Ligand ID: LYA


Drugbank ID:
DB00642
(Pemetrexed)


Indication:
Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy

Get human targets for LYA in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LYA' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		5r80 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.50A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.58A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.49A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.59A22.15
DMS  A 402 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.54A19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.51A19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 11
PHE F 970
ILE E 973
ASN E 978
GLY E1167
PHE E 970
1.76A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
PHE E 970
LEU F 966
ILE D1169
LEU E 962
LEU D 962
1.50A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
ILE F 931
LEU E 938
ILE D 934
SER D 937
LEU D 938
1.46A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.50A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.59A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.51A22.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.80A22.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.61A23.73
DMS  A 402 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.54A22.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.79A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.61A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.51A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.60A23.66
DMS  A 404 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.50A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.79A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.53A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.54A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 206
LEU B 208
THR B 199
LEU B 272
LEU B 287
1.57A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE A 230
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.46A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B 246
ILE B 249
LEU B 253
GLY B 251
VAL B 297
1.54A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE C 230
LEU C 268
THR C 199
LEU C 272
LEU C 287
1.55A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 246
ILE C 249
LEU C 253
GLY C 251
VAL C 297
1.57A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 246
ILE D 249
LEU D 253
GLY D 251
VAL D 297
1.59A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.57A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 246
ILE D 249
LEU D 253
GLY D 251
VAL D 297
1.62A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE B 230
LEU B 268
THR B 199
LEU B 272
LEU B 287
1.46A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 206
LEU B 268
THR B 199
LEU B 272
LEU B 287
1.54A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 115
GLY C 149
PHE C 159
TYR C 126
VAL C 125
1.78A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
MET C   6
VAL C 157
GLU C  14
1.57A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
MET B   6
VAL B 157
GLU B  14
1.60A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.51A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 206
LEU D 268
THR D 199
LEU D 272
LEU D 287
1.47A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.57A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.56A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
ARG A  40
THR A 135
THR A 190
1.75A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 206
LEU C 208
THR C 199
LEU C 272
LEU C 287
1.59A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 206
LEU C 268
THR C 199
LEU C 272
LEU C 287
1.48A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B 246
ILE B 249
LEU B 253
GLY B 251
VAL B 297
1.51A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 206
LEU D 208
THR D 199
LEU D 272
LEU D 287
1.58A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  64
ILE D  78
LEU D  89
TYR D  37
VAL D  36
1.78A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 115
GLY C 149
PHE C 159
TYR C 126
VAL C 125
1.79A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  64
ILE D  78
LEU D  89
TYR D  37
VAL D  36
1.76A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 246
ILE C 249
LEU C 253
GLY C 251
VAL C 297
1.60A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
MET D   6
VAL D 157
GLU D  14
1.58A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.58A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.60A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.79A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.49A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.51A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.55A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE B 147
LEU B 114
GLY B 115
TYR B 124
ALA B 135
1.71A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ILE B 147
LEU B 114
GLY B 115
TYR B 124
ALA B 135
1.72A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ILE B 147
LEU B 114
GLY B 115
TYR B 124
ALA B 135
1.72A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A  34
LEU A 207
ILE A 244
LEU A 241
LEU A 240
1.45A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 585
ILE A 696
PHE A 480
SER A 692
LEU A 576
1.66A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ILE B 119
LEU A 329
GLY A 327
VAL A 330
ALA A 379
1.77A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ARG A 173
THR A 319
THR A 394
1.42A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A  34
ASP A 126
ILE A 244
LEU A 241
LEU A 240
1.61A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASP A 390
THR A 393
TYR A 453
GLY A 327
SER A 672
1.74A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA B 110
ILE B 107
ILE A 333
LEU A 361
TYR A 273
1.78A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 757
ARG A 631
ILE A 579
LEU A 575
TYR A 746
1.71A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
ARG A 181
ILE A 244
LEU A 127
LEU A 142
1.68A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 466
PHE A 313
LEU A 316
SER A 239
LEU A 186
1.38A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		3 / 3
MET A 629
VAL A 700
GLU A 474
1.60A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 694
LEU A 630
ARG A 631
THR A 701
LEU A 469
1.72A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_B_LYAB304_1
(FOLATE RECEPTOR BETA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASP A 390
THR A 393
TYR A 453
GLY A 327
SER A 672
1.75A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ARG A 279
THR A 248
THR A 259
1.59A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 186
ARG A 285
THR A 248
LEU A 251
LEU A 245
1.72A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASP A 390
THR A 393
TYR A 453
GLY A 327
SER A 672
1.74A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 490
LEU A 527
ILE A 562
SER A 561
LEU A 372
1.74A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 185
LEU A 212
THR A 248
ILE A 244
LEU A 178
1.65A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 125
ASP A 126
LEU A 212
LEU A 178
TYR A 237
1.74A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 313
LEU A 316
ARG A 279
LEU A 282
LEU A 251
1.69A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ILE B 119
LEU A 329
GLY A 327
VAL A 330
ALA A 379
1.77A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 277
PHE A 306
TYR A  38
VAL A  36
ALA A 222
1.58A13.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE B1075
ILE B 714
ASN B1108
LEU C 894
ALA C 890
1.63A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 822
THR B 724
ILE B 726
LEU B 945
LEU B 938
1.33A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE B1075
ILE B 714
ASN B1108
LEU C 894
ALA C 890
1.63A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE B 882
GLY B 798
PHE B 797
TYR B 917
ALA B 903
1.75A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE B 168
ILE B 137
LEU B 160
LEU B 126
TYR B 113
1.71A
None
None
SO4  B 204 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ASP A 157
LEU A 160
ILE A  18
LEU A 140
LEU A 126
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG A 815
THR A 881
THR A 724
0.68A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ILE A 882
GLY A 798
TYR A 917
MET A 902
ALA A 903
1.69A13.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 116
ILE A 105
LEU A 242
ASP A 138
PHE A 135
1.66A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ILE C 882
GLY C 798
TYR C 917
MET C 902
ALA C 903
1.67A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 575
ASP B 586
LEU B 585
ILE B 326
LEU B 533
1.54A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG C 815
THR C 881
THR C 724
0.57A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
TYR C 421
GLN C 409
TRP C 353
1.45A9.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
ILE B 146
LEU B 113
GLY B 114
TYR B 123
ALA B 134
1.77A19.11
 ZN  A 202 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
ILE B 146
LEU B 113
GLY B 114
TYR B 123
ALA B 134
1.77A19.11
 ZN  A 202 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 10
ILE B 146
LEU B 113
GLY B 114
TYR B 123
ALA B 134
1.76A19.11
 ZN  A 202 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ARG A  62
THR A  49
THR A  99
1.27A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w37 PROTEIN 7A
(SARS-CoV-2)		5 / 12
ALA A  64
LEU A  62
THR A  13
LEU A  16
LEU A  41
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ILE C 410
ASP C 398
PHE C 400
ARG C 466
LEU C 461
1.72A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.47A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w4h NSP16
(SARS-CoV-2)		5 / 12
ILE A6967
LEU A6924
ILE A7005
LEU A6857
TYR A6845
1.48A22.38
None
None
None
None
SAM  A7102 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6881
LEU A6893
ILE A6926
LEU A6924
LEU A6887
1.79A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6967
LEU A6924
ILE A7005
LEU A6857
TYR A6845
1.45A
None
None
None
None
SAM  A7104 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
PHE A6954
ILE A6951
ASP A6928
GLY A6869
PHE A6868
1.75A
None
None
SAM  A7104 (-3.8A)
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.61A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 230
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B  21
LEU A 169
LEU A  12
LEU A  10
TYR B 161
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ASP A 145
ILE A 137
SER A 167
LEU A 164
LEU A 126
1.78A15.74
None
None
None
None
AMP  A 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B 129
LEU B 140
ARG B 141
LEU B  12
LEU B 153
1.75A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ASP B 157
LEU B 160
ILE B  18
LEU B 140
LEU B 126
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.43A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6870
ASP A6895
LEU A6883
ILE A6925
LEU A6924
1.70A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.74A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6914
PHE C6947
SER C6927
ILE C6967
LEU C6978
1.62A15.92
None
FMT  C7115 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6881
LEU C6893
ILE C6926
LEU C6924
LEU C6887
1.75A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6870
SER A6896
ILE A6910
GLY A6875
PHE A6901
1.72A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS C6984
ILE C6955
LEU C7004
GLY C7006
PHE C6985
1.76A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
PHE D4321
VAL C6876
ALA C6877
1.44A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 11
PHE A6954
ILE A6951
ASP A6928
GLY A6869
PHE A6868
1.74A22.40
None
None
SAM  A7102 ( 3.7A)
SAM  A7102 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.44A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6967
LEU A6924
ILE A7005
LEU A6857
TYR A6845
1.45A15.92
None
None
None
None
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6951
LEU C6959
SER C6927
ILE C6926
LEU C6924
1.73A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
PHE D4321
VAL C6876
ALA C6877
1.44A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.73A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6967
LEU C6924
ILE C7005
LEU C6857
TYR C6845
1.49A15.92
None
None
None
None
SAM  C7105 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6881
LEU A6893
ILE A6926
LEU A6924
LEU A6887
1.75A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ALA D4285
ASP D4282
ILE D4291
LEU D4328
LEU D4365
1.77A13.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS C6984
ILE C6955
LEU C7004
GLY C7006
PHE C6985
1.75A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6870
ASP C6895
LEU C6883
ILE C6925
LEU C6924
1.69A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 107
GLU C 167
LEU C 152
LEU C 162
GLY C 163
1.67A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA C 107
GLU B 167
LEU B 152
LEU B 162
GLY B 163
1.68A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 288
SER A 103
ILE A 104
LEU A 152
ASP A 108
1.77A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 107
GLU C 167
LEU C 152
LEU C 162
GLY C 163
1.67A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ARG C  82
THR B 158
THR C  90
1.22A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 288
SER A 103
ILE A 104
LEU A 152
ASP A 108
1.79A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA B 107
GLU A 167
LEU A 152
LEU A 162
GLY A 163
1.73A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ILE C 104
ARG C 140
ILE C 151
LEU C 172
TYR C 273
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 131
PHE A 127
ARG A 140
ILE A 151
LEU A 117
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA B 288
SER B 103
ILE B 104
LEU B 152
ASP B 108
1.68A21.06
None
CL  B 502 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ARG B 183
THR B 313
THR B 231
1.72A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 131
PHE A 127
ARG A 140
LEU A 117
TYR A  83
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA B 288
SER B 103
ILE B 104
LEU B 152
ASP B 108
1.67A21.06
None
CL  B 502 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA B 107
GLU A 167
LEU A 152
LEU A 162
GLY A 163
1.72A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA C 131
PHE C 127
ARG C 140
LEU C 117
TYR C  83
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA C 107
GLU B 167
LEU B 152
LEU B 162
GLY B 163
1.68A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 172
THR B 119
ILE B 123
LEU B 125
LEU B 120
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA C 288
SER C 103
ILE C 104
LEU C 152
ASP C 108
1.76A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 104
ARG A 140
ILE A 151
LEU A 172
TYR A 273
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA C 288
SER C 103
ILE C 104
LEU C 152
ASP C 108
1.78A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ARG A 140
THR A  90
THR A 168
1.02A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ASP A 157
LEU A 160
ILE A  18
LEU A 140
LEU A 126
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
ASP A 361
LEU A 364
ILE A 222
LEU A 344
LEU A 330
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
ASP A 349
ILE A 341
SER A 371
LEU A 368
LEU A 330
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 273
LEU F 353
ASP F 288
LEU F 291
GLY F 287
1.77A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 273
LEU D 353
ASP D 288
LEU D 291
GLY D 287
1.75A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 264
SER F 312
GLY E 275
PHE E 274
TYR E 360
1.78A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE B 320
ASN A 354
ASP A 288
LEU A 291
GLY A 287
1.61A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 264
SER F 312
GLY E 275
PHE E 274
TYR E 360
1.77A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 273
LEU C 353
ASP C 288
LEU C 291
GLY C 287
1.75A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA A 273
LEU A 353
ASP A 288
LEU A 291
GLY A 287
1.76A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 273
LEU D 353
ASP D 288
LEU D 291
GLY D 287
1.73A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE E 314
ILE E 320
ASP F 288
LEU F 291
GLY F 287
1.72A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA A 273
LEU A 353
ASP A 288
LEU A 291
GLY A 287
1.73A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA A 264
SER B 312
GLY A 275
PHE A 274
TYR A 360
1.76A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA A 264
SER B 312
GLY A 275
PHE A 274
TYR A 360
1.77A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 264
LEU D 353
ASP D 288
LEU D 291
GLY D 287
1.79A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE E 314
ILE E 320
ASN F 354
ASP F 288
GLY F 287
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE A 314
ILE A 320
ASN B 354
ASP B 288
GLY B 287
1.65A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE F 314
ILE F 320
ASN E 354
ASP E 288
GLY E 287
1.67A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 264
SER D 312
LEU C 353
ASP C 288
GLY C 287
1.67A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 273
LEU F 353
ASP F 288
LEU F 291
GLY F 287
1.74A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 273
LEU B 353
ASP B 288
LEU B 291
GLY B 287
1.74A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 264
SER D 312
GLY C 275
PHE C 274
TYR C 360
1.77A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 264
SER A 312
LEU B 353
ASP B 288
GLY B 287
1.62A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 264
SER E 312
GLY F 275
PHE F 274
TYR F 360
1.78A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG B 259
THR D 296
THR B 296
1.14A11.34
None
CL  D 401 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE F 314
ILE F 320
ASN E 354
ASP E 288
GLY E 287
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 264
SER E 312
LEU F 353
ASP F 288
GLY F 287
1.68A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 264
SER A 312
LEU B 353
ASP B 288
GLY B 287
1.61A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE E 314
ILE E 320
ASN F 354
ASP F 288
GLY F 287
1.61A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 264
SER E 312
GLY F 275
PHE F 274
TYR F 360
1.79A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 273
LEU B 353
ASP B 288
LEU B 291
GLY B 287
1.76A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 264
SER C 312
GLY D 275
PHE D 274
TYR D 360
1.78A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 264
SER F 312
LEU E 353
ASP E 288
GLY E 287
1.62A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE E 314
ILE E 320
ASP F 288
LEU F 291
GLY F 287
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 264
SER D 312
GLY C 275
PHE C 274
TYR C 360
1.76A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE C 314
ILE C 320
ASN D 354
ASP D 288
GLY D 287
1.68A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE B 320
ASN A 354
ASP A 288
LEU A 291
GLY A 287
1.61A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 264
SER F 312
LEU E 353
ASP E 288
GLY E 287
1.61A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 264
SER A 312
GLY B 275
PHE B 274
TYR B 360
1.79A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 273
LEU E 353
ASP E 288
LEU E 291
GLY E 287
1.79A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 264
SER C 312
LEU D 353
ASP D 288
GLY D 287
1.58A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE B 320
ASN A 354
ASP A 288
LEU A 291
GLY A 287
1.62A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE B 314
ILE B 320
ASN A 354
ASP A 288
GLY A 287
1.61A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE C 314
ILE C 320
ASN D 354
ASP D 288
GLY D 287
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE B 320
ASN A 354
ASP A 288
LEU A 291
GLY A 287
1.61A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG B 259
THR D 265
THR B 265
1.47A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 273
LEU E 353
ASP E 288
LEU E 291
GLY E 287
1.76A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 264
SER A 312
GLY B 275
PHE B 274
TYR B 360
1.79A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE A 314
ILE A 320
ASN B 354
ASP B 288
GLY B 287
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE B 314
ILE B 320
ASN A 354
ASP A 288
GLY A 287
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 264
SER C 312
GLY D 275
PHE D 274
TYR D 360
1.79A11.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE D 314
ILE D 320
ASN C 354
ASP C 288
GLY C 287
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
PHE D 314
ILE D 320
ASN C 354
ASP C 288
GLY C 287
1.62A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6914
PHE C6947
SER C6927
ILE C6967
LEU C6978
1.62A
None
SAH  C7102 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6870
SER C6896
ILE C6910
GLY C6875
PHE C6901
1.72A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
PHE A6954
ILE A6951
ASP A6928
GLY A6869
PHE A6868
1.74A
None
None
SAH  A7102 (-3.7A)
SAH  A7102 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6967
LEU A6924
ILE A7005
LEU A6857
TYR A6845
1.45A
None
None
None
None
SAH  A7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6870
ASP C6895
LEU C6883
ILE C6925
LEU C6924
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6870
ASP A6895
LEU A6883
ILE A6925
LEU A6924
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS C6984
ILE C6955
LEU C7004
GLY C7006
PHE C6985
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
PHE D4321
VAL C6876
ALA C6877
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6967
LEU C6924
ILE C7005
LEU C6857
TYR C6845
1.48A
None
None
None
None
SAH  C7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6870
SER C6896
ILE C6910
GLY C6875
PHE C6901
1.72A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6870
SER A6896
ILE A6910
GLY A6875
PHE A6901
1.71A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
PHE D4321
VAL C6876
ALA C6877
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS C6984
ILE C6955
LEU C7004
GLY C7006
PHE C6985
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ARG A7053
THR A6846
THR A6891
1.49A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6951
LEU C6959
SER C6927
ILE C6926
LEU C6924
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ILE B 146
LEU B 113
GLY B 114
TYR B 123
ALA B 134
1.76A
MES  B 201 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG C  93
THR D 141
THR C  57
1.67A12.11
None
None
ZN  D 202 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ILE D 146
LEU D 113
GLY D 114
TYR D 123
ALA D 134
1.78A19.45
MES  D 201 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG C  93
THR D 148
THR C  57
1.54A12.11
None
None
ZN  D 202 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ILE B 146
LEU B 113
GLY B 114
TYR B 123
ALA B 134
1.76A19.45
MES  B 201 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE B 146
LEU B 113
GLY B 114
TYR B 123
ALA B 134
1.75A19.45
MES  B 201 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG C  93
THR D 115
THR C  57
1.11A12.11
None
None
ZN  D 202 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ILE D 146
LEU D 113
GLY D 114
TYR D 123
ALA D 134
1.78A
MES  D 201 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE D 146
LEU D 113
GLY D 114
TYR D 123
ALA D 134
1.77A19.45
MES  D 201 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
PHE D4321
VAL C6876
ALA C6877
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 11
PHE A6954
ILE A6951
ASP A6928
GLY A6869
PHE A6868
1.75A
None
None
SFG  A7103 ( 3.6A)
SFG  A7103 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6914
PHE C6947
SER C6927
ILE C6967
LEU C6978
1.62A
None
FMT  C7105 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
PHE D4321
VAL C6876
ALA C6877
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6870
ASP C6895
LEU C6883
ILE C6925
LEU C6924
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6967
LEU C6924
ILE C7005
LEU C6857
TYR C6845
1.47A
None
None
None
None
SFG  C7103 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6870
ASP A6895
LEU A6883
ILE A6925
LEU A6924
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6951
LEU C6959
SER C6927
ILE C6926
LEU C6924
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6967
LEU A6924
ILE A7005
LEU A6857
TYR A6845
1.45A
None
None
None
None
SFG  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU B 211
LEU B 255
GLY B 254
PHE B 204
VAL B 295
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU B 211
LEU B 255
GLY B 254
PHE B 204
VAL B 295
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ARG A  62
THR A  49
THR A  99
1.26A22.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ARG B  62
THR B  49
THR B  99
1.27A22.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.62A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 230
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP B 157
LEU B 160
ILE B  18
LEU B 140
LEU B 126
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP C 157
LEU C 160
ILE C  18
LEU C 140
LEU C 126
1.65A
None
None
None
None
APR  C 201 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 157
LEU A 160
ILE A  18
LEU A 140
LEU A 126
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
PHE B4321
VAL A6876
ALA A6877
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
PHE A6954
ILE A6951
ASP A6928
GLY A6869
PHE A6868
1.75A
None
None
SAH  A7101 (-3.7A)
SAH  A7101 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ARG A7053
THR A6846
THR A6891
1.50A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6984
ILE A6955
LEU A7004
GLY A7006
PHE A6985
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6967
LEU A6924
ILE A7005
LEU A6857
TYR A6845
1.47A
None
None
None
None
SAH  A7101 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
ARG A  40
THR A 135
THR A 190
1.66A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.64A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		3 / 3
ARG A 138
THR A  74
THR A  10
1.17A21.10
None
None
CL  A 506 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ALA A 288
SER A 103
ILE A 104
LEU A 152
ASP A 108
1.69A21.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ILE A 104
ARG A 140
LEU A 120
ILE A 151
LEU A 172
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ALA A 288
SER A 103
ILE A 104
LEU A 152
ASP A 108
1.70A21.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ALA A 131
PHE A 127
ARG A 140
LEU A 117
TYR A  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6y2e REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.45A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.48A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.49A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.56A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.40A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.59A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.53A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA B 102
ILE B 106
SER A  57
ILE B 119
LEU B 122
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLU A 484
ILE A 472
LEU A 492
PHE A 490
TYR A 453
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE E 410
ASP E 398
PHE E 400
ARG E 466
LEU E 461
1.78A
None
None
None
DMS  E 904 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLU A 484
ILE A 472
LEU A 492
PHE A 490
TYR A 453
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.51A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE A 410
ASP A 398
PHE A 400
ARG A 466
LEU A 461
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE E 410
ASP E 398
PHE E 400
ARG E 466
LEU E 461
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.51A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.57A
PEG  A 405 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.54A
PEG  A 405 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.52A
None
None
PEG  A 404 (-3.0A)
PEG  A 404 (-3.4A)
PEG  A 404 (-2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.59A
None
None
PEG  A 404 (-3.0A)
PEG  A 404 (-3.4A)
PEG  A 404 (-2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B 145
ILE B 137
SER B 167
LEU B 164
LEU B 126
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP E 145
ILE E 137
SER E 167
LEU E 164
LEU E 126
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP D 157
LEU D 160
ILE D  18
LEU D 140
LEU D 126
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ARG A 141
THR A 149
THR D 146
1.52A16.50
None
EDO  A 203 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C 145
ILE C 137
SER C 167
LEU C 164
LEU C 126
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP D 145
ILE D 137
SER D 167
LEU D 164
LEU D 126
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP D 145
ILE D 137
SER D 167
LEU D 164
LEU D 126
1.68A
None
None
None
None
APR  D 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP A 157
LEU A 160
ILE A  18
LEU A 140
LEU A 126
1.70A
None
None
None
None
APR  A 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP E 157
LEU E 160
ILE E  18
LEU E 140
LEU E 126
1.72A
None
None
None
None
APR  E 201 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP E 145
ILE E 137
SER E 167
LEU E 164
LEU E 126
1.68A
None
None
None
None
APR  E 201 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C 145
ILE C 137
SER C 167
LEU C 164
LEU C 126
1.72A
None
None
None
None
APR  C 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C 157
LEU C 160
ILE C  18
LEU C 140
LEU C 126
1.70A
None
None
None
None
APR  C 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B 157
LEU B 160
ILE B  18
LEU B 140
LEU B 126
1.69A
None
None
None
None
APR  B 201 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ARG A 141
THR A 149
THR D 146
1.49A16.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B 145
ILE B 137
SER B 167
LEU B 164
LEU B 126
1.73A
None
None
None
None
APR  B 201 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP D 157
LEU D 160
ILE D  18
LEU D 140
LEU D 126
1.68A
None
None
None
None
APR  D 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP A 145
ILE A 137
SER A 167
LEU A 164
LEU A 126
1.68A
None
None
None
None
APR  A 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B 157
LEU B 160
ILE B  18
LEU B 140
LEU B 126
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C 145
ILE C 137
SER C 167
LEU C 164
LEU C 126
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP A 157
LEU A 160
ILE A  18
LEU A 140
LEU A 126
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C 157
LEU C 160
ILE C  18
LEU C 140
LEU C 126
1.72A
 MG  C 202 ( 2.6A)
EDO  C 203 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP A 145
ILE A 137
SER A 167
LEU A 164
LEU A 126
1.66A
None
EDO  A 206 (-4.6A)
EDO  A 206 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.62A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ILE B 119
LEU A 329
GLY A 327
VAL A 330
ALA A 379
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASP A  36
PHE A  45
LEU A 207
LEU A 127
LEU A 241
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 317
LEU A 251
ARG A 285
LEU A 186
LEU A 245
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ILE D 107
ASP C  67
PHE D  92
LEU C  17
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A  46
ARG A 733
SER A 239
LEU A 731
LEU A 708
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 186
ARG A 285
THR A 248
LEU A 251
LEU A 245
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 694
LEU A 630
ARG A 631
THR A 701
LEU A 469
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA B 162
LEU A 401
ASP A 390
PHE A 407
MET B 129
1.79A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
SER A 664
LEU A 351
GLY A 352
PHE A 348
1.79A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 185
LEU A 212
THR A 248
ILE A 244
LEU A 178
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
ARG A 181
ILE A 244
LEU A 127
LEU A 142
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		3 / 3
ARG A 173
THR A 319
THR A 394
1.40A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 313
LEU A 316
ARG A 279
LEU A 282
LEU A 251
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ASP C  67
PHE D  92
LEU C  13
TYR D 149
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 706
LEU A 708
LEU A 731
LEU A 727
TYR A 748
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASP A 291
SER A 239
ILE A 466
LEU A 470
ARG A 305
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		7btf NSP12
(SARS-CoV-2)		3 / 3
MET A 629
VAL A 700
GLU A 474
1.50A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
ASP A 377
SER A 363
LEU A 366
LEU B  91
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ILE D 107
ASP C  67
PHE D  92
LEU C  13
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ILE B 119
LEU A 329
GLY A 327
VAL A 330
ALA A 379
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP7
NSP8
(SARS-CoV-2)		3 / 3
ARG D 111
THR D  84
THR C   9
1.43A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ASP C  67
PHE D  92
LEU C  13
TYR D 149
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 246
ILE A 249
LEU A 253
GLY A 251
VAL A 297
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
MET A   6
VAL A 157
GLU A  14
1.59A23.03
DMS  A 406 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 208
THR A 199
LEU A 272
LEU A 287
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
THR A 199
LEU A 272
LEU A 287
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 115
GLY A 149
PHE A 159
TYR A 126
VAL A 125
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLU A 894
ASP A 851
LEU A 854
GLY A 852
VAL A 848
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLU A 894
ASP A 851
LEU A 854
GLY A 852
VAL A 848
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 125
ASP A 126
LEU A 212
LEU A 178
TYR A 237
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
ASP A 377
SER A 363
LEU A 366
LEU B  91
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 313
LEU A 316
ARG A 279
LEU A 282
LEU A 251
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 585
ILE A 696
PHE A 480
SER A 692
LEU A 576
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
MET A 629
VAL A 700
GLU A 474
1.53A14.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
MET A 626
VAL A 675
GLU A 350
1.80A14.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ASP A 291
SER A 239
ILE A 466
LEU A 470
ARG A 305
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ARG A 349
THR A 540
THR A 393
1.42A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 694
LEU A 630
ARG A 631
THR A 701
LEU A 469
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
ARG A 181
ILE A 244
LEU A 127
LEU A 142
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
ASP A 377
SER A 363
LEU A 366
LEU B  91
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ARG A 349
THR A 540
THR A 393
1.54A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ALA A 550
LEU C  55
ASP C  38
LEU C  41
PHE A 442
1.70A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 317
LEU A 251
ARG A 285
LEU A 186
LEU A 245
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
MET A 124
VAL A  31
GLU A 144
1.53A14.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ARG A 631
THR A 586
THR A 701
1.67A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ALA A 550
LEU C  55
ASP C  38
LEU C  41
PHE A 442
1.70A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 186
ARG A 285
THR A 248
LEU A 251
LEU A 245
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ARG A 631
THR A 246
THR A 701
1.36A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 125
ASP A 126
LEU A 212
LEU A 178
TYR A 237
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 706
LEU A 708
LEU A 731
LEU A 727
TYR A 748
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ARG A 457
THR A 462
THR A 680
1.61A20.04
None
None
F86  P 102 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 313
LEU A 316
ARG A 279
LEU A 282
LEU A 251
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
MET A 629
VAL A 700
GLU A 474
1.54A14.18
None