Plasmodium vivax sal-1Pfam Annotation:
PkinasecNMP_bindingLigand ID:
1E8Drugbank ID:
Ibrutinib (DB09053)HETATM residue:
1E8 A 901 No. of binding residues: 12
List of all similar binding patterns of amino acids (4RZ7_A_1E8A901_0, 12 residues)
Note that only 3-12 residue patterns can be used for ASSAM searches, thus the binding sites are divided into fragments.Hit pattern: 3D amino acid arrangements similar to known drug binding site Query pattern: Residues from known binding site for annotated drug that match the hit pattern (Click on the 'View' column to view superposed patterns of amino acids)(Click the 'Script' button to download a python script for molecular docking in UCSF Chimera) |
| Hit | Macromolecule/ Organism | Pfam | Res. | Residue Matches | HETATM Residue/s | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
|---|---|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y86 | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 (Homo sapiens) | Pkinase | 8 | ILE A 215 - ILE A 540VAL A 223 - VAL A 548ALA A 236 - ALA A 561ILE A 272 - ILE A 595GLU A 289 - GLU A 612LEU A 290 - LEU A 613LEU A 342 - LEU A 664ILE A 354 - ILE A 674 | NoneHRM A 601 ( 4.9A)HRM A 601 (-3.5A)HRM A 601 ( 4.8A)NoneHRM A 601 (-4.6A)NoneHRM A 601 (-3.7A) | 0.47A | 21.9 | 24.60 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3z | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE WITH A KINASE DOMAIN AND 4 CALMODULIN LIKE EF HANDS (Cryptosporidium parvum iowa ii) | Pkinase | 8 | ILE A 34 - ILE A 540VAL A 42 - VAL A 548ALA A 55 - ALA A 561ILE A 86 - ILE A 595GLU A 103 - GLU A 612LEU A 104 - LEU A 613LEU A 155 - LEU A 664ILE A 168 - ILE A 674 | DRK A 1 (-4.2A)DRK A 1 ( 4.9A)DRK A 1 (-3.4A)DRK A 1 ( 4.8A)NoneDRK A 1 (-4.4A)DRK A 1 (-4.6A)DRK A 1 ( 4.2A) | 0.54A | 28.7 | 14.10 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bhy | DEATH-ASSOCIATED PROTEIN KINASE 3 (Homo sapiens) | Pkinase | 8 | VAL A 27 - VAL A 548ALA A 40 - ALA A 561ILE A 77 - ILE A 595GLU A 94 - GLU A 612LEU A 95 - LEU A 613VAL A 96 - VAL A 614GLU A 100 - GLU A 618ILE A 160 - ILE A 674 | 7CP A 600 (-4.6A) CL A 1 (-3.5A)7CP A 600 (-4.6A)NoneNone CL A 1 ( 4.2A)7CP A 600 ( 4.4A)7CP A 600 (-4.0A) | 0.63A | 26.9 | 14.69 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lxc | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 (Homo sapiens) | Pkinase | 7 | VAL A 163 - VAL A 548ALA A 176 - ALA A 561ILE A 212 - ILE A 595GLU A 229 - GLU A 612LEU A 230 - LEU A 613LEU A 282 - LEU A 664ILE A 294 - ILE A 674 | 7AA A 501 (-4.5A)7AA A 501 (-3.5A)NoneNone7AA A 501 ( 4.8A)EDO A 504 (-4.7A)7AA A 501 (-4.5A) | 0.40A | 22.7 | 19.20 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzn | PROBABLE SERINE/THREONINE-PROTEIN KINASE ROCO4 (Dictyostelium discoideum) | PK_Tyr_Ser-Thr | 7 | ILE A1032 - ILE A 540VAL A1040 - VAL A 548ALA A1053 - ALA A 561GLU A1106 - GLU A 612LEU A1107 - LEU A 613VAL A1108 - VAL A 614LEU A1161 - LEU A 664 | 4K5 A1301 (-4.1A)4K5 A1301 (-4.7A)4K5 A1301 (-3.6A)None4K5 A1301 ( 4.6A)4K5 A1301 (-4.1A)4K5 A1301 (-4.7A) | 0.47A | 22.2 | 15.23 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4o | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV (Homo sapiens) | Pkinase | 7 | VAL A 60 - VAL A 548ALA A 73 - ALA A 561GLU A 119 - GLU A 612LEU A 120 - LEU A 613VAL A 121 - VAL A 614GLU A 125 - GLU A 618LEU A 171 - LEU A 664 | DKI A1338 (-4.2A)DKI A1338 ( 3.7A)NoneDKI A1338 (-4.2A)DKI A1338 (-3.9A)NoneDKI A1338 (-4.9A) | 0.51A | 20.5 | 18.20 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ow8 | SERINE/THREONINE-PROTEIN KINASE PKNA (Mycobacterium tuberculosis) | Pkinase | 7 | ILE A 19 - ILE A 540VAL A 27 - VAL A 548ALA A 40 - ALA A 561GLU A 96 - GLU A 612LEU A 97 - LEU A 613VAL A 98 - VAL A 614LEU A 148 - LEU A 664 | None | 0.55A | 20.6 | 14.47 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pf4 | DEATH-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens) | Pkinase | 7 | VAL A 27 - VAL A 548ALA A 40 - ALA A 561ILE A 77 - ILE A 595GLU A 94 - GLU A 612LEU A 95 - LEU A 613VAL A 96 - VAL A 614ILE A 160 - ILE A 674 | NoneGOL A 306 (-2.9A)GOL A 306 ( 4.0A)NoneGOL A 306 (-4.4A)GOL A 306 (-4.0A)GOL A 306 (-3.5A) | 0.57A | 26.4 | 16.08 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2a | DEATH-ASSOCIATED PROTEIN KINASE 2 (Homo sapiens) | Pkinase | 7 | VAL A 27 - VAL A 548ALA A 40 - ALA A 561ILE A 77 - ILE A 595GLU A 94 - GLU A 612LEU A 95 - LEU A 613VAL A 96 - VAL A 614ILE A 160 - ILE A 674 | NoneGOL A3001 (-3.5A)GOL A3001 (-4.8A)NoneNoneGOL A3001 (-3.8A)GOL A3001 ( 3.9A) | 0.59A | 25.7 | 16.43 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o1s | RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus) | Pkinase | 7 | ILE A 428 - ILE A 540ALA A 449 - ALA A 561ILE A 477 - ILE A 595THR A 493 - THR A 611GLU A 494 - GLU A 612LEU A 495 - LEU A 613LEU A 546 - LEU A 664 | None9HB A 803 (-3.6A)None9HB A 803 (-3.4A) NA A 801 ( 4.9A)NoneNone | 0.61A | 20.5 | 17.65 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pf4 | DEATH-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens) | Pkinase | 7 | ALA A 40 - ALA A 561ILE A 77 - ILE A 595GLU A 94 - GLU A 612LEU A 95 - LEU A 613VAL A 96 - VAL A 614GLU A 100 - GLU A 618ILE A 160 - ILE A 674 | GOL A 306 (-2.9A)GOL A 306 ( 4.0A)NoneGOL A 306 (-4.4A)GOL A 306 (-4.0A)NoneGOL A 306 (-3.5A) | 0.62A | 26.4 | 16.08 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfm | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (Mus musculus) | Pkinase | 7 | ILE A 17 - ILE A 540VAL A 25 - VAL A 548ALA A 38 - ALA A 561GLU A 87 - GLU A 612GLU A 93 - GLU A 618LEU A 139 - LEU A 664ILE A 149 - ILE A 674 | NoneANP A1000 (-4.4A)ANP A1000 (-3.5A)NoneANP A1000 (-3.5A)ANP A1000 (-4.4A)ANP A1000 ( 4.6A) | 0.62A | 25.3 | 16.47 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzj | SERINE/THREONINE-PROTEIN KINASE DCLK1 (Homo sapiens) | Pkinase | 7 | ILE A 396 - ILE A 540VAL A 404 - VAL A 548ALA A 417 - ALA A 561GLU A 466 - GLU A 612LEU A 467 - LEU A 613VAL A 468 - VAL A 614LEU A 518 - LEU A 664 | NoneAN2 A 703 (-4.3A)AN2 A 703 ( 3.7A)NoneAN2 A 703 ( 4.8A)AN2 A 703 (-4.1A)AN2 A 703 (-4.6A) | 0.64A | 25.6 | 17.99 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtc | SERINE/THREONINE-PROTEIN KINASE HASPIN (Homo sapiens) | NA | 7 | ILE A 490 - ILE A 540VAL A 498 - VAL A 548ALA A 509 - ALA A 561ILE A 557 - ILE A 595GLU A 606 - GLU A 612LEU A 656 - LEU A 664ILE A 686 - ILE A 674 | None38Z A 804 (-4.9A)38Z A 804 (-3.4A)NoneNone38Z A 804 (-4.7A)38Z A 804 ( 4.2A) | 0.69A | 14.4 | 18.07 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6d | 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (Homo sapiens) | Pkinase | 7 | VAL A 30 - VAL A 548ALA A 43 - ALA A 561ILE A 77 - ILE A 595GLU A 94 - GLU A 612VAL A 96 - VAL A 614GLU A 100 - GLU A 618LEU A 146 - LEU A 664 | None | 0.71A | 21.8 | 16.12 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o1s | RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 (Mus musculus) | Pkinase | 7 | ILE A 428 - ILE A 540ALA A 449 - ALA A 561ILE A 477 - ILE A 595GLU A 494 - GLU A 612LEU A 495 - LEU A 613GLU A 500 - GLU A 618LEU A 546 - LEU A 664 | None9HB A 803 (-3.6A)None NA A 801 ( 4.9A)NoneNoneNone | 0.83A | 20.5 | 17.65 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7o | MITOGEN-ACTIVATED PROTEIN KINASE 9 (Homo sapiens) | Pkinase | 6 | ILE A 32 - ILE A 540VAL A 40 - VAL A 548ALA A 53 - ALA A 561ILE A 86 - ILE A 595GLU A 109 - GLU A 612LEU A 110 - LEU A 613 | 35F A 1 ( 4.4A)35F A 1 ( 4.8A)35F A 1 (-3.6A)NoneNone35F A 1 (-4.5A) | 0.32A | 21.2 | 17.40 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6o | EPHRIN TYPE-A RECEPTOR 4 (Mus musculus) | PK_Tyr_Ser-Thr | 6 | ILE A 627 - ILE A 540VAL A 635 - VAL A 548ALA A 651 - ALA A 561ILE A 683 - ILE A 595THR A 699 - THR A 611GLU A 700 - GLU A 612 | 1N1 A1892 (-4.3A)None1N1 A1892 (-3.3A)1N1 A1892 ( 4.3A)1N1 A1892 (-3.1A)None | 0.38A | 19.5 | 15.27 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cbl | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FES/FPS (Homo sapiens;synthetic construct) | PK_Tyr_Ser-ThrSH2 | 6 | ILE A 567 - ILE A 540VAL A 575 - VAL A 548ALA A 588 - ALA A 561GLU A 637 - GLU A 612LEU A 638 - LEU A 613VAL A 639 - VAL A 614 | STU A 901 (-4.3A)STU A 901 ( 4.9A)STU A 901 (-3.2A)NoneSTU A 901 (-4.2A)STU A 901 ( 4.0A) | 0.42A | 21.1 | 17.97 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6umw | EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | ILE A 625 - ILE A 540VAL A 633 - VAL A 548ALA A 649 - ALA A 561ILE A 681 - ILE A 595THR A 697 - THR A 611GLU A 698 - GLU A 612 | CTC A 901 ( 4.8A)CTC A 901 ( 4.6A)CTC A 901 (-3.3A)CTC A 901 (-3.2A)CTC A 901 (-2.5A)None | 0.42A | 19.5 | 15.20 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fnk | EPHRIN TYPE-B RECEPTOR 4 (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | ILE A 621 - ILE A 540VAL A 629 - VAL A 548ALA A 645 - ALA A 561ILE A 677 - ILE A 595THR A 693 - THR A 611GLU A 694 - GLU A 612 | NoneDXK A1001 ( 4.5A)DXK A1001 (-3.1A)DXK A1001 (-4.8A)DXK A1001 (-3.2A)None | 0.43A | 19.5 | 16.11 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7kpm | EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | ILE A 625 - ILE A 540VAL A 633 - VAL A 548ALA A 649 - ALA A 561ILE A 681 - ILE A 595THR A 697 - THR A 611GLU A 698 - GLU A 612 | ADP A 901 ( 4.6A)ADP A 901 ( 4.2A)ADP A 901 ( 3.4A)NoneADP A 901 ( 4.2A)None | 0.46A | 19.3 | 15.36 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4js8 | DUAL SPECIFICITY PROTEIN KINASE TTK (Homo sapiens) | Pkinase | 6 | ILE A 531 - ILE A 540VAL A 539 - VAL A 548ALA A 551 - ALA A 561ILE A 586 - ILE A 595GLU A 603 - GLU A 612ILE A 663 - ILE A 674 | 1PF A 801 (-3.8A)1PF A 801 ( 4.8A)1PF A 801 (-3.3A)1PF A 801 (-4.8A)None1PF A 801 ( 4.5A) | 0.46A | 22.4 | 14.25 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvu | CASEIN KINASE 2, ALPHA SUBUNIT (Plasmodium falciparum (isolate 3d7)) | Pkinase | 6 | ILE A 49 - ILE A 540VAL A 57 - VAL A 548ALA A 70 - ALA A 561ILE A 99 - ILE A 595GLU A 118 - GLU A 612ILE A 178 - ILE A 674 | ATP A 403 (-4.9A)ATP A 403 (-3.9A)ATP A 403 (-3.4A)ATP A 403 (-4.9A)NoneATP A 403 ( 4.5A) | 0.52A | 22.3 | 18.89 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6q7d | EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | ILE A 619 - ILE A 540VAL A 627 - VAL A 548ALA A 644 - ALA A 561ILE A 676 - ILE A 595THR A 692 - THR A 611GLU A 693 - GLU A 612 | NoneHOT A1001 (-4.4A)HOT A1001 (-3.2A)HOT A1001 (-4.2A)HOT A1001 (-3.1A)None | 0.55A | 19.0 | 16.92 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5drb | SERINE/THREONINE-PROTEIN KINASE WNK1 (Rattus norvegicus) | Pkinase | 6 | ILE A 227 - ILE A 540VAL A 235 - VAL A 548ALA A 248 - ALA A 561THR A 301 - THR A 611GLU A 302 - GLU A 612LEU A 303 - LEU A 613 | 5FJ A 501 ( 4.4A)5FJ A 501 (-4.6A)5FJ A 501 (-3.5A)5FJ A 501 (-3.9A)None5FJ A 501 ( 4.7A) | 0.56A | 20.0 | 16.31 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ebv | FOCAL ADHESION KINASE 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | ILE A 428 - ILE A 540VAL A 436 - VAL A 548ALA A 452 - ALA A 561GLU A 500 - GLU A 612LEU A 501 - LEU A 613LEU A 553 - LEU A 664 | None | 0.56A | 17.0 | 16.27 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5li9 | PROTEIN KINASE C IOTA TYPE (Homo sapiens) | PkinasePkinase_C | 6 | ILE A 260 - ILE A 540VAL A 268 - VAL A 548ALA A 281 - ALA A 561GLU A 333 - GLU A 612VAL A 335 - VAL A 614LEU A 385 - LEU A 664 | ACP A 601 (-4.8A)ACP A 601 (-4.1A)ACP A 601 (-3.6A)NoneACP A 601 (-3.9A)ACP A 601 ( 4.8A) | 0.57A | 32.6 | 17.67 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens;helicobacter pylori) | PkinaseUBA | 6 | ILE A 59 - ILE A 540VAL A 67 - VAL A 548ALA A 80 - ALA A 561GLU A 130 - GLU A 612GLU A 136 - GLU A 618LEU A 182 - LEU A 664 | None | 0.58A | 27.1 | 15.88 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cbl | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FES/FPS (Homo sapiens;synthetic construct) | PK_Tyr_Ser-ThrSH2 | 6 | ILE A 567 - ILE A 540VAL A 575 - VAL A 548GLU A 637 - GLU A 612LEU A 638 - LEU A 613VAL A 639 - VAL A 614LEU A 690 - LEU A 664 | STU A 901 (-4.3A)STU A 901 ( 4.9A)NoneSTU A 901 (-4.2A)STU A 901 ( 4.0A)STU A 901 (-4.5A) | 0.58A | 21.1 | 17.97 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lxc | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 (Homo sapiens) | Pkinase | 6 | ILE A 155 - ILE A 540VAL A 163 - VAL A 548ALA A 176 - ALA A 561GLU A 229 - GLU A 612LEU A 230 - LEU A 613LEU A 282 - LEU A 664 | 7AA A 501 ( 4.1A)7AA A 501 (-4.5A)7AA A 501 (-3.5A)None7AA A 501 ( 4.8A)EDO A 504 (-4.7A) | 0.58A | 22.7 | 19.20 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uyj | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 2 (Homo sapiens) | Pkinase | 6 | ILE A 171 - ILE A 540VAL A 179 - VAL A 548ALA A 192 - ALA A 561LEU A 269 - LEU A 613VAL A 270 - VAL A 614LEU A 319 - LEU A 664 | 8R7 A 501 (-3.8A)8R7 A 501 (-4.3A)8R7 A 501 (-3.5A)8R7 A 501 ( 4.4A)8R7 A 501 (-3.9A)8R7 A 501 (-4.6A) | 0.59A | 25.6 | 15.72 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6o | EPHRIN TYPE-B RECEPTOR 3 (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | ILE A 639 - ILE A 540VAL A 647 - VAL A 548ALA A 663 - ALA A 561ILE A 695 - ILE A 595THR A 711 - THR A 611GLU A 712 - GLU A 612 | 6P6 A1001 (-4.0A)None6P6 A1001 (-3.3A)None6P6 A1001 (-3.5A)None | 0.59A | 19.2 | 13.93 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5i | PROTEIN KINASE (Plasmodium berghei) | NA | 6 | VAL A 71 - VAL A 548ALA A 84 - ALA A 561ILE A 128 - ILE A 595THR A 144 - THR A 611GLU A 151 - GLU A 618LEU A 197 - LEU A 664 | ANP A1634 (-4.1A)ANP A1634 (-3.6A)NoneANP A1634 (-4.6A)ANP A1634 (-4.1A)ANP A1634 (-4.4A) | 0.59A | 23.5 | 20.56 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r2p | EPHRIN TYPE-A RECEPTOR 5 (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | ILE A 681 - ILE A 540VAL A 689 - VAL A 548ALA A 705 - ALA A 561ILE A 737 - ILE A 595THR A 753 - THR A 611GLU A 754 - GLU A 612 | None | 0.60A | 21.8 | 14.74 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bdn | SERINE/THREONINE-PROTEIN KINASE TAO3 (Homo sapiens) | Pkinase | 6 | ILE A 30 - ILE A 540VAL A 38 - VAL A 548ALA A 51 - ALA A 561ILE A 85 - ILE A 595GLU A 102 - GLU A 612LEU A 154 - LEU A 664 | ADP A 404 (-4.3A)ADP A 404 (-4.3A)ADP A 404 (-3.4A)ADP A 404 ( 4.4A)NoneADP A 404 (-4.2A) | 0.61A | 25.4 | 17.56 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig1 | CAMK/CAMK2 PROTEIN KINASE (Salpingoeca rosetta) | Pkinase | 6 | VAL A 32 - VAL A 548ALA A 45 - ALA A 561GLU A 95 - GLU A 612VAL A 97 - VAL A 614GLU A 101 - GLU A 618LEU A 147 - LEU A 664 | None | 0.61A | 26.1 | 16.11 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3is5 | CALCIUM-DEPENDENT PROTEIN KINASE (Toxoplasma gondii) | NA | 6 | VAL A 149 - VAL A 548ILE A 194 - ILE A 595GLU A 211 - GLU A 612GLU A 217 - GLU A 618LEU A 267 - LEU A 664ILE A 280 - ILE A 674 | ANP A 1 (-4.9A)ANP A 1 (-4.8A)NoneANP A 1 (-4.4A)NoneANP A 1 (-4.2A) | 0.61A | 23.9 | 16.45 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6yoj | FOCAL ADHESION KINASE 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | ILE A 428 - ILE A 540VAL A 436 - VAL A 548ALA A 452 - ALA A 561GLU A 500 - GLU A 612LEU A 501 - LEU A 613LEU A 553 - LEU A 664 | P4N A 701 (-3.9A)P4N A 701 ( 4.8A)P4N A 701 (-3.4A)NoneP4N A 701 (-4.6A)P4N A 701 (-4.1A) | 0.62A | 18.5 | 15.68 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k00 | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (Homo sapiens) | Pkinase | 6 | ILE A 17 - ILE A 540VAL A 25 - VAL A 548ALA A 38 - ALA A 561GLU A 87 - GLU A 612LEU A 139 - LEU A 664ILE A 149 - ILE A 674 | 6PV A 401 ( 4.2A)6PV A 401 ( 4.7A)6PV A 401 (-3.6A)None6PV A 401 (-4.7A)6PV A 401 (-3.6A) | 0.62A | 25.4 | 16.92 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtd | MITOGEN-ACTIVATED PROTEIN KINASE 8 (Homo sapiens) | Pkinase | 6 | ILE A 32 - ILE A 540VAL A 40 - VAL A 548ALA A 53 - ALA A 561ILE A 86 - ILE A 595GLU A 109 - GLU A 612LEU A 110 - LEU A 613 | 38Z A 424 ( 4.8A)38Z A 424 (-4.6A)38Z A 424 (-3.5A)NoneNone38Z A 424 ( 4.6A) | 0.64A | 20.7 | 16.99 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3z | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE WITH A KINASE DOMAIN AND 4 CALMODULIN LIKE EF HANDS (Cryptosporidium parvum iowa ii) | Pkinase | 6 | ILE A 34 - ILE A 540ALA A 55 - ALA A 561ILE A 86 - ILE A 595LEU A 104 - LEU A 613GLU A 109 - GLU A 618LEU A 155 - LEU A 664 | DRK A 1 (-4.2A)DRK A 1 (-3.4A)DRK A 1 ( 4.8A)DRK A 1 (-4.4A)DRK A 1 (-3.4A)DRK A 1 (-4.6A) | 0.64A | 28.7 | 14.10 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzn | MITOGEN-ACTIVATED PROTEIN KINASE 1 (Homo sapiens) | Pkinase | 6 | ILE A 29 - ILE A 540VAL A 37 - VAL A 548ALA A 50 - ALA A 561ILE A 82 - ILE A 595LEU A 105 - LEU A 613LEU A 154 - LEU A 664 | CQ8 A1355 ( 4.3A)CQ8 A1355 (-4.1A)CQ8 A1355 (-3.3A)NoneCQ8 A1355 ( 4.7A)None | 0.65A | 23.1 | 16.63 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4f | MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens) | Pkinase | 6 | VAL A 120 - VAL A 548ALA A 133 - ALA A 561ILE A 164 - ILE A 595GLU A 181 - GLU A 612VAL A 183 - VAL A 614ILE A 246 - ILE A 674 | 16X A1374 (-4.8A)16X A1374 ( 3.8A)NoneNone16X A1374 (-4.0A)16X A1374 (-4.1A) | 0.68A | 23.5 | 19.44 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dtl | MITOGEN-ACTIVATED PROTEIN KINASE 6 (Arabidopsis thaliana) | Pkinase | 6 | ILE A 69 - ILE A 540VAL A 77 - VAL A 548ALA A 90 - ALA A 561GLU A 145 - GLU A 612LEU A 146 - LEU A 613LEU A 196 - LEU A 664 | None | 0.69A | 22.0 | 19.41 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4f | MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens) | Pkinase | 6 | VAL A 120 - VAL A 548ALA A 133 - ALA A 561ILE A 164 - ILE A 595GLU A 181 - GLU A 612LEU A 234 - LEU A 664ILE A 246 - ILE A 674 | 16X A1374 (-4.8A)16X A1374 ( 3.8A)NoneNone16X A1374 ( 4.8A)16X A1374 (-4.1A) | 0.69A | 23.5 | 19.44 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATED KINASE (Homo sapiens) | Pkinase | 6 | VAL A 54 - VAL A 548ALA A 67 - ALA A 561THR A 123 - THR A 611GLU A 124 - GLU A 612LEU A 125 - LEU A 613LEU A 180 - LEU A 664 | NoneSIN A 401 ( 3.7A)NoneNoneSIN A 401 ( 4.8A)SIN A 401 ( 4.5A) | 0.70A | 20.0 | 15.70 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4o | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV (Homo sapiens) | Pkinase | 6 | VAL A 60 - VAL A 548ALA A 73 - ALA A 561ILE A 102 - ILE A 595GLU A 119 - GLU A 612GLU A 125 - GLU A 618LEU A 171 - LEU A 664 | DKI A1338 (-4.2A)DKI A1338 ( 3.7A)DKI A1338 ( 4.4A)NoneNoneDKI A1338 (-4.9A) | 0.70A | 20.5 | 18.20 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6u5l | SERINE/THREONINE-PROTEIN KINASE ULK4 (Homo sapiens) | Pkinase | 6 | ILE A 10 - ILE A 540VAL A 18 - VAL A 548ALA A 31 - ALA A 561GLU A 76 - GLU A 612LEU A 77 - LEU A 613LEU A 128 - LEU A 664 | 3RJ A 301 (-4.5A)3RJ A 301 (-3.9A)3RJ A 301 (-3.2A)None3RJ A 301 ( 4.9A)3RJ A 301 (-4.6A) | 0.70A | 25.0 | 16.77 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k00 | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (Homo sapiens) | Pkinase | 6 | VAL A 25 - VAL A 548ALA A 38 - ALA A 561GLU A 87 - GLU A 612GLU A 93 - GLU A 618LEU A 139 - LEU A 664ILE A 149 - ILE A 674 | 6PV A 401 ( 4.7A)6PV A 401 (-3.6A)None6PV A 401 (-3.5A)6PV A 401 (-4.7A)6PV A 401 (-3.6A) | 0.74A | 25.4 | 16.92 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aln | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 (Homo sapiens) | Pkinase | 6 | ILE A 108 - ILE A 540VAL A 116 - VAL A 548ALA A 129 - ALA A 561GLU A 179 - GLU A 612LEU A 180 - LEU A 613LEU A 236 - LEU A 664 | ANP A 1 (-3.9A)ANP A 1 (-4.3A)ANP A 1 (-3.1A)NoneANP A 1 ( 4.6A)ANP A 1 ( 4.8A) | 0.75A | 17.3 | 17.92 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w96 | CELL DIVISION PROTEIN KINASE 4 (Homo sapiens) | Pkinase | 6 | ILE B 12 - ILE A 540VAL B 20 - VAL A 548ALA B 33 - ALA A 561GLU B 94 - GLU A 612VAL B 96 - VAL A 614LEU B 147 - LEU A 664 | None | 0.77A | 18.6 | 16.65 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hko | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE WITH A KINASE DOMAIN AND 2 CALMODULIN-LIKE EF HANDS (Cryptosporidium parvum iowa ii) | Pkinase | 6 | ILE A 16 - ILE A 540VAL A 24 - VAL A 548ALA A 37 - ALA A 561GLU A 90 - GLU A 612LEU A 91 - LEU A 613LEU A 182 - LEU A 664 | ANP A 329 ( 4.2A)ANP A 329 (-4.4A)ANP A 329 ( 3.7A)NoneANP A 329 ( 4.7A)ANP A 329 (-4.4A) | 0.81A | 24.8 | 17.79 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cz4 | PROTEIN-TYROSINE KINASE 6 (Homo sapiens) | PK_Tyr_Ser-Thr | 5 | VAL A 205 - VAL A 548ALA A 217 - ALA A 561THR A 264 - THR A 611GLU A 265 - GLU A 612LEU A 266 - LEU A 613 | FKY A9001 ( 4.6A)FKY A9001 (-3.3A)FKY A9001 (-3.0A)NoneFKY A9001 (-4.4A) | 0.21A | 19.7 | 14.54 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfi | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) | PK_Tyr_Ser-Thr | 5 | ILE A 469 - ILE A 540VAL A 477 - VAL A 548ALA A 488 - ALA A 561ILE A 522 - ILE A 595THR A 539 - THR A 611 | 4CW A 801 (-4.3A)4CW A 801 ( 4.8A)4CW A 801 (-3.3A)4CW A 801 ( 4.1A)4CW A 801 (-2.7A) | 0.28A | 18.5 | 18.93 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vcz | MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens) | Pkinase | 5 | VAL A 124 - VAL A 548ALA A 137 - ALA A 561THR A 187 - THR A 611GLU A 188 - GLU A 612LEU A 189 - LEU A 613 | EDO A 403 (-3.9A)XZN A 401 (-2.9A)XZN A 401 (-3.4A)NoneXZN A 401 ( 4.4A) | 0.31A | 21.1 | 16.63 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dtc | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens) | Pkinase | 5 | ILE A 150 - ILE A 540VAL A 158 - VAL A 548ALA A 169 - ALA A 561ILE A 204 - ILE A 595GLU A 221 - GLU A 612 | VIN A6331 (-4.0A)VIN A6331 (-4.7A)VIN A6331 (-3.4A)VIN A6331 ( 4.9A)None | 0.32A | 18.9 | 16.46 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p86 | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsis thaliana) | PK_Tyr_Ser-Thr | 5 | ILE A 557 - ILE A 540VAL A 565 - VAL A 548ALA A 576 - ALA A 561THR A 625 - THR A 611GLU A 626 - GLU A 612 | STU A 0 (-4.2A)STU A 0 (-4.8A)STU A 0 (-3.3A)STU A 0 (-4.1A)None | 0.36A | 19.5 | 16.26 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gp0 | MITOGEN-ACTIVATED PROTEIN KINASE 11 (Homo sapiens) | Pkinase | 5 | VAL A 38 - VAL A 548ALA A 51 - ALA A 561ILE A 84 - ILE A 595THR A 106 - THR A 611LEU A 108 - LEU A 613 | NIL A 1 ( 4.7A)NIL A 1 (-3.7A)NIL A 1 (-4.4A)NIL A 1 (-3.3A)NIL A 1 ( 4.4A) | 0.36A | 19.7 | 15.30 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c0i | PERIPHERAL PLASMA MEMBRANE PROTEIN CASK (Homo sapiens) | Pkinase | 5 | ILE A 18 - ILE A 540VAL A 26 - VAL A 548ALA A 39 - ALA A 561GLU A 92 - GLU A 612LEU A 148 - LEU A 664 | 3AM A 338 (-4.5A)3AM A 338 ( 4.1A)3AM A 338 (-3.3A)None3AM A 338 (-4.7A) | 0.37A | 26.0 | 17.57 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7jnt | RHO-ASSOCIATED PROTEIN KINASE 2 (Homo sapiens) | Pkinase | 5 | ILE A 98 - ILE A 540VAL A 106 - VAL A 548ALA A 119 - ALA A 561GLU A 170 - GLU A 612LEU A 221 - LEU A 664 | NoneVFA A 501 (-4.6A)VFA A 501 (-3.4A)NoneVFA A 501 (-4.7A) | 0.37A | 28.7 | 18.56 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gzd | CASEIN KINASE I ISOFORM ALPHA (Homo sapiens) | Pkinase | 5 | ILE A 23 - ILE A 540ALA A 44 - ALA A 561LEU A 92 - LEU A 613LEU A 143 - LEU A 664ILE A 156 - ILE A 674 | LCI A1018 ( 4.2A)LCI A1018 (-3.5A)LCI A1018 ( 4.8A)LCI A1018 (-4.2A)LCI A1018 ( 4.7A) | 0.38A | 21.6 | 19.93 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7jur | KINASE SUPPRESSOR OF RAS 2 (Homo sapiens;oryctolagus cuniculus) | PK_Tyr_Ser-Thr | 5 | ILE B 672 - ILE A 540VAL B 680 - VAL A 548ALA B 690 - ALA A 561THR B 739 - THR A 611LEU B 741 - LEU A 613 | ANP B1001 ( 3.8A)ANP B1001 ( 4.5A)ANP B1001 ( 3.6A)ANP B1001 ( 4.8A)ANP B1001 ( 4.5A) | 0.38A | 19.4 | 17.86 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7j | PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens) | Pkinase | 5 | ILE A 30 - ILE A 540VAL A 38 - VAL A 548ALA A 51 - ALA A 561ILE A 91 - ILE A 595LEU A 109 - LEU A 613 | B49 A1294 (-3.9A)NoneB49 A1294 (-3.2A)B49 A1294 ( 4.6A)B49 A1294 ( 4.7A) | 0.38A | 27.5 | 19.64 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awm | STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster) | Pkinase | 5 | ILE A 30 - ILE A 540VAL A 38 - VAL A 548ALA A 51 - ALA A 561ILE A 84 - ILE A 595LEU A 108 - LEU A 613 | ANP A 401 (-4.9A)ANP A 401 (-4.5A)ANP A 401 (-3.5A)NoneANP A 401 ( 4.8A) | 0.38A | 21.0 | 17.69 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5q | SERINE/THREONINE PROTEIN KINASE TAO2 (Rattus norvegicus) | Pkinase | 5 | ILE A 34 - ILE A 540VAL A 42 - VAL A 548ALA A 55 - ALA A 561ILE A 89 - ILE A 595GLU A 106 - GLU A 612 | None | 0.39A | 24.7 | 18.85 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ycf | SERINE/THREONINE-PROTEIN KINASE CHK2 (Homo sapiens) | Pkinase | 5 | VAL A 234 - VAL A 548ALA A 247 - ALA A 561ILE A 286 - ILE A 595GLU A 302 - GLU A 612LEU A 303 - LEU A 613 | YCF A 600 ( 4.7A)YCF A 600 ( 4.5A)NoneNoneNone | 0.39A | 21.4 | 17.10 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8s | RHO-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens) | Pkinase | 5 | ILE A 82 - ILE A 540VAL A 90 - VAL A 548ALA A 103 - ALA A 561GLU A 154 - GLU A 612LEU A 205 - LEU A 664 | None0HD A 501 (-4.0A)0HD A 501 (-3.3A)None0HD A 501 (-4.8A) | 0.40A | 29.6 | 19.41 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kn6 | RIBOSOMAL PROTEIN S6 KINASE ALPHA-5 (Homo sapiens) | Pkinase | 5 | ALA A 453 - ALA A 561GLU A 499 - GLU A 612LEU A 500 - LEU A 613LEU A 551 - LEU A 664ILE A 564 - ILE A 674 | None | 0.40A | 20.3 | 16.57 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xrw | MITOGEN-ACTIVATED PROTEIN KINASE 8 (Homo sapiens;synthetic construct) | Pkinase | 5 | ILE A 32 - ILE A 540VAL A 40 - VAL A 548ALA A 53 - ALA A 561ILE A 86 - ILE A 595LEU A 110 - LEU A 613 | ANP A1367 (-4.8A)ANP A1367 (-4.4A)ANP A1367 (-3.5A)ANP A1367 ( 4.8A)ANP A1367 ( 4.8A) | 0.41A | 20.2 | 17.89 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fr4 | SERINE/THREONINE-PROTEIN KINASE 32A (Homo sapiens) | Pkinase | 5 | ILE A 29 - ILE A 540VAL A 37 - VAL A 548ALA A 50 - ALA A 561LEU A 102 - LEU A 613LEU A 153 - LEU A 664 | STU A 401 (-4.1A)STU A 401 ( 4.9A)STU A 401 (-3.2A)STU A 401 (-4.4A)STU A 401 (-4.7A) | 0.42A | 28.4 | 18.65 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kn6 | RIBOSOMAL PROTEIN S6 KINASE ALPHA-5 (Homo sapiens) | Pkinase | 5 | ALA A 453 - ALA A 561GLU A 499 - GLU A 612LEU A 500 - LEU A 613GLU A 505 - GLU A 618LEU A 551 - LEU A 664 | None | 0.44A | 20.3 | 16.57 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xh0 | SIMILAR TO UNIPROT|P29295 SACCHAROMYCES CEREVISIAE YPL204W HRR25 (Candida glabrata) | Pkinase | 5 | ILE A 15 - ILE A 540ALA A 36 - ALA A 561LEU A 84 - LEU A 613LEU A 135 - LEU A 664ILE A 148 - ILE A 674 | ADP A 501 ( 4.4A)ADP A 501 ( 3.8A)ADP A 501 (-4.5A)ADP A 501 (-4.5A)ADP A 501 ( 4.3A) | 0.44A | 20.8 | 18.95 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyz | CASEIN KINASE I HOMOLOG HRR25 (Saccharomyces cerevisiae (strain atcc 204508 / s288c)) | Pkinase | 5 | ILE A 15 - ILE A 540ALA A 36 - ALA A 561LEU A 84 - LEU A 613LEU A 135 - LEU A 664ILE A 148 - ILE A 674 | MLY A 14 ( 3.8A)NoneNoneNoneNone | 0.44A | 21.3 | 18.65 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dbx | STE20/SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE (Mus musculus) | Pkinase | 5 | ILE A 81 - ILE A 540VAL A 89 - VAL A 548ALA A 102 - ALA A 561LEU A 152 - LEU A 613LEU A 211 - LEU A 664 | ANP A 401 ( 4.1A)ANP A 401 (-4.0A)ANP A 401 ( 4.0A)NoneNone | 0.44A | 20.3 | 15.19 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyv | DUAL SPECIFICITY PROTEIN KINASE CLK4 (Homo sapiens) | Pkinase | 5 | VAL A 175 - VAL A 548ALA A 189 - ALA A 561GLU A 242 - GLU A 612LEU A 243 - LEU A 613LEU A 295 - LEU A 664 | 3NG A 501 ( 4.3A)3NG A 501 (-3.5A)None3NG A 501 ( 4.7A)None | 0.45A | 23.2 | 16.96 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5byz | MITOGEN-ACTIVATED PROTEIN KINASE 7 (Homo sapiens) | Pkinase | 5 | ILE A 61 - ILE A 540VAL A 69 - VAL A 548ALA A 82 - ALA A 561ILE A 115 - ILE A 595LEU A 139 - LEU A 613 | 4WE A 401 (-4.6A)4WE A 401 ( 4.8A)4WE A 401 (-3.4A)4WE A 401 (-4.2A)None | 0.45A | 22.7 | 17.34 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oht | P38A (Salmo salar) | Pkinase | 5 | VAL A 39 - VAL A 548ALA A 52 - ALA A 561ILE A 85 - ILE A 595THR A 107 - THR A 611LEU A 109 - LEU A 613 | 1N1 A1000 (-4.6A)1N1 A1000 (-3.7A)1N1 A1000 ( 4.1A)1N1 A1000 (-3.3A)1N1 A1000 (-4.7A) | 0.45A | 15.6 | 18.71 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmp | DUAL SPECIFICITY PROTEIN KINASE TTK (Homo sapiens) | Pkinase | 5 | VAL A 539 - VAL A 548ALA A 551 - ALA A 561ILE A 586 - ILE A 595GLU A 603 - GLU A 612ILE A 663 - ILE A 674 | NoneCX4 A 1 (-3.5A)NoneNone7PE A1153 (-4.5A) | 0.46A | 22.9 | 15.94 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fyl | DUAL SPECIFICITY PROTEIN KINASE CLK2 (Homo sapiens) | Pkinase | 5 | VAL A 177 - VAL A 548ALA A 191 - ALA A 561GLU A 244 - GLU A 612LEU A 245 - LEU A 613LEU A 297 - LEU A 664 | 3NG A 501 ( 4.4A)3NG A 501 (-3.3A)None3NG A 501 ( 4.7A)None | 0.47A | 23.0 | 19.13 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ft8 | DUAL SPECIFICITY PROTEIN KINASE CLK1 (Homo sapiens) | Pkinase | 5 | VAL A 175 - VAL A 548ALA A 189 - ALA A 561GLU A 242 - GLU A 612LEU A 243 - LEU A 613LEU A 295 - LEU A 664 | E6T A 501 ( 4.7A)E6T A 501 (-3.3A)NoneEDO A 506 ( 4.4A)E6T A 501 (-4.8A) | 0.48A | 22.5 | 16.15 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7o | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II GAMMA CHAIN (Homo sapiens) | Pkinase | 5 | VAL A 28 - VAL A 548ALA A 41 - ALA A 561LEU A 92 - LEU A 613VAL A 93 - VAL A 614LEU A 143 - LEU A 664 | DRN A1303 (-4.4A)DRN A1303 (-3.4A)DRN A1303 (-4.2A)DRN A1303 (-3.7A)None | 0.49A | 26.1 | 16.77 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1phk | PHOSPHORYLASE KINASE (Oryctolagus cuniculus) | Pkinase | 5 | VAL A 33 - VAL A 548ALA A 46 - ALA A 561ILE A 87 - ILE A 595LEU A 105 - LEU A 613LEU A 156 - LEU A 664 | ATP A 381 (-4.0A)ATP A 381 (-3.5A)NoneATP A 381 ( 4.9A)ATP A 381 (-4.8A) | 0.49A | 27.4 | 16.89 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmi | TYROSINE-PROTEIN KINASE ABL2 (Homo sapiens) | PK_Tyr_Ser-Thr | 5 | VAL A 302 - VAL A 548ALA A 315 - ALA A 561THR A 361 - THR A 611GLU A 362 - GLU A 612LEU A 416 - LEU A 664 | DKI A 1 (-4.3A)DKI A 1 ( 4.0A)DKI A 1 ( 4.7A)NoneDKI A 1 (-4.2A) | 0.49A | 20.9 | 15.01 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jam | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G (Homo sapiens;unidentified) | Pkinase | 5 | ALA A 50 - ALA A 561LEU A 100 - LEU A 613VAL A 101 - VAL A 614GLU A 105 - GLU A 618LEU A 151 - LEU A 664 | J60 A1305 (-3.3A)J60 A1305 (-4.4A)J60 A1305 (-3.9A)NoneNone | 0.50A | 18.3 | 16.37 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txo | PROTEIN KINASE C ETA TYPE (Homo sapiens) | PkinasePkinase_C | 5 | VAL A 369 - VAL A 548ALA A 382 - ALA A 561GLU A 434 - GLU A 612VAL A 436 - VAL A 614LEU A 486 - LEU A 664 | 07U A 1 (-4.8A)07U A 1 (-3.3A)None07U A 1 (-3.8A)07U A 1 (-4.3A) | 0.50A | 27.4 | 17.80 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es1 | MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4 (Homo sapiens) | PkinaseUBA | 5 | ILE A 62 - ILE A 540VAL A 70 - VAL A 548ALA A 83 - ALA A 561GLU A 139 - GLU A 618LEU A 185 - LEU A 664 | 5RC A4000 (-4.0A)5RC A4000 (-4.6A)5RC A4000 (-3.6A)NoneNone | 0.50A | 24.8 | 17.50 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5q | SERINE/THREONINE PROTEIN KINASE TAO2 (Rattus norvegicus) | Pkinase | 5 | ILE A 34 - ILE A 540VAL A 42 - VAL A 548ALA A 55 - ALA A 561GLU A 106 - GLU A 612LEU A 158 - LEU A 664 | None | 0.51A | 24.7 | 18.85 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6k3l | CMGC/CK2 PROTEIN KINASE (Cryptococcus neoformans var. grubii serotype a (strain h99 / atcc 208821 / cbs 10515 / fgsc 9487)) | Pkinase | 5 | VAL B 52 - VAL A 548THR B 112 - THR A 611GLU B 113 - GLU A 612VAL B 115 - VAL A 614ILE B 173 - ILE A 674 | 3NG B 401 ( 4.5A)3NG B 401 (-3.9A)None3NG B 401 (-4.0A)3NG B 401 (-3.7A) | 0.52A | 22.8 | 16.76 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzr | ACTIVATED CDC42 KINASE 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 5 | VAL A 140 - VAL A 548ALA A 156 - ALA A 561THR A 205 - THR A 611GLU A 206 - GLU A 612LEU A 207 - LEU A 613 | None | 0.52A | 20.9 | 15.64 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtb | MITOGEN-ACTIVATED PROTEIN KINASE 3 (Homo sapiens) | Pkinase | 5 | ILE A 48 - ILE A 540VAL A 56 - VAL A 548ALA A 69 - ALA A 561ILE A 101 - ILE A 595LEU A 124 - LEU A 613 | 38Z A 418 ( 4.4A)None38Z A 418 (-3.4A)38Z A 418 ( 4.9A)38Z A 418 ( 4.8A) | 0.53A | 23.1 | 17.83 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwi | SERINE/THREONINE-PROTEIN KINASE OSR1 (Homo sapiens) | Pkinase | 5 | ILE A 23 - ILE A 540VAL A 31 - VAL A 548ALA A 44 - ALA A 561LEU A 94 - LEU A 613LEU A 153 - LEU A 664 | ANP A1294 ( 4.1A)ANP A1294 (-4.3A)ANP A1294 ( 4.0A)NoneANP A1294 (-4.9A) | 0.53A | 17.3 | 16.49 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llt | SERINE/THREONINE KINASE-1, PFLAMMER (Plasmodium falciparum 3d7) | Pkinase | 5 | VAL A 566 - VAL A 548ALA A 579 - ALA A 561GLU A 631 - GLU A 612LEU A 684 - LEU A 664ILE A 719 - ILE A 674 | ANP A 877 (-4.1A)ANP A 877 ( 3.7A)NoneNoneANP A 877 ( 4.3A) | 0.53A | 22.4 | 17.47 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uya | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK4 (Homo sapiens) | PK_Tyr_Ser-Thr | 5 | VAL A 138 - VAL A 548ALA A 149 - ALA A 561ILE A 184 - ILE A 595GLU A 201 - GLU A 612LEU A 270 - LEU A 664 | AGS A1438 (-4.4A)AGS A1438 (-3.4A)AGS A1438 (-4.2A)NoneAGS A1438 (-4.7A) | 0.54A | 18.9 | 17.65 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fe3 | MAP/MICROTUBULE AFFINITY-REGULATING KINASE 3 (Homo sapiens) | PkinaseUBA | 5 | ILE A 62 - ILE A 540VAL A 70 - VAL A 548ALA A 83 - ALA A 561GLU A 133 - GLU A 612LEU A 185 - LEU A 664 | None | 0.54A | 23.2 | 17.29 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6s14 | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A (Homo sapiens) | Pkinase | 5 | ILE A 165 - ILE A 540VAL A 173 - VAL A 548ALA A 186 - ALA A 561GLU A 239 - GLU A 612LEU A 294 - LEU A 664 | KQW A 507 (-3.9A)KQW A 507 (-3.2A)KQW A 507 (-3.4A)NoneKQW A 507 ( 4.4A) | 0.54A | 22.7 | 18.14 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfi | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) | PK_Tyr_Ser-Thr | 5 | ILE A 469 - ILE A 540VAL A 477 - VAL A 548ALA A 488 - ALA A 561ILE A 522 - ILE A 595LEU A 595 - LEU A 664 | 4CW A 801 (-4.3A)4CW A 801 ( 4.8A)4CW A 801 (-3.3A)4CW A 801 ( 4.1A)4CW A 801 (-4.4A) | 0.54A | 18.5 | 18.93 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7j | PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens) | Pkinase | 5 | ILE A 30 - ILE A 540VAL A 38 - VAL A 548ALA A 51 - ALA A 561LEU A 109 - LEU A 613LEU A 160 - LEU A 664 | B49 A1294 (-3.9A)NoneB49 A1294 (-3.2A)B49 A1294 ( 4.7A)B49 A1294 (-4.4A) | 0.55A | 27.5 | 19.64 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6mwe | ANGIOPOIETIN-1 RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 5 | ILE A 830 - ILE A 540VAL A 838 - VAL A 548ALA A 853 - ALA A 561ILE A 886 - ILE A 595GLU A 903 - GLU A 612 | 919 A1203 (-4.2A)None919 A1203 (-3.4A)919 A1203 (-4.9A)None | 0.55A | 18.3 | 17.83 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6zjf | SERINE/THREONINE-PROTEIN KINASE 17B (Homo sapiens) | Pkinase | 5 | VAL A 47 - VAL A 548ALA A 60 - ALA A 561ILE A 94 - ILE A 595GLU A 111 - GLU A 612LEU A 165 - LEU A 664 | QM2 A 401 ( 4.8A)QM2 A 401 (-3.4A)NoneNoneQM2 A 401 (-4.7A) | 0.55A | 24.2 | 16.78 | ||
| Hit | Macromolecule/ Organism | Pfam | Res. | Residue Matches | HETATM Residue/s | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock |