Ligand ID: STZ


Drugbank ID:
DB00428
(Streptozocin)


Indication:
For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

Get human targets for STZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'STZ' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 11
ASP C   5
CYH C   8
TYR A 420
VAL A 424
VAL A 435
1.77A8.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ASP B1084
THR B1136
VAL B1137
VAL B1133
ASN B1134
1.73A21.02
None
None
None
None
NAG  B1313 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ASP E 288
THR E 271
VAL E 270
ASN E 269
ASN B 345
1.71A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASP D 162
TYR D 161
VAL E 165
ASP E 162
TYR E 161
1.70A13.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ASP D 162
TYR D 161
VAL E 165
ASP E 162
TYR E 161
1.69A13.73
None
None
None
None
EDO  E 203 (-4.0A)