Ligand ID: SHH


Drugbank ID:
DB02546
(Vorinostat)


Indication:
For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.

Get human targets for SHH in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SHH' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A20.00
RZS  A1001 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.54A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A22.34
RZS  A1001 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		5r83 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A20.00
None
K0G  A1001 ( 3.9A)
CL  A1005 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.64A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.68A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.68A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.55A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.80A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU D 962
ASP F1168
ILE F1169
GLY F1167
GLY D 971
1.57A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.70A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A21.04
ALC  D   2 ( 4.1A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A23.10
ALC  D   2 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.54A21.28
ALC  D   2 ( 4.1A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.44A19.95
ALC  D   2 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A21.04
ALC  D   2 ( 4.1A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.55A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.65A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.57A21.23
N0A  D   2 ( 4.0A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A20.99
N0A  D   2 ( 4.0A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.64A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A23.04
N0A  D   2 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A20.99
N0A  D   2 ( 4.0A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.44A22.19
N0A  D   2 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.69A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 163
GLY D 149
MET B   6
GLY D 138
TYR D 126
1.72A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE B 136
HIS B 164
PHE B 140
GLY B 146
PHE B 112
1.69A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR D 126
GLY D 149
PHE D 112
ASP D 176
TYR D 182
1.73A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS D  41
HIS D 164
PHE D 181
GLY D 146
1.74A22.99
3WL  D 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A20.89
3WL  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A20.89
3WL  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.62A20.89
3WL  B 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.57A21.13
3WL  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D  58
ILE D  43
HIS D 164
GLY D 179
PHE D  66
1.56A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 163
GLY D 149
MET B   6
GLY D 138
TYR D 126
1.67A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.61A22.34
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.68A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.72A22.99
3WL  B 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C  58
ILE C  43
HIS C 164
GLY C 179
PHE C  66
1.54A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B  41
PRO B  39
GLY B 174
ASP B 176
GLY B 179
1.45A22.34
3WL  B 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B 163
GLY B 149
MET D   6
GLY B 138
TYR B 126
1.68A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR B 126
GLY B 149
PHE B 112
ASP B 176
TYR B 182
1.72A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.71A22.99
3WL  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.58A20.89
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS C  41
HIS C 164
PHE C 181
GLY C 146
1.72A22.99
3WL  C 401 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 163
GLY C 149
MET A   6
GLY C 138
TYR C 126
1.62A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE C 136
HIS C 164
PHE C 140
GLY C 146
PHE C 112
1.67A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.55A21.13
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.61A20.89
3WL  B 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B  58
ILE B  43
HIS B 164
GLY B 179
PHE B  66
1.58A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
GLY C 146
HIS C 163
GLY C 174
TYR C 161
1.55A21.13
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.57A21.13
3WL  B 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE D 136
HIS D 164
PHE D 140
GLY D 146
PHE D 112
1.74A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.63A20.00
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
PRO D  39
GLY D 174
ASP D 176
GLY D 179
1.43A22.34
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
PRO C  39
GLY C 174
ASP C 176
GLY C 179
1.43A22.34
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 163
GLY C 149
MET A   6
GLY C 138
TYR C 126
1.70A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
GLY C 146
HIS C 163
GLY C 174
TYR C 161
1.59A20.89
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 163
GLY C 149
MET A   6
GLY C 138
TYR C 126
1.68A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.59A20.89
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 163
GLY D 149
MET B   6
GLY D 138
TYR D 126
1.73A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR C 126
GLY C 149
PHE C 112
ASP C 176
TYR C 182
1.73A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
GLY C 146
HIS C 163
GLY C 174
TYR C 161
1.59A20.89
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 149
MET C   6
GLY A 138
TYR A 126
1.64A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.75A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.45A22.34
3WL  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.70A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.60A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.46A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.67A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.57A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PRO D 169
GLY D  72
PHE D  67
PHE D 111
LEU D  57
1.76A15.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 142
PHE A 134
PHE A 165
ASP A 161
TYR A 163
1.76A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
HIS A  82
PHE A 219
ASP A 221
GLY A 220
1.42A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASP A 833
HIS A 810
PRO A 832
HIS A 816
TYR A 831
1.77A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU B1024
HIS B1048
PHE B1042
HIS B1064
GLY B1044
1.68A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE A 543
ASP A 574
PHE A 541
ASP A 586
LEU A 585
1.76A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 999
PHE B 970
ASP C 994
PHE C 759
GLY B 971
1.73A14.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
HIS B1048
PHE B1042
HIS B1064
GLY B1044
1.29A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C1035
PHE C 888
PRO B1069
GLY B1046
TYR B1047
1.74A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A1003
GLY A 999
ASP A 994
LEU A 753
TYR A 756
1.42A14.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
HIS A1048
PHE A1042
HIS A1064
GLY A1044
1.34A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C1069
SER A 884
GLY A 885
PHE A 888
TYR C1047
1.67A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 999
PHE C 970
ASP A 994
PHE A 759
GLY C 971
1.62A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 999
PHE C 970
ASP A 994
PHE A 759
GLY C 971
1.55A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU B1024
HIS B1048
PHE B1042
HIS B1064
GLY B1044
1.77A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
HIS C1048
PHE C1042
HIS C1064
GLY C1044
1.19A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 999
PHE C 970
ASP A 994
PHE A 759
GLY C 971
1.54A16.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO B1069
SER C 884
GLY C 885
PHE C 888
TYR B1047
1.66A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU C 513
ILE C 434
PHE C 377
GLY H  28
PHE C 342
1.63A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.71A23.02
None
SAM  A7102 (-3.8A)
None
SAM  A7102 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAM  A7104 (-3.6A)
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6879
ASP A6904
GLY B4322
TYR B4349
1.79A
None
SAM  A7104 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAM  A7104 (-3.6A)
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.71A
KCX  A6935 ( 4.7A)
SAM  A7104 (-4.4A)
None
SAM  A7104 (-3.6A)
SAM  A7104 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A22.34
X77  A 401 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.54A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A
X77  A 401 (-3.2A)
None
X77  A 401 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.68A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.73A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A20.89
X77  A 401 (-3.2A)
None
X77  A 401 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.70A22.99
X77  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A20.89
X77  A 401 (-3.2A)
None
X77  A 401 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A20.00
None
X77  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A18.78
None
SAM  C7105 ( 3.8A)
None
SAM  C7105 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.70A18.06
FMT  A7103 ( 4.4A)
SAM  A7102 ( 4.2A)
None
SAM  A7102 ( 3.4A)
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A18.78
None
SAM  A7102 ( 3.8A)
None
SAM  A7102 ( 3.5A)
FMT  A7109 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C6930
GLY C6871
HIS C6867
GLY C6879
TYR C6845
1.69A18.06
FMT  C7107 ( 4.3A)
SAM  C7105 ( 4.2A)
None
SAM  C7105 ( 3.4A)
SAM  C7105 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6951
GLY C6953
HIS C6984
GLY C7011
TYR C7009
1.69A21.50
None
None
None
NA  C7103 ( 4.1A)
NA  C7103 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6879
ASP C6904
GLY D4322
TYR D4349
1.80A21.50
None
SAM  C7105 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A18.78
None
SAM  C7105 ( 3.8A)
None
SAM  C7105 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A18.78
None
SAM  A7102 ( 3.8A)
None
SAM  A7102 ( 3.5A)
FMT  A7109 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU F 353
ILE E 320
PHE F 286
PHE E 314
GLY F 295
1.73A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU A 353
ILE B 320
PHE A 286
PHE B 314
GLY A 295
1.68A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU D 353
ILE C 320
PHE D 286
PHE C 314
GLY D 295
1.80A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU C 353
ILE D 320
PHE C 286
PHE D 314
GLY C 295
1.70A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A7088
HIS A6867
PHE A6868
ASP A6897
GLY A6871
1.80A
None
None
None
SAH  A7102 (-2.6A)
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.73A
FMT  A7103 ( 4.3A)
SAH  A7102 (-4.4A)
None
SAH  A7102 (-3.5A)
SAH  A7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6879
ASP C6904
GLY D4322
TYR D4349
1.79A
None
SAH  C7102 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A
None
SAH  C7102 (-3.8A)
None
SAH  C7102 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAH  A7102 (-3.8A)
None
SAH  A7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.69A
None
SAH  A7102 (-3.8A)
None
SAH  A7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR C6930
GLY C6871
HIS C6867
GLY C6879
TYR C6845
1.71A
FMT  C7104 ( 4.2A)
SAH  C7102 (-4.4A)
None
SAH  C7102 (-3.5A)
SAH  C7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A
None
SAH  C7102 (-3.8A)
None
SAH  C7102 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6879
ASP A6904
GLY B4322
TYR B4349
1.79A
None
SAH  A7102 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ILE A7088
HIS A6867
PHE A6868
ASP A6897
GLY A6871
1.78A20.91
None
None
None
SAH  A7102 (-2.6A)
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
PHE B 171
ASP C  81
HIS B  59
GLY B  60
1.67A16.17
None
None
ZN  C 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
HIS A 145
ASP A  82
HIS D  59
PHE D 171
1.78A16.17
 ZN  A 201 (-3.1A)
ZN  A 201 (-2.4A)
ZN  A 201 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A  59
GLY A  60
ASP B  82
HIS B 145
PRO B 142
1.79A14.35
 ZN  B 202 (-2.6A)
None
ZN  B 202 (-2.3A)
ZN  B 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.72A
FMT  A7105 ( 4.4A)
SFG  A7103 ( 4.2A)
None
SFG  A7103 ( 3.5A)
SFG  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wkq NSP16
(SARS-CoV-2)		5 / 11
ILE A7088
HIS A6867
PHE A6868
ASP A6897
GLY A6871
1.80A20.91
None
None
None
SFG  A7103 ( 2.7A)
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SFG  A7103 ( 3.8A)
None
SFG  A7103 ( 3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6879
ASP A6904
GLY B4322
TYR B4349
1.79A
None
SFG  A7103 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.71A
None
SFG  A7103 ( 3.8A)
None
SFG  A7103 ( 3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6879
ASP C6904
GLY D4322
TYR D4349
1.79A
None
SFG  C7103 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6951
GLY C6953
HIS C6984
GLY C7011
TYR C7009
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A
None
SFG  C7103 ( 3.7A)
None
SFG  C7103 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR C6930
GLY C6871
HIS C6867
GLY C6879
TYR C6845
1.70A
FMT  C7104 ( 4.3A)
SFG  C7103 ( 4.1A)
None
SFG  C7103 ( 3.5A)
SFG  C7103 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A
None
SFG  C7103 ( 3.7A)
None
SFG  C7103 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.65A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.72A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A20.89
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A22.99
U5G  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A20.89
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.56A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.67A20.00
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.42A22.34
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A22.34
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAH  A7101 (-3.8A)
None
SAH  A7101 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.71A
GTA  A7102 ( 3.9A)
SAH  A7101 (-4.3A)
None
SAH  A7101 (-3.5A)
SAH  A7101 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6879
ASP A6904
GLY B4322
TYR B4349
1.79A
None
SAH  A7101 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAH  A7101 (-3.8A)
None
SAH  A7101 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ILE A7088
HIS A6867
PHE A6868
ASP A6897
GLY A6871
1.79A20.91
None
None
None
SAH  A7101 (-2.7A)
SAH  A7101 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.44A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.64A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.64A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.78A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.75A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.67A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ALA A  68
HIS A 175
PHE A  79
LEU A  58
TYR A 154
1.62A20.43
None
PO4  A 504 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		6xez NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.50A16.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS B  41
PRO B  39
GLY B 174
ASP B 176
GLY B 179
1.38A22.34
O6K  B 401 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.54A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A18.54
None
None
DMS  A 405 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.64A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.68A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.57A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.80A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A18.54
None
None
DMS  A 405 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
HIS A  41
PHE A 140
HIS A 164
GLY A 146
1.57A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.54A16.84
None
None
DMS  A 405 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.68A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
ILE E 434
PHE E 377
GLY H  28
PHE E 342
1.62A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
PHE E 377
PHE E 374
GLY H  28
PHE E 342
1.78A18.65
None
None
DMS  E 901 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 513
ILE A 434
PHE A 377
GLY B  28
PHE A 342
1.62A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
ILE E 434
PHE E 377
GLY H  28
PHE E 342
1.69A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.69A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.57A
None
None
P6N  A 502 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.73A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.70A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A21.13
None
None
P6N  A 502 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A21.13
None
None
P6N  A 502 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.78A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
ILE E 434
PHE E 377
GLY H  28
PHE E 342
1.63A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
PHE E 377
PHE E 374
GLY H  28
PHE E 342
1.79A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 513
ILE A 434
PHE A 377
GLY B  28
PHE A 342
1.62A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 513
PHE A 377
PHE A 374
GLY B  28
PHE A 342
1.78A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A21.13
PK8  A 401 (-3.2A)
None
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.52A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.76A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.67A22.99
PK8  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.45A22.34
PK8  A 401 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A21.13
PK8  A 401 (-3.2A)
None
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A
PK8  A 401 (-3.2A)
None
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.78A20.00
None
PK8  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.61A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.58A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.68A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.70A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.42A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A20.89
None
None
PJE  C   5 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.80A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A
None
None
PJE  C   5 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.66A20.89
None
None
PJE  C   5 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.65A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7btf NSP12
(SARS-CoV-2)		4 / 8
HIS A  99
ASP A 218
PHE A 101
GLY A 220
1.71A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASP A 833
HIS A 810
PRO A 832
HIS A 816
TYR A 831
1.80A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 862
ILE A 837
GLY A 839
PHE A 419
GLY A 413
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.42A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.46A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7btf NSP12
(SARS-CoV-2)		4 / 8
HIS A  75
PHE A 219
PHE A 101
GLY A 220
1.78A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.47A17.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7btf NSP12
(SARS-CoV-2)		4 / 8
HIS A  82
PHE A 219
ASP A 221
GLY A 220
1.42A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A20.89
JRY  A 401 (-3.9A)
None
DMS  A 402 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.70A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A20.89
JRY  A 401 (-3.9A)
None
DMS  A 402 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.73A22.99
JRY  A 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A
JRY  A 401 (-3.9A)
None
DMS  A 402 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.66A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.45A22.34
JRY  A 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.52A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.47A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.51A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PRO B 116
SER A 343
GLY A 345
ASP A 274
TYR A 273
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PRO B 116
SER A 343
GLY A 345
ASP A 274
TYR A 273
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.48A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.50A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.46A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
LEU A 544
ASP A 445
HIS C  36
GLY A 413
TYR A 546
1.58A
None