Ligand ID: FMM


Drugbank ID:
DB01259
(Lapatinib)


Indication:
Indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzuma.

Get human targets for FMM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'FMM' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.69A20.18
None
None
None
DMS  A 403 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 146
CYH A  38
LEU A  87
LEU A  27
THR A  26
1.70A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A  32
VAL A  35
LYS A  88
LEU A  87
LEU A  30
1.76A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 204
THR A 199
GLY A 275
LEU A 272
LEU A 242
1.64A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  29
CYH A  38
LEU A  87
LEU A  27
THR A  25
1.75A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.67A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 129
LEU A 282
THR A 292
ASP A 295
PHE A 294
1.45A22.98
None
None
None
DMS  A 402 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.75A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  86
MET A 130
LEU A  27
GLY A  29
PHE A 112
1.38A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
VAL E1164
ALA F 972
LEU F 977
GLY E1167
LEU D 977
1.30A17.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
LEU A 253
GLY A 251
PHE A 230
1.67A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  87
VAL A  86
LEU A  32
LEU A  30
LEU A  89
1.71A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.66A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 296
ALA A 210
LEU A 208
GLY A 302
THR A 257
1.78A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.74A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 146
CYH A  38
LEU A  87
LEU A  27
THR A  26
1.72A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  29
CYH A  38
LEU A  87
LEU A  27
THR A  25
1.74A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.71A21.45
None
None
None
DMS  A 403 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
LEU A 253
GLY A 251
PHE A 230
1.70A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  87
VAL A  86
LEU A  32
LEU A  30
LEU A  89
1.78A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.70A21.45
None
None
None
DMS  A 401 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.68A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 296
ALA A 210
LEU A 208
GLY A 302
THR A 257
1.80A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  29
CYH A  38
LEU A  87
LEU A  27
THR A  25
1.77A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.74A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 146
CYH A  38
LEU A  87
LEU A  27
THR A  26
1.67A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ALA D 386
MET D 376
GLY F 504
THR D 324
PHE D 327
1.52A16.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.70A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D 202
THR D 292
GLY D 251
LEU D 253
PHE D   3
1.73A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 202
THR B 292
GLY B 251
LEU B 253
PHE B   3
1.75A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 202
THR B 292
GLY B 251
LEU B 253
PHE B   3
1.73A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU B  87
VAL B  86
LEU B  32
LEU B  30
LEU B  89
1.76A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 125
ALA D   7
GLY D  11
LEU D 115
PHE D 140
1.74A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU C  75
VAL C  68
LEU C  27
MET C  17
LEU C  87
1.64A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU C 287
VAL C 204
LEU C 242
LEU C 271
LEU C 250
1.78A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 296
ALA A 210
LEU A 208
GLY A 302
THR A 257
1.71A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 206
LEU C 268
LEU C 253
GLY C 251
PHE C 230
1.67A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
LEU A 253
GLY A 251
PHE A 230
1.66A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  87
VAL A  86
LEU A  32
LEU A  30
LEU A  89
1.78A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.70A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 204
THR C 199
GLY C 275
LEU C 272
LEU C 242
1.75A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  18
GLY A 146
LEU A  27
THR A  26
LEU A  67
1.72A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 204
THR C 199
GLY C 275
LEU C 272
LEU C 242
1.70A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 129
LEU C 282
THR C 292
ASP C 295
PHE C 294
1.51A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 296
ALA B 210
LEU B 208
GLY B 302
THR B 257
1.71A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 206
LEU B 268
LEU B 253
GLY B 251
PHE B 230
1.64A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU D  75
VAL D  68
LEU D  27
MET D  17
LEU D  87
1.68A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 202
THR C 292
GLY C 251
LEU C 253
PHE C   3
1.72A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU B  75
VAL B  68
LEU B  27
MET B  17
LEU B  87
1.69A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU D 287
VAL D 204
LEU D 242
LEU D 271
LEU D 250
1.73A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 148
LEU B  89
LEU B  32
GLY B  15
LEU B  27
1.71A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
ALA C   7
GLY C  11
LEU C 115
PHE C 140
1.77A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU C  87
VAL C  86
LEU C  32
LEU C  30
LEU C  89
1.74A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU B  32
VAL B  35
LYS B  88
LEU B  87
LEU B  30
1.79A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.71A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU D  87
VAL D  86
LEU D  32
LEU D  30
LEU D  89
1.76A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 204
THR A 199
GLY A 275
LEU A 272
LEU A 242
1.67A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 129
LEU A 282
THR A 292
ASP A 295
PHE A 294
1.58A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
LEU A 253
GLY A 251
PHE A 230
1.69A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  87
VAL A  86
LEU A  32
LEU A  30
LEU A  89
1.74A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.69A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  32
VAL A  35
LYS A  88
LEU A  87
LEU A  30
1.79A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.72A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A 287
VAL A 204
LEU A 242
LEU A 271
LEU A 250
1.80A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 9
LEU D 122
CYH C  32
LEU C  13
LEU C  56
LEU C  60
1.63A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 115
LEU A 270
GLY A 345
PHE A 396
LEU B 122
1.75A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 9
CYH A 464
LEU A 316
LEU A 245
LEU A 460
LEU A 241
1.72A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 476
MET A 629
LEU A 630
LEU A 638
LEU A 308
1.59A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA B  86
LEU A 371
THR B  84
GLY A 510
LEU A 514
1.79A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 341
LEU A 271
LEU B 117
GLY A 385
THR B 124
1.58A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 330
ALA A 383
LEU B 122
LEU B 103
LEU A 271
1.62A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 174
ALA A 176
LEU A 178
THR A 248
LEU A 142
1.66A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 9
LEU A 245
LEU A 212
LEU A 178
LEU A 186
LEU A 142
1.77A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 976
GLY A 545
LEU A 546
THR A 573
ASP A 571
1.30A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A 522
LEU A 518
THR A 393
GLY A 526
PHE A 429
1.53A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU B  83
VAL B  82
LEU B 127
LEU B  43
LEU B 122
1.55A
None
NHE  B 203 (-4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 212
ASP C 215
ARG C 214
LEU C 189
THR C 208
1.46A14.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 517
THR A 430
LEU A 425
GLY A 413
LEU B 984
1.42A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A 570
THR A 572
GLY B 857
ASP B 737
PHE A 541
1.63A14.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
ALA A 876
LEU A 806
LEU A 877
GLY A 889
THR A 883
PHE A 797
1.75A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w02 NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.53A24.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU C 387
THR C 385
GLY H  94
THR H  31
PHE C 377
1.53A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA B 108
THR B 110
GLY A 101
LEU A  89
THR A 110
1.65A17.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.52A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w4h NSP16
(SARS-CoV-2)		5 / 9
LEU A7052
VAL A6859
LEU A6883
LEU A6924
LEU A6852
1.47A20.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
LEU A6883
VAL A6882
LEU A7042
LEU B4298
LEU A6848
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6808
GLY A7006
CYH A7007
LEU A6855
THR A6854
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
LEU A6883
GLY B4323
PHE A7048
LEU A6887
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
LEU A6834
LYS A6844
LEU A6848
LEU B4298
MET B4297
1.74A
None
EDO  A7103 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
LEU A7052
VAL A6859
LEU A6883
LEU A6924
LEU A6852
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  18
GLY A 146
LEU A  27
THR A  26
LEU A  67
1.71A
None
None
X77  A 401 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.72A
None
None
None
None
X77  A 401 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A  87
VAL A  86
LEU A  32
LEU A  30
LEU A  89
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
LEU A 253
GLY A 251
PHE A 230
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A 287
VAL A 204
LEU A 242
LEU A 271
LEU A 250
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  77
ALA A 112
LEU A  93
LEU A 109
LEU A  43
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  77
ALA B 112
LEU B  93
LEU B 109
LEU B  43
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU B  83
VAL B  82
LEU B 127
LEU B  43
LEU B 122
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A  38
LEU A  93
GLY A  51
LEU A  53
LEU A  83
1.79A19.42
AMP  A 201 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  49
ALA B  38
LEU B 126
GLY B  46
LEU B 160
1.79A
None
MES  B 201 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 9
LEU C7052
VAL C6859
LEU C6883
LEU C6924
LEU C6852
1.50A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.52A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
LEU C6834
LYS C6844
LEU C6848
LEU D4298
MET D4297
1.75A19.03
None
FMT  C7108 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 9
LEU A7052
VAL A6859
LEU A6883
LEU A6924
LEU A6852
1.50A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA D4324
GLY C6875
THR C6908
ASP C6895
LEU C6893
1.54A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.48A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6808
GLY C7006
CYH C7007
LEU C6855
THR C6854
1.76A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
LEU A6883
VAL A6882
LEU A7042
LEU B4298
LEU A6848
1.55A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA D4324
GLY C6875
THR C6908
ASP C6895
LEU C6893
1.49A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6808
GLY A7006
CYH A7007
LEU A6855
THR A6854
1.75A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
LEU C6883
VAL C6882
LEU C7042
LEU D4298
LEU C6848
1.58A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
LEU A6883
VAL A6882
LEU A7042
LEU B4298
LEU A6852
1.63A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
VAL A 110
ALA A 108
LEU A 103
LEU A  -8
LEU A  88
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A  60
GLY A  85
CYH A  92
LEU A  93
LEU A  88
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  77
ALA A 112
LEU A  93
LEU A 109
LEU A  43
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wcf NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  77
ALA A 112
LEU A  93
LEU A 109
LEU A  43
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wen NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wen NSP3
(SARS-CoV-2)		5 / 9
LEU A  93
VAL A  95
LEU A 126
LEU A 122
LEU A 109
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 281
ALA A 316
LEU A 297
LEU A 313
LEU A 247
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wey NSP3
(SARS-CoV-2)		5 / 9
LEU A 287
VAL A 286
LEU A 331
LEU A 247
LEU A 326
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 355
MET A 375
LEU A 216
THR A 217
LEU A 344
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 9
LEU B 122
CYH A  32
LEU A  13
LEU A  56
LEU A  60
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 311
MET E 322
LEU E 331
GLY F 295
LEU F 291
1.59A
 CL  F 401 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA A 311
MET A 322
LEU A 331
GLY B 295
LEU B 291
1.60A
 CL  B 401 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 305
MET F 322
LEU F 331
GLY E 295
LEU E 291
1.34A
 CL  E 401 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 311
MET D 322
LEU D 331
GLY C 295
LEU C 291
1.60A
 CL  C 401 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 305
MET A 322
LEU A 331
GLY B 295
LEU B 291
1.40A
 CL  B 401 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA A 264
LYS A 266
THR A 296
GLY A 287
LEU A 291
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 264
LYS C 266
THR C 296
GLY C 287
LEU C 291
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 305
MET C 322
LEU C 331
GLY D 295
LEU D 291
1.39A
 CL  D 401 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 305
MET D 322
LEU D 331
GLY C 295
LEU C 291
1.42A
 CL  C 401 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 305
MET E 322
LEU E 331
GLY F 295
LEU F 291
1.46A
 CL  F 401 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA A 305
MET B 322
LEU B 331
GLY A 295
LEU A 291
1.45A
 CL  A 401 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 311
MET C 322
LEU C 331
GLY D 295
LEU D 291
1.59A
 CL  D 401 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 311
MET F 322
LEU F 331
GLY E 295
LEU E 291
1.58A
 CL  E 401 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA C6877
LEU C6883
GLY D4323
PHE C7048
LEU C6887
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
LEU C7052
VAL C6859
LEU C6883
LEU C6924
LEU C6852
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
LEU C6883
VAL C6882
LEU C7042
LEU D4298
LEU C6848
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA D4324
GLY C6875
THR C6908
ASP C6895
LEU C6893
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6808
GLY A7006
CYH A7007
LEU A6855
THR A6854
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
LEU C6834
LYS C6844
LEU C6848
LEU D4298
MET D4297
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
LEU A6883
VAL A6882
LEU A7042
LEU B4298
LEU A6848
1.55A
None
None
None
FMT  B4403 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA D4324
GLY C6875
THR C6908
ASP C6895
LEU C6893
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
LEU A7052
VAL A6859
LEU A6883
LEU A6924
LEU A6852
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6808
GLY C7006
CYH C7007
LEU C6855
THR C6854
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
LEU C6883
VAL C6882
LEU C7042
LEU D4298
LEU C6848
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 9
LEU C7052
VAL C6859
LEU C6883
LEU C6924
LEU C6852
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6808
GLY A7006
CYH A7007
LEU A6855
THR A6854
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
LEU C6834
LYS C6844
LEU C6848
LEU D4298
MET D4297
1.75A
None
FMT  C7112 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA D4324
GLY C6875
THR C6908
ASP C6895
LEU C6893
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA D4324
GLY C6875
THR C6908
ASP C6895
LEU C6893
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 9
LEU A7052
VAL A6859
LEU A6883
LEU A6924
LEU A6852
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
LEU A6883
VAL A6882
LEU A7042
LEU B4298
LEU A6848
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6808
GLY C7006
CYH C7007
LEU C6855
THR C6854
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
LEU A 253
GLY A 251
PHE A 230
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.73A
None
None
None
None
U5G  A 401 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A  87
VAL A  86
LEU A  32
LEU A  30
LEU A  89
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 146
CYH A  38
LEU A  87
LEU A  27
THR A  26
1.67A
None
None
None
U5G  A 401 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A  32
VAL A  35
LYS A  88
LEU A  87
LEU A  30
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.64A
None
None
U5G  A 401 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  77
ALA D 112
LEU D  93
LEU D 109
LEU D  43
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU B  83
VAL B  82
LEU B 127
LEU B  43
LEU B 122
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  77
ALA A 112
LEU A  93
LEU A 109
LEU A  43
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  77
ALA B 112
LEU B  93
LEU B 109
LEU B  43
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  77
ALA C 112
LEU C  93
LEU C 109
LEU C  43
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU C  83
VAL C  82
LEU C 127
LEU C  43
LEU C 122
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU D  83
VAL D  82
LEU D 127
LEU D  43
LEU D 122
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
LEU A6883
VAL A6882
LEU A7042
LEU B4298
LEU A6848
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
LEU A6883
VAL A6882
LEU A7042
LEU B4298
LEU A6852
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6808
GLY A7006
CYH A7007
LEU A6855
THR A6854
1.71A
None
None
8NK  A7103 ( 3.7A)
8NK  A7103 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
LEU A7052
VAL A6859
LEU A6883
LEU A6924
LEU A6852
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA B4324
GLY A6875
THR A6908
ASP A6895
LEU A6893
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
LEU A6883
GLY B4323
PHE A7048
LEU A6887
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL C  66
ALA C  65
MET C  52
LEU C  60
LEU D  95
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 9
LEU B 122
CYH A  32
LEU A  13
LEU A  56
LEU A  60
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 9
LEU D 122
CYH C  32
LEU C  13
LEU C  56
LEU C  60
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 129
LEU A 282
THR A 292
ASP A 295
PHE A 294
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  29
CYH A  38
LEU A  87
LEU A  27
THR A  25
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 146
CYH A  38
LEU A  87
LEU A  27
THR A  26
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A 287
VAL A 204
LEU A 242
LEU A 271
LEU A 250
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 204
THR A 199
GLY A 275
LEU A 272
LEU A 242
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU B  75
VAL B  68
LEU B  27
MET B  17
LEU B  87
1.61A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA B 129
LEU B 282
THR B 292
ASP B 295
PHE B 294
1.39A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  86
MET A 130
LEU A  27
GLY A  29
PHE A 112
1.33A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU A  32
VAL A  35
LYS A  88
LEU A  87
LEU A  30
1.76A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 204
THR A 199
GLY A 275
LEU A 272
LEU A 242
1.66A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  86
MET A 130
LEU A  27
GLY A  29
PHE A 112
1.37A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 129
LEU A 282
THR A 292
ASP A 295
PHE A 294
1.44A22.98
None
None
None
DMS  A 403 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.76A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.65A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.68A20.78
None
None
None
DMS  A 406 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 9
LEU D 122
CYH C  32
LEU C  13
LEU C  56
LEU C  60
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 387
THR E 385
GLY H  98
THR H  31
PHE E 377
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
MET H   2
THR E 385
LEU E 387
GLY E 431
THR H  31
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 387
THR A 385
GLY B  98
THR B  31
PHE A 377
1.74A
DMS  A 905 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 387
THR E 385
GLY H  98
THR H  31
PHE E 377
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
MET H   2
THR E 385
LEU E 387
GLY E 431
THR H  31
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  29
CYH A  38
LEU A  87
LEU A  27
THR A  25
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 146
CYH A  38
LEU A  87
LEU A  27
THR A  26
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  86
MET A 130
LEU A  27
GLY A  29
PHE A 112
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 204
THR A 199
GLY A 275
LEU A 272
LEU A 242
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 387
THR E 385
GLY H  98
THR H  31
PHE E 377
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
MET B   2
THR A 385
LEU A 387
GLY A 431
THR B  31
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 387
THR A 385
GLY B  98
THR B  31
PHE A 377
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
MET H   2
THR E 385
LEU E 387
GLY E 431
THR H  31
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 129
LEU A 282
THR A 292
ASP A 295
PHE A 294
1.51A
None
None
None
CL  A 406 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.70A
None
None
None
None
PK8  A 401 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.74A
None
None
PK8  A 401 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.71A
PEG  A 405 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 204
THR A 199
GLY A 275
LEU A 272
LEU A 242
1.66A
None
PEG  A 404 (-3.0A)
PEG  A 404 ( 4.8A)
PEG  A 404 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  86
MET A 130
LEU A  27
GLY A  29
PHE A 112
1.40A
None
None
PK8  A 401 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.56A
None
None
EDO  A 202 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D  83
VAL D  82
LEU D 127
LEU D  43
LEU D 122
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  77
ALA C 112
LEU C  93
LEU C 109
LEU C  43
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  77
ALA B 112
LEU B  93
LEU B 109
LEU B  43
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  77
ALA D 112
LEU D  93
LEU D 109
LEU D  43
1.55A
None
None
None
EDO  D 204 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  77
ALA A 112
LEU A  93
LEU A 109
LEU A  43
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  83
VAL C  82
LEU C 127
LEU C  43
LEU C 122
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B  83
VAL B  82
LEU B 127
LEU B  43
LEU B 122
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E  83
VAL E  82
LEU E 127
LEU E  43
LEU E 122
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E  83
VAL E  82
LEU E 127
LEU E  43
LEU E 122
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  60
LEU C  88
THR C  57
GLY D  48
ASP D 157
1.69A
EDO  D 204 ( 4.8A)
None
None
EDO  D 204 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B  83
VAL B  82
LEU B 127
LEU B  43
LEU B 122
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D  83
VAL D  82
LEU D 127
LEU D  43
LEU D 122
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  83
VAL C  82
LEU C 127
LEU C  43
LEU C 122
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  77
ALA E 112
LEU E  93
LEU E 109
LEU E  43
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  77
ALA B 112
LEU B  93
LEU B 109
LEU B  43
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  77
ALA D 112
LEU D  93
LEU D 109
LEU D  43
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  77
ALA C 112
LEU C  93
LEU C 109
LEU C  43
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  77
ALA A 112
LEU A  93
LEU A 109
LEU A  43
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  77
ALA C 112
LEU C  93
LEU C 109
LEU C  43
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  49
ALA B  38
LEU B 126
GLY B  46
LEU B 160
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A  83
VAL A  82
LEU A 127
LEU A  43
LEU A 122
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B  83
VAL B  82
LEU B 127
LEU B  43
LEU B 122
1.54A
None
EDO  B 203 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  83
VAL C  82
LEU C 127
LEU C  43
LEU C 122
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  77
ALA A 112
LEU A  93
LEU A 109
LEU A  43
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  49
ALA A  38
LEU A 126
GLY A  46
LEU A 160
1.78A
None
MES  A 201 (-3.5A)
None
MES  A 201 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.70A
None
None
None
None
PJE  C   5 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 202
THR A 292
GLY A 251
LEU A 253
PHE A   3
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  87
VAL A  86
LEU A  32
LEU A  30
LEU A  89
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.60A
None
None
PJE  C   5 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 129
LEU A 282
THR A 292
ASP A 295
PHE A 294
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
LEU A 253
GLY A 251
PHE A 230
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 9
LEU A 245
LEU A 212
LEU A 178
LEU A 186
LEU A 142
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7btf NSP7
(SARS-CoV-2)		5 / 12
VAL C  66
ALA C  65
LEU C  60
LEU C  20
LEU C  56
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 330
ALA A 383
LEU B 122
LEU B 103
LEU A 271
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 9
CYH A 464
LEU A 316
LEU A 245
LEU A 460
LEU A 241
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 844
LEU A 883
GLY A 852
LEU A 891
PHE A 422
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 860
LEU A 885
GLY A 852
LEU A 891
PHE A 422
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 476
MET A 629
LEU A 630
LEU A 638
LEU A 308
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA B  86
LEU A 371
THR B  84
GLY A 510
LEU A 514
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 9
LEU A 207
LEU A 247
LEU A 131
LEU A 240
LEU A 178
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 9
LEU D 122
CYH C  32
LEU C  13
LEU C  56
LEU C  60
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 174
ALA A 176
LEU A 178
THR A 248
LEU A 142
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL C  66
MET C  52
LEU C  56
LEU C  20
LEU D  91
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 268
LEU A 253
GLY A 251
PHE A 230
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 204
THR A 199
GLY A 275
LEU A 272
LEU A 242
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
LEU A  89
LEU A  32
GLY A  15
LEU A  27
1.72A
None
None
None
DMS  A 403 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  75
VAL A  68
LEU A  27
MET A  17
LEU A  87
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 296
ALA A 210
LEU A 205
GLY A 302
THR A 257
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 296
ALA A 210
LEU A 282
GLY A   2
THR A 304
1.73A
None
None
DMS  A 404 (-4.9A)
DMS  A 404 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 9
LEU A  87
VAL A  86
LEU A  32
LEU A  30
LEU A  89
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 476
MET A 629
LEU A 630
LEU A 638
LEU A 308
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 128
LEU A 178
THR A 248
LEU A 186
LEU A 212
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 342
LEU A 366
LEU A 361
PHE B  92
LEU B  91
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 405
ALA A 406
GLY A 446
ASP A 390
LEU A 388
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 176
THR A 248
CYH A 152
ASP A 153
LEU A 146
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 115
LEU A 270
GLY A 345
PHE A 396
LEU B 122
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 382
LEU B  98
GLY A 671
LEU A 401
LEU B  91
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 342
LEU A 366
LEU A 361
PHE B  92
LEU B  91
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 405
ALA A 406
GLY A 446
ASP A 390
LEU A 388
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA B  86
THR B  89
LEU A 527
LEU A 371
PHE A 340
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 214
LEU A 119
ARG A 118
LEU A 212
ASP A 126
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 382
LEU A 387
LEU B 103
THR B 124
LEU A 270
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
LEU A 207
LEU A 247
LEU A 131
LEU A 240
LEU A 178
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 174
ALA A 176
LEU A 178
THR A 248
LEU A 142
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
CYH A 464
LEU A 316
LEU A 245
LEU A 460
LEU A 241
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
THR A 148
GLY A 214
LEU A 212
LEU A 142
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 214
LEU A 119
ARG A 118
ASP A 208
PHE A  45
1.51A
None