Ligand ID: HCY


Drugbank ID:
DB00741
(Hydrocortisone)


Indication:
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Get human targets for HCY in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'HCY' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
ALA C 956
SER C1175
VAL A 951
ILE C1179
ASN C1178
1.63A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.55A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 792
PRO A 620
ALA A 625
THR A 246
GLN A 698
1.73A17.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 764
THR A 769
ASN A 703
PHE A 766
HIS A 752
1.77A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 695
GLN A 789
MET A 626
MET A 633
ILE A 757
1.66A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 695
GLN A 789
MET A 626
MET A 633
ILE A 757
1.66A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.65A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.73A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 341
THR B 123
ILE B 107
1.77A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.70A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.50A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
LEU A 388
ILE A 539
PHE A 504
1.70A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.61A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 119
ASN A 213
GLY A 214
GLN A 210
MET A 124
1.66A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 895
MET A 906
TYR A 887
1.38A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 330
ILE B 119
ASN B 118
1.68A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A  95
PRO A  94
VAL A  96
PHE A 222
PHE A 219
1.79A18.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 695
GLN A 789
MET A 626
MET A 633
ILE A 757
1.67A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 142
MET A 124
TYR A 788
1.78A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.68A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.48A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.72A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 916
GLN B 901
THR B 881
ILE B 882
PHE B1052
1.55A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C  47
GLN C 853
PHE C 855
ARG C  44
ILE B 569
1.76A15.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 916
GLN A 901
THR A 881
ILE A 882
PHE A1052
1.52A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU A1004
MET A 740
TYR A 756
1.70A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C 174
THR C 240
PHE C  92
SER C  94
ASN C 121
1.51A16.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 317
GLY B 594
GLN B 613
LEU C 861
THR C 739
1.56A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C  47
GLN C 853
PHE C 855
ARG C  44
ILE B 569
1.71A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 123
THR C 240
PHE C  92
ASN C 188
SER C  94
1.69A15.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
MET A1050
LEU A1049
GLY A 908
LEU A 916
THR A 881
1.48A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ALA B  82
VAL B 122
THR B 115
ILE B 108
ASP B 107
1.75A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 916
GLN C 901
THR C 881
ILE C 882
PHE C1052
1.61A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C1056
VAL C1061
THR C 941
ILE C 934
LYS C 825
1.71A14.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A1056
SER A1055
VAL A1061
THR A 941
ILE A 934
1.47A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 126
PHE B 194
ILE B 203
SER B 205
ASN B 121
1.62A15.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
MET B1050
LEU B1049
GLY B 908
LEU B 916
THR B 881
1.51A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 916
GLN A 901
THR A 881
ILE A 882
PHE A1052
1.63A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU A1004
MET A 740
TYR A 756
1.62A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 916
GLN C 901
THR C 881
ILE C 882
PHE C1052
1.59A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 971
GLN A 755
LEU A 753
GLN A1002
THR B 998
1.47A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B1004
MET B 740
TYR B 756
1.62A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 971
GLN A 755
LEU A 753
GLN A1002
THR B 998
1.49A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A1056
SER A1055
VAL A1061
THR A 941
ILE A 934
1.57A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
MET B1050
LEU B1049
GLY B 908
LEU B 916
THR B 881
1.52A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 916
GLN A 901
THR A 881
ILE A 882
PHE A1052
1.61A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B1056
VAL B1061
THR B 941
ILE B 934
LYS B 825
1.64A14.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.73A24.11
None
None
None
None
CIT  B 408 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.79A23.81
None
None
None
None
CIT  B 408 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
PHE A6954
ASN A6920
HIS A6917
1.71A25.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.73A24.74
None
None
None
None
ACT  A7103 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.52A25.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.54A
None
KCX  A6935 ( 3.6A)
None
KCX  A6935 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.77A
None
None
None
None
EDO  A7103 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6881
THR C6993
PHE C7003
ILE C6926
LYS C6844
1.73A19.09
None
None
None
None
FMT  C7108 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6907
VAL C6894
PHE C6954
ASN C6920
HIS C6917
1.74A20.00
None
None
None
FMT  C7106 ( 4.1A)
FMT  C7113 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6909
GLY A6911
MET A6929
THR A6880
PHE A6901
1.60A20.24
None
None
SAM  A7102 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6960
PHE C6868
ARG C6864
ILE C6866
PHE C6954
1.79A19.09
None
None
FMT  C7106 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
GLY C6911
MET C6929
THR C6880
PHE C6901
1.60A20.24
None
NA  C7104 ( 4.1A)
SAM  C7105 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR A6934
ILE A6969
SER A7000
HIS A6972
TRP A6974
1.78A20.00
FMT  A7103 ( 4.4A)
None
FMT  A7105 ( 2.6A)
FMT  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.74A19.09
None
None
None
None
FMT  A7104 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
GLY C6911
MET C6929
THR C6880
PHE C6901
1.62A20.24
None
NA  C7104 ( 4.1A)
SAM  C7105 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
GLY C6911
MET C6929
THR C6880
PHE C6901
1.62A20.24
None
NA  C7104 ( 4.1A)
SAM  C7105 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ALA D4276
VAL B4274
ILE B4334
ASP D4335
LYS D4271
1.77A17.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6960
PHE A6868
ARG A6864
ILE A6866
PHE A6954
1.80A19.09
None
None
FMT  A7106 ( 2.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6907
VAL C6894
PHE C6954
ASN C6920
HIS C6917
1.75A20.00
None
None
None
FMT  C7106 ( 4.1A)
FMT  C7113 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.57A20.00
None
FMT  A7103 ( 4.4A)
None
FMT  A7105 ( 2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
VAL B 270
ALA B 264
THR D 296
GLN B 294
ASN B 269
1.72A16.49
None
None
CL  D 401 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.56A
FMT  A7108 ( 3.9A)
FMT  A7103 (-4.6A)
None
FMT  A7104 ( 2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ALA D4276
VAL B4274
ILE B4334
ASP D4335
LYS D4271
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ALA B4276
VAL D4274
ILE D4334
ASP B4335
LYS B4271
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6881
THR C6993
PHE C7003
ILE C6926
LYS C6844
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6960
PHE C6868
ARG C6864
ILE C6866
PHE C6954
1.76A
None
None
FMT  C7103 (-2.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6960
PHE A6868
ARG A6864
ILE A6866
PHE A6954
1.79A
None
None
FMT  A7106 (-2.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR C6934
ILE C6969
SER C7000
HIS C6972
TRP C6974
1.71A25.00
FMT  C7104 (-4.2A)
None
FMT  C7104 ( 3.7A)
FMT  C7104 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6976
THR C6934
ILE C6969
SER C7000
TRP C6974
1.58A
None
FMT  C7104 (-4.2A)
None
FMT  C7104 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
VAL D 158
THR D  57
ASN A  75
SER A  78
HIS A 145
1.68A16.89
None
ZN  A 201 ( 4.4A)
None
None
ZN  A 201 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6907
VAL C6894
PHE C6954
ASN C6920
HIS C6917
1.73A25.00
None
None
None
FMT  C7106 ( 4.1A)
FMT  C7108 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.73A
None
None
None
None
FMT  A7104 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6976
THR C6934
ILE C6969
SER C7000
TRP C6974
1.54A
None
FMT  C7104 ( 4.7A)
None
FMT  C7110 ( 3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR A6934
ILE A6969
SER A7000
HIS A6972
TRP A6974
1.79A25.00
FMT  A7105 ( 4.6A)
None
FMT  A7106 ( 2.8A)
FMT  A7105 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6907
VAL C6894
PHE C6954
ASN C6920
HIS C6917
1.72A25.00
None
None
None
FMT  C7106 ( 4.1A)
FMT  C7108 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6960
PHE A6868
ARG A6864
ILE A6866
PHE A6954
1.80A
None
None
FMT  A7109 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.55A
None
FMT  A7105 ( 4.6A)
None
FMT  A7106 ( 2.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6909
GLY A6911
MET A6929
THR A6880
PHE A6901
1.60A21.61
None
NA  A7102 ( 4.2A)
SFG  A7103 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6960
PHE C6868
ARG C6864
ILE C6866
PHE C6954
1.76A
None
None
FMT  C7106 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6881
THR C6993
PHE C7003
ILE C6926
LYS C6844
1.73A
None
None
None
None
FMT  C7112 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP10
(SARS-CoV-2)		5 / 12
ALA D4276
VAL B4274
ILE B4334
ASP D4335
LYS D4271
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
GLY C6911
MET C6929
THR C6880
PHE C6901
1.61A21.61
None
NA  C7102 ( 4.2A)
SFG  C7103 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 319
PHE A 303
ILE A 306
PHE A 342
HIS A 250
1.78A
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER B 294
VAL B 295
PHE B 241
ILE B 281
SER B 288
1.74A22.00
U5P  B 401 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.74A22.00
None
None
None
None
U5P  B 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER A 329
VAL A 319
PHE A 303
ILE A 306
PHE A 342
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.76A22.00
None
None
None
None
U5P  B 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 319
PHE A 303
ILE A 306
PHE A 342
HIS A 250
1.74A22.00
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.78A
None
None
None
None
U5P  B 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER A 329
VAL A 319
ILE A 306
PHE A 342
HIS A 250
1.76A22.00
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 319
PHE A 303
ILE A 306
PHE A 342
HIS A 250
1.80A22.14
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER B 294
VAL B 295
PHE B 241
ILE B 281
SER B 288
1.68A22.00
U5P  B 401 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER A 294
VAL A 295
PHE A 241
ILE A 281
SER A 288
1.66A22.00
U5P  A 401 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ALA B  82
VAL B 122
THR B 115
ILE B 108
ASP B 107
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 319
PHE A 303
ILE A 306
PHE A 342
HIS A 250
1.75A22.00
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER A 294
VAL A 295
PHE A 241
ILE A 281
SER A 288
1.72A22.00
U5P  A 401 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.52A
None
None
None
GTA  A7102 (-2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR A6934
ILE A6969
SER A7000
HIS A6972
TRP A6974
1.71A25.00
None
None
GTA  A7102 (-2.6A)
GTA  A7102 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
GLN A6957
ASN A6920
HIS A6917
1.68A25.00
None
None
None
SO4  A7106 (-4.1A)
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
PHE A6954
ASN A6920
HIS A6917
1.75A25.00
None
None
None
SO4  A7106 (-4.1A)
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7037
GLY A6829
GLN A6847
MET A6840
ILE A7035
1.70A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7037
ASN A6827
GLY A6829
MET A6840
ILE A7035
1.76A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.74A
None
None
None
None
GTA  A7102 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
PHE A6954
ASN A6920
HIS A6917
1.76A24.81
None
None
None
SO4  A7106 (-4.1A)
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
GLN A6957
ASN A6920
HIS A6917
1.66A25.00
None
None
None
SO4  A7106 (-4.1A)
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A 117
LEU A 172
GLN A 122
THR A 277
ILE A 285
1.72A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA B 152
SER B 151
THR B 187
PHE B 147
TRP B 154
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 119
GLY A 135
ARG A  67
THR A  36
ILE A  34
1.41A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 119
GLY A 135
ARG A  67
THR A  36
ILE A  34
1.42A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
SER A  11
ARG A 109
ILE A 106
ASN A  37
SER A  38
1.79A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 119
GLY A 135
ARG A  67
THR A  36
ILE A  34
1.43A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER E 128
PHE B 132
ILE B 131
ASN E 101
HIS B  45
1.77A19.05
EPE  E 202 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.51A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.76A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.71A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 330
ILE B 119
ASN B 118
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.72A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 330
GLN A 661
THR A 538
ARG A 331
ASN A 356
1.76A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 341
THR B 123
ILE B 107
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.47A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.41A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 634
SER A 635
THR A 586
ILE A 579
PHE A 480
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.43A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.67A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 119
ASN A 213
GLY A 214
GLN A 210
MET A 124
1.67A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 343
VAL A 330
THR B 124
ILE B 119
ASN B 118
1.76A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.75A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
ALA D 152
SER D 151
THR D 187
PHE D 147
TRP D 154
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 634
SER A 635
THR A 586
ILE A 579
PHE A 480
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.70A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.57A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.45A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.55A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.35A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.53A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A  95
PRO A  94
VAL A  96
PHE A 222
PHE A 219
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 341
THR B 123
ILE B 107
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A  95
PRO A  94
VAL A  96
GLN A 224
PHE A 219
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 239
PHE A 317
ASN A 312
PHE A 287
TRP A 290
1.68A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.50A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.32A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 656
VAL A 354
PHE A 326
ASN A 314
SER A 318
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.54A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 330
ILE B 119
ASN B 118
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.47A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
LEU A 388
ILE A 539
PHE A 504
1.62A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 343
VAL A 330
THR B 124
ILE B 119
ASN B 118
1.66A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A  95
PRO A  94
VAL A  96
PHE A 222
PHE A 219
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.70A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 330
GLN A 661
THR A 538
ARG A 331
ASN A 356
1.78A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 634
SER A 635
THR A 586
ILE A 579
PHE A 480
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.56A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 341
THR B 123
ILE B 107
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.32A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.35A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.71A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 239
PHE A 317
ASN A 312
PHE A 287
TRP A 290
1.66A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.31A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.51A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.55A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.42A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 330
ILE B 119
ASN B 118
1.69A
None