Ligand ID: T1C


Drugbank ID:
DB00560
(Tigecycline)


Indication:
For the treatment of infections caused by susceptible strains of the designated microorganisms in the following conditions: Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes and Bacteroides fragilis. Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros.

Get human targets for T1C in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'T1C' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN B 498
PHE B 497
GLY B 447
SER B 443
GLY B 504
1.61A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 11
ASP B  38
ASN E 439
GLN E 506
GLY E 502
GLY E 447
1.79A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE C   3
HIS A 172
GLY C   2
ALA C   7
GLY A 124
1.75A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR C 169
HIS C 172
GLY C 138
ALA A 211
GLY A 215
1.75A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE B   3
HIS D 172
GLY B   2
ALA B   7
GLY D 124
1.78A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE B   3
HIS D 172
GLY B   2
ALA B   7
GLY D 124
1.79A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE A   3
HIS C 172
GLY A   2
ALA A   7
GLY C 124
1.76A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR D 169
HIS D 172
GLY D 138
ALA B 211
GLY B 215
1.78A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE D   3
HIS B 172
GLY D   2
ALA D   7
GLY B 124
1.74A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE D   3
HIS B 172
GLY D   2
ALA D   7
GLY B 124
1.76A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE C   3
HIS A 172
GLY C   2
ALA C   7
GLY A 124
1.73A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR A 169
HIS A 172
GLY A 138
ALA C 211
GLY C 215
1.63A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR B 169
HIS B 172
GLY B 138
ALA D 211
GLY D 215
1.56A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE A   3
HIS C 172
GLY A   2
ALA A   7
GLY C 124
1.75A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY A 148
PRO A 118
ALA D 153
GLY A 121
ASN D 151
1.31A22.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY A 148
PRO A 118
ALA D 153
GLY A 121
ASN D 151
1.44A17.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 769
PHE A 753
HIS A 613
ALA A 706
GLY A 774
1.69A17.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.51A16.57
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.49A16.41
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.49A16.57
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 758
GLN C 957
THR C 961
GLN A 762
LEU A1012
1.68A10.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.49A16.65
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A 613
GLY A 594
ALA B 766
GLY B 769
GLN B 762
1.46A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.49A16.57
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.52A16.41
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
PHE B 135
ASN B 137
GLY B 141
GLY B 126
GLU B 146
1.73A27.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASN B   9
HIS B  15
GLY B  14
ALA B  55
ASN B  46
1.47A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER C 758
GLN B 957
THR B 961
GLN C 762
LEU C1012
1.67A10.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLN C 920
PHE C 898
ASN B 709
GLY C 799
MET C1050
1.47A16.18
None
None
NAG  B1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN C 920
PHE C 898
ASN B 709
GLY C 799
MET C1050
1.51A16.38
None
None
NAG  B1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN C 920
PHE C 898
ASN B 709
GLY C 799
MET C1050
1.53A16.38
None
None
NAG  B1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A 920
PHE A 898
ASN C 709
GLY A 798
MET A1050
1.50A16.18
None
None
NAG  C1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLN C 920
PHE C 898
ASN B 709
GLY C 799
MET C1050
1.51A16.38
None
None
NAG  B1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN C 920
PHE C 898
ASN B 709
GLY C 799
MET C1050
1.52A16.46
None
None
NAG  B1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
THR C1066
GLN C 926
ALA A 892
GLY A 891
GLN A 787
1.34A16.18
None
NAG  C1312 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.52A16.46
None
None
NAG  A1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
THR A1027
ARG C1039
GLY C1044
ALA C1025
GLN C 784
1.35A16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.52A16.54
None
None
NAG  A1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN B 920
PHE B 898
ASN A 709
GLY B 798
MET B1050
1.47A16.26
None
None
NAG  A1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.51A16.46
None
None
NAG  A1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 758
GLN C 957
THR C 961
GLN A 762
LEU A1012
1.54A10.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.53A16.46
None
None
NAG  A1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLN B 920
PHE B 898
ASN A 709
GLY B 799
MET B1050
1.46A16.26
None
None
NAG  A1311 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE B 241
HIS B 235
GLY B 247
ALA B 256
GLY B 254
1.48A23.63
None
CIT  B 408 (-4.2A)
CIT  B 408 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 11
GLN C 498
PHE C 497
GLY C 447
SER C 443
GLY C 504
1.53A14.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4323
MET A6839
1.54A15.83
None
None
SAM  A7102 ( 4.5A)
None
BDF  B4403 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4322
MET A6839
1.57A
None
None
SAM  A7104 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6w61 NSP10
(SARS-CoV-2)		5 / 11
ARG B4331
PHE B4321
GLY B4322
GLY B4362
ASN B4358
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR A6915
PHE A6954
GLY A6953
ALA A6919
ASN A6920
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4323
MET A6839
1.49A
None
None
SAM  A7104 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS D4333
GLY C6875
SER C6872
GLY D4323
MET C6839
1.42A15.83
None
None
SAM  C7105 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4322
MET A6839
1.49A15.83
None
None
SAM  A7102 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR C6915
PHE C6954
GLY C6953
ALA C6919
ASN C6920
1.69A17.59
None
None
None
None
FMT  C7106 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6w75 NSP10
(SARS-CoV-2)		5 / 11
ARG B4331
PHE B4321
GLY B4322
GLY B4362
ASN B4358
1.78A15.18
None
None
None
None
NA  B4403 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6w75 NSP10
(SARS-CoV-2)		5 / 11
ARG D4331
PHE D4321
GLY D4322
GLY D4362
ASN D4358
1.76A15.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS D4333
GLY C6875
SER C6872
GLY D4322
MET C6839
1.47A15.83
None
None
SAM  C7105 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4323
MET A6839
1.46A15.83
None
None
SAM  A7102 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR A6915
PHE A6954
GLY A6953
ALA A6919
ASN A6920
1.71A17.59
None
None
None
None
FMT  A7106 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
PHE C 173
ASN C 128
HIS C 175
MET C 243
GLN C 237
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 173
ASN A 128
HIS A 175
MET A 243
GLN A 237
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
PHE B 173
ASN B 128
HIS B 175
MET B 243
GLN B 237
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
ASN A 101
ALA A  50
GLY A  48
ASN A  37
1.78A
MES  A 201 (-2.5A)
None
MES  A 201 ( 3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE F 315
GLY F 316
ALA E 336
GLY E 335
GLN F 260
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE E 315
GLY E 316
ALA F 336
GLY F 335
GLN E 260
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE A 315
GLY A 316
ALA B 336
GLY B 335
GLN A 260
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR E 332
GLN E 281
ALA E 336
GLY E 335
GLN F 260
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR B 332
GLN B 281
ALA B 336
GLY B 335
GLN A 260
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE B 315
GLY B 316
ALA A 336
GLY A 335
GLN B 260
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE C 315
GLY C 316
ALA D 336
GLY D 335
GLN C 260
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE D 315
GLY D 316
ALA C 336
GLY C 335
GLN D 260
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR D 332
GLN D 281
ALA D 336
GLY D 335
GLN C 260
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
HIS D4333
GLY C6875
SER C6872
GLY D4322
MET C6839
1.38A
None
None
SAH  C7102 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
HIS D4333
GLY C6875
SER C6872
GLY D4323
MET C6839
1.32A
None
None
SAH  C7102 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4322
MET A6839
1.37A
None
None
SAH  A7102 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR C6915
PHE C6954
GLY C6953
ALA C6919
ASN C6920
1.76A
FMT  C7107 (-3.7A)
None
None
None
FMT  C7103 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4323
MET A6839
1.36A
None
None
SAH  A7102 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR A6915
PHE A6954
GLY A6953
ALA A6919
ASN A6920
1.68A
None
None
None
None
FMT  A7106 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6wjt NSP10
(SARS-CoV-2)		5 / 11
ARG D4331
PHE D4321
GLY D4322
GLY D4362
ASN D4358
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6wjt NSP10
(SARS-CoV-2)		5 / 11
ARG B4331
PHE B4321
GLY B4322
GLY B4362
ASN B4358
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ASP C 144
ASN C  75
ARG B 107
HIS B  59
GLY C 147
1.60A
None
None
None
ZN  C 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN D 126
GLY D 129
PRO D 117
ALA D 119
GLY D 120
1.63A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN B 126
GLY B 129
PRO B 117
ALA B 119
GLY B 120
1.58A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR A6915
PHE A6954
GLY A6953
ALA A6919
ASN A6920
1.71A
None
None
None
None
FMT  A7109 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS D4333
GLY C6875
SER C6872
GLY D4323
MET C6839
1.39A
None
None
SFG  C7103 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6wkq NSP10
(SARS-CoV-2)		5 / 11
ARG B4331
PHE B4321
GLY B4322
GLY B4362
ASN B4358
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4322
MET A6839
1.41A
None
None
SFG  A7103 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS D4333
GLY C6875
SER C6872
GLY D4322
MET C6839
1.43A
None
None
SFG  C7103 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6wkq NSP10
(SARS-CoV-2)		5 / 11
ARG D4331
PHE D4321
GLY D4322
GLY D4362
ASN D4358
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4323
MET A6839
1.39A
None
None
SFG  A7103 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR C6915
PHE C6954
GLY C6953
ALA C6919
ASN C6920
1.73A
None
None
None
None
FMT  C7106 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE B 241
HIS B 235
GLY B 247
ALA B 256
GLY B 254
1.51A25.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ARG B 136
PHE B 135
ASN B 137
GLY B 141
ASN B 178
1.79A
None
None
None
None
ACT  B 407 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE A 241
HIS A 235
GLY A 247
ALA A 256
GLY A 254
1.51A25.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
PHE A 135
ASN A 137
GLY A 141
GLY A 126
ASN A 178
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ARG A 136
PHE A 135
ASN A 137
GLY A 141
ASN A 178
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
PHE B 135
ASN B 137
GLY B 141
GLY B 126
ASN B 178
1.72A
None
None
None
ACT  B 408 (-4.2A)
ACT  B 407 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE B 135
ASN B 137
GLY B 141
GLY B 126
ASN B 178
1.78A25.48
None
None
None
ACT  B 408 (-4.2A)
ACT  B 407 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE A 135
ASN A 137
GLY A 141
GLY A 126
ASN A 178
1.78A25.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR B 149
ASN B 117
ALA C  50
GLY C  51
ASN C  37
1.47A
None
None
APR  C 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR D 149
ASN D 117
ALA A  50
GLY A  48
ASN A  37
1.32A
None
None
APR  A 201 (-3.4A)
APR  A 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR B 149
ASN B 117
ALA C  50
GLY C  47
ASN C  37
1.51A
None
None
APR  C 201 (-3.5A)
APR  C 201 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR B 149
ASN B 117
ALA C  50
GLY C  48
ASN C  37
1.37A
None
None
APR  C 201 (-3.5A)
APR  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR D 149
ASN D 117
ALA A  50
GLY A  51
ASN A  37
1.44A
None
None
APR  A 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR D 149
ASN D 117
ALA A  50
GLY A  47
ASN A  37
1.48A
None
None
APR  A 201 (-3.4A)
APR  A 201 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4323
MET A6839
1.39A
None
None
SO4  A7109 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
HIS B4333
GLY A6875
SER A6872
GLY B4322
MET A6839
1.50A
None
None
SO4  A7109 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
PHE A 173
ASN A 128
HIS A 175
MET A 243
GLN A 237
1.64A
None
PO4  A 504 (-3.7A)
PO4  A 504 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
PHE A 173
ASN A 128
HIS A 175
GLY A 201
MET A 243
1.80A20.00
None
PO4  A 504 (-3.7A)
PO4  A 504 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
PHE A 173
ASN A 128
HIS A 175
ALA A 204
GLY A 201
1.42A20.00
None
PO4  A 504 (-3.7A)
PO4  A 504 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
HIS C  36
ARG B  80
THR B  89
LEU A  20
SER A  15
1.74A17.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLN E 498
PHE E 497
GLY E 447
SER E 443
GLY E 504
1.78A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
THR C  57
ASN C  87
HIS C  86
ALA D  50
GLY D  51
ASN D  37
1.79A
None
None
None
EDO  D 206 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASN A 115
GLN D 118
HIS D 119
SER A  80
GLY D  78
1.78A
EDO  D 201 (-3.4A)
EDO  D 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASN D 115
GLN A 118
HIS A 119
SER D  80
GLY A  78
1.78A
EDO  D 201 (-3.6A)
EDO  D 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASN E 101
GLY B 130
PRO B 125
ALA B 154
GLU B  26
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
GLN D 118
ASN A 117
ALA A  38
ASN A  37
1.49A
None
EDO  D 201 ( 4.4A)
None
EDO  A 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN C  87
HIS C  86
ALA D  50
GLY D  51
ASN D  37
1.70A19.83
None
None
EDO  D 206 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASN A 115
GLN D 118
HIS D 119
SER A  80
GLY D  78
1.79A
EDO  A 207 (-3.9A)
EDO  A 207 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASN E 101
GLY B 130
PRO B 125
ALA B 154
GLU B  26
1.64A
None
APR  B 201 (-3.2A)
None
APR  B 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN C  87
HIS C  86
ALA D  50
GLY D  51
ASN D  37
1.66A19.83
None
None
APR  D 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
THR C  57
ASN C  87
HIS C  86
ALA D  50
GLY D  51
ASN D  37
1.72A
None
None
None
APR  D 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
GLN D 118
ASN A 117
ALA A  38
ASN A  37
1.49A
None
EDO  A 207 ( 4.7A)
None
APR  A 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASN C 115
GLN A 118
HIS A 119
SER C  80
GLY A  78
1.75A
EDO  A 202 (-3.6A)
EDO  A 202 (-4.6A)
None
EDO  A 204 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASN A 115
GLN C 118
HIS C 119
SER A  80
GLY C  78
1.76A
EDO  A 202 ( 3.5A)
EDO  A 204 (-4.1A)
None
EDO  A 204 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 769
PHE A 753
HIS A 613
ALA A 706
GLY A 774
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 769
PHE A 753
HIS A 613
ALA A 706
GLY A 774
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
THR A 769
PHE A 753
HIS A 613
ALA A 706
GLY A 774
1.75A
None