Ligand ID: C41


Drugbank ID:
DB09026
(Aliskiren)


Indication:
For the treatment of hypertension, to lower blood pressure.

Get human targets for C41 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'C41' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.70A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  69
SER A  10
1.80A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6m03 MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PRO A  99
PHE A 159
SER A  10
1.57A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.75A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN B 127
VAL B 114
GLY D   2
ALA B   7
GLY B 138
1.59A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C  13
PHE C 150
VAL C 157
GLY C  11
SER A  10
1.54A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  13
PHE A 150
VAL A 157
GLY A  11
SER C  10
1.63A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN A 127
VAL A 114
GLY C   2
ALA A   7
GLY A 138
1.63A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 124
ALA D 210
PHE D   3
SER D 301
ILE D 152
1.42A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 148
GLY B 120
PHE B 159
GLN B  19
SER B  10
1.73A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D  13
PHE D 150
VAL D 157
GLY D  11
SER B  10
1.55A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 148
GLY C 120
PHE C 159
GLN C  69
SER C  10
1.78A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C  13
PHE C 150
VAL C 157
GLY C  11
SER A  10
1.52A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN D 127
VAL D 114
GLY B   2
ALA D   7
GLY D 138
1.65A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN C 127
VAL C 114
GLY A   2
ALA C   7
GLY C 138
1.66A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
TYR A  37
SER A 144
THR A  26
THR C 304
1.69A22.86
None
3WL  A 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D  13
PHE D 150
VAL D 157
GLY D  11
SER B  10
1.53A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 148
GLY B 120
PHE B 159
GLN B  69
SER B  10
1.79A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  13
PHE A 150
VAL A 157
GLY A  11
SER C  10
1.65A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  69
SER A  10
1.72A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 148
GLY C 120
PHE C 159
GLN C  19
SER C  10
1.70A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
TYR B  37
SER B 144
THR B  26
THR D 304
1.72A22.86
None
3WL  B 401 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.73A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 124
ALA C 210
PHE C   3
SER C 301
ILE C 152
1.46A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.67A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
TYR A 546
SER A 501
SER A 682
THR A 540
1.72A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 318
THR A 324
PRO B 116
LEU A 271
1.13A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 451
PRO A 169
LEU A 172
THR A 556
1.74A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 664
PHE A 396
VAL A 675
GLY A 327
SER A 325
1.68A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 664
PRO A 328
LEU A 329
THR A 680
1.62A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
TYR A 122
SER A 709
SER A 784
LEU A 247
1.65A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 128
ALA A  34
GLN A 698
ASP A 465
SER A 236
1.69A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 674
PRO A 328
LEU B 117
THR A 565
1.54A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 674
SER A 384
LEU B 122
THR B  93
1.64A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 318
SER A 664
PRO A 328
LEU B 117
1.61A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 681
PRO A 378
LEU B 117
THR A 556
1.70A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 445
GLY A 446
VAL C  33
GLN A 408
ILE A 450
1.22A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
TYR A 915
THR A 817
LEU A 869
THR A 604
1.43A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
SER A 564
THR A 565
LEU A 498
1.67A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 674
TYR A 346
SER A 343
PRO B 116
1.63A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m71 NSP8
(SARS-CoV-2)		4 / 8
SER B 151
THR B 124
PRO B 121
LEU B 117
1.65A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR C1007
SER C1003
THR C1006
LEU A1012
1.37A14.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP B 240
GLY B 247
GLN B 245
GLY B 239
ILE B 281
1.41A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A1007
SER A1003
THR A1006
LEU B1012
1.34A14.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR C1007
SER C1003
THR C1006
LEU A1012
1.26A14.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN B1113
VAL B1104
VAL B1096
GLN C 901
GLY B1093
1.44A14.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
TYR B 343
SER B 274
THR B 275
LEU B 298
1.37A22.47
CIT  B 408 (-3.4A)
EDO  B 403 (-2.8A)
EDO  B 403 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
TYR C 396
TYR C 380
PRO C 384
LEU C 387
1.76A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
TYR C 453
SER C 438
SER C 375
THR C 376
1.43A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
TYR C 505
SER C 438
SER C 375
THR C 376
1.43A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
TYR C 423
SER C 375
TYR C 508
SER C 438
1.51A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6897
GLY A6871
ALA A6914
GLY A6869
SER A6927
1.71A
SAM  A7104 (-2.8A)
SAM  A7104 (-4.4A)
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TYR A6845
SER A7041
THR A6854
LEU A7050
1.66A
SAM  A7104 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A7074
SER A6964
LEU A6978
THR A7055
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A7074
SER A6964
LEU A6978
THR A7055
1.72A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4347
PHE B4321
VAL B4350
ASP A6904
GLY B4322
1.71A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
SER D4325
VAL C6902
GLY D4347
1.80A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
TYR A6845
SER A7041
THR A6854
LEU A7050
1.65A17.17
SAM  A7102 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
TYR A7040
SER A7041
PRO A6835
LEU A6834
1.77A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
TYR C6845
SER C7041
THR C6854
LEU C7050
1.64A17.17
SAM  C7105 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
TYR C6845
SER C6964
THR C6891
PRO C6888
1.77A17.17
SAM  C7105 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A6907
SER A6896
LEU A7093
THR A6880
1.64A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
TYR C6861
THR C6891
PRO C6888
LEU C7050
1.76A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 8
SER A7046
PRO A6888
LEU A7052
THR B4302
1.79A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP A6897
GLY A6871
ALA A6914
GLY A6869
SER A6927
1.71A17.17
SAM  A7102 ( 2.6A)
SAM  A7102 ( 4.2A)
None
SAM  A7102 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER C7074
SER C6964
LEU C6978
THR C7055
1.77A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP C6897
GLY C6871
ALA C6914
GLY C6869
SER C6927
1.71A17.17
SAM  C7105 ( 2.7A)
SAM  C7105 ( 4.2A)
None
SAM  C7105 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR B 136
SER B 262
TYR B 273
LEU B 152
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR C  72
TYR C 171
THR C 168
LEU C 152
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
VAL B 202
ALA B 176
VAL B 205
GLN B 236
GLY B 201
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR B  72
TYR B 171
THR B 168
LEU B 152
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A 136
SER A 262
TYR A 273
LEU A 152
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR C 136
SER C 262
TYR C 273
LEU C 152
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
SER C  85
TYR C  35
LEU C  64
THR C  90
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
SER B  85
TYR B  35
LEU B  64
THR B  90
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A  95
SER A 262
THR A 168
LEU A 132
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A 171
TYR A  83
SER A  85
LEU A 113
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A  72
TYR A 171
THR A 168
LEU A 152
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
SER A  85
TYR A  35
LEU A  64
THR A  90
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A 124
PHE A 116
GLY A  97
SER A 139
ILE A 131
1.78A
None
None
None
None
MES  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wey NSP3
(SARS-CoV-2)		4 / 8
SER A 343
TYR A 317
SER A 315
LEU A 279
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
VAL C 270
ALA D 313
PHE C 274
GLN E 303
GLY C 295
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY D 287
PHE D 274
VAL D 270
GLY D 284
SER C 318
1.76A15.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY B 287
PHE B 274
VAL B 270
GLY B 284
SER A 318
1.76A15.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY F 287
PHE F 274
VAL F 270
GLY F 284
SER E 318
1.75A15.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY C 287
PHE C 274
VAL C 270
GLY C 284
SER D 318
1.79A15.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 313
PHE C 274
GLN E 306
ASP C 297
GLY C 295
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
TYR A 333
TYR B 298
THR B 296
THR E 265
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
VAL C 270
ALA D 313
PHE C 274
GLN E 306
GLY C 295
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 313
PHE E 274
GLN B 349
ASP E 297
GLY E 295
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY E 287
PHE E 274
VAL E 270
GLY E 284
SER F 318
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY E 287
PHE E 274
VAL E 270
GLY E 284
SER F 318
1.77A15.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY D 287
PHE D 274
VAL D 270
GLY D 284
SER C 318
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY D4347
PHE D4321
VAL D4350
ASP C6904
GLY D4322
1.73A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TYR A7040
SER A7041
PRO A6835
LEU A6834
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
SER D4325
VAL C6902
GLY D4347
1.80A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4347
PHE B4321
VAL B4350
ASP A6904
GLY B4322
1.73A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A7074
SER A6964
LEU A6978
THR A7055
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6897
GLY A6871
ALA A6914
GLY A6869
SER A6927
1.69A
SAH  A7102 (-2.6A)
SAH  A7102 (-4.4A)
None
SAH  A7102 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TYR C6845
SER C7041
THR C6854
LEU C7050
1.65A
SAH  C7102 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TYR A6845
SER A7041
THR A6854
LEU A7050
1.67A
SAH  A7102 (-4.6A)
None
None
FMT  A7107 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4347
ALA B4357
VAL B4350
ASP A6904
GLY B4322
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP C6897
GLY C6871
ALA C6914
GLY C6869
SER C6927
1.69A
SAH  C7102 (-2.6A)
SAH  C7102 (-4.4A)
None
SAH  C7102 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER A  78
TYR A 112
THR A 115
THR D  57
1.40A
None
None
None
ZN  A 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER C  78
TYR C 112
THR C 115
THR B  57
1.46A
None
None
None
ZN  C 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASP C 144
GLY C 114
ALA B  55
GLY C 147
ILE C  84
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASP A6897
GLY A6871
ALA A6914
GLY A6869
SER A6927
1.70A
SFG  A7103 ( 2.7A)
SFG  A7103 ( 4.2A)
None
SFG  A7103 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASP C6897
GLY C6871
ALA C6914
GLY C6869
SER C6927
1.69A
SFG  C7103 ( 2.6A)
SFG  C7103 ( 4.1A)
None
SFG  C7103 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP C6904
GLY D4322
SER D4325
VAL C6902
GLY D4347
1.78A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
TYR A6845
SER A7041
THR A6854
LEU A7050
1.66A
SFG  A7103 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A7074
SER A6964
LEU A6978
THR A7055
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
TYR C6845
SER C7041
THR C6854
LEU C7050
1.65A
SFG  C7103 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
TYR C6861
THR C6891
PRO C6888
LEU C7050
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP A6904
GLY B4322
SER B4325
VAL A6902
GLY B4347
1.79A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP B 240
GLY B 247
GLN B 245
GLY B 239
ILE B 281
1.58A
None
None
U5P  B 401 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B  85
GLY B 101
ALA B  95
ASP B 107
ILE B 116
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP A 240
GLY A 247
GLN A 245
GLY A 239
ILE A 281
1.60A
None
None
U5P  A 401 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A  85
GLY A 101
ALA A  95
ASP A 107
ILE A 116
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  69
SER A  10
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A7074
SER A6964
LEU A6978
THR A7055
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TYR A6845
SER A7041
THR A6854
LEU A7050
1.65A
SAH  A7101 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6897
GLY A6871
ALA A6914
GLY A6869
SER A6927
1.70A
SAH  A7101 (-2.7A)
SAH  A7101 (-4.3A)
None
SAH  A7101 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  69
SER A  10
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
SER A 111
SER A 262
LEU A 282
THR A 168
1.36A
PO4  A 502 (-2.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
VAL A 202
ALA A 176
VAL A 205
GLN A 236
GLY A 201
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
SER A 111
SER A 262
THR A 301
PRO A 248
1.69A
PO4  A 502 (-2.9A)
None
GOL  A 508 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
SER A 111
TYR A 273
SER A 262
PRO A 248
1.74A
PO4  A 502 (-2.9A)
GOL  A 508 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
TYR A  95
SER A 262
THR A 168
LEU A 132
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
GLN C  63
VAL D 131
TYR D 149
VAL D 130
GLY D 113
1.76A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 132
SER A  11
PRO A  33
LEU A 121
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A 414
ASP A 405
GLY A 504
ALA A 419
GLN A 506
1.78A
None
None
DMS  A 903 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A 414
GLY A 404
ALA A 411
GLN A 506
ASP A 405
1.70A
None
DMS  A 903 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLN L  43
VAL L  64
SER A 366
PHE L  68
GLY L  63
1.77A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER C  69
THR C  80
LEU C  11
THR E 328
1.66A
None
None
None
NAG  E 906 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR E 505
SER E 438
SER E 375
THR E 376
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN E 414
GLY E 504
ALA E 411
GLN E 506
ASP E 405
1.76A
MLI  E 908 ( 4.8A)
DMS  E 902 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 505
SER A 438
SER A 375
THR A 376
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLN B   1
VAL B 108
GLY B  35
PRO A 384
GLY B  98
1.79A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN E 414
GLY E 404
ALA E 411
GLN E 506
ASP E 405
1.80A
MLI  E 908 ( 4.8A)
DMS  E 902 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR E 505
SER E 438
SER E 375
THR E 376
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN E 414
GLY E 404
ALA E 411
GLN E 506
ASP E 405
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A 414
GLY A 504
ALA A 411
GLN A 506
ASP A 405
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER H 119
THR H 120
PRO H 206
THR A 478
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
TYR A 489
THR H   9
LEU H  18
THR H 155
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN E 414
GLY E 504
ALA E 411
GLN E 506
ASP E 405
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 505
SER A 438
SER A 375
THR A 376
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR E 505
SER E 438
SER E 375
THR E 376
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A 414
GLY A 404
ALA A 411
GLN A 506
ASP A 405
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 289
TYR A 239
PRO A 241
VAL A 204
ASP A 197
1.79A22.86
None
PEG  A 404 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  69
SER A  10
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 168
VAL D 144
GLN A 107
ASP D  14
SER E   7
1.39A
None
None
EDO  D 202 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 168
VAL D 144
GLN A 107
ASP D  14
SER E   7
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 124
PHE A 116
GLY A  97
SER A 139
ILE A 131
1.78A
None
None
None
None
MES  A 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  69
SER A  10
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 318
THR A 324
PRO B 116
LEU A 271
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
TYR A 515
PHE A 368
VAL B  83
ASP A 517
SER A 520
1.70A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 664
PHE A 396
VAL A 675
GLY A 327
SER A 325
1.79A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 445
GLY A 446
VAL C  33
GLN A 408
ILE A 450
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 122
SER A 709
SER A 784
LEU A 247
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASP A 218
GLY A 220
ALA A 125
ASP A 221
ILE A 201
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 664
TYR A 346
PRO B 116
THR A 540
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 674
SER A 681
SER A 561
PRO A 537
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 456
THR A 538
PRO A 378
LEU A 673
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP8
(SARS-CoV-2)		4 / 8
SER B 151
THR B 124
PRO B 121
LEU B 117
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 674
PRO A 328
LEU B 117
THR A 565
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 831
SER A 592
TYR A 595
THR A 926
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 217
TYR A 238
SER A 239
LEU A 127
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 265
TYR B 149
THR B 148
THR B 137
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 128
ALA A  34
GLN A 698
ASP A 465
SER A 236
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 681
PRO A 378
LEU B 117
THR A 556
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 564
SER A 664
PRO A 328
LEU A 329
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 674
TYR A 346
SER A 343
PRO B 116
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 148
GLY A 120
PHE A 159
GLN A  19
SER A  10
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 674
PRO A 328
LEU B 117
THR A 565
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 128
ALA A  34
GLN A 698
ASP A 465
SER A 236
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 163
THR A 462
PRO A 627
THR A 252
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLN C  31
VAL C  33
ASP A 445
GLY A 446
SER C  25
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 445
GLY A 446
VAL C  33
GLN A 408
ILE A 450
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 664
PRO A 328
LEU A 329
THR A 680
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 674
TYR A 346
SER A 343
PRO B 116
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 318
THR A 324
PRO B 116
LEU A 271
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 915
THR A 817
LEU A 869
THR A 604
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
VAL D 131
TYR D 149
VAL D 130
ASP D 112
GLY D 113
1.64A19.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 681
PRO A 378
LEU B 117
THR A 556
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		7bv1 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  26
PRO B 133
ASP A 445
GLY A 446
SER A 451
1.73A12.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 674
SER A 681
SER A 501
PRO A 505
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 476
ASP A 477
ALA A 634
VAL A 473
ASP A 481
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 265
TYR B 149
THR B 148
THR B 137
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 778
SER A 768
THR A 769
THR A 801
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
TYR A 515
PHE A 368
VAL B  83
ASP A 517
SER A 520
1.65A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TYR A 915
THR A 817
LEU A 869
THR A 604
1.57A
 U  T  16 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv2 NSP8
(SARS-CoV-2)		4 / 8
SER B 151
THR B 124
PRO B 121
LEU B 117
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
SER A 564
THR A 565
LEU A 498
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
TYR A 674
PRO A 328
LEU B 117
THR A 565
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		7bv2 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  26
PRO B 133
ASP A 445
GLY A 446
SER A 451
1.72A12.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TYR A 163
THR A 462
PRO A 627
THR A 252
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 681
PRO A 378
LEU B 117
THR A 556
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 476
ASP A 477
ALA A 634
VAL A 473
ASP A 481
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
SER A 318
THR A 324
PRO B 116
LEU A 271
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 128
ALA A  34
GLN A 698
ASP A 465
SER A 236
1.55A
None