Homo sapiensPfam Annotation:
PK_Tyr_Ser-ThrLigand ID:
0LIDrugbank ID:
Ponatinib (DB08901)HETATM residue:
0LI A1000 No. of binding residues: 12
List of all similar binding patterns of amino acids (3ZOS_A_0LIA1000_0, 12 residues)
Note that only 3-12 residue patterns can be used for ASSAM searches, thus the binding sites are divided into fragments.Hit pattern: 3D amino acid arrangements similar to known drug binding site Query pattern: Residues from known binding site for annotated drug that match the hit pattern (Click on the 'View' column to view superposed patterns of amino acids)(Click the 'Script' button to download a python script for molecular docking in UCSF Chimera) |
| Hit | Macromolecule/ Organism | Pfam | Res. | Residue Matches | HETATM Residue/s | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
|---|---|---|---|---|---|---|---|---|---|---|---|
 Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 7aym | DISCOIDIN DOMAIN-CONTAINING RECEPTOR 2,EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 11 | LEU A 569 - LEU A 616VAL A 577 - VAL A 624ALA A 606 - ALA A 653VAL A 607 - VAL A 654LYS A 608 - LYS A 655MET A 652 - MET A 699THR A 654 - THR A 701TYR A 656 - TYR A 703MET A 657 - MET A 704GLY A 660 - GLY A 707LEU A 726 - LEU A 773 | 4VD A 901 ( 4.0A)4VD A 901 ( 4.3A)4VD A 901 (-3.0A)4VD A 901 ( 4.6A)4VD A 901 (-3.4A)4VD A 901 (-3.7A)4VD A 901 (-2.6A)4VD A 901 ( 3.9A)4VD A 901 (-4.4A)4VD A 901 ( 3.3A)4VD A 901 (-4.4A) | 0.44A | 38.2 | 71.34 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU A 599 - LEU A 616VAL A 607 - VAL A 624ALA A 625 - ALA A 653VAL A 626 - VAL A 654LYS A 627 - LYS A 655THR A 674 - THR A 701TYR A 676 - TYR A 703GLY A 680 - GLY A 707LEU A 825 - LEU A 773 | 748 A1001 (-3.8A)748 A1001 ( 4.7A)748 A1001 (-3.7A)None748 A1001 (-4.0A)748 A1001 (-3.2A)748 A1001 (-4.0A)748 A1001 ( 4.0A)748 A1001 (-4.3A) | 0.36A | 34.8 | 30.59 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fex | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU A 616 - LEU A 616VAL A 624 - VAL A 624ALA A 653 - ALA A 653VAL A 654 - VAL A 654MET A 699 - MET A 699TYR A 703 - TYR A 703MET A 704 - MET A 704GLY A 707 - GLY A 707LEU A 773 - LEU A 773 | D6Z A1001 ( 4.1A)D6Z A1001 (-4.1A)D6Z A1001 (-3.0A)NoneD6Z A1001 ( 3.1A)D6Z A1001 (-4.1A)NoneD6Z A1001 ( 4.0A)D6Z A1001 (-4.1A) | 0.39A | 41.4 | 95.64 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU A 595 - LEU A 616VAL A 603 - VAL A 624ALA A 621 - ALA A 653VAL A 622 - VAL A 654LYS A 623 - LYS A 655THR A 670 - THR A 701TYR A 672 - TYR A 703GLY A 676 - GLY A 707LEU A 799 - LEU A 773 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 4.9A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.39A | 34.3 | 32.84 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fex | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU A 616 - LEU A 616VAL A 624 - VAL A 624ALA A 653 - ALA A 653VAL A 654 - VAL A 654THR A 701 - THR A 701TYR A 703 - TYR A 703MET A 704 - MET A 704GLY A 707 - GLY A 707LEU A 773 - LEU A 773 | D6Z A1001 ( 4.1A)D6Z A1001 (-4.1A)D6Z A1001 (-3.0A)NoneD6Z A1001 (-4.5A)D6Z A1001 (-4.1A)NoneD6Z A1001 ( 4.0A)D6Z A1001 (-4.1A) | 0.41A | 41.4 | 95.64 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4csv | SRC-ABL TYROSINE KINASE ANCESTOR (Synthetic construct) | NA | 9 | LEU A 14 - LEU A 616VAL A 22 - VAL A 624ALA A 35 - ALA A 653VAL A 36 - VAL A 654THR A 81 - THR A 701TYR A 83 - TYR A 703MET A 84 - MET A 704GLY A 87 - GLY A 707LEU A 136 - LEU A 773 | STI A1265 ( 4.7A)STI A1265 ( 4.9A)STI A1265 (-3.5A)NoneSTI A1265 (-3.0A)STI A1265 (-3.9A)NoneSTI A1265 ( 4.0A)STI A1265 (-4.4A) | 0.41A | 31.7 | 39.81 | ||
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ng0 | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | VAL A 32 - VAL A 624ALA A 45 - ALA A 653VAL A 46 - VAL A 654LYS A 47 - LYS A 655THR A 95 - THR A 701TYR A 97 - TYR A 703MET A 98 - MET A 704GLY A 101 - GLY A 707LEU A 153 - LEU A 773 | ACP A1000 (-4.3A)ACP A1000 (-3.3A)NoneACP A1000 (-3.0A)ACP A1000 (-4.0A)ACP A1000 ( 4.4A)NoneNoneACP A1000 (-4.8A) | 0.47A | 25.4 | 28.74 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU X 17 - LEU A 616VAL X 25 - VAL A 624ALA X 37 - ALA A 653LYS X 39 - LYS A 655THR X 82 - THR A 701TYR X 84 - TYR A 703MET X 85 - MET A 704GLY X 88 - GLY A 707LEU X 137 - LEU A 773 | STU X 902 (-3.8A)STU X 902 ( 4.8A)STU X 902 (-3.1A)STU X 902 (-3.1A)STU X 902 (-4.1A)STU X 902 (-4.6A)NoneSTU X 902 (-3.5A)STU X 902 (-4.4A) | 0.50A | 29.9 | 35.24 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpc | TYROSINE-PROTEIN KINASE LCK (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | VAL A 259 - VAL A 624ALA A 271 - ALA A 653VAL A 272 - VAL A 654LYS A 273 - LYS A 655THR A 316 - THR A 701TYR A 318 - TYR A 703MET A 319 - MET A 704GLY A 322 - GLY A 707LEU A 371 - LEU A 773 | ANP A 904 (-4.6A)ANP A 904 (-3.4A)NoneEDO A 905 (-3.3A)EDO A 905 (-4.3A)ANP A 904 ( 4.1A)NoneANP A 904 ( 3.8A)ANP A 904 (-4.5A) | 0.53A | 29.7 | 36.84 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6kzd | NT-3 GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU A 544 - LEU A 616VAL A 552 - VAL A 624ALA A 570 - ALA A 653VAL A 571 - VAL A 654MET A 615 - MET A 699TYR A 619 - TYR A 703MET A 620 - MET A 704GLY A 623 - GLY A 707LEU A 686 - LEU A 773 | DZ6 A 901 ( 4.5A)NoneDZ6 A 901 (-3.1A)NoneNoneDZ6 A 901 (-4.6A)NoneDZ6 A 901 (-3.5A)DZ6 A 901 (-4.5A) | 0.56A | 33.8 | 43.16 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hmi | TYROSINE-PROTEIN KINASE ABL2 (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU A 294 - LEU A 616VAL A 302 - VAL A 624ALA A 315 - ALA A 653VAL A 316 - VAL A 654THR A 361 - THR A 701TYR A 363 - TYR A 703MET A 364 - MET A 704GLY A 367 - GLY A 707LEU A 416 - LEU A 773 | DKI A 1 (-4.6A)DKI A 1 (-4.3A)DKI A 1 ( 4.0A)NoneDKI A 1 ( 4.7A)DKI A 1 (-4.3A)NoneDKI A 1 (-3.5A)DKI A 1 (-4.2A) | 0.62A | 30.3 | 35.01 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpc | TYROSINE-PROTEIN KINASE LCK (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU A 251 - LEU A 616VAL A 259 - VAL A 624ALA A 271 - ALA A 653VAL A 272 - VAL A 654LYS A 273 - LYS A 655THR A 316 - THR A 701TYR A 318 - TYR A 703GLY A 322 - GLY A 707LEU A 371 - LEU A 773 | ANP A 904 (-4.1A)ANP A 904 (-4.6A)ANP A 904 (-3.4A)NoneEDO A 905 (-3.3A)EDO A 905 (-4.3A)ANP A 904 ( 4.1A)ANP A 904 ( 3.8A)ANP A 904 (-4.5A) | 0.63A | 29.7 | 36.84 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ng0 | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) | PK_Tyr_Ser-Thr | 9 | LEU A 24 - LEU A 616VAL A 32 - VAL A 624ALA A 45 - ALA A 653VAL A 46 - VAL A 654LYS A 47 - LYS A 655THR A 95 - THR A 701TYR A 97 - TYR A 703MET A 98 - MET A 704GLY A 101 - GLY A 707 | NoneACP A1000 (-4.3A)ACP A1000 (-3.3A)NoneACP A1000 (-3.0A)ACP A1000 (-4.0A)ACP A1000 ( 4.4A)NoneNone | 0.66A | 25.4 | 28.74 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hng | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 833 - LEU A 616VAL A 841 - VAL A 624ALA A 859 - ALA A 653VAL A 860 - VAL A 654LYS A 861 - LYS A 655TYR A 911 - TYR A 703GLY A 915 - GLY A 707LEU A1029 - LEU A 773 | 8ST A2001 ( 4.7A)8ST A2001 ( 4.6A)8ST A2001 ( 3.8A)None8ST A2001 (-4.0A)8ST A2001 (-4.9A)NoneNone | 0.42A | 33.2 | 30.08 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hzr | ACTIVATED CDC42 KINASE 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 132 - LEU A 616VAL A 140 - VAL A 624ALA A 156 - ALA A 653VAL A 157 - VAL A 654MET A 203 - MET A 699THR A 205 - THR A 701GLY A 211 - GLY A 707LEU A 259 - LEU A 773 | None | 0.43A | 28.1 | 37.19 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8s | RHO-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens) | Pkinase | 8 | VAL A 90 - VAL A 624ALA A 103 - ALA A 653LYS A 105 - LYS A 655MET A 151 - MET A 699TYR A 155 - TYR A 703MET A 156 - MET A 704GLY A 159 - GLY A 707LEU A 205 - LEU A 773 | 0HD A 501 (-4.0A)0HD A 501 (-3.3A)0HD A 501 ( 4.0A)None0HD A 501 (-4.7A)NoneNone0HD A 501 (-4.8A) | 0.45A | 19.3 | 23.54 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z55 | ALK TYROSINE KINASE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A1122 - LEU A 616VAL A1130 - VAL A 624ALA A1148 - ALA A 653VAL A1149 - VAL A 654LYS A1150 - LYS A 655MET A1199 - MET A 704GLY A1202 - GLY A 707LEU A1256 - LEU A 773 | 4LO A1503 (-3.9A)4LO A1503 ( 4.4A)4LO A1503 (-3.3A)None4LO A1503 (-3.5A)None4LO A1503 ( 3.7A)4LO A1503 (-4.5A) | 0.48A | 29.4 | 32.97 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y6o | EPHRIN TYPE-A RECEPTOR 4 (Mus musculus) | PK_Tyr_Ser-Thr | 8 | VAL A 635 - VAL A 624ALA A 651 - ALA A 653LYS A 653 - LYS A 655THR A 699 - THR A 701TYR A 701 - TYR A 703MET A 702 - MET A 704GLY A 705 - GLY A 707LEU A 753 - LEU A 773 | None1N1 A1892 (-3.3A)1N1 A1892 (-4.0A)1N1 A1892 (-3.1A)1N1 A1892 (-4.4A)None1N1 A1892 (-3.5A)1N1 A1892 ( 4.6A) | 0.48A | 31.1 | 36.06 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt7 | RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3 (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 616 - LEU A 616VAL A 624 - VAL A 624ALA A 642 - ALA A 653VAL A 643 - VAL A 654LYS A 644 - LYS A 655TYR A 693 - TYR A 703GLY A 697 - GLY A 707LEU A 818 - LEU A 773 | P30 A1001 (-3.8A)NoneP30 A1001 (-3.4A)NoneP30 A1001 (-3.4A)P30 A1001 (-4.1A)P30 A1001 (-3.4A)P30 A1001 (-4.6A) | 0.48A | 34.7 | 28.10 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 484 - LEU A 616VAL A 492 - VAL A 624ALA A 512 - ALA A 653VAL A 513 - VAL A 654LYS A 514 - LYS A 655TYR A 563 - TYR A 703GLY A 567 - GLY A 707LEU A 630 - LEU A 773 | 07J A 1 ( 4.3A)07J A 1 (-4.0A)07J A 1 (-3.5A)None07J A 1 (-4.5A)07J A 1 (-4.7A)07J A 1 (-3.7A)07J A 1 ( 4.4A) | 0.48A | 30.3 | 31.06 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7jnt | RHO-ASSOCIATED PROTEIN KINASE 2 (Homo sapiens) | Pkinase | 8 | VAL A 106 - VAL A 624ALA A 119 - ALA A 653LYS A 121 - LYS A 655MET A 167 - MET A 699TYR A 171 - TYR A 703MET A 172 - MET A 704GLY A 175 - GLY A 707LEU A 221 - LEU A 773 | VFA A 501 (-4.6A)VFA A 501 (-3.4A)VFA A 501 (-2.7A)NoneVFA A 501 (-4.6A)NoneNoneVFA A 501 (-4.7A) | 0.49A | 19.7 | 22.68 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jfw | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 516 - LEU A 616VAL A 524 - VAL A 624ALA A 542 - ALA A 653VAL A 543 - VAL A 654TYR A 591 - TYR A 703MET A 592 - MET A 704GLY A 595 - GLY A 707LEU A 657 - LEU A 773 | 6K2 A4000 ( 4.5A)6K2 A4000 ( 4.8A)6K2 A4000 (-3.4A)None6K2 A4000 ( 4.9A)None6K2 A4000 ( 4.4A)6K2 A4000 (-4.4A) | 0.52A | 31.0 | 43.94 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yex | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) | Pkinase | 8 | LEU A 15 - LEU A 616VAL A 23 - VAL A 624ALA A 36 - ALA A 653VAL A 37 - VAL A 654LYS A 38 - LYS A 655TYR A 86 - TYR A 703GLY A 90 - GLY A 707LEU A 137 - LEU A 773 | YEX A1278 (-3.8A)YEX A1278 ( 4.5A)YEX A1278 (-3.3A)NoneNoneYEX A1278 (-4.5A)YEX A1278 (-3.4A)YEX A1278 (-4.5A) | 0.53A | 20.3 | 24.02 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jfw | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 516 - LEU A 616VAL A 524 - VAL A 624ALA A 542 - ALA A 653VAL A 543 - VAL A 654MET A 587 - MET A 699TYR A 591 - TYR A 703GLY A 595 - GLY A 707LEU A 657 - LEU A 773 | 6K2 A4000 ( 4.5A)6K2 A4000 ( 4.8A)6K2 A4000 (-3.4A)NoneNone6K2 A4000 ( 4.9A)6K2 A4000 ( 4.4A)6K2 A4000 (-4.4A) | 0.54A | 31.0 | 43.94 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6t2w | MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 588 - LEU A 616VAL A 596 - VAL A 624ALA A 614 - ALA A 653VAL A 615 - VAL A 654THR A 663 - THR A 701TYR A 665 - TYR A 703GLY A 669 - GLY A 707LEU A 785 - LEU A 773 | M9T A1001 ( 4.3A)M9T A1001 (-4.4A)M9T A1001 (-3.5A)NoneM9T A1001 (-3.7A)M9T A1001 (-4.3A)M9T A1001 (-3.6A)M9T A1001 (-4.5A) | 0.55A | 33.6 | 33.62 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 616 - LEU A 616VAL A 624 - VAL A 624ALA A 642 - ALA A 653VAL A 643 - VAL A 654LYS A 644 - LYS A 655TYR A 693 - TYR A 703GLY A 697 - GLY A 707LEU A 818 - LEU A 773 | None | 0.56A | 32.8 | 32.11 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0t | LIKELY PROTEIN KINASE (Candida albicans) | Pkinase | 8 | LEU A 246 - LEU A 616VAL A 254 - VAL A 624ALA A 267 - ALA A 653VAL A 268 - VAL A 654LYS A 269 - LYS A 655TYR A 320 - TYR A 703GLY A 324 - GLY A 707LEU A 371 - LEU A 773 | None | 0.58A | 21.9 | 16.51 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hzr | ACTIVATED CDC42 KINASE 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | LEU A 132 - LEU A 616VAL A 140 - VAL A 624ALA A 156 - ALA A 653VAL A 157 - VAL A 654LYS A 158 - LYS A 655THR A 205 - THR A 701GLY A 211 - GLY A 707LEU A 259 - LEU A 773 | None | 0.58A | 28.1 | 37.19 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dg3 | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Mus musculus;synthetic construct) | Pkinase | 8 | LEU E 49 - LEU A 616VAL E 57 - VAL A 624ALA E 70 - ALA A 653LYS E 72 - LYS A 655MET E 118 - MET A 699TYR E 122 - TYR A 703GLY E 126 - GLY A 707LEU E 173 - LEU A 773 | ANP E 401 ( 4.2A)ANP E 401 (-3.9A)ANP E 401 (-3.4A)ANP E 401 (-2.8A)NoneANP E 401 (-4.8A)NoneANP E 401 (-4.5A) | 0.59A | 20.9 | 25.32 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2pvf | FIBROBLAST GROWTH FACTOR RECEPTOR 2 (Homo sapiens;synthetic construct) | PK_Tyr_Ser-Thr | 8 | LEU A 487 - LEU A 616VAL A 495 - VAL A 624ALA A 515 - ALA A 653VAL A 516 - VAL A 654LYS A 517 - LYS A 655TYR A 566 - TYR A 703GLY A 570 - GLY A 707LEU A 633 - LEU A 773 | ACP A 300 (-3.8A)ACP A 300 (-4.5A)ACP A 300 (-3.2A)NoneACP A 300 (-2.7A)ACP A 300 ( 4.9A)ACP A 300 ( 4.7A)ACP A 300 (-4.4A) | 0.60A | 30.7 | 33.52 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n1f | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Cricetulus griseus) | Pkinase | 8 | LEU A 49 - LEU A 616VAL A 57 - VAL A 624ALA A 70 - ALA A 653LYS A 72 - LYS A 655MET A 118 - MET A 699TYR A 122 - TYR A 703GLY A 126 - GLY A 707LEU A 173 - LEU A 773 | 8ET A 403 ( 3.7A)8ET A 403 (-4.7A)8ET A 403 (-3.3A)8ET A 403 (-2.6A)None8ET A 403 (-3.7A)None8ET A 403 (-4.8A) | 0.61A | 21.3 | 24.19 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4asz | BDNF/NT-3 GROWTH FACTORS RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | VAL A 568 - VAL A 624ALA A 586 - ALA A 653VAL A 587 - VAL A 654LYS A 588 - LYS A 655MET A 631 - MET A 699TYR A 635 - TYR A 703GLY A 639 - GLY A 707LEU A 699 - LEU A 773 | None | 0.61A | 32.4 | 47.06 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens) | PK_Tyr_Ser-Thr | 8 | VAL A 649 - VAL A 624ALA A 665 - ALA A 653LYS A 667 - LYS A 655THR A 713 - THR A 701TYR A 715 - TYR A 703MET A 716 - MET A 704GLY A 719 - GLY A 707LEU A 767 - LEU A 773 | NoneNoneNoneNoneGOL A 403 (-4.1A)NoneGOL A 403 (-3.4A)None | 0.63A | 31.3 | 37.18 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1phk | PHOSPHORYLASE KINASE (Oryctolagus cuniculus) | Pkinase | 8 | LEU A 25 - LEU A 616VAL A 33 - VAL A 624ALA A 46 - ALA A 653VAL A 47 - VAL A 654LYS A 48 - LYS A 655MET A 106 - MET A 704GLY A 109 - GLY A 707LEU A 156 - LEU A 773 | ATP A 381 (-3.7A)ATP A 381 (-4.0A)ATP A 381 (-3.5A)NoneATP A 381 (-2.8A)ATP A 381 (-4.8A)NoneATP A 381 (-4.8A) | 0.66A | 23.0 | 25.51 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysj | CALMODULIN-LIKE DOMAIN PROTEIN KINASE (Eimeria tenella) | EF-hand_7Pkinase | 8 | LEU A 34 - LEU A 616VAL A 42 - VAL A 624ALA A 55 - ALA A 653VAL A 56 - VAL A 654LYS A 57 - LYS A 655THR A 105 - THR A 701GLY A 111 - GLY A 707LEU A 158 - LEU A 773 | ADP A 506 ( 3.8A)ADP A 506 (-4.3A)ADP A 506 (-3.3A)NoneADP A 506 (-2.4A)ADP A 506 ( 4.6A)NoneADP A 506 (-4.7A) | 0.68A | 19.6 | 21.95 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEIN KINASE LYN (Mus musculus) | PK_Tyr_Ser-Thr | 8 | LEU A 253 - LEU A 616VAL A 261 - VAL A 624ALA A 273 - ALA A 653VAL A 274 - VAL A 654LYS A 275 - LYS A 655THR A 319 - THR A 701MET A 322 - MET A 704LEU A 374 - LEU A 773 | None | 0.70A | 29.6 | 33.75 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wno | RECEPTOR TYROSINE-PROTEIN KINASE LET-23 (Caenorhabditis elegans) | PK_Tyr_Ser-Thr | 8 | LEU A 891 - LEU A 616VAL A 899 - VAL A 624ALA A 917 - ALA A 653LYS A 919 - LYS A 655THR A 963 - THR A 701TYR A 965 - TYR A 703GLY A 969 - GLY A 707LEU A1017 - LEU A 773 | ANP A1201 (-4.1A)ANP A1201 (-4.4A)ANP A1201 (-3.3A)ANP A1201 (-3.8A)ANP A1201 (-3.9A)ANP A1201 (-4.4A)ANP A1201 ( 4.6A)ANP A1201 (-4.7A) | 0.71A | 25.9 | 34.20 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1luf | MUSCLE-SPECIFIC TYROSINE KINASE RECEPTOR MUSK (Rattus norvegicus) | PK_Tyr_Ser-Thr | 7 | VAL A 588 - VAL A 624ALA A 606 - ALA A 653VAL A 607 - VAL A 654TYR A 656 - TYR A 703MET A 657 - MET A 704GLY A 660 - GLY A 707LEU A 731 - LEU A 773 | None | 0.34A | 35.5 | 39.20 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lwm | TYROSINE-PROTEIN KINASE JAK3 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 828 - LEU A 616VAL A 836 - VAL A 624ALA A 853 - ALA A 653VAL A 854 - VAL A 654TYR A 904 - TYR A 703GLY A 908 - GLY A 707LEU A 956 - LEU A 773 | 79T A1201 (-4.0A)79T A1201 (-4.5A)79T A1201 (-3.3A)None79T A1201 (-4.7A)79T A1201 ( 4.0A)79T A1201 (-4.6A) | 0.37A | 28.9 | 34.12 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6oko | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 3 (Mus musculus) | Pkinase | 7 | VAL A 36 - VAL A 624ALA A 49 - ALA A 653VAL A 50 - VAL A 654LYS A 51 - LYS A 655THR A 95 - THR A 701GLY A 101 - GLY A 707LEU A 150 - LEU A 773 | 1FN A4000 (-4.2A)1FN A4000 (-3.3A)None1FN A4000 (-2.7A)1FN A4000 (-3.5A)1FN A4000 ( 4.3A)1FN A4000 (-4.5A) | 0.44A | 22.9 | 27.18 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6pnx | FIBROBLAST GROWTH FACTOR RECEPTOR 3 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 478 - LEU A 616VAL A 486 - VAL A 624ALA A 506 - ALA A 653VAL A 507 - VAL A 654TYR A 557 - TYR A 703GLY A 561 - GLY A 707LEU A 624 - LEU A 773 | ACP A 801 (-4.1A)ACP A 801 ( 4.8A)ACP A 801 (-3.4A)NoneACP A 801 (-4.5A)ACP A 801 ( 3.9A)ACP A 801 (-4.9A) | 0.44A | 30.5 | 34.50 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wno | SERINE/THREONINE-PROTEIN KINASE ULK1 (Homo sapiens) | Pkinase | 7 | VAL A 30 - VAL A 624ALA A 44 - ALA A 653VAL A 45 - VAL A 654LYS A 46 - LYS A 655TYR A 94 - TYR A 703GLY A 98 - GLY A 707LEU A 145 - LEU A 773 | 3RF A 401 (-3.8A)3RF A 401 (-3.3A)None3RF A 401 ( 3.1A)3RF A 401 (-3.8A)3RF A 401 (-3.6A)3RF A 401 (-4.0A) | 0.46A | 22.6 | 27.46 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (Homo sapiens) | PK_Tyr_Ser-ThrTGF_beta_GS | 7 | VAL A 218 - VAL A 624ALA A 229 - ALA A 653VAL A 230 - VAL A 654THR A 279 - THR A 701TYR A 281 - TYR A 703GLY A 285 - GLY A 707LEU A 339 - LEU A 773 | LDN A 1 ( 4.8A)LDN A 1 (-3.6A)NoneLDN A 1 (-3.8A)LDN A 1 ( 4.8A)LDN A 1 (-3.3A)LDN A 1 (-4.5A) | 0.46A | 23.6 | 24.79 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8s | TGF-BETA RECEPTOR TYPE-1 (Homo sapiens) | Pkinase | 7 | VAL A 219 - VAL A 624ALA A 230 - ALA A 653VAL A 231 - VAL A 654LYS A 232 - LYS A 655TYR A 282 - TYR A 703GLY A 286 - GLY A 707LEU A 340 - LEU A 773 | None | 0.47A | 24.3 | 25.79 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5p9j | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 408 - LEU A 616VAL A 416 - VAL A 624ALA A 428 - ALA A 653LYS A 430 - LYS A 655THR A 474 - THR A 701TYR A 476 - TYR A 703MET A 477 - MET A 704 | 8E8 A 701 (-4.2A)8E8 A 701 ( 4.5A)8E8 A 701 (-3.3A)8E8 A 701 (-3.4A)8E8 A 701 (-3.2A)8E8 A 701 ( 4.9A)None | 0.50A | 29.3 | 28.92 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ew8 | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 484 - LEU A 616VAL A 492 - VAL A 624ALA A 512 - ALA A 653VAL A 513 - VAL A 654TYR A 563 - TYR A 703GLY A 567 - GLY A 707LEU A 630 - LEU A 773 | 5SF A 803 (-3.8A)5SF A 803 ( 4.2A)5SF A 803 (-3.2A)None5SF A 803 (-3.9A)5SF A 803 (-3.5A)5SF A 803 (-4.1A) | 0.50A | 30.8 | 37.54 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ork | SERINE/THREONINE PROTEIN KINASE (Mycobacterium tuberculosis) | Pkinase | 7 | LEU A 17 - LEU A 616VAL A 25 - VAL A 624ALA A 38 - ALA A 653VAL A 39 - VAL A 654LYS A 40 - LYS A 655TYR A 94 - TYR A 703GLY A 97 - GLY A 707 | AGS A 340 (-3.9A)AGS A 340 (-4.1A)AGS A 340 (-3.4A)NoneAGS A 340 (-2.3A)NoneNone | 0.51A | 22.4 | 25.21 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-A RECEPTOR 5 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | VAL A 689 - VAL A 624ALA A 705 - ALA A 653THR A 753 - THR A 701TYR A 755 - TYR A 703MET A 756 - MET A 704GLY A 759 - GLY A 707LEU A 807 - LEU A 773 | None | 0.51A | 30.6 | 35.98 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATED KINASE (Homo sapiens) | Pkinase | 7 | LEU A 46 - LEU A 616VAL A 54 - VAL A 624ALA A 67 - ALA A 653LYS A 69 - LYS A 655THR A 123 - THR A 701GLY A 128 - GLY A 707LEU A 180 - LEU A 773 | SIN A 401 ( 3.9A)NoneSIN A 401 ( 3.7A)NoneNoneSIN A 401 (-3.5A)SIN A 401 ( 4.5A) | 0.51A | 19.9 | 25.56 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3p86 | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsis thaliana) | PK_Tyr_Ser-Thr | 7 | VAL A 565 - VAL A 624ALA A 576 - ALA A 653VAL A 577 - VAL A 654THR A 625 - THR A 701TYR A 627 - TYR A 703GLY A 631 - GLY A 707LEU A 683 - LEU A 773 | STU A 0 (-4.8A)STU A 0 (-3.3A)NoneSTU A 0 (-4.1A)STU A 0 (-4.6A)STU A 0 (-3.3A)STU A 0 (-4.4A) | 0.51A | 26.7 | 31.65 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ugc | TYROSINE-PROTEIN KINASE JAK2 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 855 - LEU A 616VAL A 863 - VAL A 624ALA A 880 - ALA A 653VAL A 881 - VAL A 654TYR A 931 - TYR A 703GLY A 935 - GLY A 707LEU A 983 - LEU A 773 | 046 A1201 (-3.4A)046 A1201 (-4.7A)046 A1201 (-3.5A)None046 A1201 (-4.3A)046 A1201 (-3.6A)046 A1201 (-4.8A) | 0.51A | 30.5 | 32.62 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6oko | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 3 (Mus musculus) | Pkinase | 7 | VAL A 36 - VAL A 624ALA A 49 - ALA A 653VAL A 50 - VAL A 654THR A 95 - THR A 701MET A 98 - MET A 704GLY A 101 - GLY A 707LEU A 150 - LEU A 773 | 1FN A4000 (-4.2A)1FN A4000 (-3.3A)None1FN A4000 (-3.5A)1FN A4000 (-4.5A)1FN A4000 ( 4.3A)1FN A4000 (-4.5A) | 0.52A | 22.9 | 27.18 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k00 | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE (Homo sapiens) | Pkinase | 7 | VAL A 25 - VAL A 624ALA A 38 - ALA A 653LYS A 40 - LYS A 655MET A 84 - MET A 699TYR A 88 - TYR A 703GLY A 92 - GLY A 707LEU A 139 - LEU A 773 | 6PV A 401 ( 4.7A)6PV A 401 (-3.6A)6PV A 401 (-2.7A)None6PV A 401 (-4.5A)6PV A 401 (-3.5A)6PV A 401 (-4.7A) | 0.54A | 22.7 | 23.44 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4csv | SRC-ABL TYROSINE KINASE ANCESTOR (Synthetic construct) | NA | 7 | LEU A 14 - LEU A 616VAL A 22 - VAL A 624ALA A 35 - ALA A 653VAL A 36 - VAL A 654LYS A 37 - LYS A 655THR A 81 - THR A 701TYR A 83 - TYR A 703 | STI A1265 ( 4.7A)STI A1265 ( 4.9A)STI A1265 (-3.5A)NoneNoneSTI A1265 (-3.0A)STI A1265 (-3.9A) | 0.54A | 31.7 | 39.81 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sxs | CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 423 - LEU A 616VAL A 431 - VAL A 624ALA A 443 - ALA A 653VAL A 444 - VAL A 654THR A 489 - THR A 701TYR A 491 - TYR A 703LEU A 543 - LEU A 773 | PP2 A 1 (-4.1A)PP2 A 1 (-4.5A)PP2 A 1 (-3.2A)NonePP2 A 1 (-3.3A)PP2 A 1 ( 4.9A)PP2 A 1 (-4.6A) | 0.54A | 28.4 | 30.70 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5p9j | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 408 - LEU A 616VAL A 416 - VAL A 624ALA A 428 - ALA A 653THR A 474 - THR A 701TYR A 476 - TYR A 703MET A 477 - MET A 704LEU A 528 - LEU A 773 | 8E8 A 701 (-4.2A)8E8 A 701 ( 4.5A)8E8 A 701 (-3.3A)8E8 A 701 (-3.2A)8E8 A 701 ( 4.9A)None8E8 A 701 (-4.6A) | 0.54A | 29.3 | 28.92 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l68 | LEUCINE-RICH REPEAT PROTEIN KINASE-LIKE PROTEIN (Arabidopsis thaliana) | PK_Tyr_Ser-Thr | 7 | ALA A 333 - ALA A 653VAL A 334 - VAL A 654LYS A 335 - LYS A 655TYR A 381 - TYR A 703MET A 382 - MET A 704GLY A 385 - GLY A 707LEU A 436 - LEU A 773 | None | 0.55A | 18.6 | 26.08 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xir | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (NA) | PK_Tyr_Ser-Thr | 7 | LEU A 840 - LEU A 616VAL A 848 - VAL A 624ALA A 866 - ALA A 653VAL A 867 - VAL A 654LYS A 868 - LYS A 655GLY A 922 - GLY A 707LEU A1035 - LEU A 773 | 00J A2169 (-3.5A)00J A2169 (-4.3A)00J A2169 (-3.4A)None00J A2169 (-3.8A)00J A2169 (-3.5A)00J A2169 (-4.5A) | 0.56A | 34.1 | 32.74 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uim | BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (Arabidopsis thaliana) | Pkinase | 7 | LEU A 295 - LEU A 616VAL A 303 - VAL A 624ALA A 315 - ALA A 653VAL A 316 - VAL A 654TYR A 365 - TYR A 703MET A 366 - MET A 704GLY A 369 - GLY A 707 | ANP A1000 (-4.4A)ANP A1000 (-4.3A)ANP A1000 (-3.4A)NoneANP A1000 (-4.3A)NoneANP A1000 ( 4.5A) | 0.57A | 20.5 | 24.72 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ziw | INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 3 (Homo sapiens) | Pkinase | 7 | VAL I 179 - VAL A 624ALA I 190 - ALA A 653VAL I 191 - VAL A 654TYR I 243 - TYR A 703MET I 244 - MET A 704GLY I 247 - GLY A 707LEU I 300 - LEU A 773 | AGS I 501 (-4.2A)AGS I 501 (-3.5A)NoneAGS I 501 ( 4.1A)NoneNoneAGS I 501 (-4.8A) | 0.58A | 21.8 | 24.50 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u6b | TYROSINE-PROTEIN KINASE RECEPTOR UFO (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 542 - LEU A 616VAL A 550 - VAL A 624ALA A 565 - ALA A 653VAL A 566 - VAL A 654LYS A 567 - LYS A 655MET A 623 - MET A 704GLY A 626 - GLY A 707 | 7YS A9001 (-4.1A)7YS A9001 (-4.2A)7YS A9001 (-3.3A)NoneNone7YS A9001 (-4.7A)7YS A9001 (-3.4A) | 0.59A | 28.6 | 39.52 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) | PkinasePkinase_C | 7 | LEU A 663 - LEU A 616VAL A 671 - VAL A 624ALA A 684 - ALA A 653LYS A 686 - LYS A 655TYR A 739 - TYR A 703GLY A 743 - GLY A 707LEU A 789 - LEU A 773 | AGS A1985 (-4.2A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)AGS A1985 (-3.0A)NoneNoneAGS A1985 (-4.8A) | 0.59A | 20.6 | 24.58 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pp0 | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 726 - LEU A 616VAL A 734 - VAL A 624ALA A 751 - ALA A 653THR A 798 - THR A 701MET A 801 - MET A 704GLY A 804 - GLY A 707LEU A 852 - LEU A 773 | 03Q A 1 (-3.8A)03Q A 1 (-4.5A)03Q A 1 (-3.1A)03Q A 1 (-4.1A)None03Q A 1 ( 3.9A)03Q A 1 (-4.4A) | 0.59A | 28.2 | 33.24 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6srh | ACTIVIN RECEPTOR TYPE-1 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | VAL A 222 - VAL A 624ALA A 233 - ALA A 653VAL A 234 - VAL A 654LYS A 235 - LYS A 655THR A 283 - THR A 701GLY A 289 - GLY A 707LEU A 343 - LEU A 773 | LU8 A 501 ( 3.8A)LU8 A 501 (-2.7A)LU8 A 501 ( 4.8A)LU8 A 501 (-4.0A)LU8 A 501 (-2.3A)LU8 A 501 (-3.4A)LU8 A 501 (-4.2A) | 0.59A | 23.7 | 29.13 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sxs | CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 423 - LEU A 616ALA A 443 - ALA A 653VAL A 444 - VAL A 654THR A 489 - THR A 701TYR A 491 - TYR A 703GLY A 495 - GLY A 707LEU A 543 - LEU A 773 | PP2 A 1 (-4.1A)PP2 A 1 (-3.2A)NonePP2 A 1 (-3.3A)PP2 A 1 ( 4.9A)PP2 A 1 ( 4.2A)PP2 A 1 (-4.6A) | 0.59A | 28.4 | 30.70 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zbf | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | VAL A1959 - VAL A 624ALA A1978 - ALA A 653VAL A1979 - VAL A 654LYS A1980 - LYS A 655MET A2029 - MET A 704GLY A2032 - GLY A 707LEU A2086 - LEU A 773 | NoneVGH A3000 (-3.4A)NoneVGH A3000 ( 4.7A)NoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.59A | 30.2 | 35.80 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6pnx | FIBROBLAST GROWTH FACTOR RECEPTOR 3 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 478 - LEU A 616VAL A 486 - VAL A 624ALA A 506 - ALA A 653LYS A 508 - LYS A 655TYR A 557 - TYR A 703GLY A 561 - GLY A 707LEU A 624 - LEU A 773 | ACP A 801 (-4.1A)ACP A 801 ( 4.8A)ACP A 801 (-3.4A)NoneACP A 801 (-4.5A)ACP A 801 ( 3.9A)ACP A 801 (-4.9A) | 0.60A | 30.5 | 34.50 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5p9j | TYROSINE-PROTEIN KINASE BTK (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 408 - LEU A 616ALA A 428 - ALA A 653THR A 474 - THR A 701TYR A 476 - TYR A 703MET A 477 - MET A 704GLY A 480 - GLY A 707LEU A 528 - LEU A 773 | 8E8 A 701 (-4.2A)8E8 A 701 (-3.3A)8E8 A 701 (-3.2A)8E8 A 701 ( 4.9A)None8E8 A 701 (-3.3A)8E8 A 701 (-4.6A) | 0.60A | 29.3 | 28.92 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6zjf | SERINE/THREONINE-PROTEIN KINASE 17B (Homo sapiens) | Pkinase | 7 | LEU A 39 - LEU A 616VAL A 47 - VAL A 624ALA A 60 - ALA A 653LYS A 62 - LYS A 655TYR A 112 - TYR A 703GLY A 116 - GLY A 707LEU A 165 - LEU A 773 | QM2 A 401 (-3.8A)QM2 A 401 ( 4.8A)QM2 A 401 (-3.4A)QM2 A 401 (-2.7A)QM2 A 401 (-4.4A)QM2 A 401 (-3.6A)QM2 A 401 (-4.7A) | 0.60A | 23.1 | 24.31 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r4b | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 724 - LEU A 616VAL A 732 - VAL A 624ALA A 749 - ALA A 653THR A 796 - THR A 701MET A 799 - MET A 704GLY A 802 - GLY A 707LEU A 850 - LEU A 773 | GW7 A 1 ( 4.2A)GW7 A 1 ( 4.8A)GW7 A 1 (-3.3A)GW7 A 1 (-4.0A)NoneGW7 A 1 (-3.6A)GW7 A 1 (-4.2A) | 0.61A | 28.1 | 32.76 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6d | 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (Homo sapiens) | Pkinase | 7 | LEU A 22 - LEU A 616VAL A 30 - VAL A 624ALA A 43 - ALA A 653VAL A 44 - VAL A 654LYS A 45 - LYS A 655MET A 91 - MET A 699TYR A 95 - TYR A 703 | None | 0.62A | 20.6 | 27.49 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5i | PROTEIN KINASE (Plasmodium berghei) | NA | 7 | LEU A 63 - LEU A 616VAL A 71 - VAL A 624ALA A 84 - ALA A 653LYS A 86 - LYS A 655THR A 144 - THR A 701GLY A 150 - GLY A 707LEU A 197 - LEU A 773 | ANP A1634 ( 4.3A)ANP A1634 (-4.1A)ANP A1634 (-3.6A)ANP A1634 (-3.1A)ANP A1634 (-4.6A)NoneANP A1634 (-4.4A) | 0.62A | 20.4 | 22.31 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4yjr | TYROSINE-PROTEIN KINASE SYK (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 377 - LEU A 616VAL A 385 - VAL A 624ALA A 400 - ALA A 653VAL A 401 - VAL A 654LYS A 402 - LYS A 655GLY A 454 - GLY A 707LEU A 501 - LEU A 773 | 4DJ A 701 ( 4.4A)4DJ A 701 (-3.9A)4DJ A 701 (-3.3A)4DJ A 701 ( 4.7A)4DJ A 701 (-4.0A)4DJ A 701 (-3.5A)4DJ A 701 (-4.2A) | 0.65A | 26.7 | 32.82 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gr8 | AURORA KINASE C (Homo sapiens) | Pkinase | 7 | LEU A 49 - LEU A 616VAL A 57 - VAL A 624ALA A 70 - ALA A 653LYS A 72 - LYS A 655TYR A 122 - TYR A 703GLY A 126 - GLY A 707LEU A 173 - LEU A 773 | F8Z A 401 (-3.8A)F8Z A 401 (-4.5A)F8Z A 401 (-3.4A)F8Z A 401 (-2.6A)F8Z A 401 ( 4.8A)F8Z A 401 ( 4.5A)F8Z A 401 (-4.2A) | 0.65A | 21.9 | 26.89 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r4b | RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 724 - LEU A 616VAL A 732 - VAL A 624ALA A 749 - ALA A 653LYS A 751 - LYS A 655MET A 799 - MET A 704GLY A 802 - GLY A 707LEU A 850 - LEU A 773 | GW7 A 1 ( 4.2A)GW7 A 1 ( 4.8A)GW7 A 1 (-3.3A)GW7 A 1 (-3.9A)NoneGW7 A 1 (-3.6A)GW7 A 1 (-4.2A) | 0.65A | 28.1 | 32.76 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oz6 | MITOGEN-ACTIVATED PROTEIN KINASE 1, SERINE/THREONINE PROTEIN KINASE (Cryptosporidium parvum iowa ii) | Pkinase | 7 | VAL A 25 - VAL A 624ALA A 38 - ALA A 653VAL A 39 - VAL A 654LYS A 40 - LYS A 655ASP A 91 - ASP A 702TYR A 92 - TYR A 703LEU A 141 - LEU A 773 | None | 0.66A | 19.6 | 25.18 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4asz | BDNF/NT-3 GROWTH FACTORS RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 560 - LEU A 616VAL A 568 - VAL A 624ALA A 586 - ALA A 653VAL A 587 - VAL A 654LYS A 588 - LYS A 655MET A 631 - MET A 699TYR A 635 - TYR A 703 | None | 0.66A | 32.4 | 47.06 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uim | BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (Arabidopsis thaliana) | Pkinase | 7 | VAL A 303 - VAL A 624ALA A 315 - ALA A 653VAL A 316 - VAL A 654TYR A 365 - TYR A 703MET A 366 - MET A 704GLY A 369 - GLY A 707LEU A 423 - LEU A 773 | ANP A1000 (-4.3A)ANP A1000 (-3.4A)NoneANP A1000 (-4.3A)NoneANP A1000 ( 4.5A)ANP A1000 (-4.8A) | 0.66A | 20.5 | 24.72 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6srh | ACTIVIN RECEPTOR TYPE-1 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | ALA A 233 - ALA A 653VAL A 234 - VAL A 654LYS A 235 - LYS A 655THR A 283 - THR A 701TYR A 285 - TYR A 703GLY A 289 - GLY A 707LEU A 343 - LEU A 773 | LU8 A 501 (-2.7A)LU8 A 501 ( 4.8A)LU8 A 501 (-4.0A)LU8 A 501 (-2.3A)LU8 A 501 (-3.2A)LU8 A 501 (-3.4A)LU8 A 501 (-4.2A) | 0.66A | 23.7 | 29.13 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uim | BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (Arabidopsis thaliana) | Pkinase | 7 | LEU A 295 - LEU A 616VAL A 303 - VAL A 624ALA A 315 - ALA A 653LYS A 317 - LYS A 655TYR A 365 - TYR A 703MET A 366 - MET A 704GLY A 369 - GLY A 707 | ANP A1000 (-4.4A)ANP A1000 (-4.3A)ANP A1000 (-3.4A)ANP A1000 ( 3.8A)ANP A1000 (-4.3A)NoneANP A1000 ( 4.5A) | 0.67A | 20.5 | 24.72 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fex | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 616 - LEU A 616VAL A 624 - VAL A 624ALA A 653 - ALA A 653VAL A 654 - VAL A 654MET A 699 - MET A 699ASP A 702 - ASP A 702TYR A 703 - TYR A 703 | D6Z A1001 ( 4.1A)D6Z A1001 (-4.1A)D6Z A1001 (-3.0A)NoneD6Z A1001 ( 3.1A)NoneD6Z A1001 (-4.1A) | 0.67A | 41.4 | 95.64 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtk | SERINE/THREONINE-PROTEIN KINASE 11 (Homo sapiens) | Pkinase | 7 | LEU C 55 - LEU A 616VAL C 63 - VAL A 624ALA C 76 - ALA A 653VAL C 77 - VAL A 654MET C 127 - MET A 699TYR C 131 - TYR A 703LEU C 183 - LEU A 773 | ANP C 2 ( 4.4A)ANP C 2 (-4.2A)ANP C 2 (-3.4A)NoneNoneNoneNone | 0.68A | 22.1 | 25.42 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fex | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 616 - LEU A 616VAL A 624 - VAL A 624ALA A 653 - ALA A 653VAL A 654 - VAL A 654THR A 701 - THR A 701ASP A 702 - ASP A 702TYR A 703 - TYR A 703 | D6Z A1001 ( 4.1A)D6Z A1001 (-4.1A)D6Z A1001 (-3.0A)NoneD6Z A1001 (-4.5A)NoneD6Z A1001 (-4.1A) | 0.69A | 41.4 | 95.64 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lvo | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (Homo sapiens) | Pkinase | 7 | LEU A 88 - LEU A 616VAL A 96 - VAL A 624ALA A 109 - ALA A 653LYS A 111 - LYS A 655TYR A 161 - TYR A 703GLY A 165 - GLY A 707LEU A 212 - LEU A 773 | ATP A 401 ( 4.4A)ATP A 401 (-4.3A)ATP A 401 (-3.6A)ATP A 401 (-2.4A)ATP A 401 ( 4.3A)NoneNone | 0.70A | 22.3 | 25.21 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (Homo sapiens) | PK_Tyr_Ser-ThrTGF_beta_GS | 7 | VAL A 218 - VAL A 624ALA A 229 - ALA A 653VAL A 230 - VAL A 654THR A 279 - THR A 701ASP A 280 - ASP A 702TYR A 281 - TYR A 703GLY A 285 - GLY A 707 | LDN A 1 ( 4.8A)LDN A 1 (-3.6A)NoneLDN A 1 (-3.8A)NoneLDN A 1 ( 4.8A)LDN A 1 (-3.3A) | 0.70A | 23.6 | 24.79 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7j | PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens) | Pkinase | 7 | VAL A 38 - VAL A 624ALA A 51 - ALA A 653VAL A 52 - VAL A 654ASP A 108 - ASP A 702MET A 110 - MET A 704GLY A 113 - GLY A 707LEU A 160 - LEU A 773 | NoneB49 A1294 (-3.2A)NoneNoneNoneB49 A1294 (-3.6A)B49 A1294 (-4.4A) | 0.70A | 23.3 | 25.95 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sxs | CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 423 - LEU A 616ALA A 443 - ALA A 653VAL A 444 - VAL A 654LYS A 445 - LYS A 655THR A 489 - THR A 701TYR A 491 - TYR A 703LEU A 543 - LEU A 773 | PP2 A 1 (-4.1A)PP2 A 1 (-3.2A)NonePP2 A 1 (-4.5A)PP2 A 1 (-3.3A)PP2 A 1 ( 4.9A)PP2 A 1 (-4.6A) | 0.71A | 28.4 | 30.70 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEIN KINASE LYN (Mus musculus) | PK_Tyr_Ser-Thr | 7 | LEU A 253 - LEU A 616ALA A 273 - ALA A 653VAL A 274 - VAL A 654THR A 319 - THR A 701MET A 322 - MET A 704GLY A 325 - GLY A 707LEU A 374 - LEU A 773 | None | 0.72A | 29.6 | 33.75 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9i | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (Homo sapiens) | Pkinase | 7 | LEU A 78 - LEU A 616VAL A 86 - VAL A 624ALA A 99 - ALA A 653LYS A 101 - LYS A 655MET A 150 - MET A 704GLY A 153 - GLY A 707LEU A 201 - LEU A 773 | ATP A 535 (-3.9A)ATP A 535 (-4.1A)ATP A 535 (-3.6A)ATP A 535 ( 2.5A)NoneATP A 535 ( 4.7A)ATP A 535 (-4.8A) | 0.74A | 21.0 | 24.03 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tos | SERINE/THREONINE-PROTEIN KINASE BIK1 (Arabidopsis thaliana) | PK_Tyr_Ser-Thr | 7 | VAL A 81 - VAL A 624ALA A 103 - ALA A 653VAL A 104 - VAL A 654LYS A 105 - LYS A 655MET A 153 - MET A 704GLY A 156 - GLY A 707LEU A 209 - LEU A 773 | None | 0.76A | 20.8 | 24.76 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6d | 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (Homo sapiens) | Pkinase | 7 | LEU A 22 - LEU A 616VAL A 30 - VAL A 624ALA A 43 - ALA A 653VAL A 44 - VAL A 654LYS A 45 - LYS A 655MET A 91 - MET A 699GLY A 99 - GLY A 707 | None | 0.77A | 20.6 | 27.49 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uim | BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (Arabidopsis thaliana) | Pkinase | 7 | VAL A 303 - VAL A 624ALA A 315 - ALA A 653LYS A 317 - LYS A 655TYR A 365 - TYR A 703MET A 366 - MET A 704GLY A 369 - GLY A 707LEU A 423 - LEU A 773 | ANP A1000 (-4.3A)ANP A1000 (-3.4A)ANP A1000 ( 3.8A)ANP A1000 (-4.3A)NoneANP A1000 ( 4.5A)ANP A1000 (-4.8A) | 0.77A | 20.5 | 24.72 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6vg3 | INACTIVE TYROSINE-PROTEIN KINASE 7 (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 802 - LEU A 616VAL A 810 - VAL A 624VAL A 829 - VAL A 654LYS A 830 - LYS A 655MET A 873 - MET A 699GLY A 881 - GLY A 707LEU A 937 - LEU A 773 | None | 0.80A | 32.9 | 34.97 | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jfw | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (Homo sapiens) | PK_Tyr_Ser-Thr | 7 | LEU A 516 - LEU A 616VAL A 524 - VAL A 624ALA A 542 - ALA A 653VAL A 543 - VAL A 654LYS A 544 - LYS A 655TYR A 591 - TYR A 703GLY A 595 - GLY A 707 | 6K2 A4000 ( 4.5A)6K2 A4000 ( 4.8A)6K2 A4000 (-3.4A)None6K2 A4000 ( 4.3A)6K2 A4000 ( 4.9A)6K2 A4000 ( 4.4A) | 0.82A | 31.0 | 43.94 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h0b | TYROSINE-PROTEIN KINASE HCK (Homo sapiens) | PK_Tyr_Ser-ThrSH2SH3_1 | 7 | LEU A 273 - LEU A 616ALA A 293 - ALA A 653VAL A 294 - VAL A 654THR A 338 - THR A 701MET A 341 - MET A 704GLY A 344 - GLY A 707LEU A 393 - LEU A 773 | OOQ A 601 (-4.6A)OOQ A 601 (-3.1A)NoneOOQ A 601 (-3.3A)NoneOOQ A 601 ( 4.0A)OOQ A 601 (-4.4A) | 0.84A | 27.9 | 25.63 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfi | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) | PK_Tyr_Ser-Thr | 6 | VAL A 477 - VAL A 624ALA A 488 - ALA A 653THR A 539 - THR A 701TYR A 541 - TYR A 703GLY A 545 - GLY A 707LEU A 595 - LEU A 773 | 4CW A 801 ( 4.8A)4CW A 801 (-3.3A)4CW A 801 (-2.7A)4CW A 801 (-4.2A)4CW A 801 ( 3.9A)4CW A 801 (-4.4A) | 0.28A | 23.8 | 29.53 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af3 | AURORA KINASE B (Homo sapiens) | Pkinase | 6 | LEU A 83 - LEU A 616VAL A 91 - VAL A 624ALA A 104 - ALA A 653TYR A 156 - TYR A 703GLY A 160 - GLY A 707LEU A 207 - LEU A 773 | VX6 A 500 (-3.8A)VX6 A 500 ( 4.8A)VX6 A 500 (-3.4A)VX6 A 500 (-4.2A)VX6 A 500 (-3.3A)VX6 A 500 (-4.6A) | 0.31A | 19.4 | 26.57 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTOR TYPE IIB (Homo sapiens) | Pkinase | 6 | ALA A 215 - ALA A 653VAL A 216 - VAL A 654LYS A 217 - LYS A 655THR A 265 - THR A 701GLY A 271 - GLY A 707LEU A 328 - LEU A 773 | ADE A 488 (-3.2A)NoneNoneADE A 488 (-4.3A)ADE A 488 ( 4.1A)ADE A 488 (-4.4A) | 0.35A | 23.7 | 25.00 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5loh | SERINE/THREONINE-PROTEIN KINASE GREATWALL (Homo sapiens) | Pkinase | 6 | VAL A 49 - VAL A 624ALA A 60 - ALA A 653VAL A 61 - VAL A 654TYR A 112 - TYR A 703GLY A 116 - GLY A 707LEU A 163 - LEU A 773 | NoneSTU A 901 (-3.3A)NoneSTU A 901 (-4.6A)STU A 901 (-3.5A)STU A 901 (-4.5A) | 0.35A | 20.1 | 25.07 | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0y | SERINE/THREONINE-PROTEIN KINASE TOUSLED-LIKE 2 (Homo sapiens) | Pkinase | 6 | LEU A 468 - LEU A 616VAL A 476 - VAL A 624ALA A 489 - ALA A 653VAL A 490 - VAL A 654LYS A 491 - LYS A 655TYR A 546 - TYR A 703 | AGS A 801 (-4.1A)AGS A 801 (-4.0A)AGS A 801 (-3.6A)NoneAGS A 801 (-2.8A)AGS A 801 ( 4.8A) | 0.37A | 20.8 | 19.73 | ||
| Hit | Macromolecule/ Organism | Pfam | Res. | Residue Matches | HETATM Residue/s | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock |