KNOWN TARGETS FROM HUMAN (PROTEIN-DRUG COMPLEXES IN THE PDB)

1) Click on the entry ID to view details of interfaces and pattern clusters
2) Note that ASSAM search use only 3-12 residue containing patterns
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM View
207L_A_SC2A200 207l SC2

DB06151
(Acetylcysteine)		 Homo sapiens LYSOZYME PF00062
(Lys)		 4 TRP A  64
HIS A  78
LEU A  79
CYS A  95
 SC2 A 200
2J1G_F_SC2F1290 2j1g SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 10 SER F  91
LEU F 107
ASP F 109
ASP F 111
THR F 112
ARG F 122
SER E 143
LEU E 145
GLU F 282
LYS F 284
 SC2 F1290
2J2P_A_SC2A1290 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 PF00147
(Fibrinogen_C)
no annotation		 5 ARG B 122
ASP A 125
SER A 127
LEU A 145
GLY A 146
 SC2 A1290
2J2P_B_SC2B1289 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 4 ARG B 132
ASP B 133
THR B 136
LYS B 221
 SC2 B1289
2J2P_B_SC2B1290 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 PF00147
(Fibrinogen_C)
no annotation		 8 SER B  91
LEU B 107
ASP B 109
ASP B 111
ARG B 122
SER A 143
LEU A 145
GLU B 282
 SC2 B1290
2J2P_B_SC2B1294 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 9 SER C  91
LEU C 107
ASP C 109
ASP C 111
VAL B 128
GLY B 142
SER B 143
LEU B 145
GLU C 282
 SC2 B1294
2J2P_C_SC2C1289 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 PF00147
(Fibrinogen_C)
no annotation		 6 ARG A 122
ASP C 125
SER C 127
SER C 143
LEU C 145
GLY C 146
 SC2 C1289
2J2P_C_SC2C1290 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 4 ARG C 132
ASP C 133
THR C 136
LYS C 221
 SC2 C1290
2J2P_D_SC2D1290 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 5 GLY D  92
TRP D  93
TRP F  93
ARG F 144
LEU F 145
 SC2 D1290
2J2P_E_SC2E1289 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 6 ASP F 111
ASP E 129
ARG E 132
ASP E 133
THR E 136
LYS E 221
 SC2 E1289
2J2P_E_SC2E1290 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 9 SER E  91
LEU E 107
ASP E 109
ARG E 122
SER D 127
VAL D 128
SER D 143
LEU D 145
GLU E 282
 SC2 E1290
2J2P_E_SC2E1291 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 4 ARG E 122
ASP D 125
LEU D 145
GLY D 146
 SC2 E1291
2J2P_F_SC2F1289 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 6 ARG D 122
ASP F 125
SER F 127
SER F 143
LEU F 145
GLY F 146
 SC2 F1289
2J2P_F_SC2F1290 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 4 ARG F 132
ASP F 133
THR F 136
LYS F 221
 SC2 F1290
2J2P_F_SC2F1291 2j2p SC2

DB06151
(Acetylcysteine)		 Homo sapiens FICOLIN-2 no annotation 6 SER F  91
ASP F 109
ASP F 111
SER E 143
LEU E 145
GLU F 282
 SC2 F1291
5ICX_E_SC2E1 5icx SC2

DB06151
(Acetylcysteine)		 Homo sapiens;
Mus musculus;
synthetic
construct		 CETUXIMAB FAB LIGHT
CHAIN;
MEDITOPE		 PF07654
(C1-set)
PF07686
(V-set)
no annotation		 3 GLN E   2
VAL A   9
CYS E  12
 SC2 E   1
5ICX_F_SC2F1 5icx SC2

DB06151
(Acetylcysteine)		 Homo sapiens;
Mus musculus;
synthetic
construct		 CETUXIMAB FAB LIGHT
CHAIN;
MEDITOPE		 no annotation 3 GLN F   2
VAL C   9
CYS F  12
 SC2 F   1
5NN4_A_SC2A1016 5nn4 SC2

DB06151
(Acetylcysteine)		 Homo sapiens LYSOSOMAL
ALPHA-GLUCOSIDASE		 no annotation 4 HIS A 432
GLY A 435
ARG A 437
THR A 834
 SC2 A1016