Ligand ID: BHA


Drugbank ID:
DB00233
(Aminosalicylic Acid)


Indication:
For the treatment of tuberculosis

Get human targets for BHA in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'BHA' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.57A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 115
VAL A  13
LEU A  30
VAL A 157
1.76A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.54A17.58
None
DMS  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.34A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  20
1.77A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.42A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 6
LEU B 984
ARG C 983
VAL B 987
ARG A 983
VAL A 987
1.66A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.32A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m03 MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.31A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.33A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B 262
VAL B 261
LEU B 205
VAL B 247
1.30A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.47A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B  89
VAL B  68
LEU B  75
VAL B  18
1.44A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.45A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.36A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C  75
ARG C  76
VAL C  91
VAL C  36
1.51A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D 262
VAL D 261
LEU D 205
VAL D 247
1.38A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D  75
ARG D  76
VAL D  91
VAL D  36
1.60A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C 262
VAL C 261
LEU C 205
VAL C 247
1.47A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.60A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.31A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.57A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.44A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6m71 NSP12
(SARS-CoV-2)		5 / 10
GLY A 179
VAL A 182
LEU A 245
TYR A 286
ALA A 185
1.66A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 241
ARG A 132
LEU A 131
VAL A 182
1.60A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ARG A 750
VAL A 475
LEU A 749
VAL A 472
1.47A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLY A 857
VAL A 736
LEU A1004
TYR A1007
LEU A 962
1.43A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 141
VAL A 120
LEU A 118
VAL A 127
1.34A8.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w02 NSP3
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.17A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w02 NSP3
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.44A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL B  16
LEU B 153
ARG B 141
VAL B 144
1.77A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL A  95
LEU A 127
TYR A 113
LEU A 109
SER A 128
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 9
VAL A  95
LEU A 127
TYR A 113
LEU A 109
SER A 128
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
GLY B 130
LEU B 126
TYR B 113
LEU B 109
ALA B  38
1.64A
MES  B 201 ( 3.4A)
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 122
VAL A  36
LEU A 127
VAL A  95
1.74A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 122
VAL A 151
ARG A 148
VAL A 147
1.74A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
ARG A 141
VAL A 144
VAL A  16
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C6864
VAL A7094
LEU C6892
VAL A7092
1.75A19.66
FMT  C7106 ( 2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL A7094
LEU C6892
ARG C7081
VAL C7086
1.78A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 10
GLY A 100
LEU A 106
TYR A  31
LEU A   9
SER A 105
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wcf NSP3
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wcf NSP3
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.37A
None
None
None
None
MES  A 201 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wcf NSP3
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wcf NSP3
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.61A
MES  A 201 (-3.2A)
None
None
None
MES  A 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wen NSP3
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wen NSP3
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wen NSP3
(SARS-CoV-2)		5 / 10
VAL A  95
LEU A 127
TYR A 113
LEU A 109
SER A 128
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wen NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
ARG A 141
VAL A 144
VAL A  16
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wey NSP3
(SARS-CoV-2)		5 / 9
VAL A 299
LEU A 331
TYR A 317
LEU A 313
SER A 332
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wey NSP3
(SARS-CoV-2)		5 / 10
VAL A 299
LEU A 331
TYR A 317
LEU A 313
SER A 332
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wey NSP3
(SARS-CoV-2)		4 / 6
LEU A 357
VAL A 355
LEU A 326
VAL A 351
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wey NSP3
(SARS-CoV-2)		4 / 6
LEU A 216
VAL A 220
LEU A 357
VAL A 348
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wey NSP3
(SARS-CoV-2)		5 / 10
GLY A 283
VAL A 299
LEU A 297
TYR A 272
ALA A 243
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B   3
VAL B  25
LEU B  43
VAL B  23
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A   3
VAL A  25
LEU A  43
VAL A  23
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY B 130
LEU B 126
TYR B 113
LEU B 109
ALA B  38
1.59A
APR  B 201 (-3.3A)
None
None
None
APR  B 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU D 153
VAL D 151
LEU D 122
VAL D 147
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
VAL D  95
LEU D 127
TYR D 113
LEU D 109
SER D 128
1.74A
None
None
None
None
APR  D 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY D 130
LEU D 126
TYR D 113
LEU D 109
ALA D  38
1.58A
APR  D 201 (-3.2A)
None
None
None
APR  D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU D  12
VAL D  16
LEU D 153
VAL D 144
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY C 130
LEU C 126
TYR C 113
LEU C 109
ALA C  38
1.60A
APR  C 201 (-3.0A)
APR  C 201 (-4.9A)
None
None
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.61A
APR  A 201 (-3.5A)
None
None
None
APR  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY C  79
VAL C  95
LEU C  93
TYR C  68
ALA C  39
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.74A
None
None
None
None
APR  B 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.78A
None
None
None
None
APR  B 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY D  79
VAL D  95
LEU D  93
TYR D  68
ALA D  39
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU C 153
VAL C 151
LEU C 122
VAL C 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL D  95
LEU D 127
TYR D 113
LEU D 109
SER D 128
1.78A
None
None
None
None
APR  D 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 10
GLY A 160
VAL A 159
LEU A 113
TYR A 112
ALA A  86
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.59A18.18
DMS  A 408 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  20
1.77A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.45A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 115
VAL A  13
LEU A  30
VAL A 157
1.78A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.54A18.18
None
DMS  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.51A
None
DMS  A 501 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  27
VAL A  20
LEU A  89
VAL A  18
1.62A
PK8  A 401 ( 3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 153
VAL E 151
LEU E 122
VAL E 147
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  12
VAL C  16
LEU C 153
VAL C 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 140
ARG E 141
VAL E 144
VAL E  16
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 153
VAL C 151
LEU C 122
VAL C 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY E  79
VAL E  95
LEU E  93
TYR E  68
ALA E  39
1.42A
EPE  E 203 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D  12
VAL D  16
LEU D 153
VAL D 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY E 130
LEU E 126
TYR E 113
LEU E 109
ALA E  38
1.74A
EPE  E 202 ( 4.5A)
None
None
None
EPE  E 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C  79
VAL C  95
LEU C  93
TYR C  68
ALA C  39
1.40A
EPE  C 202 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.74A
EDO  A 202 ( 4.4A)
None
None
None
EDO  A 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C 130
LEU C 126
TYR C 113
LEU C 109
ALA C  38
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY D  79
VAL D  95
LEU D  93
TYR D  68
ALA D  39
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D 153
VAL D 151
LEU D 122
VAL D 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D 153
VAL D 151
LEU D 122
VAL D 147
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY E  79
VAL E  95
LEU E  93
TYR E  68
ALA E  39
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  95
LEU A 127
TYR A 113
LEU A 109
SER A 128
1.79A
None
None
None
None
APR  A 201 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY D 130
LEU D 126
TYR D 113
LEU D 109
ALA D  38
1.66A
APR  D 201 (-3.2A)
APR  D 201 (-4.5A)
None
None
APR  D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.63A
APR  A 201 ( 3.2A)
APR  A 201 (-4.8A)
None
None
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 140
ARG E 141
VAL E 144
VAL E  16
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D  12
VAL D  16
LEU D 153
VAL D 144
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY E 130
LEU E 126
TYR E 113
LEU E 109
ALA E  38
1.64A
APR  E 201 (-3.2A)
APR  E 201 (-4.7A)
None
None
APR  E 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E  12
VAL E  16
LEU E 153
VAL E 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B 130
LEU B 126
TYR B 113
LEU B 109
ALA B  38
1.65A
APR  B 201 (-3.2A)
APR  B 201 (-4.7A)
None
None
APR  B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  12
VAL C  16
LEU C 153
VAL C 144
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C 130
LEU C 126
TYR C 113
LEU C 109
ALA C  38
1.66A
APR  C 201 (-3.2A)
APR  C 201 (-4.8A)
None
None
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  95
LEU C 127
TYR C 113
LEU C 109
SER C 128
1.80A
None
None
None
None
APR  C 201 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY D  79
VAL D  95
LEU D  93
TYR D  68
ALA D  39
1.50A
EDO  D 203 (-3.1A)
None
None
EDO  D 202 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C  79
VAL C  95
LEU C  93
TYR C  68
ALA C  39
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.79A
None
None
None
None
APR  B 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D  95
LEU D 127
TYR D 113
LEU D 109
SER D 128
1.80A
None
None
None
None
APR  D 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 153
VAL E 151
LEU E 122
VAL E 147
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 153
VAL C 151
LEU C 122
VAL C 147
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.40A
EDO  A 204 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B 130
LEU B 126
TYR B 113
LEU B 109
ALA B  38
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.62A
MES  A 201 (-3.1A)
None
None
None
MES  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 153
VAL C 151
LEU C 122
VAL C 147
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C  79
VAL C  95
LEU C  93
TYR C  68
ALA C  39
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  12
VAL C  16
LEU C 153
VAL C 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU A 514
TYR A 515
SER A 518
ARG B  80
ALA B  86
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7btf NSP8
(SARS-CoV-2)		4 / 6
LEU D 184
VAL D 159
LEU D 169
VAL D 167
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		5 / 10
GLY A 179
VAL A 182
LEU A 245
TYR A 286
ALA A 185
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
LEU A 241
TYR A 237
TYR A 286
ALA A 185
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
GLY A 179
VAL A 182
LEU A 245
TYR A 286
ALA A 185
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 241
ARG A 132
LEU A 131
VAL A 182
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
GLY A 179
VAL A 182
LEU A 241
TYR A 286
ALA A 185
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
LEU A 241
TYR A 237
TYR A 286
ALA A 185
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ARG A 750
VAL A 475
LEU A 749
VAL A 472
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU A 514
TYR A 515
SER A 518
ARG B  80
ALA B  86
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 638
ARG A 631
VAL A 693
VAL A 476
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU A 514
TYR A 515
SER A 518
ARG B  80
ALA B  86
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ARG A 750
VAL A 475
LEU A 749
VAL A 472
1.52A
None