Ligand ID: DMO


Drugbank ID:
DB06243
(Eflornithine)


Indication:
Eflornithine is indicated in the treatment of facial hirsutism (excessive hair growth).

Get human targets for DMO in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'DMO' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6m71 NSP12
(SARS-CoV-2)		4 / 6
CYH A 139
ASP A 135
PHE A 134
TYR A 163
1.39A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6m71 NSP12
(SARS-CoV-2)		4 / 5
TYR A 163
CYH A 139
ASP A 135
PHE A 134
1.38A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6m71 NSP12
(SARS-CoV-2)		4 / 5
CYH A 139
ASP A 135
PHE A 134
TYR A 163
1.40A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6m71 NSP12
(SARS-CoV-2)		4 / 5
TYR A 163
CYH A 139
ASP A 135
PHE A 134
1.39A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
TYR A  37
ASP A  53
PHE A  55
ASP A  40
1.60A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
TYR A  37
ASP A  53
PHE A  55
ASP A  40
1.58A16.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
TYR C  37
ASP C  53
PHE C  55
ASP C  40
1.58A16.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
TYR A 226
ASP A 213
PHE A 222
ASP A 301
1.71A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
TYR B 226
ASP B 213
PHE B 222
ASP B 301
1.73A23.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
TYR A 226
ASP A 213
PHE A 222
ASP A 301
1.71A23.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7btf NSP12
(SARS-CoV-2)		4 / 6
TYR A 787
PHE A 134
ASP A 164
TYR A 163
1.61A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7btf NSP12
(SARS-CoV-2)		4 / 5
TYR A 163
CYH A 139
ASP A 135
PHE A 134
1.43A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7btf NSP12
(SARS-CoV-2)		4 / 5
CYH A 139
ASP A 135
PHE A 134
TYR A 163
1.43A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7btf NSP12
(SARS-CoV-2)		4 / 5
TYR A 163
CYH A 139
ASP A 135
PHE A 134
1.43A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7btf NSP12
(SARS-CoV-2)		4 / 6
CYH A 139
ASP A 135
PHE A 134
TYR A 163
1.44A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv1 NSP12
(SARS-CoV-2)		4 / 5
TYR A 163
CYH A 139
ASP A 135
PHE A 134
1.60A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv1 NSP12
(SARS-CoV-2)		4 / 5
CYH A 139
ASP A 135
PHE A 134
TYR A 163
1.61A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv1 NSP12
(SARS-CoV-2)		4 / 5
TYR A 163
CYH A 139
ASP A 135
PHE A 134
1.59A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv1 NSP12
(SARS-CoV-2)		4 / 6
CYH A 139
ASP A 135
PHE A 134
TYR A 163
1.60A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv2 NSP12
(SARS-CoV-2)		4 / 6
CYH A 139
ASP A 135
PHE A 134
TYR A 163
1.41A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv2 NSP12
(SARS-CoV-2)		4 / 6
TYR A 456
ASP A 623
ASP A 452
TYR A 455
1.78A19.62
None
POP  A1003 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv2 NSP12
(SARS-CoV-2)		4 / 6
TYR A 746
CYH A 482
ASP A 481
ASP A 477
1.77A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv2 NSP12
(SARS-CoV-2)		4 / 5
CYH A 139
ASP A 135
PHE A 134
TYR A 163
1.40A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv2 NSP12
(SARS-CoV-2)		4 / 5
TYR A 163
CYH A 139
ASP A 135
PHE A 134
1.39A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		7bv2 NSP12
(SARS-CoV-2)		4 / 5
TYR A 163
CYH A 139
ASP A 135
PHE A 134
1.39A19.62
None