ILE A  40
PHE A 106
VAL A  48
None
1.45A17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens)		5 / 9LEU A 229
LEU A 276
ILE A 296
GLN A 269
PHE A 341
None
1.17A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3tkr PEROXIREDOXIN-4
(Homo
sapiens)		5 / 9LEU A 155
LEU A 182
ILE A 177
GLU A  90
VAL A 153
None
1.17A22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		5 / 9LEU A1021
LEU A1144
ILE A1088
ILE A1066
VAL A1042
None
1.22A20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens)		5 / 9LEU A 387
LEU A 333
ILE A 248
ILE A 355
GLN A 356
None
1.11A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens)		5 / 9LEU A 587
LEU A 627
ILE A 599
PHE A 592
VAL A 685
None
CL  A1751 (-4.6A)
None
None
None
0.89A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		4a5w COMPLEMENT C5
(Homo
sapiens)		5 / 9LEU A 541
LEU A 504
ILE A  39
ILE A  41
PHE A 646
None
1.15A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		4jpz FIBROBLAST GROWTH
FACTOR 13
(Homo
sapiens)		5 / 9LEU A  70
LEU A  28
ILE A  16
PHE A  90
VAL A  59
None
1.47A18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Escherichia
virus
T4;
Homo
sapiens)		5 / 9LEU A1133
LEU A1121
ILE A1078
PHE A1114
VAL A1111
None
None
None
SO4  A 504 (-4.9A)
None
1.38A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens)		5 / 9LEU A 252
LEU A 214
ILE A 175
PHE A 221
VAL A 220
None
1.45A23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens)		5 / 9LEU A 280
LEU A 228
ILE A 224
ILE A 116
PHE A 270
None
1.50A23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2
(Escherichia
coli;
Escherichia
virus
T4;
Homo
sapiens)		5 / 9LEU A1133
LEU A1121
ILE A1078
PHE A1114
VAL A1111
None
1.40A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens)		5 / 9LEU f 249
GLN f 213
GLU f 210
PHE f 256
VAL f 255
None
1.30A20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 9ILE A 101
ILE A 209
GLN A 215
GLU A 218
GLU A 387
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 4.8A)
None
None
None
0.90A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 9LEU A  52
ILE A 101
ILE A 209
GLN A 215
GLU A 218
None
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 4.8A)
None
None
1.17A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 9LEU A  70
ILE A 101
ILE A 209
GLN A 215
GLU A 387
None
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 4.8A)
None
None
0.86A86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 9LEU A 408
LEU A1104
ILE A1108
ILE A 412
VAL A 425
None
1.04A11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens)		5 / 8ILE A 558
PHE A 542
SER A 507
GLU A 500
LEU A 519
None
1.24A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1czv PROTEIN (COAGULATION
FACTOR V)
(Homo
sapiens)		5 / 8ILE A  71
ILE A 131
PHE A 127
GLU A  59
LEU A  62
None
1.36A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1fyc DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(E2P)
(Homo
sapiens)		4 / 8ILE A  66
ILE A  84
LEU A  14
VAL A  26
None
0.85A11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens)		4 / 8ILE A1288
ILE A1128
SER A1294
LEU A1069
None
0.83A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1iu1 GAMMA1-ADAPTIN
(Homo
sapiens)		5 / 8ILE A 735
ILE A 796
SER A 767
LEU A 715
VAL A 770
None
1.46A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1u6g TIP120 PROTEIN
(Homo
sapiens)		4 / 8ILE C1008
ILE C 993
THR C1091
VAL C1048
None
0.82A17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens)		4 / 8ILE A2421
PHE A2459
SER A2393
VAL A2183
None
0.78A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens)		5 / 8ILE A 558
PHE A 542
SER A 507
GLU A 500
LEU A 519
None
1.29A22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1zli CARBOXYPEPTIDASE B
(Homo
sapiens)		5 / 8ILE A 297
ILE A  62
PHE A 105
GLU A 306
LEU A 222
None
1.42A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2a38 TITIN
(Homo
sapiens)		5 / 8ILE A 144
ILE A 163
PHE A 150
GLU A 190
LEU A 110
None
1.36A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
SODIUM/HYDROGEN
EXCHANGER 1
(Homo
sapiens)		5 / 8ILE B 534
PHE A  90
GLU A  68
LEU A  51
VAL A  78
None
1.11A6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2ehr INAD-LIKE PROTEIN
(Homo
sapiens)		4 / 8ILE A  75
PHE A 104
SER A  87
GLU A  93
None
0.87A14.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2hi4 CYTOCHROME P450 1A2
(Homo
sapiens)		4 / 8ILE A 339
PHE A 427
GLU A 369
LEU A 433
None
0.81A32.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens)		5 / 11LEU B  81
ARG B 115
LEU B  67
GLU B 373
PHE B  85
None
1.31A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		4hj2 GLUTATHIONE
S-TRANSFERASE A1
(Homo
sapiens)		5 / 11ARG A 155
LEU A  22
PRO A 203
GLU A  32
PHE A  30
None
1.46A19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 11ARG A  73
GLN A 215
GLU A 218
PRO A 368
GLU A 387
None
1.09A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 11ARG A  73
GLN A 215
PRO A 368
GLU A 387
VAL A 477
None
1.20A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		6 / 11ARG A  73
MET A 365
PRO A 368
GLU A 387
PHE A 389
VAL A 477
None
0.83A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 11GLN A 215
GLU A 218
LEU A 219
PRO A 368
GLU A 387
None
1.07A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 11GLN A 215
LEU A 219
PRO A 368
GLU A 387
VAL A 477
None
1.12A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 11LEU A 219
PRO A 368
GLU A 387
PHE A 389
VAL A 477
None
1.03A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens)		4 / 7ILE A1288
ILE A1128
SER A1294
LEU A1069
None
0.73A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN
(Homo
sapiens)		4 / 7ILE A 135
SER A  32
LEU A 125
VAL A  30
None
0.88A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2i6b ADENOSINE KINASE
(Homo
sapiens)		4 / 7ILE A 192
SER A 308
GLU A 318
THR A 317
None
0.87A22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2xsz RUVB-LIKE 1
(Homo
sapiens)		4 / 7ILE A 239
ILE A 272
GLU A  68
LEU A  38
None
0.65A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		4 / 7ILE A  61
ILE A  43
GLU A  83
VAL A  75
None
0.87A23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens)		4 / 7ILE A1417
ILE A1283
THR A1367
LEU A1317
None
0.86A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens)		4 / 7ILE A  51
SER A  32
GLU A  38
VAL A  30
None
0.88A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		4o00 TITIN
(Homo
sapiens)		4 / 7ILE A  42
SER A  14
LEU A  70
VAL A  22
None
0.87A13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5jpn COMPLEMENT C4-A
(Homo
sapiens)		4 / 7ILE B1307
ILE B1147
SER B1313
LEU B1088
None
0.71A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5m5e INTERLEUKIN-2
(Homo
sapiens)		4 / 7ILE D  86
ILE D  24
LEU D  17
VAL D  93
None
0.80A15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens)		4 / 7ILE C 339
SER C 391
GLU C 357
LEU C 323
None
0.86A9.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		4 / 7ILE A 114
THR A 302
LEU A 363
VAL A 477
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 3.9A)
HEM  A 501 (-4.3A)
None
0.66A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		1x27 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK
(Homo
sapiens)		5 / 10LEU A 205
GLU A 125
LEU A 122
PRO A 223
PHE A 151
None
1.48A15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		3v96 METALLOPROTEINASE
INHIBITOR 1
(Homo
sapiens)		5 / 10LEU A 146
GLN A 160
LEU A 152
PRO A   5
VAL A 129
None
1.37A16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens)		5 / 10LEU A 845
ARG A 623
MET A 915
GLU A 921
VAL A 910
None
1.49A21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		6 / 10ARG A  73
GLN A 215
GLU A 218
LEU A 219
PRO A 368
GLU A 387
None
1.11A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		6 / 10ARG A  73
GLN A 215
LEU A 219
PRO A 368
GLU A 387
VAL A 477
None
1.20A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		6 / 10ARG A  73
LEU A 219
PRO A 368
GLU A 387
PHE A 389
VAL A 477
None
1.11A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 10MET A 365
PRO A 368
GLU A 387
PHE A 389
VAL A 477
None
0.76A100.00