COVID-19 Resource

This resource is a special database module of the Drug ReposER tool. This database contains curated and pre-computed side chain similarity searches of known drug binding sites that can be found in the protein structures of SARS-CoV-2, SARS related proteins and human protein as well as their homologs.

This resource can be used to explore potential drugs repurposing strategies for SARS and COVID-19 as well as for investigating the molecular interactions of drugs to be repurposed for these diseases including potential toxicity issues. To explore other structures not covered in this database, please use the main Drug ReposER tool.


Protein structures related to COVID-19
Protein structures related to SARS
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Browse clusters of sequences


Searching a protein structure for potential 3D drug binding patterns based on sub-structural similarity search using SPRITE program

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e.g., "5eid" or "5EID"

View the precomputed results for 5gkx:(View)





Citation for referencing the COVID-19 Resource in Drug ReposER:
Ab Ghani, N.S., Emrizal, R., Makmur, H. and Firdaus-Raih, M. (2020). Side chain similarity comparisons for integrated drug repositioning and potential toxicity assessments in epidemic response scenarios: The case for COVID-19. Computational and Structural Biotechnology Journal, 18, pp.2931-2944. HTML, PDF.