Ligand ID: KLN


Drugbank ID:
DB01026
(Ketoconazole)


Indication:
For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.

Get human targets for KLN in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'KLN' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		5r80 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
PHE A 230
LEU A 282
ALA A 285
GLU A 270
LEU A 287
1.59A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		5r81 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.61A20.43
DMS  A1005 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
ILE A 136
THR A 169
ILE A 106
GLY A 195
1.80A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
PHE A 230
LEU A 282
ALA A 285
GLU A 270
LEU A 287
1.62A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.65A15.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
ALA B 958
LEU B 959
ALA B 956
GLN A 954
GLN A 957
1.52A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 286
LEU A 287
THR A 201
MET A 264
GLU A 270
1.78A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.65A20.63
ELL  D   3 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6m0j ACE2
SPIKE RECEPTOR
BINDING DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 9
PHE E 456
SER A  77
LEU A  85
ALA A  99
LEU A  29
1.58A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.65A20.58
ELL  D   3 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 286
LEU A 287
THR A 201
MET A 264
GLU A 270
1.77A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 286
LEU A 287
THR A 201
MET A 264
GLU A 270
1.67A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 271
LEU B 272
ALA B 266
THR B 225
GLU B 240
1.78A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 172
MET D  17
PRO D 122
ALA D 173
PHE D 112
1.62A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 285
LEU D 286
ALA D 285
THR D 280
GLN D 299
1.73A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 285
LEU A 286
ALA A 285
THR A 280
GLN A 299
1.66A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 285
LEU B 286
ALA B 285
THR B 280
GLN B 299
1.71A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 285
LEU C 286
ALA C 285
THR C 280
GLN C 299
1.74A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.68A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 348
LEU B 117
ILE B 107
GLY A 327
1.27A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 7
PHE A 415
SER C  10
LEU A 437
GLY A 839
1.27A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 5
PHE A 419
PHE A 440
SER A 549
PHE A 429
1.73A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 7
PHE A 415
SER C  10
ILE C  39
GLY A 839
1.67A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PRO A 537
LEU A 387
ALA B 125
THR B 124
MET A 380
1.78A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 103
LEU D  98
ILE C  39
ALA C  48
THR C  45
1.67A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 317
LEU A 245
PHE A 287
ILE A 466
1.54A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 429
PHE A 859
ILE A 888
ILE A 864
1.45A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		5 / 11
SER A 692
ILE A 589
ALA A 580
ARG A 640
LEU A 575
1.79A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 321
PHE A 287
LEU A 316
ILE A 466
1.58A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 745
PHE A 782
ILE A 779
THR A 701
1.50A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE A 396
ARG A 392
LEU B 128
ILE B 185
THR A 402
1.64A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  10
LEU D 103
ILE C  39
ALA C  48
THR C  45
1.60A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE A 506
LEU B  95
LEU B  91
PHE A 340
ALA A 383
1.71A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		5 / 11
SER A 692
ILE A 589
ALA A 580
ARG A 640
LEU A 575
1.74A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 506
SER A 384
LEU B  91
PHE A 340
1.67A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 7
PHE A 859
PHE A 415
SER C  15
GLY A 841
1.49A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 859
PHE A 415
LEU A 437
GLY A 841
1.22A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 883
PHE A 419
ILE A 837
ALA A 866
GLU A 857
1.54A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 326
LEU A 316
PHE A 287
ILE A 466
1.61A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 859
ILE A 888
ILE A 864
GLY A 839
1.44A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 375
ALA A 376
THR A 538
GLN A 570
GLN A 524
1.80A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 7
PHE A 415
SER C  10
ILE C  39
GLY A 839
1.47A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 168
ILE A 128
ILE A 203
GLY A 232
1.23A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE C 855
SER B 555
PHE C  43
ILE B 584
1.14A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 10
ASP A 867
ARG A 815
ILE A 818
LEU A 865
ILE A 934
GLY A1059
1.74A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
LEU A 552
ILE A 584
ALA A 575
GLY A 545
LEU A 546
1.57A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
SER A  98
ILE A  97
ILE A 108
GLY A  77
0.94A21.78
None
None
None
GOL  A 404 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 300
LEU B 251
PHE B 233
ILE B 306
THR B 196
1.64A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 7
PHE A 214
PHE A 241
SER A 262
LEU A 255
GLY A 254
1.71A21.78
None
None
MG  A 403 (-2.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A 892
LEU A 894
ALA A 893
THR A 883
GLN A1036
1.46A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
SER B1003
LEU B 858
ALA B 958
ARG B 765
LEU B 767
1.58A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE C 543
LEU C 552
ILE C 584
GLY C 550
1.11A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
LEU B 552
ILE B 584
ALA B 575
GLY B 545
LEU B 546
1.53A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
SER B1003
LEU B 858
ALA B 958
ARG B 765
LEU B 767
1.59A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 543
LEU A 552
ILE A 584
GLY A 550
1.08A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
LEU C 552
ILE C 584
ALA C 575
GLY C 545
LEU C 546
1.46A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER C 816
PHE C 782
LEU C 864
ILE C 805
GLY C1059
1.48A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A 892
LEU A 894
ALA A 893
THR A 883
GLN A1036
1.48A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU B 552
ILE B 584
ALA B 575
THR B 573
LEU B 546
1.56A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ASP B 273
SER B  98
ILE B  97
ILE B 108
GLY B  77
1.51A21.78
None
None
None
None
PEG  B 411 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
PHE C 377
LEU C 513
PHE C 342
GLY C 431
1.34A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER L  27
LEU C 425
PHE C 464
GLY C 413
1.61A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE C 429
SER L  27
ILE L  28
GLY H  97
1.28A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
PHE C 377
SER L  27
LEU C 390
LEU C 387
ILE L  28
1.70A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE C 338
PHE C 392
SER L  27
ILE L  28
1.53A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE C 429
SER L  27
ILE L  28
GLY H  97
1.36A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
PHE C 429
SER C 359
ILE C 358
GLY C 431
1.74A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
PHE C 515
LEU C 425
ILE C 402
GLY C 431
1.72A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE C 377
SER L  27
LEU C 387
ILE L  28
1.70A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER L  27
PHE C 515
ILE L  28
GLY H  97
1.64A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6w4b NSP9
(SARS-CoV-2)		5 / 9
LEU A  89
ILE A  92
ALA A  31
GLY B 105
LEU A  10
1.49A14.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6947
ILE A6951
THR A6934
ILE A6925
1.36A
EDO  A7102 (-3.8A)
None
KCX  A6935 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6959
PHE A6954
ILE A6967
GLY A6962
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6901
ILE A6925
ILE A6967
GLY A6871
1.54A
None
None
None
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6927
LEU A6959
ILE A6951
GLY A6963
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6948
ILE A6951
THR A6934
ILE A6955
1.65A16.67
EDO  A7102 (-4.8A)
None
KCX  A6935 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
THR A6856
ILE A6866
GLY A6962
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6927
THR A6891
ILE A6951
GLY A6963
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
PHE B4321
SER B4325
THR B4354
GLY A6837
1.73A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6967
THR A6934
ILE A6955
GLY A6946
1.44A
None
KCX  A6935 ( 3.6A)
None
EDO  A7102 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6901
THR A6880
ILE A6955
GLY A6869
1.64A16.67
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6948
ILE A6951
ILE A6955
GLY A7019
1.56A
EDO  A7102 (-4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6925
THR A6908
ILE A6967
GLY A6871
1.76A16.67
None
None
None
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PRO A6932
ALA A6881
ALA A6905
THR A6908
PHE A6901
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 7
PHE A7003
ILE A6967
THR A6993
ILE A6951
GLY A6879
1.80A
None
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 286
LEU A 287
THR A 201
MET A 264
GLU A 270
1.69A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.66A
X77  A 401 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w6y NSP3
(SARS-CoV-2)		4 / 7
PHE B 116
THR B 146
ILE B  23
GLY B  97
1.62A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w6y NSP3
(SARS-CoV-2)		4 / 7
PHE A 116
THR A 146
ILE A  23
GLY A  97
1.65A17.01
None
None
AMP  A 201 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
PHE C6954
ILE C6967
ALA C6966
ARG C6884
1.68A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6925
THR A6908
ILE A6967
GLY A6871
1.75A14.79
None
None
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE A6948
ILE A6951
THR A6934
ILE A6955
1.74A14.79
None
None
FMT  A7103 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C6901
THR C6880
ILE C6955
GLY C6869
1.65A14.79
None
None
None
SAM  C7105 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE A6947
ILE A6951
THR A6934
ILE A6925
1.43A14.79
SAM  A7102 ( 4.8A)
None
FMT  A7103 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6926
THR C6856
ILE C6866
GLY C6962
1.51A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
SER C6927
THR C6891
ILE C6951
GLY C6963
1.52A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6927
LEU A6959
PHE A6954
ILE A6967
ARG A6884
1.73A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE A6948
ILE A6951
ILE A6955
GLY A7019
1.59A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
SER A6927
LEU A6959
ILE A6951
GLY A6963
1.41A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C6901
ILE C6925
ILE C6951
GLY C6871
1.61A14.79
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6959
PHE C6954
ILE C6967
GLY C6962
1.49A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6926
THR A6856
ILE A6866
GLY A6962
1.51A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w75 NSP10
(SARS-CoV-2)		4 / 7
PHE B4272
LEU D4365
ILE D4334
GLY D4362
1.73A15.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
SER A7089
ILE A7088
THR A6880
GLY A6869
1.80A14.79
None
None
None
SAM  A7102 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C6868
ILE C6926
THR C6918
GLY C6953
1.75A14.79
None
None
FMT  C7113 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6927
LEU C6959
PHE C6954
ILE C6967
ARG C6884
1.71A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
SER C7089
ILE C7088
THR C6880
GLY C6869
1.78A14.79
None
None
None
SAM  C7105 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6925
THR C6908
ILE C6967
GLY C6871
1.76A14.79
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C6948
ILE C6967
ILE C7005
GLY C7019
1.71A14.79
FMT  C7115 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
SER C6927
LEU C6959
ILE C6951
GLY C6963
1.36A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6959
PHE A6954
ILE A6967
GLY A6962
1.52A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE A6901
THR A6880
ILE A6955
GLY A6869
1.65A14.79
None
None
None
SAM  A7102 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
PHE A6954
ILE A6967
ALA A6966
ARG A6884
1.71A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PRO C6932
ALA C6881
ALA C6905
THR C6908
PHE C6901
1.78A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		5 / 7
PHE A7003
ILE A6967
THR A6993
ILE A6951
GLY A6879
1.75A14.79
None
None
None
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE A6948
ILE A6967
ILE A7005
GLY A7019
1.71A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE A6901
ILE A6925
ILE A6967
GLY A6871
1.56A14.79
None
None
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6924
ILE A7079
ALA A6858
THR A6856
MET A6982
1.80A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C6901
ILE C6925
ILE C6967
GLY C6871
1.56A14.79
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6967
THR A6934
ILE A6955
GLY A6946
1.51A14.79
None
FMT  A7103 ( 4.4A)
None
FMT  A7108 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE A6868
ILE A6926
THR A6918
GLY A6953
1.76A14.79
None
None
FMT  A7109 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6924
ILE C7079
ALA C6858
THR C6856
MET C6982
1.80A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C7003
THR C6993
ILE C6951
GLY C6879
1.67A14.79
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C6948
ILE C6951
ILE C6955
GLY C7019
1.58A14.79
FMT  C7115 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
LEU C 152
ILE C 104
ALA C 144
GLY C  38
LEU C  87
1.65A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
PHE B 241
LEU B 150
ALA B 144
GLU B 124
LEU B 120
1.61A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PHE C 241
LEU C 150
PHE C 147
ALA C 144
LEU C 120
1.73A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
PHE C 241
LEU C 150
ALA C 139
GLU C 124
LEU C 120
1.72A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 135
LEU A 132
ALA A 131
PHE A  79
MET A  84
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PHE A 241
LEU A 150
PHE A 147
ALA A 139
LEU A 120
1.70A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
HIS B 275
ALA B 114
LEU B 117
ALA B 116
THR B 168
1.78A
None
CL  B 502 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
PHE A 127
SER A 103
PHE A 173
ILE A 285
1.75A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
MET C  84
ALA C 114
LEU C 113
ALA C 116
PHE C 147
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA C 135
LEU C 132
ALA C 131
PHE C  79
MET C  84
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PHE A 241
PHE A 147
ALA A 139
GLU A 124
LEU A 120
1.80A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PHE C 241
LEU C 150
PHE C 147
ALA C 139
LEU C 120
1.69A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
PHE B 127
SER B 103
PHE B 173
ILE B 285
1.70A21.25
None
CL  B 502 ( 4.4A)
None
CL  B 502 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
HIS B 275
ALA B 114
LEU B 117
THR B 168
ILE B 123
1.40A
None
CL  B 502 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
PHE B 241
PHE B 147
PHE B 173
ILE B 104
1.80A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
PHE A 241
LEU A 150
ALA A 144
GLU A 124
LEU A 120
1.62A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
PHE C 127
SER C 103
PHE C 173
ILE C 285
1.68A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
PHE A 241
PHE A 147
PHE A 173
ILE A 104
1.73A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PHE A 241
LEU A 150
PHE A 147
ALA A 144
LEU A 120
1.77A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PHE B 241
PHE B 147
ALA B 139
GLU B 124
LEU B 120
1.74A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
MET A  84
ALA A 114
LEU A 113
ALA A 116
PHE A 147
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PHE B 241
LEU B 150
PHE B 147
ALA B 144
LEU B 120
1.77A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
PHE C 241
LEU C 150
ALA C 144
GLU C 124
LEU C 120
1.53A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
PHE C 241
PHE C 147
PHE C 173
ILE C 104
1.75A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PHE B 241
LEU B 150
PHE B 147
ALA B 139
LEU B 120
1.63A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER A  10
LEU B 103
ILE A  39
ALA A  48
THR A  45
1.53A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  10
LEU B 103
ILE A  39
PHE A  49
ALA A  48
1.63A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  10
ILE A  39
ALA A  48
ARG B  96
LEU B 103
1.38A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
THR B  84
ILE B 119
GLY A  64
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
ILE B 120
THR B 141
GLY B 113
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE D 314
SER C 318
LEU D 331
GLY D 321
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE E 314
SER F 318
LEU E 331
GLY E 321
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
ILE B 320
THR A 282
ILE A 304
GLY A 275
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
SER D 318
LEU C 353
ILE D 320
GLY C 295
LEU C 291
1.79A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PHE C 274
LEU C 353
ILE C 337
ALA C 336
GLY D 316
1.66A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE F 314
SER E 318
LEU F 331
GLY F 321
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
ILE F 320
THR E 282
ILE E 304
GLY E 275
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PHE A 274
LEU A 353
ILE A 337
ALA A 336
GLY B 316
1.65A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE C 274
THR C 296
ILE C 337
GLY D 316
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ARG F 262
PHE F 314
ILE E 337
ALA E 336
THR F 282
1.72A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE B 314
SER A 318
LEU B 331
GLY B 321
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE C 314
SER D 318
LEU C 331
GLY C 321
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE F 274
SER F 310
THR F 296
GLY E 316
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ARG A 262
PHE A 314
ILE B 337
ALA B 336
THR A 282
1.77A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE E 274
THR E 296
ILE E 337
GLY F 316
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
SER B 318
LEU A 353
ILE B 320
GLY A 295
LEU A 291
1.79A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
ILE D 320
THR C 282
ILE C 304
GLY C 275
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE A 274
THR A 296
ILE A 337
GLY B 316
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE A 314
SER B 318
LEU A 331
GLY A 321
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
ILE E 320
THR F 282
ILE F 304
GLY F 275
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE B 274
THR B 296
ILE B 337
GLY A 316
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
ILE A 320
THR B 282
ILE B 304
GLY B 275
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
ILE C 320
THR D 282
ILE D 304
GLY D 275
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE D 274
THR D 296
ILE D 337
GLY C 316
1.34A
None
CL  D 401 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6947
ILE A6951
THR A6934
ILE A6925
1.38A
SAH  A7102 (-4.7A)
None
FMT  A7103 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6901
ILE A6925
ILE A6967
GLY A6871
1.55A
None
None
None
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER C6927
LEU C6959
ILE C6951
GLY C6963
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6959
PHE A6954
ILE A6967
GLY A6962
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6967
THR A6934
ILE A6955
GLY A6946
1.52A
None
FMT  A7103 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6927
LEU A6959
ILE A6951
GLY A6963
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE C6926
THR C6856
ILE C6866
GLY C6962
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
PHE A6954
ILE A6967
ALA A6966
ARG A6884
1.74A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A7003
THR A6993
ILE A6951
GLY A6879
1.55A
None
None
None
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
THR A6856
ILE A6866
GLY A6962
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE C6947
ILE C6951
THR C6934
ILE C6925
1.43A
SAH  C7102 (-4.6A)
None
FMT  C7104 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU C6959
PHE C6954
ILE C6967
GLY C6962
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE C6967
THR C6934
ILE C6955
GLY C6946
1.52A
None
FMT  C7104 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6927
LEU C6959
PHE C6954
ILE C6967
ARG C6884
1.74A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER C6927
THR C6891
ILE C6951
GLY C6963
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6959
PHE C6954
ILE C6967
ALA C6966
ARG C6884
1.71A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
LEU A6959
PHE A6954
ILE A6967
ARG A6884
1.77A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE C  66
ILE C 131
THR C 166
GLY C 170
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B  59
LEU B  56
ALA B  55
THR B  54
GLN C  83
1.77A
 ZN  C 201 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE A  66
ILE A 131
THR A 166
GLY A 170
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE D  66
ILE D 131
THR D 166
GLY D 170
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER C  78
PHE C  53
ILE C 146
GLY C  71
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE C  66
PHE C  53
ILE C 157
GLY C  71
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE B  66
ILE B 131
THR B 166
GLY B 170
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE A  66
PHE A  53
ILE A 157
GLY A  71
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER A  78
PHE A  53
ILE A 146
GLY A  71
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER D  78
PHE D  53
ILE D 146
GLY D  71
1.46A
None
None
MES  D 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE B  66
PHE B  53
ILE B 157
GLY B  71
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
PHE D  66
PHE D  53
ILE D 157
GLY D  71
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6927
LEU A6959
PHE A6954
ILE A6967
ARG A6884
1.77A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
PHE A6947
ILE A6951
THR A6934
ILE A6925
1.39A
SFG  A7103 ( 4.8A)
None
FMT  A7105 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE C6926
THR C6856
ILE C6866
GLY C6962
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
PHE A6901
ILE A6925
ILE A6967
GLY A6871
1.56A
None
None
None
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
SER A6927
LEU A6959
ILE A6951
GLY A6963
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE C6967
THR C6934
ILE C6955
GLY C6946
1.57A
None
FMT  C7104 ( 4.7A)
None
FMT  C7105 ( 2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
PHE C6947
ILE C6951
THR C6934
ILE C6925
1.35A
FMT  C7105 ( 3.5A)
None
FMT  C7104 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE A6967
THR A6934
ILE A6955
GLY A6946
1.52A
None
FMT  A7105 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
PHE A7003
THR A6993
ILE A6951
GLY A6879
1.54A
None
None
None
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
PHE C6901
ILE C6925
ILE C6967
GLY C6871
1.57A
None
None
None
SFG  C7103 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
SER C6927
LEU C6959
ILE C6951
GLY C6963
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
PHE A6954
ILE A6967
ALA A6966
ARG A6884
1.74A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
SER C6927
THR C6891
ILE C6951
GLY C6963
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU A6959
PHE A6954
ILE A6967
GLY A6962
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
PHE C6954
ILE C6967
ALA C6966
ARG C6884
1.70A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6924
ILE C7079
ALA C6858
THR C6856
MET C6982
1.79A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU C6959
PHE C6954
ILE C6967
GLY C6962
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
SER A6927
THR A6891
ILE A6951
GLY A6963
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE A6926
THR A6856
ILE A6866
GLY A6962
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6927
LEU C6959
PHE C6954
ILE C6967
ARG C6884
1.71A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 204
PHE A 233
ILE A 223
GLY A 254
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 233
LEU B 300
ILE B 306
GLY B 254
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 222
LEU B 300
ILE B 307
GLY B 254
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
SER B  98
ILE B  97
ILE B 108
GLY B 141
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ASP B 283
ARG B 258
LEU B 266
ILE B 223
GLY B 248
1.74A20.84
None
None
None
None
U5P  B 401 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 330
LEU A 300
PHE A 214
ILE A 223
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
SER A  98
ILE A  97
ILE A 108
GLY A 141
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ASP A 273
SER A  98
ILE A  97
ILE A 108
GLY A  77
1.54A20.84
EDO  A 408 (-3.0A)
None
None
None
EDO  A 406 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
SER B  98
ILE B  97
ILE B 108
GLY B  77
0.91A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ASP B 273
SER B  98
ILE B  97
ILE B 108
GLY B  77
1.51A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
SER A  98
ILE A  97
ILE A 108
GLY A  77
0.91A
None
None
None
EDO  A 406 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 204
PHE B 303
ILE B 307
GLY B 254
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 7
PHE A 214
PHE A 241
SER A 262
LEU A 255
GLY A 254
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 300
LEU A 251
PHE A 233
ILE A 306
THR A 196
1.66A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 214
SER A 262
LEU A 249
GLY A 254
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 233
LEU A 300
ILE A 306
GLY A 254
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 7
PHE B 214
PHE B 241
SER B 262
LEU B 255
GLY B 254
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 204
PHE B 233
ILE B 223
GLY B 254
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
SER B 309
LEU B 228
ILE B 306
GLY B 230
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 300
LEU B 251
PHE B 233
ILE B 306
THR B 196
1.65A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 214
PHE B 241
SER B 262
GLY B 254
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 303
ILE A 306
ILE A 328
GLY A 248
1.58A
None
None
None
U5P  A 401 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 330
LEU B 300
PHE B 214
ILE B 223
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 222
LEU A 300
ILE A 307
GLY A 254
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 330
SER B 309
LEU B 298
PHE B 303
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 233
LEU B 251
PHE B 303
GLY B 254
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 233
LEU A 251
PHE A 303
GLY A 254
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 286
LEU A 287
THR A 201
MET A 264
GLU A 270
1.66A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6967
THR A6934
ILE A6955
GLY A6946
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6959
PHE A6954
ILE A6967
GLY A6962
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
THR A6856
ILE A6866
GLY A6962
1.53A
None
8NK  A7103 (-2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6927
THR A6891
ILE A6951
GLY A6963
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6927
LEU A6959
ILE A6951
GLY A6963
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A7003
THR A6993
ILE A6951
GLY A6879
1.54A
None
None
None
SAH  A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6901
ILE A6925
ILE A6967
GLY A6871
1.56A
None
None
None
SAH  A7101 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
ILE A7079
ALA A6858
THR A6856
MET A6982
1.77A21.38
None
None
None
8NK  A7103 (-2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6947
ILE A6951
THR A6934
ILE A6925
1.42A
SAH  A7101 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  10
ILE C  39
ALA C  48
ARG D  96
LEU D 103
1.78A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
ILE B 120
THR B 141
GLY B 113
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
ILE A  39
ALA A  48
THR A  45
ARG B  96
1.68A12.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  10
ILE A  39
ALA A  48
THR A  45
ARG B  96
1.58A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  10
LEU D 103
ILE C  39
ALA C  48
THR C  45
1.51A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 103
LEU D  98
ILE C  39
ALA C  48
THR C  45
1.54A12.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B 103
LEU B  98
ILE A  39
ALA A  48
THR A  45
1.49A12.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  10
ILE A  39
ALA A  48
ARG B  96
LEU B 103
1.78A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
LEU B 122
ILE A  39
ALA A  48
THR A  45
ARG B  96
1.67A12.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  10
ILE C  39
ALA C  48
THR C  45
ARG D  96
1.55A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER C  57
ILE D 120
THR D 141
GLY D 113
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER A  10
ILE A  39
ALA A  48
THR A  45
ARG B  96
1.62A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  10
LEU B 103
ILE A  39
PHE A  49
ALA A  48
1.63A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  10
ILE C  39
ALA C  48
THR C  45
ARG D  96
1.60A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 122
ILE C  39
ALA C  48
THR C  45
ARG D  96
1.72A12.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER A  10
LEU B 103
ILE A  39
ALA A  48
THR A  45
1.48A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
LEU D 122
ILE C  39
ALA C  48
THR C  45
ARG D  96
1.70A12.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  10
LEU D 103
ILE C  39
PHE C  49
ALA C  48
1.66A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
HIS A 275
ALA A 114
LEU A 117
THR A 168
ILE A 123
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
PHE A 241
PHE A 147
PHE A 173
ILE A 104
1.75A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
PHE A  55
SER A  49
THR A  10
GLY A  38
1.57A
None
PO4  A 503 (-2.9A)
CL  A 506 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 11
PHE A 241
LEU A 150
PHE A 147
ALA A 139
LEU A 120
1.56A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
MET A  84
ALA A 114
LEU A 113
ALA A 116
PHE A 147
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 11
PHE A 241
LEU A 150
PHE A 147
ALA A 144
LEU A 120
1.75A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
HIS A 275
ALA A 114
LEU A 117
ALA A 116
THR A 168
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6xez NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  10
ILE C  39
ALA C  48
ARG D  96
LEU D 103
1.45A12.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		6y2f REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
PHE A 305
PHE A   3
SER A   1
PHE A 294
1.55A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.66A16.38
DMS  A 405 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE A 136
THR A 169
ILE A 106
GLY A 195
1.78A16.21
None
None
None
DMS  A 404 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE A 230
LEU A 282
ALA A 285
GLU A 270
LEU A 287
1.62A16.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
SER A  57
ILE B 120
THR B 141
GLY B 113
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
LEU B  98
ILE A  39
PHE A  49
ALA A  48
THR A  46
1.77A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER C  10
ILE C  39
ALA C  48
ARG D  96
LEU D 103
1.36A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER C  10
LEU D 103
ILE C  39
ALA C  48
THR C  45
1.61A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER A  10
ILE A  39
ALA A  48
ARG B  96
LEU B 103
1.35A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER A  10
ILE A  39
ALA A  48
THR A  45
ARG B  96
1.78A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER C  10
LEU D 103
ILE C  39
PHE C  49
ALA C  48
1.66A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER C  10
ILE C  39
ALA C  48
ARG D  96
LEU D 103
1.33A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D 103
LEU D  98
ILE C  39
ALA C  48
THR C  45
1.58A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B 103
LEU B  98
ILE A  39
ALA A  48
THR A  45
1.51A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
SER C  57
ILE D 120
THR D 141
GLY D 113
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER A  10
ILE A  39
ALA A  48
ARG B  96
LEU B 103
1.38A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER A  10
LEU B 103
ILE A  39
ALA A  48
THR A  45
1.55A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A  26
PHE A  13
ILE A 117
GLY A  31
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
SER A  38
THR A 125
ILE A 106
GLY A  29
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A  26
ILE A  91
THR A 126
GLY A 130
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
SER A  38
PHE A  13
ILE A 106
GLY A  31
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
SER A  38
PHE A  70
ILE A 106
GLY A  97
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 515
LEU A 425
ILE A 402
GLY A 431
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER C  33
LEU A 425
PHE A 464
GLY A 413
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 377
SER C  33
ILE C  34
THR A 385
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 429
SER B 103
ILE B 102
GLY A 413
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 377
LEU E 513
PHE E 342
GLY E 431
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 377
LEU A 513
PHE A 342
GLY A 431
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 515
LEU E 425
ILE E 402
GLY E 431
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 429
SER L  33
ILE L  34
GLY H 101
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 464
SER C  33
ILE C  34
GLY A 413
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 338
PHE E 392
SER L  33
ILE L  34
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER L  33
LEU E 425
PHE E 464
GLY E 413
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 377
SER L  33
LEU E 387
ILE L  34
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 429
SER C  33
ILE C  34
GLY B 101
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
PHE E 377
SER L  33
LEU E 390
LEU E 387
ILE L  34
1.71A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 377
LEU E 513
PHE E 342
GLY E 431
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 515
LEU E 425
ILE E 402
GLY E 431
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 338
PHE E 392
SER L  33
ILE L  34
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 377
SER L  33
ILE L  34
THR E 385
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6ym0 HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 429
SER L  33
ILE L  34
GLY H 101
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE A 230
LEU A 282
ALA A 285
GLU A 270
LEU A 287
1.58A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER L  33
LEU E 425
PHE E 464
GLY E 413
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 429
SER C  33
ILE C  34
GLY B 101
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 377
SER L  33
LEU E 387
ILE L  34
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 515
LEU E 425
ILE E 402
GLY E 431
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 377
LEU E 513
PHE E 342
GLY E 431
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 377
SER C  33
LEU A 387
ILE C  34
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 429
SER L  33
ILE L  34
GLY H 101
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 338
PHE E 392
SER L  33
ILE L  34
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
PHE A 377
SER C  33
LEU A 390
LEU A 387
ILE C  34
1.71A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 338
PHE A 392
SER C  33
ILE C  34
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
PHE E 377
SER L  33
LEU E 390
LEU E 387
ILE L  34
1.71A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 515
LEU A 425
ILE A 402
GLY A 431
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 377
LEU A 513
PHE A 342
GLY A 431
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 456
LEU H  86
ILE H  20
GLY H  15
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER C  33
LEU A 425
PHE A 464
GLY A 413
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 205
ILE A 259
MET A 276
GLU A 270
1.77A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
SER E 167
LEU E  12
ILE E 137
GLY D   8
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
SER B 167
ILE B 137
ALA A  56
THR A  57
LEU A  53
1.73A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		4 / 7
ILE B 293
THR B 286
ILE B 304
GLY B 400
1.19A24.36
None
PO4  B 704 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 286
LEU A 287
THR A 201
MET A 264
GLU A 270
1.76A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.64A
PJE  C   5 (-4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D  95
LEU D  98
ILE D 106
ALA D 102
GLU C  47
1.77A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  10
LEU D 122
ILE C  39
ALA C  48
THR C  45
1.64A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 7
PHE A 415
SER C  10
ILE C  39
GLY A 839
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		5 / 10
ASP A 218
ARG A 116
SER A  68
LEU A 205
ILE A  66
1.79A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		5 / 11
SER A 692
ILE A 589
ALA A 580
ARG A 640
LEU A 575
1.74A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 102
SER A  68
ILE A  66
GLY A  13
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  10
LEU D 103
ILE C  39
ALA C  48
THR C  45
1.53A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 429
PHE A 859
ILE A 888
ILE A 864
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		7btf NSP12
(SARS-CoV-2)		5 / 12
HIS A 572
ALA A 639
PHE A 528
GLN A 573
ILE A 488
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER C  57
ILE D 120
THR D 141
GLY D 113
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  10
LEU D 122
ILE C  39
ALA C  48
THR C  45
1.68A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 7
PHE A 415
SER C  10
LEU A 437
GLY A 839
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE A 506
LEU B  95
LEU B  91
PHE A 340
ALA A 383
1.78A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		5 / 10
ASP A 218
ARG A 116
SER A  68
LEU A  90
ILE A  66
1.78A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 317
LEU A 245
PHE A 287
ILE A 466
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 859
ILE A 888
ILE A 864
GLY A 839
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 5
PHE A 102
SER A  68
PHE A   7
ILE A  66
1.49A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 11
LEU D  98
ILE C  39
PHE C  49
THR C  46
GLU A 436
1.65A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		5 / 10
ARG A 116
SER A  68
LEU A  90
ILE A  66
GLY A 214
1.63A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 883
PHE A 419
ILE A 837
ALA A 866
GLU A 857
1.56A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		5 / 11
SER A 692
ILE A 589
ALA A 580
ARG A 640
LEU A 575
1.69A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 326
LEU A 316
PHE A 287
ILE A 466
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
SER A 343
LEU B 103
LEU B  98
ALA A 382
1.69A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 348
LEU B 117
ILE B 107
GLY A 327
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 321
PHE A 287
LEU A 316
ILE A 466
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE A 396
ARG A 392
LEU B 128
ILE B 185
THR A 402
1.60A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B  98
LEU B  95
THR B  89
ARG A 365
GLU A 370
1.74A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		5 / 9
LEU A 207
ILE A 244
ALA A 130
GLU A 180
LEU A 212
1.78A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 11
LEU D  98
ILE C  39
PHE C  49
ALA C  48
THR C  46
1.78A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  10
LEU D 122
ILE C  39
ALA C  48
LEU D 103
1.59A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 326
LEU A 329
ILE B 107
GLY A 327
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 745
PHE A 782
ILE A 779
THR A 701
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 103
LEU D  98
ILE C  39
ALA C  48
THR C  45
1.48A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  10
LEU D 103
ILE C  39
PHE C  49
ALA C  48
1.70A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 9
SER C  10
LEU D 122
ILE C  39
ALA C  48
LEU D 103
1.50A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 843
PHE A 429
SER A 434
GLY A 839
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
MET A  17
PRO A 122
ALA A 173
PHE A 112
1.63A
DMS  A 402 (-4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 286
LEU A 287
THR A 201
MET A 264
GLU A 270
1.77A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
SER A 692
ILE A 589
ALA A 580
ARG A 640
LEU A 575
1.63A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
SER A 692
ILE A 589
ALA A 580
ARG A 640
LEU A 575
1.67A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 812
THR A 817
ILE A 589
GLY A 597
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 7
PHE A 415
SER C  10
LEU A 437
GLY A 839
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 326
LEU A 316
PHE A 287
ILE A 466
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
SER A 343
LEU B 103
LEU B  98
ALA A 382
1.56A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 399
LEU A 388
THR A 393
MET A 542
GLN A 541
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 506
SER A 384
LEU B  91
PHE A 340
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 317
LEU A 245
PHE A 287
ILE A 466
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 321
PHE A 287
LEU A 316
ILE A 466
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 326
LEU A 329
ILE B 107
GLY A 327
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 429
PHE A 859
ILE A 888
ILE A 864
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 745
PHE A 782
ILE A 779
THR A 701
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ARG A 583
LEU A 638
LEU A 575
PHE A 480
ILE A 589
1.68A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
PHE A 419
PHE A 440
SER A 549
PHE A 429
1.74A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  10
LEU D 103
PHE C  49
ALA C  48
THR C  45
1.72A12.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 859
ILE A 888
ILE A 864
GLY A 839
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
HIS A 572
ALA A 639
PHE A 528
GLN A 573
ILE A 488
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
HIS A 572
ALA A 639
PHE A 528
GLN A 573
ILE A 488
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
PHE A 419
PHE A 440
SER A 549
PHE A 429
1.72A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 326
LEU A 329
ILE B 107
GLY A 327
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ARG A 733
SER A 236
ARG A 726
GLU A 729
LEU A 708
1.73A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 348
LEU B 117
ILE B 107
GLY A 327
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 382
ALA A 399
GLN A 408
MET A 542
GLN A 541
1.49A
None
None
None
None
U  T   8 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 321
PHE A 287
LEU A 316
ILE A 466
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 843
PHE A 429
SER A 434
GLY A 839
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
SER A 692
ILE A 589
ALA A 580
ARG A 640
LEU A 575
1.67A19.10
None
None
A  T  13 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
SER B  85
LEU A 514
PHE A 368
GLY A 510
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
SER A 692
ILE A 589
ALA A 580
ARG A 640
LEU A 575
1.63A19.10
None
None
A  T  13 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 745
PHE A 782
ILE A 779
THR A 701
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
SER A 363
LEU B  91
PHE B  92
ILE A 333
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 326
LEU A 316
PHE A 287
ILE A 466
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 7
PHE A 415
SER C  10
LEU A 437
GLY A 839
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 340
PHE A 368
ILE A 562
THR A 538
MET A 380
1.78A19.10
None