KNOWN TARGETS FROM HUMAN (PROTEIN-DRUG COMPLEXES IN THE PDB)

1) Click on the entry ID to view details of interfaces and pattern clusters
2) Note that ASSAM search use only 3-12 residue containing patterns
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM View
2ZT7_A_GLYA1300 2zt7 GLY

DB00145
(Glycine)		 Homo sapiens GLYCYL-TRNA
SYNTHETASE		 PF00587
(HGTP_anticodon)
PF03129
(tRNA-synt_2b)		 7 GLU A 245
ARG A 277
GLU A 296
TYR A 386
ARG A 410
GLU A 522
SER A 524
 GLY A1300
4KR3_A_GLYA701 4kr3 GLY

DB00145
(Glycine)		 Homo sapiens GLYCINE--TRNA LIGASE PF00587
(HGTP_anticodon)
PF03129
(tRNA-synt_2b)		 6 GLU A 245
ARG A 277
GLU A 296
ARG A 410
GLU A 522
SER A 524
 GLY A 701
6DWD_A_GLYA715 6dwd GLY

DB00145
(Glycine)		 Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1		 None
PF01966
(HD)		 6 GLY A 357
ASN A 358
ASP A 361
SER C 368
ARG C 371
ARG C 372
 GLY A 715
6DWD_A_GLYA717 6dwd GLY

DB00145
(Glycine)		 Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1		 PF01966
(HD)		 5 SER A 192
ARG A 194
ASP A 195
ARG A 290
LYS A 294
 GLY A 717
6DWD_B_GLYB709 6dwd GLY

DB00145
(Glycine)		 Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1		 None 5 GLY B 357
ASN B 358
ASP B 361
ARG D 371
ARG D 372
 GLY B 709
6DWD_C_GLYC713 6dwd GLY

DB00145
(Glycine)		 Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1		 None 3 GLN C 447
TYR C 450
ASN C 452
 GLY C 713
6DWD_D_GLYD713 6dwd GLY

DB00145
(Glycine)		 Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1		 None 3 ARG D 305
HIS D 517
ARG D 531
 GLY D 713
6DWJ_B_GLYB710 6dwj GLY

DB00145
(Glycine)		 Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1		 None 5 GLY D 357
ASN D 358
ASP D 361
ARG B 371
ARG B 372
 GLY B 710