Ligand ID: MN9


Drugbank ID:
DB00141
(N-Acetyl-D-glucosamine)


Indication:
For the treatment and prevention of osteoarthritis, by itself or in combination with chondroitin sulfate.

Get human targets for MN9 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'MN9' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  30
TYR A 101
LEU A 177
THR A  98
1.62A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.64A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
THR A 257
SER A 267
ASP A 263
LEU A 205
1.72A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 6
THR A 941
SER B 939
LEU B 938
LEU B1186
1.39A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
THR A  98
LEU A  30
TYR A 101
LEU A 177
1.66A22.42

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.66A22.42

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
THR A 257
SER A 267
ASP A 263
LEU A 205
1.65A22.42

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
THR A  98
LEU A  30
TYR A 101
LEU A 177
1.66A22.42

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.25A22.42

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.65A22.42

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER B  81
LEU B  87
TYR B  54
LEU B  58
1.31A22.45

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
THR B  98
LEU B  30
TYR B 101
LEU B 177
1.64A22.45

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER C  81
LEU C  87
TYR C  54
LEU C  58
1.37A22.45

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER C 267
LEU C 268
TYR C 209
LEU C 208
1.68A22.45

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.32A22.45

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
THR D 257
SER D 267
ASP D 263
LEU D 205
1.68A22.45

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.70A22.45

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.63A22.45

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE B 147
THR B 116
GLY B 117
SER B  52
PHE B  54
1.42A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 5
LEU A 389
ASP A 390
LEU B 128
THR B 141
1.55A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
THR A 189
SER A 239
LEU A 241
LEU A 207
1.41A16.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
LEU A 127
TYR A 149
LEU A 178
THR A 120
1.57A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ILE A 562
TYR A 516
ASP A 517
SER A 518
PHE A 368
1.69A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
LEU A 127
TYR A 122
LEU A 212
THR A 141
1.59A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
LEU A 614
TYR A 828
LEU A 805
THR A 817
1.62A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
THR A 141
LEU A 127
TYR A 122
LEU A 212
1.57A16.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
THR A 120
LEU A 127
TYR A 149
LEU A 178
1.58A16.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
THR B 141
LEU A 389
ASP A 390
LEU B 128
1.53A18.91

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
THR A 817
LEU A 614
TYR A 828
LEU A 805
1.63A16.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE A 285
LEU A 277
GLU A 191
GLY A 219
PHE A  58
1.38A13.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU B1034
ASP A1041
TYR B 789
LEU B 877
1.47A14.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A1034
ASP C1041
TYR A 789
LEU A 877
1.40A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU A1034
ASP C1041
TYR A 789
LEU A 877
1.42A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A1034
ASP C1041
TYR A 789
LEU A 877
1.36A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE B 285
LEU B 277
GLU B 191
GLY B 219
PHE B  58
1.46A13.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU A1034
ASP C1041
TYR A 789
LEU A 877
1.38A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 10
ILE B 146
THR B 115
GLY B 116
SER B  51
PHE B  53
1.41A19.32
 ZN  A 202 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 228
GLY B 239
TYR B 238
GLY B 248
PHE B 303
1.57A26.42
None
None
None
CIT  B 408 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP A 133
TYR A 180
LEU A 152
THR A 145
1.56A24.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 6
THR C 345
SER C 438
LEU C 441
ASP C 442
1.38A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6w4b NSP9
(SARS-CoV-2)		4 / 5
LEU B  10
TYR B  32
LEU B  43
THR B 110
1.61A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w4h NSP16
(SARS-CoV-2)		4 / 6
SER A7071
LEU A7070
ASP A7067
LEU A7073
1.39A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7071
LEU A7070
ASP A7067
LEU A7073
1.37A18.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7071
LEU A7070
ASP A7067
LEU A7010
1.73A18.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
THR B 146
SER B 128
LEU B 127
LEU B 126
1.61A18.08
None
MES  B 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
THR A 146
SER A 128
LEU A 127
LEU A 126
1.63A18.08
None
None
None
AMP  A 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
SER B   7
LEU A  12
TYR A  17
LEU A  10
1.70A18.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
THR A7055
SER A7071
LEU A7072
LEU A7073
1.74A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER C6831
LEU C7037
ASP C6830
TYR C7040
1.32A17.59
None
None
None
FMT  C7111 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
THR C7055
SER C7071
LEU C7072
LEU C7073
1.74A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER A6831
LEU A7037
ASP A6830
TYR A7040
1.39A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR A  90
LEU A 113
TYR A  95
LEU A 117
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
SER B  78
LEU B  80
TYR B  35
LEU B  58
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU B  58
TYR B  35
LEU B  80
THR B  42
1.41A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR C  42
LEU C  58
TYR C  35
LEU C  80
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
SER A  78
LEU A  80
TYR A  35
LEU A  58
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU C  58
TYR C  35
LEU C  80
THR C  42
1.37A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU C 113
TYR C  95
LEU C 117
THR C  90
1.63A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR B  42
LEU B  58
TYR B  35
LEU B  80
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A 113
TYR A  95
LEU A 117
THR A  90
1.67A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR B  90
LEU B 113
TYR B  95
LEU B 117
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR B 168
SER B 262
ASP B 302
TYR B 112
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR A 168
SER A 262
ASP A 302
TYR A 112
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR A  42
LEU A  58
TYR A  35
LEU A  80
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR C  90
LEU C 113
TYR C  95
LEU C 117
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR C 168
SER C 262
ASP C 302
TYR C 112
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  58
TYR A  35
LEU A  80
THR A  42
1.35A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU B 113
TYR B  95
LEU B 117
THR B  90
1.61A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 10
ILE A  65
GLY A  63
ASP A  60
GLY A  61
SER A  59
1.79A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wcf NSP3
(SARS-CoV-2)		4 / 6
THR A 146
SER A 128
LEU A 127
LEU A 126
1.60A
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wen NSP3
(SARS-CoV-2)		4 / 6
THR A 146
SER A 128
LEU A 127
LEU A 126
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wey NSP3
(SARS-CoV-2)		4 / 6
THR A 350
SER A 332
LEU A 331
LEU A 330
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE C 304
LEU C 352
TYR C 298
GLU C 290
GLY C 287
1.79A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE A 304
LEU A 352
TYR A 298
GLU A 290
GLY A 287
1.78A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE F 304
LEU F 352
TYR F 298
GLU F 290
GLY F 287
1.78A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6831
LEU A7037
ASP A6830
TYR A7040
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER C6831
LEU C7037
ASP C6830
TYR C7040
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE A 146
THR A 115
GLY A 116
SER A  51
PHE A  53
1.54A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR A 115
GLY A 116
TYR A  86
SER A  51
PHE A  53
1.73A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR D 115
GLY D 116
TYR D  86
SER D  51
PHE D  53
1.71A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE C 146
THR C 115
GLY C 116
SER C  51
PHE C  53
1.58A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE B 146
THR B 115
GLY B 116
SER B  51
PHE B  53
1.51A19.66
MES  B 201 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR B 115
GLY B 116
TYR B  86
SER B  51
PHE B  53
1.70A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE D 146
THR D 115
GLY D 116
SER D  51
PHE D  53
1.49A19.66
MES  D 201 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR C 115
GLY C 116
TYR C  86
SER C  51
PHE C  53
1.70A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER A6831
LEU A7037
ASP A6830
TYR A7040
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER C6831
LEU C7037
ASP C6830
TYR C7040
1.35A
None
None
None
FMT  C7111 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP B 133
TYR B 180
LEU B 152
THR B 145
1.56A23.82
None
None
None
ACT  B 408 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP A 133
TYR A 180
LEU A 152
THR A 145
1.53A23.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 252
ASP A 297
TYR A 279
LEU A 255
1.64A
None
None
EDO  A 405 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
THR B 145
ASP B 133
TYR B 180
LEU B 152
1.56A
ACT  B 408 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
THR A 145
ASP A 133
TYR A 180
LEU A 152
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 228
GLY B 239
TYR B 238
GLY B 248
PHE B 303
1.57A24.47
None
None
None
U5P  B 401 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 252
ASP B 297
TYR B 279
LEU B 255
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LEU A 252
ASP A 297
TYR A 279
LEU A 255
1.66A23.82
None
None
EDO  A 405 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LEU B 252
ASP B 297
TYR B 279
LEU B 255
1.65A23.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
THR A 146
SER A 128
LEU A 127
LEU A 126
1.62A
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
THR B 146
SER B 128
LEU B 127
LEU B 126
1.68A
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
THR D 146
SER D 128
LEU D 127
LEU D 126
1.67A
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7071
LEU A7070
ASP A7067
LEU A7073
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7071
LEU A7070
ASP A7067
LEU A7010
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
THR A  90
LEU A 113
TYR A  95
LEU A 117
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
LEU A 113
TYR A  95
LEU A 117
THR A  90
1.68A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6y2f REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.32A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
THR A 257
SER A 267
ASP A 263
LEU A 205
1.76A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.66A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
LEU A 387
THR A 385
ASP B 107
GLU C  61
GLY B  99
1.73A22.81
DMS  A 905 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
THR A 345
SER A 438
LEU A 441
ASP A 442
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
THR C  59
LEU A 390
ASP A 389
LEU A 517
1.43A
None
DMS  A 905 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 5
LEU A 390
ASP A 389
LEU A 517
THR C  59
1.42A20.38
DMS  A 905 (-4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
THR E 345
SER E 438
LEU E 441
ASP E 442
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
THR E 345
SER E 438
LEU E 441
ASP E 442
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
THR B  69
SER B  17
ASP E 405
LEU B  18
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
THR H  69
SER H  17
ASP A 405
LEU H  18
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
THR A 345
SER A 438
LEU A 441
ASP A 442
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
THR E 345
SER E 438
LEU E 441
ASP E 442
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
THR A  98
LEU A  30
TYR A 101
LEU A 177
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR A 146
SER A 128
LEU A 127
LEU A 126
1.64A
None
EDO  A 202 (-4.3A)
EDO  A 202 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER D   7
LEU E  12
TYR E  17
LEU E  10
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR E 146
SER E 128
LEU E 127
LEU E 126
1.63A
None
EPE  E 202 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR D 146
SER D 128
LEU D 127
LEU D 126
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR B 146
SER B 128
LEU B 127
LEU B 126
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR C 146
SER C 128
LEU C 127
LEU C 126
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR C 146
SER C 128
LEU C 127
LEU C 126
1.68A
None
APR  C 201 (-4.4A)
None
APR  C 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER D   7
LEU E  12
TYR E  17
LEU E  10
1.67A
None
None
None
EDO  E 203 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR A 146
SER A 128
LEU A 127
LEU A 126
1.67A
None
APR  A 201 (-4.4A)
None
APR  A 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR B 146
SER B 128
LEU B 127
LEU B 126
1.67A
None
APR  B 201 (-4.3A)
None
APR  B 201 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR D 146
SER D 128
LEU D 127
LEU D 126
1.67A
None
APR  D 201 (-4.3A)
None
APR  D 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER E   7
LEU D  12
TYR D  17
LEU D  10
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR C 146
SER C 128
LEU C 127
LEU C 126
1.62A
None
MES  C 201 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
THR B 146
SER B 128
LEU B 127
LEU B 126
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
THR A 141
LEU A 127
TYR A 122
LEU A 212
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
THR A 120
LEU A 127
TYR A 149
LEU A 178
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP7
(SARS-CoV-2)		4 / 6
THR C   9
SER C  57
LEU C  56
LEU C  59
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 5
LEU A 389
ASP A 390
LEU B 128
THR B 141
1.53A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
THR A 189
SER A 239
LEU A 241
LEU A 207
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
THR B 141
LEU A 389
ASP A 390
LEU B 128
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 127
TYR A 122
LEU A 212
THR A 141
1.54A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP12
(SARS-CoV-2)		5 / 10
ILE A 562
TYR A 516
ASP A 517
SER A 518
PHE A 368
1.64A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 127
TYR A 149
LEU A 178
THR A 120
1.53A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
SER A 267
LEU A 268
TYR A 209
LEU A 208
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
THR A  98
LEU A  30
TYR A 101
LEU A 177
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 127
TYR A 122
LEU A 212
THR A 141
1.58A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ILE A 562
TYR A 516
ASP A 517
SER A 518
PHE A 368
1.64A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
THR B 141
LEU A 389
ASP A 390
LEU B 128
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 575
ASP A 484
LEU A 576
THR A 582
1.77A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
THR A 141
LEU A 127
TYR A 122
LEU A 212
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 5
LEU A 389
ASP A 390
LEU B 128
THR B 141
1.50A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
SER A 367
LEU A 366
TYR A 374
LEU A 371
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
THR A 189
SER A 239
LEU A 241
LEU A 207
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ILE A 562
TYR A 516
ASP A 517
SER A 518
PHE A 368
1.61A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
THR B 141
LEU A 389
ASP A 390
LEU B 128
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 575
ASP A 484
LEU A 576
THR A 582
1.78A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
THR A 189
SER A 239
LEU A 241
LEU A 207
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 127
TYR A 122
LEU A 212
THR A 141
1.55A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
THR A 141
LEU A 127
TYR A 122
LEU A 212
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
SER A 367
LEU A 366
TYR A 374
LEU A 371
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 212
ASP A 211
LEU A 127
THR A 148
1.79A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 5
LEU A 389
ASP A 390
LEU B 128
THR B 141
1.54A16.10
None