Ligand ID: HLZ


Drugbank ID:
DB01275
(Hydralazine)


Indication:
For the treatment of essential hypertension, alone or as an adjunct. Also for the management of severe hypertension when the drug cannot be given orally or when blood pressure must be lowered immediately, congestive heart failure (in combination with cardiac glycosides and diuretics and/or with isosorbide dinitrate), and hypertension secondary to pre-eclampsia/eclampsia.

Get human targets for HLZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'HLZ' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE B 429
TYR B 380
VAL B 510
THR B 376
1.63A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6m71 NSP12
(SARS-CoV-2)		4 / 6
PHE A 859
TYR A 887
VAL A 880
PHE A 419
1.52A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6m71 NSP12
(SARS-CoV-2)		4 / 6
TYR A 483
CYH A 482
THR A 586
PHE A 480
1.73A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6m71 NSP12
(SARS-CoV-2)		4 / 6
TYR A 420
CYH A 842
VAL A 880
PHE A 429
1.78A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE B 759
TYR B 756
THR A 998
PHE A 970
1.57A11.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE B 759
TYR B 756
THR A 998
PHE A 970
1.79A12.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 6
PHE C 429
TYR C 380
VAL C 510
THR C 376
1.75A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6w75 NSP16
(SARS-CoV-2)		4 / 6
PHE A6868
TYR A6950
THR A6918
PHE A6954
1.63A21.25
None
FMT  A7109 ( 4.9A)
FMT  A7109 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6w75 NSP16
(SARS-CoV-2)		4 / 6
PHE C6868
TYR C6950
THR C6918
PHE C6954
1.62A21.25
None
None
FMT  C7113 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE C 173
VAL C 165
THR C 115
PHE C 304
1.55A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE B 173
VAL B 165
THR B 115
PHE B 304
1.54A20.55
None
None
CL  B 502 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 173
VAL A 165
THR A 115
PHE A 304
1.46A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
PHE C6868
TYR C6950
THR C6918
PHE C6954
1.60A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
PHE A6868
VAL A7086
THR A6918
PHE A6954
1.71A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6wkq NSP16
(SARS-CoV-2)		4 / 6
PHE A6868
TYR A6950
THR A6918
PHE A6954
1.68A21.66
None
None
FMT  A7108 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6wkq NSP16
(SARS-CoV-2)		4 / 6
PHE C6868
TYR C6950
THR C6918
PHE C6954
1.62A21.66
None
None
FMT  C7108 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6wkq NSP16
(SARS-CoV-2)		4 / 6
PHE A6868
VAL A7086
THR A6918
PHE A6954
1.75A21.66
None
None
FMT  A7108 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
PHE A6868
VAL A7086
THR A6918
PHE A6954
1.70A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6wrh NSP3
(SARS-CoV-2)		4 / 6
PHE A 173
VAL A 165
THR A 115
PHE A 304
1.34A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE E 429
TYR E 380
VAL E 510
THR E 376
1.71A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE A 429
TYR A 380
VAL A 510
THR A 376
1.73A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE E 429
TYR E 380
VAL E 510
THR E 376
1.72A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE A 429
TYR A 380
VAL A 510
THR A 376
1.71A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE E 429
TYR E 380
VAL E 510
THR E 376
1.71A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		7btf NSP12
(SARS-CoV-2)		4 / 6
TYR A 483
CYH A 482
THR A 586
PHE A 480
1.74A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 859
TYR A 887
VAL A 880
PHE A 419
1.56A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
TYR A 420
CYH A 842
VAL A 880
PHE A 429
1.76A15.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
TYR A 483
CYH A 482
THR A 586
PHE A 480
1.70A15.00
None