POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	1h4l	CELL DIVISION PROTEIN KINASE 5 (Homo sapiens)	6 / 12	ILE A  10 VAL A  18 ALA A  31 LYS A  33 CYH A  83 GLY A 146	None	1.14A	23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	1h4l	CELL DIVISION PROTEIN KINASE 5 (Homo sapiens)	6 / 12	ILE A  10 VAL A  18 ALA A  31 LYS A  33 LEU A  55 CYH A  83	None	0.88A	23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	1h4l	CELL DIVISION PROTEIN KINASE 5 (Homo sapiens)	6 / 12	ILE A  10 VAL A  18 LYS A  33 LEU A  55 CYH A  83 PHE A 145	None	1.07A	23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	6 / 12	VAL A 416 ALA A 428 LYS A 430 THR A 474 PHE A 540 GLY A 541	None	0.87A	29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	5 / 12	ILE A 369 VAL A 377 ALA A 389 LYS A 391 PHE A 501	None	0.58A	29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	1t46	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens)	5 / 12	VAL A 603 ALA A 621 LYS A 623 LEU A 644 THR A 670	STI  A   3 ( 4.6A) STI  A   3 (-3.5A) STI  A   3 (-3.7A) STI  A   3 (-4.4A) STI  A   3 (-3.2A)	0.74A	30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	1t46	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens)	5 / 12	VAL A 603 ALA A 621 LYS A 623 THR A 670 CYH A 673	STI  A   3 ( 4.6A) STI  A   3 (-3.5A) STI  A   3 (-3.7A) STI  A   3 (-3.2A) STI  A   3 (-4.5A)	0.35A	30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	1zlt	SERINE/THREONINE-PRO TEIN KINASE CHK1 (Homo sapiens)	5 / 12	VAL A  23 ALA A  36 LYS A  38 CYH A  87 PHE A 149	HYM  A 400 (-4.3A) HYM  A 400 (-3.5A) HYM  A 400 (-3.2A) HYM  A 400 (-4.2A) None	0.74A	25.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2a1a	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (Homo sapiens)	6 / 12	ILE B 273 VAL B 281 LYS B 296 CYH B 369 PHE B 421 GLY B 434	None	1.06A	30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2a1a	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (Homo sapiens)	6 / 12	ILE B 273 VAL B 281 LYS B 296 CYH B 369 PHE B 421 PHE B 433	None	0.96A	30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2a1a	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (Homo sapiens)	6 / 12	ILE B 273 VAL B 281 LYS B 296 LEU B 312 PHE B 421 PHE B 433	None	1.22A	30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	5 / 12	VAL A 259 ALA A 271 LYS A 273 THR A 316 PHE A 383	1BM  A 499 ( 4.8A) 1BM  A 499 (-3.6A) 1BM  A 499 (-3.8A) 1BM  A 499 (-3.2A) None	0.65A	31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	6 / 12	VAL A  63 ALA A  76 LYS A  78 LEU A  98 LEU A 108 PHE A 230	None	1.01A	26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2jgz	CELL DIVISION PROTEIN KINASE 2 (Homo sapiens)	6 / 12	ILE A  10 VAL A  18 ALA A  31 LYS A  33 LEU A  55 PHE A 146	None	1.18A	25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2ogv	MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR PRECURSOR (Homo sapiens)	5 / 12	VAL A 596 ALA A 614 LYS A 616 THR A 663 CYH A 666	None	0.60A	28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	VAL A 204 ALA A 215 LYS A 217 LEU A 245 THR A 265 GLY A 341	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None ADE  A 488 ( 4.5A) ADE  A 488 (-4.3A) None	0.83A	26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	VAL A 204 ALA A 215 LYS A 217 LEU A 245 THR A 265 PHE A 340	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None ADE  A 488 ( 4.5A) ADE  A 488 (-4.3A) None	0.85A	26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	5 / 12	VAL A 732 ALA A 749 LYS A 751 THR A 796 PHE A 862	GW7  A   1 ( 4.8A) GW7  A   1 (-3.3A) GW7  A   1 (-3.9A) GW7  A   1 (-4.0A) GW7  A   1 (-3.8A)	0.73A	33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2z2w	WEE1-LIKE PROTEIN KINASE (Homo sapiens)	5 / 12	ILE A 305 VAL A 313 CYH A 379 PHE A 433 GLY A 465	770  A 901 (-3.8A) 770  A 901 ( 4.7A) 770  A 901 (-3.9A) 770  A 901 (-4.0A) None	0.73A	28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	2z2w	WEE1-LIKE PROTEIN KINASE (Homo sapiens)	5 / 12	VAL A 313 ALA A 326 CYH A 379 PHE A 433 GLY A 465	770  A 901 ( 4.7A) 770  A 901 (-3.5A) 770  A 901 (-3.9A) 770  A 901 (-4.0A) None	0.78A	28.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	6 / 12	ILE A 201 VAL A 209 ALA A 220 LYS A 222 THR A 266 GLY A 334	None	0.93A	30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3hng	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	5 / 12	VAL A 841 ALA A 859 LYS A 861 LEU A 882 CYH A 912	8ST  A2001 ( 4.6A) 8ST  A2001 ( 3.8A) 8ST  A2001 (-4.0A) None 8ST  A2001 (-3.8A)	0.68A	27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	5 / 12	VAL A 649 ALA A 665 LYS A 667 THR A 713 PHE A 779	None	0.79A	32.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3mdy	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (Homo sapiens)	5 / 12	VAL A 218 ALA A 229 LYS A 231 LEU A 259 THR A 279	LDN  A   1 ( 4.8A) LDN  A   1 (-3.6A) None None LDN  A   1 (-3.8A)	0.53A	29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3mi9	CELL DIVISION PROTEIN KINASE 9 (Homo sapiens)	6 / 12	VAL A  33 ALA A  46 LYS A  48 LEU A  70 CYH A 106 PHE A 168	None	1.05A	25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3my0	SERINE/THREONINE-PRO TEIN KINASE RECEPTOR R3 (Homo sapiens)	5 / 12	VAL A 216 ALA A 227 LYS A 229 LEU A 257 THR A 277	LDN  A 600 (-4.5A) LDN  A 600 (-3.2A) LDN  A 600 (-4.0A) None LDN  A 600 (-4.0A)	0.34A	26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	10 / 12	ILE A 355 VAL A 363 ALA A 373 LEU A 397 LEU A 406 THR A 421 TRP A 423 CYH A 424 PHE A 475 PHE A 487	SM5  A   1 (-4.3A) SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) None None SM5  A   1 (-4.4A) SM5  A   1 (-4.3A) SM5  A   1 ( 4.4A) SM5  A   1 (-3.0A) None	0.79A	72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	10 / 12	ILE A 355 VAL A 363 ALA A 373 LYS A 375 LEU A 397 LEU A 406 THR A 421 TRP A 423 PHE A 475 PHE A 487	SM5  A   1 (-4.3A) SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) None None SM5  A   1 (-4.4A) SM5  A   1 (-4.3A) SM5  A   1 (-3.0A) None	0.81A	72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	7 / 12	ILE A 355 VAL A 363 ALA A 373 LYS A 375 TRP A 423 PHE A 475 GLY A 488	SM5  A   1 (-4.3A) SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) SM5  A   1 (-4.3A) SM5  A   1 (-3.0A) None	1.05A	72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	7 / 12	ILE A 355 VAL A 363 ALA A 373 TRP A 423 CYH A 424 PHE A 475 GLY A 488	SM5  A   1 (-4.3A) SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) SM5  A   1 (-4.3A) SM5  A   1 ( 4.4A) SM5  A   1 (-3.0A) None	0.97A	72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3q4t	ACTIVIN RECEPTOR TYPE-2A (Homo sapiens)	6 / 12	VAL A 206 ALA A 217 LYS A 219 LEU A 247 THR A 267 PHE A 341	TAK  A   2 ( 4.9A) TAK  A   2 (-3.5A) TAK  A   2 (-2.9A) None TAK  A   2 (-3.5A) None	0.82A	30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	3zfx	EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens)	6 / 12	ILE A 625 VAL A 633 ALA A 649 LYS A 651 THR A 697 PHE A 763	None	0.97A	32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4a4l	SERINE/THREONINE-PRO TEIN KINASE PLK1 (Homo sapiens)	5 / 12	ALA A  80 LYS A  82 CYH A 133 PHE A 183 PHE A 195	939  A1331 (-3.5A) 939  A1331 (-2.6A) 939  A1331 (-4.0A) 939  A1331 (-4.0A) None	0.72A	26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4agu	CYCLIN-DEPENDENT KINASE-LIKE 1 (Homo sapiens)	5 / 12	VAL A  18 ALA A  31 LYS A  33 LEU A  55 CYH A  83	D15  A 500 (-4.6A) D15  A 500 (-3.4A) D15  A 500 ( 4.1A) None D15  A 500 (-4.3A)	0.76A	24.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4aw5	EPHRIN TYPE-B RECEPTOR 4 (Homo sapiens)	6 / 12	ILE A  97 VAL A 105 ALA A 121 LYS A 123 THR A 169 PHE A 235	30K  A1365 (-4.5A) 30K  A1365 ( 4.6A) 30K  A1365 (-3.2A) 30K  A1365 (-3.8A) 30K  A1365 (-3.8A) None	1.01A	32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	5 / 12	VAL A 222 ALA A 233 LYS A 235 LEU A 263 GLY A 356	TAK  A1507 (-4.7A) TAK  A1507 (-3.3A) TAK  A1507 ( 4.5A) FLC  A1503 ( 4.5A) None	0.73A	28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	5 / 12	VAL A 222 ALA A 233 LYS A 235 LEU A 263 THR A 283	TAK  A1507 (-4.7A) TAK  A1507 (-3.3A) TAK  A1507 ( 4.5A) FLC  A1503 ( 4.5A) TAK  A1507 (-3.6A)	0.32A	28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4e93	TYROSINE-PROTEIN KINASE FES/FPS (Homo sapiens)	6 / 12	ILE A 567 VAL A 575 ALA A 588 LYS A 590 LEU A 611 PHE A 702	GUI  A 901 (-4.0A) GUI  A 901 (-4.5A) GUI  A 901 (-3.4A) GUI  A 901 (-2.8A) None None	1.29A	27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4euu	SERINE/THREONINE-PRO TEIN KINASE TBK1 (Homo sapiens)	5 / 12	VAL A  23 ALA A  36 LYS A  38 LEU A  59 CYH A  89	BX7  A 401 ( 4.6A) BX7  A 401 (-3.4A) BX7  A 401 (-3.5A) None BX7  A 401 (-4.1A)	0.77A	26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4g34	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 (Homo sapiens)	6 / 12	VAL A 606 ALA A 619 CYH A 890 PHE A 943 PHE A 955 GLY A 956	924  A1101 ( 4.8A) 924  A1101 (-3.5A) 924  A1101 (-3.9A) 924  A1101 ( 4.2A) 924  A1101 ( 4.4A) None	0.84A	27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4g34	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 (Homo sapiens)	6 / 12	VAL A 606 ALA A 619 LYS A 621 CYH A 890 PHE A 955 GLY A 956	924  A1101 ( 4.8A) 924  A1101 (-3.5A) None 924  A1101 (-3.9A) 924  A1101 ( 4.4A) None	0.79A	27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4g34	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 (Homo sapiens)	6 / 12	VAL A 606 LYS A 621 LEU A 642 CYH A 890 PHE A 955 GLY A 956	924  A1101 ( 4.8A) None 924  A1101 (-3.9A) 924  A1101 (-3.9A) 924  A1101 ( 4.4A) None	0.75A	27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4jxf	SERINE/THREONINE-PRO TEIN KINASE PLK4 (Homo sapiens)	6 / 12	VAL A  26 ALA A  39 LYS A  41 LEU A  73 CYH A  92 PHE A 155	631  A 301 (-4.6A) 631  A 301 (-3.3A) 631  A 301 (-2.7A) None 631  A 301 (-4.5A) None	0.86A	26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	6 / 12	VAL A  54 ALA A  67 LYS A  69 THR A 123 CYH A 126 PHE A 192	None SIN  A 401 ( 3.7A) None None SIN  A 401 (-4.3A) None	0.67A	26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5a46	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens)	5 / 12	VAL A 492 ALA A 512 LYS A 514 PHE A 642 GLY A 643	38O  A1769 (-4.5A) 38O  A1769 (-3.6A) 38O  A1769 ( 3.1A) EDO  A1766 (-3.7A) EDO  A1766 (-3.6A)	0.70A	27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5d7a	TRAF2 AND NCK-INTERACTING PROTEIN KINASE (Homo sapiens)	5 / 12	VAL A  39 ALA A  52 LYS A  54 LEU A  73 PHE A 172	VAL  A  39 (-0.6A) ALA  A  52 (-0.0A) LYS  A  54 ( 0.0A) LEU  A  73 ( 0.6A) PHE  A 172 ( 1.3A)	0.67A	29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5e8y	TGF-BETA RECEPTOR TYPE-2 (Homo sapiens)	6 / 12	VAL A 258 ALA A 275 LYS A 277 LEU A 305 THR A 325 PHE A 398	STU  A 601 (-4.0A) STU  A 601 (-3.1A) STU  A 601 (-2.4A) STU  A 601 ( 3.8A) STU  A 601 ( 3.7A) None	0.81A	27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	12 / 12	ILE A 463 VAL A 471 ALA A 481 LYS A 483 LEU A 505 LEU A 514 THR A 529 TRP A 531 CYH A 532 PHE A 583 PHE A 595 GLY A 596	5XJ  A 801 ( 4.7A) 5XJ  A 801 (-4.6A) 5XJ  A 801 (-3.1A) 5XJ  A 801 (-3.8A) 5XJ  A 801 (-3.8A) 5XJ  A 801 (-4.5A) 5XJ  A 801 (-3.4A) 5XJ  A 801 (-4.4A) 5XJ  A 801 (-4.6A) 5XJ  A 801 (-4.3A) 5XJ  A 801 (-3.7A) 5XJ  A 801 (-3.7A)	0.57A	90.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5grn	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens)	5 / 12	VAL A 607 ALA A 625 LYS A 627 THR A 674 CYH A 677	748  A1001 ( 4.7A) 748  A1001 (-3.7A) 748  A1001 (-4.0A) 748  A1001 (-3.2A) 748  A1001 (-4.5A)	0.38A	28.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	VAL A  30 ALA A  43 LYS A  45 LEU A  57 THR A  82 PHE A 152 GLY A 153	032  A 401 (-4.4A) 032  A 401 (-3.2A) 032  A 401 (-4.4A) 032  A 401 ( 4.7A) 032  A 401 (-3.7A) 032  A 401 (-4.1A) 032  A 401 (-3.6A)	0.60A	31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5hor	HEPATOCYTE GROWTH FACTOR RECEPTOR (Homo sapiens)	5 / 12	VAL A1092 ALA A1108 LEU A1140 PHE A1223 GLY A1224	63K  A1401 (-4.9A) 63K  A1401 (-3.5A) None None None	0.54A	29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5j5t	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3 (Homo sapiens)	5 / 12	VAL A  30 ALA A  43 LYS A  45 CYH A  93 PHE A 155	6G2  A 901 ( 4.9A) 6G2  A 901 (-3.2A) 6G2  A 901 ( 3.9A) TPO  A 145 (-4.1A) None	0.74A	25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5kkr	KINASE SUPPRESSOR OF RAS 2 (Homo sapiens)	6 / 12	ILE B 672 VAL B 680 ALA B 690 THR B 739 CYH B 742 PHE B 804	6U7  B1001 ( 4.8A) 6U7  B1001 ( 4.3A) 6U7  B1001 (-3.6A) 6U7  B1001 (-4.0A) 6U7  B1001 (-3.5A) 6U7  B1001 (-3.8A)	1.01A	36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5kkr	KINASE SUPPRESSOR OF RAS 2 (Homo sapiens)	5 / 12	ILE B 672 VAL B 680 ALA B 690 THR B 739 PHE B 793	6U7  B1001 ( 4.8A) 6U7  B1001 ( 4.3A) 6U7  B1001 (-3.6A) 6U7  B1001 (-4.0A) 6U7  B1001 (-4.3A)	0.71A	36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5ko1	MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN (Homo sapiens)	5 / 12	ALA A 228 LYS A 230 LEU A 263 CYH A 286 PHE A 350	6UY  A 501 (-3.4A) 6UY  A 501 (-4.0A) None 6UY  A 501 (-4.3A) None	0.79A	26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5l6o	EPHRIN TYPE-B RECEPTOR 3 (Homo sapiens)	5 / 12	ILE A 639 VAL A 647 ALA A 663 LYS A 665 THR A 711	6P6  A1001 (-4.0A) None 6P6  A1001 (-3.3A) None 6P6  A1001 (-3.5A)	0.74A	30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5o2c	SERINE/THREONINE-PRO TEIN KINASE WNK3 (Homo sapiens)	5 / 12	VAL A 161 ALA A 174 LEU A 198 THR A 227 PHE A 282	None GOL  A 604 ( 3.8A) None GOL  A 604 (-3.9A) GOL  A 604 ( 4.5A)	0.73A	26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5tvt	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (Homo sapiens)	5 / 12	VAL A  25 ALA A  38 LYS A  40 CYH A  89 PHE A 151	7LV  A 401 ( 4.6A) 7LV  A 401 (-3.4A) 7LV  A 401 (-3.0A) 7LV  A 401 (-4.3A) None	0.79A	26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	6 / 12	VAL A 124 ALA A 137 LYS A 139 THR A 187 CYH A 190 GLY A 253	H8H  A 401 (-4.7A) H8H  A 401 (-3.3A) H8H  A 401 (-4.9A) H8H  A 401 (-3.5A) H8H  A 401 (-4.3A) None	1.13A	25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	6 / 12	VAL A 124 ALA A 137 THR A 187 CYH A 190 PHE A 240 GLY A 253	H8H  A 401 (-4.7A) H8H  A 401 (-3.3A) H8H  A 401 (-3.5A) H8H  A 401 (-4.3A) H8H  A 401 (-4.3A) None	0.67A	25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	6 / 12	VAL A 124 ALA A 137 THR A 187 CYH A 190 PHE A 240 PHE A 252	H8H  A 401 (-4.7A) H8H  A 401 (-3.3A) H8H  A 401 (-3.5A) H8H  A 401 (-4.3A) H8H  A 401 (-4.3A) None	0.83A	25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5vdk	WEE1-LIKE PROTEIN KINASE 2 (Homo sapiens)	5 / 12	ILE A 218 VAL A 226 CYH A 292 PHE A 346 GLY A 382	8X7  A 501 ( 4.0A) 8X7  A 501 ( 4.5A) 8X7  A 501 (-3.8A) 8X7  A 501 (-3.7A) None	0.78A	28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5vo1	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 (Homo sapiens)	5 / 12	VAL A 139 ALA A 150 LYS A 152 CYH A 193 PHE A 255	9FS  A 501 (-4.5A) 9FS  A 501 (-3.4A) None 9FS  A 501 (-4.3A) None	0.74A	37.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	5w5j	RECEPTOR-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	5 / 12	VAL A  32 ALA A  45 LYS A  47 LEU A  79 THR A  95	9WS  A 401 ( 4.6A) 9WS  A 401 (-3.3A) 9WS  A 401 (-3.3A) 9WS  A 401 (-4.9A) 9WS  A 401 (-3.2A)	0.57A	29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	6ao5	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	5 / 12	VAL A  41 ALA A  54 CYH A 102 PHE A 165 GLY A 166	ANP  A 501 (-4.4A) ANP  A 501 ( 3.7A) ANP  A 501 (-4.2A) None None	0.69A	24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	6b4w	DUAL SPECIFICITY PROTEIN KINASE TTK (Homo sapiens)	5 / 12	ILE A 531 VAL A 539 ALA A 551 LYS A 553 PHE A 665	CQ7  A 801 (-3.6A) CQ7  A 801 ( 4.8A) CQ7  A 801 (-3.2A) CQ7  A 801 (-3.2A) None	0.74A	28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	ILE A 218 VAL A 226 ALA A 237 LYS A 239 LEU A 263 PHE A 359	DL1  A 601 (-4.0A) None DL1  A 601 (-3.4A) DL1  A 601 ( 4.1A) None None	1.27A	13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	6cmj	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE KINASE 2 (Homo sapiens)	6 / 12	ILE A 171 VAL A 179 ALA A 192 LYS A 194 LEU A 240 PHE A 331	F6J  A 501 (-4.3A) F6J  A 501 (-4.6A) F6J  A 501 (-3.4A) F6J  A 501 (-2.9A) None None	1.18A	16.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	6 / 12	ALA A 428 LYS A 430 ILE A 472 THR A 474 PHE A 540 GLY A 541	None	0.63A	30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2a1a	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (Homo sapiens)	5 / 12	LYS B 296 ILE B 364 PHE B 421 GLY B 431 PHE B 433	None	0.94A	30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	5 / 12	ALA X  37 LYS X  39 ILE X  80 THR X  82 SER X  89	STU  X 902 (-3.1A) STU  X 902 (-3.1A) None STU  X 902 (-4.1A) STU  X 902 ( 4.0A)	0.68A	33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	5 / 12	ALA A 293 ILE A 336 THR A 338 SER A 345 PHE A 405	H8H  A 534 (-3.2A) H8H  A 534 ( 4.5A) H8H  A 534 (-3.1A) H8H  A 534 ( 4.5A) None	0.72A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	5 / 12	ALA A 293 LYS A 295 ILE A 336 THR A 338 SER A 345	H8H  A 534 (-3.2A) H8H  A 534 (-3.7A) H8H  A 534 ( 4.5A) H8H  A 534 (-3.1A) H8H  A 534 ( 4.5A)	0.85A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	5 / 12	ILE A 336 THR A 338 SER A 345 PHE A 405 GLY A 406	H8H  A 534 ( 4.5A) H8H  A 534 (-3.1A) H8H  A 534 ( 4.5A) None None	0.94A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	5 / 12	ALA A 293 ILE A 336 THR A 338 SER A 345 PHE A 405	QUE  A   1 (-3.5A) None QUE  A   1 (-3.3A) QUE  A   1 ( 4.7A) None	0.75A	23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	5 / 12	ALA A 271 LYS A 273 ILE A 314 THR A 316 SER A 323	1BM  A 499 (-3.6A) 1BM  A 499 (-3.8A) 1BM  A 499 (-3.9A) 1BM  A 499 (-3.2A) None	0.57A	32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	5 / 12	ALA A 271 LYS A 273 THR A 316 SER A 323 PHE A 383	1BM  A 499 (-3.6A) 1BM  A 499 (-3.8A) 1BM  A 499 (-3.2A) None None	0.93A	32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2i6l	MITOGEN-ACTIVATED PROTEIN KINASE 6 (Homo sapiens)	5 / 12	ALA A  47 LYS A  49 ILE A 106 PHE A 159 GLY A 170	None	0.48A	27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2og8	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens)	5 / 12	ALA A 271 LYS A 273 ILE A 314 THR A 316 SER A 323	1N8  A 501 ( 3.4A) 1N8  A 501 ( 3.4A) 1N8  A 501 ( 4.6A) 1N8  A 501 ( 3.3A) None	0.53A	33.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	ALA A 215 LYS A 217 LEU A 245 THR A 265 SER A 272 PHE A 340	ADE  A 488 (-3.2A) None ADE  A 488 ( 4.5A) ADE  A 488 (-4.3A) None None	0.86A	25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2qob	EPHRIN RECEPTOR (Homo sapiens)	5 / 12	ALA A 651 LYS A 653 ILE A 697 THR A 699 SER A 706	PTR  A 701 ( 4.7A) None None None None	0.52A	27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2qob	EPHRIN RECEPTOR (Homo sapiens)	5 / 12	ALA A 651 LYS A 653 THR A 699 SER A 706 PHE A 765	PTR  A 701 ( 4.7A) None None None None	0.92A	27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2r2p	EPHRIN TYPE-A RECEPTOR 5 (Homo sapiens)	5 / 12	ALA A 705 LYS A 707 ILE A 751 THR A 753 SER A 760	None	0.72A	31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2z2w	WEE1-LIKE PROTEIN KINASE (Homo sapiens)	5 / 12	ALA A 326 ILE A 374 SER A 383 PHE A 433 GLY A 462	770  A 901 (-3.5A) None None 770  A 901 (-4.0A) None	0.36A	27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	6 / 12	ALA A 220 LYS A 222 ILE A 264 THR A 266 SER A 273 PHE A 333	None	0.81A	31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	5 / 12	ALA A 665 LYS A 667 ILE A 711 THR A 713 PHE A 779	None	0.71A	33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	5 / 12	ALA A 665 LYS A 667 ILE A 711 THR A 713 SER A 720	None	0.49A	33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3mdy	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (Homo sapiens)	5 / 12	ALA A 229 LYS A 231 LEU A 259 THR A 279 SER A 286	LDN  A   1 (-3.6A) None None LDN  A   1 (-3.8A) None	0.67A	29.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3my0	SERINE/THREONINE-PRO TEIN KINASE RECEPTOR R3 (Homo sapiens)	5 / 12	ALA A 227 LYS A 229 LEU A 257 THR A 277 SER A 284	LDN  A 600 (-3.2A) LDN  A 600 (-4.0A) None LDN  A 600 (-4.0A) None	0.76A	27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	7 / 12	ALA A 373 LEU A 406 ILE A 419 THR A 421 SER A 427 SER A 428 PHE A 475	SM5  A   1 (-3.6A) None SM5  A   1 ( 4.3A) SM5  A   1 (-4.4A) None None SM5  A   1 (-3.0A)	0.77A	70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	9 / 12	ALA A 373 LEU A 406 ILE A 419 THR A 421 TRP A 423 SER A 427 PHE A 475 GLY A 485 PHE A 487	SM5  A   1 (-3.6A) None SM5  A   1 ( 4.3A) SM5  A   1 (-4.4A) SM5  A   1 (-4.3A) None SM5  A   1 (-3.0A) None None	0.85A	70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	5 / 12	ALA A 373 LEU A 406 THR A 421 TRP A 423 SER A 427	SM5  A   1 (-3.6A) None SM5  A   1 (-4.4A) SM5  A   1 (-4.3A) None	0.98A	70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	7 / 12	ALA A 373 LYS A 375 ILE A 419 THR A 421 SER A 427 SER A 428 PHE A 475	SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) SM5  A   1 ( 4.3A) SM5  A   1 (-4.4A) None None SM5  A   1 (-3.0A)	0.80A	70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	9 / 12	ALA A 373 LYS A 375 ILE A 419 THR A 421 TRP A 423 SER A 427 PHE A 475 GLY A 485 PHE A 487	SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) SM5  A   1 ( 4.3A) SM5  A   1 (-4.4A) SM5  A   1 (-4.3A) None SM5  A   1 (-3.0A) None None	0.87A	70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	8 / 12	ALA A 373 LYS A 375 ILE A 419 TRP A 423 SER A 427 PHE A 475 GLY A 485 GLY A 488	SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) SM5  A   1 ( 4.3A) SM5  A   1 (-4.3A) None SM5  A   1 (-3.0A) None None	1.21A	70.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3q4t	ACTIVIN RECEPTOR TYPE-2A (Homo sapiens)	6 / 12	ALA A 217 LYS A 219 LEU A 247 THR A 267 SER A 274 PHE A 341	TAK  A   2 (-3.5A) TAK  A   2 (-2.9A) None TAK  A   2 (-3.5A) None None	0.96A	28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3zbf	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens)	5 / 12	ALA A1978 LYS A1980 LEU A2010 GLY A2101 PHE A2103	VGH  A3000 (-3.4A) VGH  A3000 ( 4.7A) VGH  A3000 (-4.8A) VGH  A3000 (-3.5A) None	0.97A	30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3zbf	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens)	5 / 12	ALA A1978 LYS A1980 LEU A2010 ILE A2024 GLY A2101	VGH  A3000 (-3.4A) VGH  A3000 ( 4.7A) VGH  A3000 (-4.8A) None VGH  A3000 (-3.5A)	0.74A	30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4a4l	SERINE/THREONINE-PRO TEIN KINASE PLK1 (Homo sapiens)	6 / 12	ALA A  80 LYS A  82 SER A 137 PHE A 183 GLY A 193 GLY A 196	939  A1331 (-3.5A) 939  A1331 (-2.6A) 939  A1331 (-3.5A) 939  A1331 (-4.0A) None None	1.35A	26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4a4l	SERINE/THREONINE-PRO TEIN KINASE PLK1 (Homo sapiens)	6 / 12	ALA A  80 LYS A  82 SER A 137 PHE A 183 GLY A 193 PHE A 195	939  A1331 (-3.5A) 939  A1331 (-2.6A) 939  A1331 (-3.5A) 939  A1331 (-4.0A) None None	0.92A	26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4b6l	SERINE/THREONINE-PRO TEIN KINASE PLK3 (Homo sapiens)	6 / 12	ALA A  89 LYS A  91 ILE A 137 SER A 146 PHE A 192 GLY A 202	9ZP  A1333 (-3.5A) None None None 9ZP  A1333 (-3.6A) 9ZP  A1333 ( 4.4A)	0.61A	29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4b6l	SERINE/THREONINE-PRO TEIN KINASE PLK3 (Homo sapiens)	6 / 12	ALA A  89 LYS A  91 SER A 146 PHE A 192 GLY A 202 PHE A 204	9ZP  A1333 (-3.5A) None None 9ZP  A1333 (-3.6A) 9ZP  A1333 ( 4.4A) None	0.92A	29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	5 / 12	ALA A 233 LYS A 235 LEU A 263 THR A 283 SER A 290	TAK  A1507 (-3.3A) TAK  A1507 ( 4.5A) FLC  A1503 ( 4.5A) TAK  A1507 (-3.6A) None	0.74A	29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4fm9	DNA TOPOISOMERASE 2-ALPHA (Homo sapiens)	5 / 12	LEU A 552 SER A 654 PHE A 653 GLY A 551 GLY A 546	None	0.98A	16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	5 / 12	ALA A 156 LYS A 158 THR A 205 SER A 212 GLY A 269	None	0.89A	28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	5 / 12	ALA A 156 THR A 205 SER A 212 GLY A 269 PHE A 271	None	0.62A	28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4i6f	SERINE/THREONINE-PRO TEIN KINASE PLK2 (Homo sapiens)	6 / 12	ALA A 109 LYS A 111 ILE A 157 SER A 166 PHE A 212 GLY A 222	1C7  A 401 (-3.2A) 1C7  A 401 ( 4.7A) None None 1C7  A 401 (-4.0A) None	0.64A	26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4i6f	SERINE/THREONINE-PRO TEIN KINASE PLK2 (Homo sapiens)	6 / 12	ALA A 109 LYS A 111 SER A 166 PHE A 212 GLY A 222 GLY A 225	1C7  A 401 (-3.2A) 1C7  A 401 ( 4.7A) None 1C7  A 401 (-4.0A) None None	1.28A	26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4i6f	SERINE/THREONINE-PRO TEIN KINASE PLK2 (Homo sapiens)	6 / 12	ALA A 109 LYS A 111 SER A 166 PHE A 212 GLY A 222 PHE A 224	1C7  A 401 (-3.2A) 1C7  A 401 ( 4.7A) None 1C7  A 401 (-4.0A) None None	0.94A	26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	6 / 12	ALA A 156 LYS A 158 THR A 205 SER A 212 GLY A 269 PHE A 271	1G0  A 401 (-3.6A) 1G0  A 401 (-3.7A) 1G0  A 401 (-3.2A) 1G0  A 401 ( 4.3A) None 1G0  A 401 ( 4.8A)	1.10A	30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4idt	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 (Homo sapiens)	5 / 12	ALA A 427 LYS A 429 ILE A 467 SER A 476 PHE A 535	T28  A 701 (-3.0A) T28  A 701 ( 3.8A) None T28  A 701 (-3.8A) None	0.90A	23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	5 / 12	ALA A 293 LYS A 295 ILE A 336 SER A 345 PHE A 405	0J9  A 601 (-3.3A) 0J9  A 601 ( 4.7A) 0J9  A 601 (-4.4A) 0J9  A 601 (-4.5A) None	0.95A	25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4o27	SERINE/THREONINE-PRO TEIN KINASE 24 (Homo sapiens)	5 / 12	ALA B  51 LYS B  53 ILE B  97 SER B 106 PHE B 163	ADP  B 500 (-3.3A) ADP  B 500 (-3.1A) None ADP  B 500 (-3.4A) None	0.77A	29.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4pwn	SERINE/THREONINE-PRO TEIN KINASE WNK1 (Homo sapiens)	5 / 12	ALA A 248 THR A 301 PHE A 356 GLY A 367 GLY A 370	None	0.95A	32.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	6 / 12	ALA A 488 LYS A 490 ILE A 537 THR A 539 SER A 546 GLY A 608	4CV  A 801 (-3.5A) 4CV  A 801 (-3.9A) None 4CV  A 801 (-2.8A) None None	1.11A	31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	5 / 12	ALA A 488 LYS A 490 THR A 539 SER A 546 PHE A 607	4CV  A 801 (-3.5A) 4CV  A 801 (-3.9A) 4CV  A 801 (-2.8A) None None	0.91A	31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	10 / 12	ALA A 481 LYS A 483 LEU A 514 ILE A 527 THR A 529 SER A 536 PHE A 583 GLY A 593 PHE A 595 GLY A 596	5XJ  A 801 (-3.1A) 5XJ  A 801 (-3.8A) 5XJ  A 801 (-4.5A) 5XJ  A 801 ( 4.0A) 5XJ  A 801 (-3.4A) None 5XJ  A 801 (-4.3A) 5XJ  A 801 ( 3.7A) 5XJ  A 801 (-3.7A) 5XJ  A 801 (-3.7A)	0.66A	93.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	10 / 12	ALA A 481 LYS A 483 LEU A 514 ILE A 527 THR A 529 TRP A 531 PHE A 583 GLY A 593 PHE A 595 GLY A 596	5XJ  A 801 (-3.1A) 5XJ  A 801 (-3.8A) 5XJ  A 801 (-4.5A) 5XJ  A 801 ( 4.0A) 5XJ  A 801 (-3.4A) 5XJ  A 801 (-4.4A) 5XJ  A 801 (-4.3A) 5XJ  A 801 ( 3.7A) 5XJ  A 801 (-3.7A) 5XJ  A 801 (-3.7A)	0.53A	93.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	10 / 12	LYS A 483 LEU A 514 ILE A 527 THR A 529 SER A 535 SER A 536 PHE A 583 GLY A 593 PHE A 595 GLY A 596	5XJ  A 801 (-3.8A) 5XJ  A 801 (-4.5A) 5XJ  A 801 ( 4.0A) 5XJ  A 801 (-3.4A) None None 5XJ  A 801 (-4.3A) 5XJ  A 801 ( 3.7A) 5XJ  A 801 (-3.7A) 5XJ  A 801 (-3.7A)	0.71A	93.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5gwj	DNA TOPOISOMERASE 2-BETA (Homo sapiens)	5 / 12	LEU A 568 SER A 670 PHE A 669 GLY A 567 GLY A 562	None	0.98A	16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	ALA A  43 ILE A  80 THR A  82 SER A  86 PHE A 152 GLY A 153	032  A 401 (-3.2A) 032  A 401 (-4.0A) 032  A 401 (-3.7A) None 032  A 401 (-4.1A) 032  A 401 (-3.6A)	1.46A	32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	ALA A  43 LYS A  45 ILE A  80 THR A  82 SER A  89 PHE A 152 GLY A 153	032  A 401 (-3.2A) 032  A 401 (-4.4A) 032  A 401 (-4.0A) 032  A 401 (-3.7A) None 032  A 401 (-4.1A) 032  A 401 (-3.6A)	0.58A	32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	6 / 12	ALA A 137 THR A 187 SER A 193 PHE A 240 GLY A 250 GLY A 253	H8H  A 401 (-3.3A) H8H  A 401 (-3.5A) H8H  A 401 ( 4.4A) H8H  A 401 (-4.3A) None None	1.11A	26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	6 / 12	ALA A 137 THR A 187 SER A 193 PHE A 240 GLY A 250 PHE A 252	H8H  A 401 (-3.3A) H8H  A 401 (-3.5A) H8H  A 401 ( 4.4A) H8H  A 401 (-4.3A) None None	0.78A	26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vdk	WEE1-LIKE PROTEIN KINASE 2 (Homo sapiens)	5 / 12	ALA A 239 ILE A 287 SER A 296 PHE A 346 GLY A 379	8X7  A 501 ( 3.7A) PO4  A 502 (-3.4A) None 8X7  A 501 (-3.7A) None	0.70A	26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vil	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5 (Homo sapiens)	5 / 12	ALA A 707 LYS A 709 ILE A 752 SER A 761 PHE A 823	9E1  A1001 (-3.5A) 9E1  A1001 (-2.8A) None 9E1  A1001 ( 3.9A) None	0.97A	12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5w5j	RECEPTOR-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	6 / 12	ALA A  45 LYS A  47 LEU A  79 ILE A  93 THR A  95 SER A 102	9WS  A 401 (-3.3A) 9WS  A 401 (-3.3A) 9WS  A 401 (-4.9A) 9WS  A 401 (-3.9A) 9WS  A 401 (-3.2A) None	0.85A	28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6ao5	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	5 / 12	ALA A  54 ILE A  97 SER A 106 PHE A 165 GLY A 166	ANP  A 501 ( 3.7A) None ANP  A 501 (-2.4A) None None	0.77A	25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6c7y	TYROSINE-PROTEIN KINASE JAK1 (Homo sapiens)	5 / 12	ALA A 906 LYS A 908 SER A 963 GLY A1020 PHE A1022	ADP  A1201 (-3.4A) ADP  A1201 (-2.8A) ADP  A1201 (-3.3A) None None	0.93A	15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	6 / 12	ALA A 217 LEU A 248 ILE A 262 THR A 264 SER A 271 GLY A 329	FKY  A9001 (-3.3A) FKY  A9001 (-4.2A) None FKY  A9001 (-3.0A) None FKY  A9001 (-3.4A)	1.16A	14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1cmi	PROTEIN INHIBITOR OF NEURONAL NITRIC OXIDE SYNTHASE (Homo sapiens)	4 / 5	ILE A  38 VAL A  58 PHE A  73 CYH A  24	None	1.31A	17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1fs2	SKP2 (Homo sapiens)	4 / 5	VAL A 235 PHE A 193 CYH A 267 HIS A 292	None	1.17A	21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1q4x	THYROID HORMONE RECEPTOR BETA-1 (Homo sapiens)	4 / 5	ILE A 431 VAL A 349 PHE A 451 CYH A 309	None None G24  A 462 (-4.7A) None	1.27A	21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1q8k	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 (Homo sapiens)	4 / 5	ILE A  62 VAL A  33 PHE A  12 CYH A  69	None	1.38A	21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1rj7	ECTODYSPLASIN A (Homo sapiens)	4 / 5	ILE A 369 VAL A 309 PHE A 379 HIS A 366	None	1.35A	22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1z68	FIBROBLAST ACTIVATION PROTEIN, ALPHA SUBUNIT (Homo sapiens)	4 / 5	ILE A 697 VAL A 647 PHE A 641 HIS A 743	None	1.20A	16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1zxn	DNA TOPOISOMERASE II, ALPHA ISOZYME (Homo sapiens)	4 / 5	ILE A 368 VAL A 314 PHE A 363 CYH A 392	None	1.31A	18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2b3x	IRON-RESPONSIVE ELEMENT BINDING PROTEIN 1 (Homo sapiens)	4 / 5	ILE A 177 VAL A 123 PHE A 147 HIS A 207	None None None SF4  A1000 (-4.1A)	1.15A	15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2gry	KINESIN-LIKE PROTEIN KIF2 (Homo sapiens)	4 / 5	ILE A 274 VAL A 271 PHE A 265 CYH A 282	None	1.36A	19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2i3b	HUMAN CANCER-RELATED NTPASE (Homo sapiens)	4 / 5	ILE A 157 VAL A 154 PHE A 120 HIS A   3	None	1.24A	19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	4 / 5	ILE A 355 VAL A 363 PHE A 408 CYH A 424	SM5  A   1 (-4.3A) SM5  A   1 (-4.0A) None SM5  A   1 ( 4.4A)	0.46A	70.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3thz	DNA MISMATCH REPAIR PROTEIN MSH2 (Homo sapiens)	4 / 5	ILE A 632 VAL A 702 PHE A 694 HIS A 665	None	1.35A	15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3w4k	D-AMINO-ACID OXIDASE (Homo sapiens)	4 / 5	ILE A  32 VAL A   3 CYH A  18 HIS A  24	None	1.33A	21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4h2d	NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1 (Homo sapiens)	4 / 5	ILE A  55 VAL A  54 PHE A  76 CYH A  58	None	1.36A	19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4mob	ACYL-COENZYME A THIOESTERASE 12 (Homo sapiens)	4 / 5	ILE A  71 VAL A  91 PHE A 108 HIS A  19	None	1.25A	20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5a31	ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 (Homo sapiens)	4 / 5	ILE A 485 VAL A 482 PHE A  20 HIS A 645	None	1.33A	11.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	4 / 5	ILE A 463 VAL A 471 PHE A 516 CYH A 532	5XJ  A 801 ( 4.7A) 5XJ  A 801 (-4.6A) None 5XJ  A 801 (-4.6A)	0.54A	93.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	4 / 5	VAL A 471 PHE A 516 CYH A 532 HIS A 539	5XJ  A 801 (-4.6A) None 5XJ  A 801 (-4.6A) None	0.98A	93.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hmp	UNCONVENTIONAL MYOSIN-VC (Homo sapiens)	4 / 5	ILE A 158 VAL A 159 PHE A 138 HIS A 466	None	1.28A	17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5i6z	SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens)	4 / 5	ILE A  93 VAL A  92 PHE A 334 CYH A 369	None	1.07A	18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5iy9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Homo sapiens)	4 / 5	ILE A 419 VAL A 446 PHE A 397 HIS A 432	None	0.88A	11.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	6 / 12	VAL A 416 ALA A 428 LYS A 430 THR A 474 PHE A 540 GLY A 541	None	0.80A	30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1py5	TGF-BETA RECEPTOR TYPE I (Homo sapiens)	5 / 12	VAL A 219 ALA A 230 LYS A 232 LEU A 260 SER A 287	PY1  A 700 ( 4.7A) PY1  A 700 (-3.5A) PY1  A 700 (-3.9A) PY1  A 700 (-4.2A) None	0.70A	30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1t46	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens)	5 / 12	VAL A 603 ALA A 621 LYS A 623 THR A 670 CYH A 673	STI  A   3 ( 4.6A) STI  A   3 (-3.5A) STI  A   3 (-3.7A) STI  A   3 (-3.2A) STI  A   3 (-4.5A)	0.31A	30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1zlt	SERINE/THREONINE-PRO TEIN KINASE CHK1 (Homo sapiens)	5 / 12	VAL A  23 ALA A  36 LYS A  38 CYH A  87 PHE A 149	HYM  A 400 (-4.3A) HYM  A 400 (-3.5A) HYM  A 400 (-3.2A) HYM  A 400 (-4.2A) None	0.80A	26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2a1a	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (Homo sapiens)	6 / 12	VAL B 281 LYS B 296 CYH B 369 PHE B 421 GLY B 431 GLY B 434	None	1.35A	30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2a1a	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (Homo sapiens)	6 / 12	VAL B 281 LYS B 296 CYH B 369 PHE B 421 GLY B 431 PHE B 433	None	1.01A	30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	5 / 12	VAL X  25 ALA X  37 LYS X  39 THR X  82 SER X  89	STU  X 902 ( 4.8A) STU  X 902 (-3.1A) STU  X 902 (-3.1A) STU  X 902 (-4.1A) STU  X 902 ( 4.0A)	0.71A	33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	5 / 12	VAL A 281 ALA A 293 LYS A 295 THR A 338 SER A 345	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 (-3.7A) H8H  A 534 (-3.1A) H8H  A 534 ( 4.5A)	0.79A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	5 / 12	VAL A 281 ALA A 293 THR A 338 SER A 345 PHE A 405	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 (-3.1A) H8H  A 534 ( 4.5A) None	0.56A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	5 / 12	VAL A 281 ALA A 293 THR A 338 SER A 345 PHE A 405	QUE  A   1 ( 4.8A) QUE  A   1 (-3.5A) QUE  A   1 (-3.3A) QUE  A   1 ( 4.7A) None	0.78A	23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	5 / 12	VAL A 259 ALA A 271 LYS A 273 THR A 316 PHE A 383	1BM  A 499 ( 4.8A) 1BM  A 499 (-3.6A) 1BM  A 499 (-3.8A) 1BM  A 499 (-3.2A) None	0.77A	32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	5 / 12	VAL A 259 ALA A 271 LYS A 273 THR A 316 SER A 323	1BM  A 499 ( 4.8A) 1BM  A 499 (-3.6A) 1BM  A 499 (-3.8A) 1BM  A 499 (-3.2A) None	0.63A	32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hw6	MAP KINASE-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 1 (Homo sapiens)	5 / 12	VAL A  63 ALA A  76 LYS A  78 LEU A 108 SER A 131	None	0.81A	26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2i6l	MITOGEN-ACTIVATED PROTEIN KINASE 6 (Homo sapiens)	6 / 12	VAL A  34 ALA A  47 LYS A  49 PHE A 159 GLY A 170 GLY A 173	None	1.42A	27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2ogv	MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR PRECURSOR (Homo sapiens)	6 / 12	VAL A 596 ALA A 614 LYS A 616 THR A 663 CYH A 666 GLY A 795	None	0.75A	28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	VAL A 204 ALA A 215 LYS A 217 LEU A 245 THR A 265 PHE A 340	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None ADE  A 488 ( 4.5A) ADE  A 488 (-4.3A) None	0.85A	25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	VAL A 204 ALA A 215 LYS A 217 LEU A 245 THR A 265 SER A 272	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None ADE  A 488 ( 4.5A) ADE  A 488 (-4.3A) None	0.61A	25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	5 / 12	VAL A 204 ALA A 215 LYS A 217 SER A 272 GLY A 341	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None None None	0.83A	25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2qob	EPHRIN RECEPTOR (Homo sapiens)	5 / 12	VAL A 635 ALA A 651 LYS A 653 THR A 699 SER A 706	BME  A   1 (-4.9A) PTR  A 701 ( 4.7A) None None None	0.73A	27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2z2w	WEE1-LIKE PROTEIN KINASE (Homo sapiens)	7 / 12	VAL A 313 ALA A 326 CYH A 379 SER A 383 PHE A 433 GLY A 462 GLY A 465	770  A 901 ( 4.7A) 770  A 901 (-3.5A) 770  A 901 (-3.9A) None 770  A 901 (-4.0A) None None	1.20A	27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	6 / 12	VAL A 209 ALA A 220 LYS A 222 THR A 266 SER A 273 PHE A 333	None	0.88A	31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3kex	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens)	5 / 12	VAL A 704 LYS A 723 THR A 768 SER A 775 PHE A 834	ANP  A   1 (-3.9A) ANP  A   1 (-3.4A) ANP  A   1 ( 4.8A) None None	0.85A	29.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	5 / 12	VAL A 649 ALA A 665 LYS A 667 THR A 713 PHE A 779	None	0.83A	33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	5 / 12	VAL A 649 ALA A 665 LYS A 667 THR A 713 SER A 720	None	0.78A	33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3mdy	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (Homo sapiens)	6 / 12	VAL A 218 ALA A 229 LYS A 231 LEU A 259 THR A 279 SER A 286	LDN  A   1 ( 4.8A) LDN  A   1 (-3.6A) None None LDN  A   1 (-3.8A) None	0.63A	29.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3my0	SERINE/THREONINE-PRO TEIN KINASE RECEPTOR R3 (Homo sapiens)	6 / 12	VAL A 216 ALA A 227 LYS A 229 LEU A 257 THR A 277 SER A 284	LDN  A 600 (-4.5A) LDN  A 600 (-3.2A) LDN  A 600 (-4.0A) None LDN  A 600 (-4.0A) None	0.74A	27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	7 / 12	VAL A 363 ALA A 373 LEU A 406 THR A 421 TRP A 423 CYH A 424 SER A 427	SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) None SM5  A   1 (-4.4A) SM5  A   1 (-4.3A) SM5  A   1 ( 4.4A) None	1.05A	70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	10 / 12	VAL A 363 ALA A 373 LYS A 375 LEU A 406 THR A 421 TRP A 423 CYH A 424 PHE A 475 GLY A 485 PHE A 487	SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) None SM5  A   1 (-4.4A) SM5  A   1 (-4.3A) SM5  A   1 ( 4.4A) SM5  A   1 (-3.0A) None None	0.95A	70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	9 / 12	VAL A 363 ALA A 373 LYS A 375 LEU A 406 THR A 421 TRP A 423 CYH A 424 SER A 428 PHE A 475	SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) None SM5  A   1 (-4.4A) SM5  A   1 (-4.3A) SM5  A   1 ( 4.4A) None SM5  A   1 (-3.0A)	1.00A	70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	8 / 12	VAL A 363 ALA A 373 LYS A 375 TRP A 423 CYH A 424 PHE A 475 GLY A 485 GLY A 488	SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) SM5  A   1 (-4.3A) SM5  A   1 ( 4.4A) SM5  A   1 (-3.0A) None None	1.30A	70.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3q4t	ACTIVIN RECEPTOR TYPE-2A (Homo sapiens)	7 / 12	VAL A 206 ALA A 217 LYS A 219 LEU A 247 THR A 267 SER A 274 PHE A 341	TAK  A   2 ( 4.9A) TAK  A   2 (-3.5A) TAK  A   2 (-2.9A) None TAK  A   2 (-3.5A) None None	0.97A	28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4a4l	SERINE/THREONINE-PRO TEIN KINASE PLK1 (Homo sapiens)	6 / 12	ALA A  80 LYS A  82 CYH A 133 PHE A 183 GLY A 193 GLY A 196	939  A1331 (-3.5A) 939  A1331 (-2.6A) 939  A1331 (-4.0A) 939  A1331 (-4.0A) None None	1.36A	26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4a4l	SERINE/THREONINE-PRO TEIN KINASE PLK1 (Homo sapiens)	6 / 12	ALA A  80 LYS A  82 CYH A 133 PHE A 183 GLY A 193 PHE A 195	939  A1331 (-3.5A) 939  A1331 (-2.6A) 939  A1331 (-4.0A) 939  A1331 (-4.0A) None None	0.90A	26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4a4l	SERINE/THREONINE-PRO TEIN KINASE PLK1 (Homo sapiens)	6 / 12	ALA A  80 LYS A  82 CYH A 133 SER A 137 PHE A 183 GLY A 193	939  A1331 (-3.5A) 939  A1331 (-2.6A) 939  A1331 (-4.0A) 939  A1331 (-3.5A) 939  A1331 (-4.0A) None	0.72A	26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4b6l	SERINE/THREONINE-PRO TEIN KINASE PLK3 (Homo sapiens)	6 / 12	ALA A  89 LYS A  91 CYH A 142 PHE A 192 GLY A 202 GLY A 205	9ZP  A1333 (-3.5A) None 9ZP  A1333 (-4.1A) 9ZP  A1333 (-3.6A) 9ZP  A1333 ( 4.4A) None	1.36A	29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4b6l	SERINE/THREONINE-PRO TEIN KINASE PLK3 (Homo sapiens)	6 / 12	ALA A  89 LYS A  91 CYH A 142 PHE A 192 GLY A 202 PHE A 204	9ZP  A1333 (-3.5A) None 9ZP  A1333 (-4.1A) 9ZP  A1333 (-3.6A) 9ZP  A1333 ( 4.4A) None	0.97A	29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4b6l	SERINE/THREONINE-PRO TEIN KINASE PLK3 (Homo sapiens)	6 / 12	ALA A  89 LYS A  91 CYH A 142 SER A 146 PHE A 192 GLY A 202	9ZP  A1333 (-3.5A) None 9ZP  A1333 (-4.1A) None 9ZP  A1333 (-3.6A) 9ZP  A1333 ( 4.4A)	0.65A	29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	6 / 12	VAL A 222 ALA A 233 LYS A 235 LEU A 263 THR A 283 SER A 290	TAK  A1507 (-4.7A) TAK  A1507 (-3.3A) TAK  A1507 ( 4.5A) FLC  A1503 ( 4.5A) TAK  A1507 (-3.6A) None	0.70A	29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4eut	SERINE/THREONINE-PRO TEIN KINASE TBK1 (Homo sapiens)	5 / 12	VAL A  23 ALA A  36 LYS A  38 CYH A  89 PHE A 158	BX7  A 401 (-4.4A) BX7  A 401 (-3.4A) BX7  A 401 ( 4.0A) BX7  A 401 (-4.1A) None	0.85A	23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4euu	SERINE/THREONINE-PRO TEIN KINASE TBK1 (Homo sapiens)	6 / 12	VAL A  23 ALA A  36 LYS A  38 CYH A  89 SER A  93 PHE A 158	BX7  A 401 ( 4.6A) BX7  A 401 (-3.4A) BX7  A 401 (-3.5A) BX7  A 401 (-4.1A) BX7  A 401 ( 4.7A) None	1.11A	25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4g34	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 (Homo sapiens)	6 / 12	VAL A 606 ALA A 619 CYH A 890 PHE A 943 GLY A 953 PHE A 955	924  A1101 ( 4.8A) 924  A1101 (-3.5A) 924  A1101 (-3.9A) 924  A1101 ( 4.2A) 924  A1101 (-4.6A) 924  A1101 ( 4.4A)	0.99A	28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4g34	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 (Homo sapiens)	6 / 12	VAL A 606 ALA A 619 CYH A 890 PHE A 943 PHE A 955 GLY A 956	924  A1101 ( 4.8A) 924  A1101 (-3.5A) 924  A1101 (-3.9A) 924  A1101 ( 4.2A) 924  A1101 ( 4.4A) None	0.80A	28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4g34	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 (Homo sapiens)	6 / 12	VAL A 606 ALA A 619 LYS A 621 CYH A 890 PHE A 955 GLY A 956	924  A1101 ( 4.8A) 924  A1101 (-3.5A) None 924  A1101 (-3.9A) 924  A1101 ( 4.4A) None	0.73A	28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	6 / 12	VAL A 140 ALA A 156 THR A 205 SER A 212 GLY A 269 PHE A 271	None	0.84A	28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4i6f	SERINE/THREONINE-PRO TEIN KINASE PLK2 (Homo sapiens)	7 / 12	ALA A 109 LYS A 111 CYH A 162 SER A 166 PHE A 212 GLY A 222 GLY A 225	1C7  A 401 (-3.2A) 1C7  A 401 ( 4.7A) 1C7  A 401 (-4.1A) None 1C7  A 401 (-4.0A) None None	1.42A	26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4i6f	SERINE/THREONINE-PRO TEIN KINASE PLK2 (Homo sapiens)	7 / 12	ALA A 109 LYS A 111 CYH A 162 SER A 166 PHE A 212 GLY A 222 PHE A 224	1C7  A 401 (-3.2A) 1C7  A 401 ( 4.7A) 1C7  A 401 (-4.1A) None 1C7  A 401 (-4.0A) None None	1.04A	26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	6 / 12	VAL A 140 ALA A 156 LYS A 158 THR A 205 GLY A 269 PHE A 271	1G0  A 401 (-4.4A) 1G0  A 401 (-3.6A) 1G0  A 401 (-3.7A) 1G0  A 401 (-3.2A) None 1G0  A 401 ( 4.8A)	0.87A	30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	6 / 12	VAL A 140 ALA A 156 LYS A 158 THR A 205 SER A 212 GLY A 269	1G0  A 401 (-4.4A) 1G0  A 401 (-3.6A) 1G0  A 401 (-3.7A) 1G0  A 401 (-3.2A) 1G0  A 401 ( 4.3A) None	1.06A	30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4jxf	SERINE/THREONINE-PRO TEIN KINASE PLK4 (Homo sapiens)	5 / 12	VAL A  26 ALA A  39 LEU A  73 CYH A  92 PHE A 155	631  A 301 (-4.6A) 631  A 301 (-3.3A) None 631  A 301 (-4.5A) None	0.71A	27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4jxf	SERINE/THREONINE-PRO TEIN KINASE PLK4 (Homo sapiens)	5 / 12	VAL A  26 ALA A  39 LYS A  41 LEU A  73 CYH A  92	631  A 301 (-4.6A) 631  A 301 (-3.3A) 631  A 301 (-2.7A) None 631  A 301 (-4.5A)	0.75A	27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4lg4	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	5 / 12	VAL A  41 ALA A  54 LYS A  56 CYH A 102 SER A 106	GOL  A 404 (-4.5A) GOL  A 404 ( 3.1A) GOL  A 403 ( 4.6A) GOL  A 403 (-4.0A) None	0.82A	29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4o27	SERINE/THREONINE-PRO TEIN KINASE 24 (Homo sapiens)	5 / 12	VAL B  38 ALA B  51 LYS B  53 SER B 106 PHE B 163	ADP  B 500 (-4.5A) ADP  B 500 (-3.3A) ADP  B 500 (-3.1A) ADP  B 500 (-3.4A) None	0.85A	29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	6 / 12	VAL A  54 ALA A  67 LYS A  69 THR A 123 CYH A 126 PHE A 192	None SIN  A 401 ( 3.7A) None None SIN  A 401 (-4.3A) None	0.73A	26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	6 / 12	VAL A 477 ALA A 488 LYS A 490 THR A 539 SER A 546 PHE A 607	None 4CV  A 801 (-3.5A) 4CV  A 801 (-3.9A) 4CV  A 801 (-2.8A) None None	0.91A	31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5a46	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens)	5 / 12	VAL A 492 ALA A 512 LYS A 514 PHE A 642 GLY A 643	38O  A1769 (-4.5A) 38O  A1769 (-3.6A) 38O  A1769 ( 3.1A) EDO  A1766 (-3.7A) EDO  A1766 (-3.6A)	0.65A	28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5d7a	TRAF2 AND NCK-INTERACTING PROTEIN KINASE (Homo sapiens)	5 / 12	VAL A  39 ALA A  52 LYS A  54 SER A 112 PHE A 172	VAL  A  39 (-0.6A) ALA  A  52 (-0.0A) LYS  A  54 ( 0.0A) SER  A 112 (-0.0A) PHE  A 172 ( 1.3A)	0.65A	31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5e8y	TGF-BETA RECEPTOR TYPE-2 (Homo sapiens)	5 / 12	VAL A 258 ALA A 275 LYS A 277 LEU A 305 THR A 325	STU  A 601 (-4.0A) STU  A 601 (-3.1A) STU  A 601 (-2.4A) STU  A 601 ( 3.8A) STU  A 601 ( 3.7A)	0.43A	27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5f1z	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	6 / 12	VAL A 911 ALA A 928 LYS A 930 SER A 985 GLY A1040 PHE A1042	5U3  A1200 ( 4.4A) 5U3  A1200 (-3.5A) None None 5U3  A1200 ( 4.9A) None	1.08A	28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	12 / 12	VAL A 471 ALA A 481 LYS A 483 LEU A 514 THR A 529 TRP A 531 CYH A 532 SER A 536 PHE A 583 GLY A 593 PHE A 595 GLY A 596	5XJ  A 801 (-4.6A) 5XJ  A 801 (-3.1A) 5XJ  A 801 (-3.8A) 5XJ  A 801 (-4.5A) 5XJ  A 801 (-3.4A) 5XJ  A 801 (-4.4A) 5XJ  A 801 (-4.6A) None 5XJ  A 801 (-4.3A) 5XJ  A 801 ( 3.7A) 5XJ  A 801 (-3.7A) 5XJ  A 801 (-3.7A)	0.82A	93.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5grn	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens)	5 / 12	VAL A 607 ALA A 625 LYS A 627 THR A 674 CYH A 677	748  A1001 ( 4.7A) 748  A1001 (-3.7A) 748  A1001 (-4.0A) 748  A1001 (-3.2A) 748  A1001 (-4.5A)	0.35A	28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	7 / 12	VAL A  30 ALA A  43 LYS A  45 THR A  82 SER A  89 PHE A 152 GLY A 153	032  A 401 (-4.4A) 032  A 401 (-3.2A) 032  A 401 (-4.4A) 032  A 401 (-3.7A) None 032  A 401 (-4.1A) 032  A 401 (-3.6A)	0.63A	32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5hor	HEPATOCYTE GROWTH FACTOR RECEPTOR (Homo sapiens)	5 / 12	VAL A1092 ALA A1108 LEU A1140 PHE A1223 GLY A1224	63K  A1401 (-4.9A) 63K  A1401 (-3.5A) None None None	0.63A	29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5j5t	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3 (Homo sapiens)	5 / 12	VAL A  30 ALA A  43 LYS A  45 CYH A  93 PHE A 155	6G2  A 901 ( 4.9A) 6G2  A 901 (-3.2A) 6G2  A 901 ( 3.9A) TPO  A 145 (-4.1A) None	0.82A	25.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5kkr	KINASE SUPPRESSOR OF RAS 2 (Homo sapiens)	5 / 12	VAL B 680 ALA B 690 THR B 739 CYH B 742 PHE B 804	6U7  B1001 ( 4.3A) 6U7  B1001 (-3.6A) 6U7  B1001 (-4.0A) 6U7  B1001 (-3.5A) 6U7  B1001 (-3.8A)	0.80A	36.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	7 / 12	ALA A 137 THR A 187 CYH A 190 SER A 193 PHE A 240 GLY A 250 GLY A 253	H8H  A 401 (-3.3A) H8H  A 401 (-3.5A) H8H  A 401 (-4.3A) H8H  A 401 ( 4.4A) H8H  A 401 (-4.3A) None None	1.17A	26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	7 / 12	ALA A 137 THR A 187 CYH A 190 SER A 193 PHE A 240 GLY A 250 PHE A 252	H8H  A 401 (-3.3A) H8H  A 401 (-3.5A) H8H  A 401 (-4.3A) H8H  A 401 ( 4.4A) H8H  A 401 (-4.3A) None None	0.88A	26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	6 / 12	VAL A 124 ALA A 137 LYS A 139 THR A 187 CYH A 190 GLY A 253	H8H  A 401 (-4.7A) H8H  A 401 (-3.3A) H8H  A 401 (-4.9A) H8H  A 401 (-3.5A) H8H  A 401 (-4.3A) None	1.11A	26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	7 / 12	VAL A 124 ALA A 137 THR A 187 CYH A 190 SER A 193 PHE A 240 GLY A 253	H8H  A 401 (-4.7A) H8H  A 401 (-3.3A) H8H  A 401 (-3.5A) H8H  A 401 (-4.3A) H8H  A 401 ( 4.4A) H8H  A 401 (-4.3A) None	0.96A	26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	7 / 12	VAL A 124 ALA A 137 THR A 187 CYH A 190 SER A 193 PHE A 240 PHE A 252	H8H  A 401 (-4.7A) H8H  A 401 (-3.3A) H8H  A 401 (-3.5A) H8H  A 401 (-4.3A) H8H  A 401 ( 4.4A) H8H  A 401 (-4.3A) None	0.91A	26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vdk	WEE1-LIKE PROTEIN KINASE 2 (Homo sapiens)	6 / 12	VAL A 226 ALA A 239 CYH A 292 PHE A 346 GLY A 379 GLY A 382	8X7  A 501 ( 4.5A) 8X7  A 501 ( 3.7A) 8X7  A 501 (-3.8A) 8X7  A 501 (-3.7A) None None	1.17A	26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5vdk	WEE1-LIKE PROTEIN KINASE 2 (Homo sapiens)	6 / 12	VAL A 226 ALA A 239 CYH A 292 SER A 296 PHE A 346 GLY A 379	8X7  A 501 ( 4.5A) 8X7  A 501 ( 3.7A) 8X7  A 501 (-3.8A) None 8X7  A 501 (-3.7A) None	0.91A	26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5w5j	RECEPTOR-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	6 / 12	VAL A  32 ALA A  45 LYS A  47 LEU A  79 THR A  95 SER A 102	9WS  A 401 ( 4.6A) 9WS  A 401 (-3.3A) 9WS  A 401 (-3.3A) 9WS  A 401 (-4.9A) 9WS  A 401 (-3.2A) None	0.83A	28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6ao5	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	6 / 12	VAL A  41 ALA A  54 CYH A 102 SER A 106 PHE A 165 GLY A 166	ANP  A 501 (-4.4A) ANP  A 501 ( 3.7A) ANP  A 501 (-4.2A) ANP  A 501 (-2.4A) None None	0.78A	25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	VAL A 226 ALA A 237 LYS A 239 SER A 295 GLY A 357 GLY A 360	None DL1  A 601 (-3.4A) DL1  A 601 ( 4.1A) DL1  A 601 ( 4.6A) DL1  A 601 ( 4.8A) None	1.10A	15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6c7y	TYROSINE-PROTEIN KINASE JAK1 (Homo sapiens)	6 / 12	VAL A 889 ALA A 906 LYS A 908 SER A 963 GLY A1020 GLY A1023	ADP  A1201 (-4.3A) ADP  A1201 (-3.4A) ADP  A1201 (-2.8A) ADP  A1201 (-3.3A) None MG  A1203 ( 4.7A)	1.39A	15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1xfd	DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6 (Homo sapiens)	4 / 5	ILE A 742 SER A 740 HIS A 824 ASP A 629	None	1.31A	17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2hi4	CYTOCHROME P450 1A2 (Homo sapiens)	4 / 5	ILE A 117 PHE A 384 SER A 126 ASP A 237	None	1.29A	19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2kav	SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA (Homo sapiens)	4 / 5	ILE A1831 PHE A1795 SER A1819 ASP A1826	None	1.37A	20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2xy9	ANGIOTENSIN-CONVERTI NG ENZYME (Homo sapiens)	4 / 5	PHE A 322 SER A 355 HIS A 353 ASP A 415	None 3ES  A1636 (-4.3A) 3ES  A1635 (-3.8A) 3ES  A1635 ( 3.9A)	1.23A	18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2xyd	ANGIOTENSIN-CONVERTI NG ENZYME (Homo sapiens)	4 / 5	PHE A 300 SER A 333 HIS A 331 ASP A 393	None 3ES  A1611 (-4.4A) 3ES  A1611 (-3.8A) 3ES  A1611 (-3.4A)	1.26A	19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3gdh	TRIMETHYLGUANOSINE SYNTHASE HOMOLOG (Homo sapiens)	4 / 5	ILE A 790 PHE A 754 SER A 763 ASP A 747	None None SAH  A 854 ( 2.7A) SAH  A 854 (-3.6A)	1.26A	21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3kv4	PHD FINGER PROTEIN 8 (Homo sapiens)	4 / 5	ILE A 103 PHE A 293 SER A 304 ASP A  97	None	1.44A	21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3mvj	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Homo sapiens)	4 / 5	ILE A 335 PHE A 108 SER A 114 ASP A  41	None None SEP  A 338 ( 2.9A) None	1.38A	25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4h6j	ARYL HYDROCARBON NUCLEAR TRANSLOCATOR HYPOXIA INDUCIBLE FACTOR 1-ALPHA (Homo sapiens)	4 / 5	ILE A 324 PHE A 242 SER B 443 ASP B 377	None	0.97A	18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4i8v	CYTOCHROME P450 1A1 (Homo sapiens)	4 / 5	ILE A 115 PHE A 384 SER A 124 ASP A 235	BHF  A 602 (-4.7A) None None None	1.26A	20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4uhi	STEROL 14-ALPHA DEMETHYLASE (Homo sapiens)	4 / 5	ILE A 306 PHE A 250 HIS A 211 ASP A 231	None	1.39A	21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5j1s	TORSIN-1A-INTERACTIN G PROTEIN 2 (Homo sapiens)	4 / 5	ILE B 328 PHE B 280 SER B 326 ASP B 391	None	1.41A	21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5xeq	MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PROTEIN 1 (Homo sapiens)	4 / 5	PHE B 231 SER B 177 HIS B 178 ASP B 208	None	1.33A	22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5y30	LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1 (Homo sapiens)	4 / 5	ILE A 158 PHE A 121 SER A 131 HIS A 133	None	1.28A	13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6f9w	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER PROTEIN LSM14 HOMOLOG A (Homo sapiens)	4 / 5	ILE A  72 PHE A  62 SER A  34 ASP B 979	None	1.39A	17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1by8	PROTEIN (PROCATHEPSIN K) (Homo sapiens)	6 / 12	GLY A 267 VAL A 230 ALA A 309 ILE A  93 ALA A 219 GLY A 208	None	1.42A	20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	6 / 12	ALA A 428 ILE A 472 THR A 474 TYR A 476 PHE A 540 GLY A 541	None	0.80A	29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	6 / 12	VAL A 416 ALA A 428 ILE A 472 TYR A 476 PHE A 540 GLY A 541	None	0.73A	29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1s9i	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (Homo sapiens)	5 / 12	VAL A  86 ALA A  99 ILE A 145 CYH A 211 PHE A 213	ATP  A 535 (-4.1A) ATP  A 535 (-3.6A) 5EA  A1001 ( 3.7A) ATP  A 535 ( 4.5A) 5EA  A1001 (-3.6A)	0.56A	25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	5 / 12	VAL X  25 ALA X  37 ILE X  80 THR X  82 ASP X  92	STU  X 902 ( 4.8A) STU  X 902 (-3.1A) None STU  X 902 (-4.1A) None	0.43A	29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	5 / 12	VAL X  25 ALA X  37 ILE X  80 THR X  82 TYR X  84	STU  X 902 ( 4.8A) STU  X 902 (-3.1A) None STU  X 902 (-4.1A) STU  X 902 (-4.6A)	0.58A	29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	6 / 12	ALA A 293 ILE A 336 THR A 338 ASP A 348 PHE A 405 GLY A 406	H8H  A 534 (-3.2A) H8H  A 534 ( 4.5A) H8H  A 534 (-3.1A) None None None	0.88A	19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	7 / 12	VAL A 281 ALA A 293 ILE A 336 THR A 338 TYR A 340 ASP A 348 PHE A 405	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 ( 4.5A) H8H  A 534 (-3.1A) H8H  A 534 (-4.3A) None None	0.85A	19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	6 / 12	VAL A 281 ALA A 293 ILE A 336 THR A 338 ASP A 348 PHE A 405	QUE  A   1 ( 4.8A) QUE  A   1 (-3.5A) None QUE  A   1 (-3.3A) QUE  A   1 ( 4.1A) None	0.84A	20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	5 / 12	VAL A 259 ALA A 271 ILE A 314 THR A 316 ASP A 326	1BM  A 499 ( 4.8A) 1BM  A 499 (-3.6A) 1BM  A 499 (-3.9A) 1BM  A 499 (-3.2A) None	0.59A	26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2hz0	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	5 / 12	VAL A 256 ALA A 269 ILE A 313 THR A 315 ASP A 325	GIN  A 600 ( 4.7A) GIN  A 600 (-3.1A) GIN  A 600 (-3.8A) GIN  A 600 (-3.4A) None	0.63A	32.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2og8	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens)	6 / 12	VAL A 259 ALA A 271 ILE A 314 THR A 316 TYR A 318 ASP A 326	None 1N8  A 501 ( 3.4A) 1N8  A 501 ( 4.6A) 1N8  A 501 ( 3.3A) 1N8  A 501 ( 3.7A) None	0.64A	27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2psq	FIBROBLAST GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	6 / 12	VAL A 495 ALA A 515 ILE A 548 ALA A 567 PHE A 645 GLY A 646	None	1.03A	26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2psq	FIBROBLAST GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	6 / 12	VAL A 495 ALA A 515 ILE A 548 TYR A 566 ALA A 567 PHE A 645	None	0.83A	26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	VAL A 204 ALA A 215 THR A 265 ASP A 275 PHE A 340 GLY A 341	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) ADE  A 488 (-4.3A) None None None	1.10A	29.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2qob	EPHRIN RECEPTOR (Homo sapiens)	5 / 12	VAL A 635 ALA A 651 ILE A 683 ILE A 697 THR A 699	BME  A   1 (-4.9A) PTR  A 701 ( 4.7A) None None None	0.54A	31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2r2p	EPHRIN TYPE-A RECEPTOR 5 (Homo sapiens)	6 / 12	VAL A 689 ALA A 705 ILE A 737 ILE A 751 THR A 753 TYR A 755	None	0.59A	27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2r2p	EPHRIN TYPE-A RECEPTOR 5 (Homo sapiens)	6 / 12	VAL A 689 ALA A 705 ILE A 737 THR A 753 TYR A 755 PHE A 819	None	0.79A	27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2z2w	WEE1-LIKE PROTEIN KINASE (Homo sapiens)	5 / 12	VAL A 313 ALA A 326 ILE A 374 TYR A 378 ASP A 386	770  A 901 ( 4.7A) 770  A 901 (-3.5A) None 770  A 901 (-4.2A) None	0.54A	26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3b2t	FIBROBLAST GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	6 / 12	VAL A 495 ALA A 515 ILE A 548 ALA A 567 PHE A 645 GLY A 646	M33  A1996 ( 4.7A) M33  A1996 (-3.3A) None M33  A1996 (-3.8A) None None	1.05A	30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3b2t	FIBROBLAST GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	6 / 12	VAL A 495 ALA A 515 ILE A 548 TYR A 566 ALA A 567 PHE A 645	M33  A1996 ( 4.7A) M33  A1996 (-3.3A) None M33  A1996 ( 4.7A) M33  A1996 (-3.8A) None	0.84A	30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3c4f	BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	6 / 12	VAL A 492 ALA A 512 ILE A 545 ALA A 564 PHE A 642 GLY A 643	None C4F  A   1 (-3.3A) C4F  A   1 ( 4.0A) C4F  A   1 (-3.5A) C4F  A   1 ( 4.5A) None	0.88A	30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	7 / 12	VAL A 209 ALA A 220 ILE A 264 THR A 266 ASP A 276 PHE A 333 GLY A 334	None	0.99A	31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	7 / 12	VAL A 209 ALA A 220 ILE A 264 THR A 266 TYR A 268 ASP A 276 PHE A 333	None	0.85A	31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3dtc	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	5 / 12	VAL A 158 ALA A 169 ILE A 204 ALA A 223 PHE A 295	VIN  A6331 (-4.7A) VIN  A6331 (-3.4A) VIN  A6331 ( 4.9A) VIN  A6331 (-3.8A) None	0.50A	40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3f2a	PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE PIM-1 (Homo sapiens)	6 / 12	VAL A  52 ALA A  65 ILE A 104 ASP A 131 PHE A 187 GLY A 188	985  A   1 (-4.5A) 985  A   1 (-3.5A) 985  A   1 ( 4.7A) None None None	1.21A	24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3kex	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens)	5 / 12	VAL A 704 THR A 768 TYR A 770 ASP A 778 PHE A 834	ANP  A   1 (-3.9A) ANP  A   1 ( 4.8A) ANP  A   1 (-4.3A) None None	0.70A	30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	6 / 12	ALA A 665 ILE A 697 ILE A 711 THR A 713 TYR A 715 PHE A 779	None None None None GOL  A 403 (-4.1A) None	0.84A	30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	7 / 12	VAL A 649 ALA A 665 ILE A 697 ILE A 711 THR A 713 PHE A 779 GLY A 780	None	1.09A	30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3lm5	SERINE/THREONINE-PRO TEIN KINASE 17B (Homo sapiens)	6 / 12	VAL A  47 ALA A  60 ILE A  94 TYR A 112 ALA A 113 PHE A 180	QUE  A   1 ( 4.6A) QUE  A   1 (-3.2A) QUE  A   1 (-4.6A) QUE  A   1 (-4.9A) QUE  A   1 (-3.9A) None	0.91A	26.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3sxs	CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens)	5 / 12	VAL A 431 ALA A 443 ILE A 487 THR A 489 TYR A 491	PP2  A   1 (-4.5A) PP2  A   1 (-3.2A) PP2  A   1 (-3.6A) PP2  A   1 (-3.3A) PP2  A   1 ( 4.9A)	0.45A	31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3tt0	BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 ILE A 545 TYR A 563 ALA A 564 PHE A 642 GLY A 643	07J  A   1 (-4.0A) 07J  A   1 (-3.5A) 07J  A   1 (-3.8A) 07J  A   1 (-4.7A) 07J  A   1 (-3.8A) 07J  A   1 ( 4.6A) None	0.88A	28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3zfx	EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens)	5 / 12	VAL A 633 ALA A 649 ILE A 681 ILE A 695 THR A 697	None	0.44A	31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4aw5	EPHRIN TYPE-B RECEPTOR 4 (Homo sapiens)	5 / 12	VAL A 105 ALA A 121 ILE A 153 ILE A 167 THR A 169	30K  A1365 ( 4.6A) 30K  A1365 (-3.2A) None None 30K  A1365 (-3.8A)	0.43A	31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4ckr	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens)	5 / 12	VAL A 624 ALA A 653 ILE A 685 THR A 701 TYR A 703	DI1  A1000 (-4.8A) DI1  A1000 (-3.6A) DI1  A1000 (-4.5A) DI1  A1000 (-3.6A) DI1  A1000 (-4.0A)	0.61A	27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	6 / 12	ILE A 190 THR A 205 ALA A 208 ASP A 215 PHE A 271 GLY A 272	None	0.83A	33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	7 / 12	VAL A 140 ALA A 156 ILE A 190 THR A 205 ALA A 208 ASP A 215 PHE A 271	None	0.72A	33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	7 / 12	VAL A 140 ALA A 156 ILE A 190 THR A 205 ALA A 208 ASP A 215 PHE A 271	1G0  A 401 (-4.4A) 1G0  A 401 (-3.6A) 1G0  A 401 (-4.3A) 1G0  A 401 (-3.2A) 1G0  A 401 (-3.8A) None 1G0  A 401 ( 4.8A)	0.95A	32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	5 / 12	VAL A 281 ALA A 293 ILE A 336 TYR A 340 PHE A 405	0J9  A 601 (-4.4A) 0J9  A 601 (-3.3A) 0J9  A 601 (-4.4A) 0J9  A 601 ( 4.7A) None	0.45A	20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4k33	FIBROBLAST GROWTH FACTOR RECEPTOR 3 (Homo sapiens)	6 / 12	VAL A 486 ALA A 506 ILE A 539 ALA A 558 PHE A 636 GLY A 637	ACP  A 801 (-4.2A) ACP  A 801 (-3.3A) None ACP  A 801 (-3.7A) None None	1.15A	29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4k33	FIBROBLAST GROWTH FACTOR RECEPTOR 3 (Homo sapiens)	6 / 12	VAL A 486 ALA A 506 ILE A 539 TYR A 557 ALA A 558 PHE A 636	ACP  A 801 (-4.2A) ACP  A 801 (-3.3A) None None ACP  A 801 (-3.7A) None	0.94A	29.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4o27	SERINE/THREONINE-PRO TEIN KINASE 24 (Homo sapiens)	6 / 12	VAL B  38 ALA B  51 ILE B  97 TYR B 101 ASP B 109 PHE B 163	ADP  B 500 (-4.5A) ADP  B 500 (-3.3A) None ADP  B 500 ( 4.7A) None None	0.85A	30.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4p2k	EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens)	6 / 12	VAL A 627 ALA A 644 ILE A 676 ILE A 690 THR A 692 TYR A 694	None	0.55A	30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4qtb	MITOGEN-ACTIVATED PROTEIN KINASE 3 (Homo sapiens)	5 / 12	VAL A  56 ALA A  69 ILE A 101 ILE A 120 CYH A 183	None 38Z  A 418 (-3.4A) 38Z  A 418 ( 4.9A) None 38Z  A 418 ( 3.8A)	0.68A	27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4rew	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (Homo sapiens)	6 / 12	VAL A  32 ALA A  45 ILE A  79 TYR A  97 ASP A 105 GLY A 161	STU  A 601 ( 4.8A) STU  A 601 (-3.2A) STU  A 601 ( 4.6A) STU  A 601 (-4.4A) None None	1.20A	21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4uy9	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	5 / 12	VAL A 158 ALA A 169 ILE A 204 ALA A 223 PHE A 295	None	0.53A	40.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4wsq	AP2-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens)	6 / 12	VAL A  60 ALA A  72 ILE A 124 CYH A 193 PHE A 195 GLY A 196	KSA  A 405 ( 4.9A) KSA  A 405 (-3.2A) None KSA  A 405 (-3.4A) None None	1.11A	24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4xcu	FIBROBLAST GROWTH FACTOR RECEPTOR 4 (Homo sapiens)	5 / 12	ALA A 501 ILE A 534 ALA A 553 PHE A 631 GLY A 632	40M  A1002 ( 4.1A) 40M  A1002 (-4.0A) 40M  A1002 (-3.7A) 40M  A1002 ( 4.2A) None	0.68A	30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4xcu	FIBROBLAST GROWTH FACTOR RECEPTOR 4 (Homo sapiens)	5 / 12	VAL A 481 ALA A 501 ILE A 534 ALA A 553 PHE A 631	40M  A1002 ( 4.5A) 40M  A1002 ( 4.1A) 40M  A1002 (-4.0A) 40M  A1002 (-3.7A) 40M  A1002 ( 4.2A)	0.61A	30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4xey	TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	5 / 12	VAL B 275 ALA B 288 ILE B 332 THR B 334 ASP B 344	1N1  B 601 ( 4.9A) 1N1  B 601 (-3.5A) 1N1  B 601 (-4.1A) 1N1  B 601 (-3.3A) None	0.59A	26.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	6 / 12	ALA A 488 ILE A 522 ILE A 537 THR A 539 TYR A 541 GLY A 608	4CV  A 801 (-3.5A) 4CV  A 801 ( 4.2A) None 4CV  A 801 (-2.8A) 4CV  A 801 (-3.9A) None	0.80A	31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	6 / 12	ALA A 488 ILE A 522 THR A 539 TYR A 541 PHE A 607 GLY A 608	4CV  A 801 (-3.5A) 4CV  A 801 ( 4.2A) 4CV  A 801 (-2.8A) 4CV  A 801 (-3.9A) None None	1.04A	31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	6 / 12	VAL A 477 ALA A 488 ILE A 522 ILE A 537 THR A 539 TYR A 541	None 4CV  A 801 (-3.5A) 4CV  A 801 ( 4.2A) None 4CV  A 801 (-2.8A) 4CV  A 801 (-3.9A)	0.48A	31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	6 / 12	VAL A 477 ALA A 488 ILE A 522 THR A 539 TYR A 541 PHE A 607	None 4CV  A 801 (-3.5A) 4CV  A 801 ( 4.2A) 4CV  A 801 (-2.8A) 4CV  A 801 (-3.9A) None	0.84A	31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5a46	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 ILE A 545 TYR A 563 ALA A 564 PHE A 642 GLY A 643	38O  A1769 (-4.5A) 38O  A1769 (-3.6A) 38O  A1769 ( 3.3A) 38O  A1769 (-4.2A) 38O  A1769 (-3.9A) EDO  A1766 (-3.7A) EDO  A1766 (-3.6A)	0.85A	30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5es1	MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4 (Homo sapiens)	6 / 12	VAL A  70 ALA A  83 TYR A 134 ALA A 135 ASP A 142 GLY A 198	5RC  A4000 (-4.6A) 5RC  A4000 (-3.6A) 5RC  A4000 (-4.5A) 5RC  A4000 (-3.7A) None None	1.15A	27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5es1	MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4 (Homo sapiens)	6 / 12	VAL A  70 TYR A 134 ALA A 135 ASP A 142 PHE A 197 GLY A 198	5RC  A4000 (-4.6A) 5RC  A4000 (-4.5A) 5RC  A4000 (-3.7A) None None None	1.33A	27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5f1z	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	6 / 12	VAL A 911 ALA A 928 ILE A 960 TYR A 980 ASP A 988 PHE A1042	5U3  A1200 ( 4.4A) 5U3  A1200 (-3.5A) 5U3  A1200 (-4.6A) 5U3  A1200 (-4.5A) None None	1.06A	29.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	6 / 12	VAL A 471 ALA A 481 ILE A 527 THR A 529 PHE A 595 GLY A 596	5XJ  A 801 (-4.6A) 5XJ  A 801 (-3.1A) 5XJ  A 801 ( 4.0A) 5XJ  A 801 (-3.4A) 5XJ  A 801 (-3.7A) 5XJ  A 801 (-3.7A)	0.37A	31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5grn	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens)	6 / 12	VAL A 607 ALA A 625 ILE A 672 THR A 674 TYR A 676 CYH A 835	748  A1001 ( 4.7A) 748  A1001 (-3.7A) 748  A1001 (-3.9A) 748  A1001 (-3.2A) 748  A1001 (-4.0A) 748  A1001 (-4.5A)	0.72A	28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5hor	HEPATOCYTE GROWTH FACTOR RECEPTOR (Homo sapiens)	5 / 12	VAL A1092 ALA A1108 TYR A1159 PHE A1223 GLY A1224	63K  A1401 (-4.9A) 63K  A1401 (-3.5A) 63K  A1401 (-3.5A) None None	0.69A	28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5i3o	BMP-2-INDUCIBLE PROTEIN KINASE (Homo sapiens)	6 / 12	VAL A  65 ALA A  77 ILE A 128 TYR A 132 CYH A 197 PHE A 199	IDV  A 401 (-4.6A) IDV  A 401 (-3.6A) None IDV  A 401 (-3.5A) IDV  A 401 (-3.6A) None	0.93A	23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5idn	CYCLIN-DEPENDENT KINASE 8 (Homo sapiens)	6 / 12	VAL A  35 ALA A  50 ILE A  79 TYR A  99 ALA A 100 GLY A 175	6A7  A 401 ( 4.5A) 6A7  A 401 (-3.3A) 6A7  A 401 (-4.2A) 6A7  A 401 (-4.9A) 6A7  A 401 (-3.7A) FMT  A 404 ( 4.3A)	0.97A	27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5kkr	KINASE SUPPRESSOR OF RAS 2 (Homo sapiens)	5 / 12	VAL B 680 ALA B 690 ILE B 737 THR B 739 PHE B 804	6U7  B1001 ( 4.3A) 6U7  B1001 (-3.6A) 6U7  B1001 ( 4.1A) 6U7  B1001 (-4.0A) 6U7  B1001 (-3.8A)	0.70A	28.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5l6o	EPHRIN TYPE-B RECEPTOR 3 (Homo sapiens)	5 / 12	VAL A 647 ALA A 663 ILE A 695 ILE A 709 THR A 711	None 6P6  A1001 (-3.3A) None 6P6  A1001 ( 4.5A) 6P6  A1001 (-3.5A)	0.48A	30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1ck7	PROTEIN (GELATINASE A) (Homo sapiens)	4 / 6	PHE A 389 PHE A 184 VAL A  41 ASP A 188	None	1.12A	18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1eak	72 KDA TYPE IV COLLAGENASE (Homo sapiens)	4 / 6	PHE A 389 PHE A 184 VAL A  41 ASP A 188	None	1.15A	21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1jv1	GLCNAC1P URIDYLTRANSFERASE ISOFORM 1: AGX1 (Homo sapiens)	4 / 6	PHE A 332 SER A 246 VAL A 103 ASP A 261	None	1.27A	22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1pvh	INTERLEUKIN-6 RECEPTOR BETA CHAIN (Homo sapiens)	4 / 6	PHE A 147 PHE A 136 VAL A 162 ASP A 149	None	1.23A	17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	4 / 6	LYS A 217 PHE A 247 SER A 272 ASP A 339	None	0.68A	29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2ve7	KINETOCHORE PROTEIN HEC1, KINETOCHORE PROTEIN SPC25 (Homo sapiens)	4 / 6	PHE A 129 SER A 113 VAL A 112 ASP A 124	None	1.29A	22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3g2f	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2 (Homo sapiens)	4 / 6	LYS A 230 PHE A 260 SER A 286 ASP A 351	ADP  A 900 (-2.8A) None ADP  A 900 (-3.6A) ADP  A 900 ( 2.7A)	0.80A	29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3mdy	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (Homo sapiens)	4 / 6	LYS A 231 PHE A 261 SER A 286 ASP A 350	None None None LDN  A   1 (-3.9A)	0.59A	29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3pd7	DNA TOPOISOMERASE 2-BINDING PROTEIN 1 (Homo sapiens)	4 / 6	LYS A 915 SER A 960 VAL A 961 ASP A 953	None	1.26A	15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3q4t	ACTIVIN RECEPTOR TYPE-2A (Homo sapiens)	4 / 6	LYS A 219 PHE A 249 SER A 274 ASP A 340	TAK  A   2 (-2.9A) None None None	0.95A	28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3rmv	GLYCOGENIN-1 (Homo sapiens)	4 / 6	LYS A 209 SER A 121 VAL A 138 ASP A 113	None	1.20A	21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	4 / 6	LYS A 235 PHE A 265 SER A 290 ASP A 354	TAK  A1507 ( 4.5A) None None TAK  A1507 (-3.5A)	1.01A	28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4i6f	SERINE/THREONINE-PRO TEIN KINASE PLK2 (Homo sapiens)	4 / 6	LYS A 111 PHE A 145 SER A 166 ASP A 223	1C7  A 401 ( 4.7A) None None None	0.83A	25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4ni2	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 (Homo sapiens)	4 / 6	PHE B 457 PHE B 468 SER B 425 ASP B 502	None	1.25A	23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4y85	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8 (Homo sapiens)	4 / 6	LYS A 167 SER A 214 VAL A 260 ASP A 270	499  A 401 (-2.8A) 499  A 401 (-3.7A) 499  A 401 (-4.6A) 499  A 401 (-3.7A)	0.69A	27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	4 / 6	LYS A 490 PHE A 524 SER A 546 ASP A 606	4CV  A 801 (-3.9A) None None 4CV  A 801 (-3.5A)	0.81A	31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	4 / 6	PHE A 680 SER A 637 VAL A 636 ASP A 617	None	0.95A	18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	4 / 6	LYS A 483 PHE A 516 SER A 536 ASP A 594	5XJ  A 801 (-3.8A) None None None	0.59A	31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_A_032A401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	6ek6	LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B (Homo sapiens)	4 / 6	PHE A  46 SER A 470 VAL A 471 ASP A 606	None	1.29A	13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1gng	GLYCOGEN SYNTHASE KINASE-3 BETA (Homo sapiens)	6 / 12	VAL A  70 ALA A  83 LYS A  85 TYR A 134 CYH A 199 PHE A 201	None	1.01A	26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	8 / 12	VAL A 416 ALA A 428 LYS A 430 ILE A 472 THR A 474 TYR A 476 PHE A 540 GLY A 541	None	0.78A	29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1t46	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens)	6 / 12	VAL A 603 ALA A 621 LYS A 623 THR A 670 TYR A 672 CYH A 809	STI  A   3 ( 4.6A) STI  A   3 (-3.5A) STI  A   3 (-3.7A) STI  A   3 (-3.2A) STI  A   3 ( 4.0A) STI  A   3 (-4.5A)	0.66A	28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1zlt	SERINE/THREONINE-PRO TEIN KINASE CHK1 (Homo sapiens)	6 / 12	VAL A  23 ALA A  36 LYS A  38 TYR A  86 ASP A  94 PHE A 149	HYM  A 400 (-4.3A) HYM  A 400 (-3.5A) HYM  A 400 (-3.2A) HYM  A 400 (-4.7A) None None	0.96A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	6 / 12	VAL X  25 ALA X  37 LYS X  39 ILE X  80 THR X  82 ASP X  92	STU  X 902 ( 4.8A) STU  X 902 (-3.1A) STU  X 902 (-3.1A) None STU  X 902 (-4.1A) None	0.48A	29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	7 / 12	VAL A 281 ALA A 293 ILE A 336 THR A 338 ASP A 348 PHE A 405 GLY A 406	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 ( 4.5A) H8H  A 534 (-3.1A) None None None	0.80A	19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	7 / 12	VAL A 281 ALA A 293 ILE A 336 THR A 338 TYR A 340 ASP A 348 PHE A 405	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 ( 4.5A) H8H  A 534 (-3.1A) H8H  A 534 (-4.3A) None None	0.78A	19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	7 / 12	VAL A 281 ALA A 293 LYS A 295 ILE A 336 THR A 338 TYR A 340 PHE A 405	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 (-3.7A) H8H  A 534 ( 4.5A) H8H  A 534 (-3.1A) H8H  A 534 (-4.3A) None	0.66A	19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	7 / 12	VAL A 259 ALA A 271 LYS A 273 ILE A 314 THR A 316 ASP A 326 PHE A 383	1BM  A 499 ( 4.8A) 1BM  A 499 (-3.6A) 1BM  A 499 (-3.8A) 1BM  A 499 (-3.9A) 1BM  A 499 (-3.2A) None None	0.79A	26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2hz0	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	6 / 12	VAL A 256 ALA A 269 LYS A 271 ILE A 313 THR A 315 ASP A 325	GIN  A 600 ( 4.7A) GIN  A 600 (-3.1A) GIN  A 600 (-3.6A) GIN  A 600 (-3.8A) GIN  A 600 (-3.4A) None	0.56A	32.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2i6l	MITOGEN-ACTIVATED PROTEIN KINASE 6 (Homo sapiens)	6 / 12	VAL A  34 ALA A  47 LYS A  49 ILE A 106 TYR A 110 GLY A 173	None	1.10A	28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2og8	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens)	7 / 12	VAL A 259 ALA A 271 LYS A 273 ILE A 314 THR A 316 TYR A 318 ASP A 326	None 1N8  A 501 ( 3.4A) 1N8  A 501 ( 3.4A) 1N8  A 501 ( 4.6A) 1N8  A 501 ( 3.3A) 1N8  A 501 ( 3.7A) None	0.67A	27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	VAL A 204 ALA A 215 LYS A 217 THR A 265 ASP A 275 GLY A 341	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None ADE  A 488 (-4.3A) None None	0.88A	29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	VAL A 204 ALA A 215 LYS A 217 THR A 265 ASP A 275 PHE A 340	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None ADE  A 488 (-4.3A) None None	0.84A	29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2z2w	WEE1-LIKE PROTEIN KINASE (Homo sapiens)	6 / 12	VAL A 313 ALA A 326 ILE A 374 TYR A 378 ASP A 386 GLY A 465	770  A 901 ( 4.7A) 770  A 901 (-3.5A) None 770  A 901 (-4.2A) None None	0.98A	26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	7 / 12	VAL A 209 ALA A 220 LYS A 222 ILE A 264 THR A 266 ASP A 276 GLY A 334	None	0.88A	31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	8 / 12	VAL A 209 ALA A 220 LYS A 222 ILE A 264 THR A 266 TYR A 268 ASP A 276 PHE A 333	None	0.83A	31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3fme	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 (Homo sapiens)	6 / 12	VAL A  67 ALA A  80 LYS A  82 ILE A 127 ASP A 137 CYH A 196	None STU  A   1 (-3.4A) STU  A   1 ( 4.2A) None STU  A   1 (-3.5A) STU  A   1 ( 3.7A)	0.84A	26.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3kex	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens)	6 / 12	VAL A 704 LYS A 723 THR A 768 TYR A 770 ASP A 778 PHE A 834	ANP  A   1 (-3.9A) ANP  A   1 (-3.4A) ANP  A   1 ( 4.8A) ANP  A   1 (-4.3A) None None	0.78A	30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	6 / 12	VAL A 649 ALA A 665 LYS A 667 ILE A 711 THR A 713 GLY A 780	None	1.08A	30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	6 / 12	VAL A 649 ALA A 665 LYS A 667 ILE A 711 THR A 713 PHE A 779	None	0.75A	30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3my0	SERINE/THREONINE-PRO TEIN KINASE RECEPTOR R3 (Homo sapiens)	5 / 12	VAL A 216 ALA A 227 LYS A 229 THR A 277 TYR A 279	LDN  A 600 (-4.5A) LDN  A 600 (-3.2A) LDN  A 600 (-4.0A) LDN  A 600 (-4.0A) LDN  A 600 (-4.7A)	0.36A	27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3nuu	PKB-LIKE (Homo sapiens)	6 / 12	VAL A  96 ALA A 109 LYS A 111 TYR A 161 ALA A 162 PHE A 224	JOZ  A 361 ( 4.7A) JOZ  A 361 (-3.4A) SO4  A   5 (-2.8A) None JOZ  A 361 (-3.8A) None	0.90A	25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3omv	RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	6 / 12	VAL A 363 ALA A 373 LYS A 375 ILE A 419 THR A 421 PHE A 487	SM5  A   1 (-4.0A) SM5  A   1 (-3.6A) SM5  A   1 (-3.5A) SM5  A   1 ( 4.3A) SM5  A   1 (-4.4A) None	0.78A	30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3sxs	CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens)	6 / 12	VAL A 431 ALA A 443 LYS A 445 ILE A 487 THR A 489 TYR A 491	PP2  A   1 (-4.5A) PP2  A   1 (-3.2A) PP2  A   1 (-4.5A) PP2  A   1 (-3.6A) PP2  A   1 (-3.3A) PP2  A   1 ( 4.9A)	0.73A	31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3tt0	BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 LYS A 514 TYR A 563 ALA A 564 PHE A 642 GLY A 643	07J  A   1 (-4.0A) 07J  A   1 (-3.5A) 07J  A   1 (-4.5A) 07J  A   1 (-4.7A) 07J  A   1 (-3.8A) 07J  A   1 ( 4.6A) None	0.82A	28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	3zfx	EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens)	5 / 12	VAL A 633 ALA A 649 LYS A 651 ILE A 695 THR A 697	None	0.42A	31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4af3	AURORA KINASE B (Homo sapiens)	6 / 12	VAL A  91 ALA A 104 LYS A 106 TYR A 156 ALA A 157 GLY A 220	VX6  A 500 ( 4.8A) VX6  A 500 (-3.4A) VX6  A 500 (-3.3A) VX6  A 500 (-4.2A) VX6  A 500 (-3.7A) None	0.99A	26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4agu	CYCLIN-DEPENDENT KINASE-LIKE 1 (Homo sapiens)	6 / 12	VAL A  18 ALA A  31 LYS A  33 TYR A  82 CYH A 143 GLY A 146	D15  A 500 (-4.6A) D15  A 500 (-3.4A) D15  A 500 ( 4.1A) D15  A 500 (-4.8A) D15  A 500 ( 4.0A) None	1.02A	24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4aw5	EPHRIN TYPE-B RECEPTOR 4 (Homo sapiens)	5 / 12	VAL A 105 ALA A 121 LYS A 123 ILE A 167 THR A 169	30K  A1365 ( 4.6A) 30K  A1365 (-3.2A) 30K  A1365 (-3.8A) None 30K  A1365 (-3.8A)	0.27A	31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	6 / 12	VAL A 222 ALA A 233 LYS A 235 THR A 283 TYR A 285 ASP A 293	TAK  A1507 (-4.7A) TAK  A1507 (-3.3A) TAK  A1507 ( 4.5A) TAK  A1507 (-3.6A) TAK  A1507 ( 4.6A) None	0.78A	28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4crs	SERINE/THREONINE-PRO TEIN KINASE N2 (Homo sapiens)	6 / 12	VAL A 671 ALA A 684 LYS A 686 TYR A 739 ALA A 740 PHE A 801	AGS  A1985 (-4.6A) AGS  A1985 (-3.5A) AGS  A1985 (-3.0A) None AGS  A1985 (-3.9A) None	0.81A	29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4f99	CELL DIVISION CYCLE 7-RELATED PROTEIN KINASE (Homo sapiens)	6 / 12	VAL A  72 ALA A  88 LYS A  90 ILE A 132 TYR A 136 PHE A 197	ADP  A 601 (-4.0A) ADP  A 601 (-3.5A) ADP  A 601 (-2.6A) None ADP  A 601 (-4.1A) None	0.92A	23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4g34	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 (Homo sapiens)	6 / 12	VAL A 606 ALA A 619 LYS A 621 ILE A 885 PHE A 955 GLY A 956	924  A1101 ( 4.8A) 924  A1101 (-3.5A) None 924  A1101 ( 4.6A) 924  A1101 ( 4.4A) None	0.81A	27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4gv1	RAC-ALPHA SERINE/THREONINE-PRO TEIN KINASE (Homo sapiens)	6 / 12	VAL A 164 ALA A 177 LYS A 179 TYR A 229 ALA A 230 PHE A 293	0XZ  A 501 (-4.5A) 0XZ  A 501 (-3.3A) GOL  A 503 ( 2.8A) 0XZ  A 501 ( 4.9A) 0XZ  A 501 (-3.7A) None	0.80A	24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	7 / 12	VAL A 140 ALA A 156 LYS A 158 THR A 205 ALA A 208 ASP A 215 PHE A 271	None	0.75A	33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	7 / 12	VAL A 140 ALA A 156 LYS A 158 THR A 205 ALA A 208 ASP A 215 PHE A 271	1G0  A 401 (-4.4A) 1G0  A 401 (-3.6A) 1G0  A 401 (-3.7A) 1G0  A 401 (-3.2A) 1G0  A 401 (-3.8A) None 1G0  A 401 ( 4.8A)	0.88A	32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4idt	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 (Homo sapiens)	6 / 12	VAL A 414 ALA A 427 LYS A 429 ILE A 467 CYH A 533 GLY A 536	T28  A 701 (-4.7A) T28  A 701 (-3.0A) T28  A 701 ( 3.8A) None T28  A 701 (-3.7A) None	1.27A	23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4idt	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 (Homo sapiens)	6 / 12	VAL A 414 ALA A 427 LYS A 429 ILE A 467 CYH A 533 PHE A 535	T28  A 701 (-4.7A) T28  A 701 (-3.0A) T28  A 701 ( 3.8A) None T28  A 701 (-3.7A) None	0.99A	23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	6 / 12	VAL A 281 ALA A 293 ILE A 336 TYR A 340 ASP A 348 PHE A 405	0J9  A 601 (-4.4A) 0J9  A 601 (-3.3A) 0J9  A 601 (-4.4A) 0J9  A 601 ( 4.7A) None None	0.86A	20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	6 / 12	VAL A 281 ALA A 293 LYS A 295 ILE A 336 TYR A 340 PHE A 405	0J9  A 601 (-4.4A) 0J9  A 601 (-3.3A) 0J9  A 601 ( 4.7A) 0J9  A 601 (-4.4A) 0J9  A 601 ( 4.7A) None	0.54A	20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4k33	FIBROBLAST GROWTH FACTOR RECEPTOR 3 (Homo sapiens)	6 / 12	VAL A 486 ALA A 506 LYS A 508 TYR A 557 ALA A 558 PHE A 636	ACP  A 801 (-4.2A) ACP  A 801 (-3.3A) ACP  A 801 (-2.7A) None ACP  A 801 (-3.7A) None	0.94A	29.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4l52	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 CHIMERA (Homo sapiens)	6 / 12	VAL A  50 ALA A  61 LYS A  63 ALA A 107 CYH A 174 PHE A 176	1UL  A 501 ( 4.9A) 1UL  A 501 (-3.1A) None 1UL  A 501 (-3.6A) 1UL  A 501 (-3.6A) None	0.81A	35.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4o27	SERINE/THREONINE-PRO TEIN KINASE 24 (Homo sapiens)	7 / 12	VAL B  38 ALA B  51 LYS B  53 ILE B  97 TYR B 101 ASP B 109 PHE B 163	ADP  B 500 (-4.5A) ADP  B 500 (-3.3A) ADP  B 500 (-3.1A) None ADP  B 500 ( 4.7A) None None	0.76A	30.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4o27	SERINE/THREONINE-PRO TEIN KINASE 24 (Homo sapiens)	7 / 12	VAL B  38 ALA B  51 LYS B  53 ILE B  97 TYR B 101 PHE B 163 GLY B 164	ADP  B 500 (-4.5A) ADP  B 500 (-3.3A) ADP  B 500 (-3.1A) None ADP  B 500 ( 4.7A) None None	0.89A	30.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	6 / 12	VAL A  54 ALA A  67 LYS A  69 THR A 123 CYH A 190 PHE A 192	None SIN  A 401 ( 3.7A) None None None None	0.76A	25.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4p2k	EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens)	5 / 12	VAL A 627 ALA A 644 ILE A 690 THR A 692 TYR A 694	None	0.45A	30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4xey	TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	6 / 12	VAL B 275 ALA B 288 LYS B 290 ILE B 332 THR B 334 ASP B 344	1N1  B 601 ( 4.9A) 1N1  B 601 (-3.5A) 1N1  B 601 (-4.6A) 1N1  B 601 (-4.1A) 1N1  B 601 (-3.3A) None	0.65A	26.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	7 / 12	VAL A 477 ALA A 488 LYS A 490 ILE A 537 THR A 539 TYR A 541 PHE A 607	None 4CV  A 801 (-3.5A) 4CV  A 801 (-3.9A) None 4CV  A 801 (-2.8A) 4CV  A 801 (-3.9A) None	0.83A	31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5a46	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 LYS A 514 TYR A 563 ALA A 564 PHE A 642 GLY A 643	38O  A1769 (-4.5A) 38O  A1769 (-3.6A) 38O  A1769 ( 3.1A) 38O  A1769 (-4.2A) 38O  A1769 (-3.9A) EDO  A1766 (-3.7A) EDO  A1766 (-3.6A)	0.66A	30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5e8y	TGF-BETA RECEPTOR TYPE-2 (Homo sapiens)	5 / 12	VAL A 258 ALA A 275 LYS A 277 THR A 325 CYH A 396	STU  A 601 (-4.0A) STU  A 601 (-3.1A) STU  A 601 (-2.4A) STU  A 601 ( 3.7A) STU  A 601 (-3.2A)	0.41A	30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5es1	MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4 (Homo sapiens)	7 / 12	VAL A  70 ALA A  83 LYS A  85 TYR A 134 ALA A 135 ASP A 142 GLY A 198	5RC  A4000 (-4.6A) 5RC  A4000 (-3.6A) 5RC  A4000 (-2.8A) 5RC  A4000 (-4.5A) 5RC  A4000 (-3.7A) None None	1.19A	27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5es1	MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4 (Homo sapiens)	6 / 12	VAL A  70 LYS A  85 TYR A 134 ALA A 135 ASP A 142 PHE A 197	5RC  A4000 (-4.6A) 5RC  A4000 (-2.8A) 5RC  A4000 (-4.5A) 5RC  A4000 (-3.7A) None None	1.07A	27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5f1z	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	6 / 12	VAL A 911 ALA A 928 LYS A 930 TYR A 980 ASP A 988 PHE A1042	5U3  A1200 ( 4.4A) 5U3  A1200 (-3.5A) None 5U3  A1200 (-4.5A) None None	0.99A	29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5fbh	EXTRACELLULAR CALCIUM-SENSING RECEPTOR (Homo sapiens)	6 / 12	GLY B  67 ALA B 168 TYR B 167 ALA B 144 ASP B  99 GLY B 219	None TCR  B 609 (-4.1A) None CL  B 605 ( 3.8A) None None	1.35A	20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5fd2	SERINE/THREONINE-PRO TEIN KINASE B-RAF (Homo sapiens)	7 / 12	VAL A 471 ALA A 481 LYS A 483 ILE A 527 THR A 529 PHE A 595 GLY A 596	5XJ  A 801 (-4.6A) 5XJ  A 801 (-3.1A) 5XJ  A 801 (-3.8A) 5XJ  A 801 ( 4.0A) 5XJ  A 801 (-3.4A) 5XJ  A 801 (-3.7A) 5XJ  A 801 (-3.7A)	0.32A	31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5grn	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens)	7 / 12	VAL A 607 ALA A 625 LYS A 627 ILE A 672 THR A 674 TYR A 676 CYH A 835	748  A1001 ( 4.7A) 748  A1001 (-3.7A) 748  A1001 (-4.0A) 748  A1001 (-3.9A) 748  A1001 (-3.2A) 748  A1001 (-4.0A) 748  A1001 (-4.5A)	0.67A	28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5i3o	BMP-2-INDUCIBLE PROTEIN KINASE (Homo sapiens)	6 / 12	VAL A  65 ALA A  77 ILE A 128 TYR A 132 CYH A 197 PHE A 199	IDV  A 401 (-4.6A) IDV  A 401 (-3.6A) None IDV  A 401 (-3.5A) IDV  A 401 (-3.6A) None	0.97A	23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5i3o	BMP-2-INDUCIBLE PROTEIN KINASE (Homo sapiens)	6 / 12	VAL A  65 ALA A  77 LYS A  79 ILE A 128 CYH A 197 GLY A 200	IDV  A 401 (-4.6A) IDV  A 401 (-3.6A) IDV  A 401 ( 4.8A) None IDV  A 401 (-3.6A) None	1.24A	23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5i3o	BMP-2-INDUCIBLE PROTEIN KINASE (Homo sapiens)	6 / 12	VAL A  65 ALA A  77 LYS A  79 ILE A 128 CYH A 197 PHE A 199	IDV  A 401 (-4.6A) IDV  A 401 (-3.6A) IDV  A 401 ( 4.8A) None IDV  A 401 (-3.6A) None	0.90A	23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5idn	CYCLIN-DEPENDENT KINASE 8 (Homo sapiens)	6 / 12	VAL A  35 ALA A  50 LYS A  52 TYR A  99 ALA A 100 GLY A 175	6A7  A 401 ( 4.5A) 6A7  A 401 (-3.3A) 6A7  A 401 ( 2.9A) 6A7  A 401 (-4.9A) 6A7  A 401 (-3.7A) FMT  A 404 ( 4.3A)	0.99A	27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5w5j	RECEPTOR-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	6 / 12	VAL A  32 ALA A  45 LYS A  47 ILE A  93 THR A  95 TYR A  97	9WS  A 401 ( 4.6A) 9WS  A 401 (-3.3A) 9WS  A 401 (-3.3A) 9WS  A 401 (-3.9A) 9WS  A 401 (-3.2A) None	0.65A	31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	6ao5	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	6 / 12	VAL A  41 ALA A  54 ILE A  97 TYR A 101 PHE A 165 GLY A 166	ANP  A 501 (-4.4A) ANP  A 501 ( 3.7A) None ANP  A 501 ( 4.2A) None None	0.81A	27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	6bsz	METABOTROPIC GLUTAMATE RECEPTOR 8 (Homo sapiens)	6 / 12	GLY A  72 ALA A 177 TYR A 176 ALA A 153 ASP A 104 GLY A 228	None GGL  A 601 (-3.5A) None None None None	1.18A	15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_1 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	6fyo	DUAL SPECIFICITY PROTEIN KINASE CLK1 (Homo sapiens)	6 / 12	VAL A 175 ALA A 189 LYS A 191 ILE A 239 ASP A 250 GLY A 327	None EAQ  A 501 (-3.6A) EAQ  A 501 (-3.2A) None None None	0.97A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	1l8k	T-CELL PROTEIN-TYROSINE PHOSPHATASE (Homo sapiens)	4 / 4	CYH A  94 PHE A  97 ILE A 115 GLY A  88	None	1.09A	19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2h31	MULTIFUNCTIONAL PROTEIN ADE2 (Homo sapiens)	4 / 4	CYH A 288 PHE A 291 ILE A 348 GLY A 382	None	1.42A	22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	2p82	CYSTEINE PROTEASE ATG4A (Homo sapiens)	4 / 4	CYH A 247 PHE A 244 ILE A 226 GLY A 255	None	1.37A	21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5k7m	N6-ADENOSINE-METHYLT RANSFERASE SUBUNIT METTL14 (Homo sapiens)	4 / 4	CYH B 288 PHE B 232 ILE B 221 GLY B 291	None	1.40A	21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HES_B_032B401_2 (MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT)	5x68	KYNURENINE 3-MONOOXYGENASE (Homo sapiens)	4 / 4	CYH A  25 PHE A  26 ILE A  75 GLY A  70	None	1.14A	14.80