Ligand ID: SFY


Drugbank ID:
DB00891
(Sulfapyridine)


Indication:
For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum

Get human targets for SFY in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SFY' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.73A22.43
DMS  A 401 ( 4.9A)
None
DMS  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.66A22.43
None
None
N0A  D   2 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 167
PHE B 134
MET B 165
ALA B 173
MET B 130
1.72A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.67A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.70A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU D  57
PHE D  54
TYR D  88
PRO D 163
ALA D 174
1.54A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU D  57
PHE D  54
TYR D  88
PRO D 163
ALA D 174
1.55A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 731
LEU A 207
PHE A  45
TYR A 732
PRO A 243
1.78A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
LEU A 731
LEU A 207
PHE A  45
TYR A 732
PRO A 243
1.78A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.75A22.94
None
None
X77  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		5 / 12
PHE D4321
PRO D4353
MET D4316
GLN D4318
ALA D4314
1.74A17.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6wjt NSP10
(SARS-CoV-2)		5 / 12
PHE D4321
PRO D4353
MET D4316
GLN D4318
ALA D4314
1.76A17.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6wkq NSP10
(SARS-CoV-2)		5 / 12
PHE D4321
PRO D4353
MET D4316
GLN D4318
ALA D4314
1.75A17.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.74A22.94
U5G  A 401 (-3.9A)
None
U5G  A 401 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.69A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.63A22.94
None
None
O6K  A 402 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A  16
PHE A  13
TYR A  47
PRO A 122
ALA A 133
1.56A17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
LEU A  16
PHE A  13
TYR A  47
PRO A 122
ALA A 133
1.56A17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
LEU A  16
PHE A  13
TYR A  47
PRO A 122
ALA A 133
1.57A17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.72A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.62A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.76A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.79A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.76A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.76A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.79A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.77A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
LEU A 731
SER A 239
PHE A  45
TYR A 732
PRO A 243
1.72A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.78A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.79A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 167
PHE A 134
MET A 165
ALA A 173
MET A 130
1.69A22.94
DMS  A 405 ( 4.9A)
None
JRY  A 401 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.63A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.74A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.75A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.64A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.64A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.64A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.75A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.59A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.58A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.79A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.78A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.59A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
LEU A 186
LEU A 240
TYR A 238
GLN A 210
ALA A 185
1.79A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.59A15.07
None