Ligand ID: AKN


Drugbank ID:
DB00479
(Amikacin)


Indication:
For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. Amikacin may also be used to treat Mycobacterium avium and Mycobacterium tuberculosis infections.

Get human targets for AKN in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'AKN' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		6lzg ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
GLY A 354
TYR B 505
VAL B 350
TYR B 453
GLU B 406
1.70A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		6m0j ACE2
SPIKE RECEPTOR
BINDING DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
GLY A 354
TYR E 505
VAL E 350
TYR E 453
GLU E 406
1.72A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLY E 502
TYR E 505
VAL E 350
TYR E 453
GLU E 406
1.78A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLY E 502
TYR E 505
VAL E 350
TYR E 453
GLU E 406
1.72A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLY E 502
TYR E 505
VAL E 350
TYR E 453
GLU E 406
1.77A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLY A 502
TYR A 505
VAL A 350
TYR A 453
GLU A 406
1.78A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_D_AKND600_1
(BIFUNCTIONAL AAC/APH)		7btf NSP12
(SARS-CoV-2)		5 / 11
SER A 318
ASN A 314
ASP A 274
GLU A 350
TYR A 346
1.58A14.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_D_AKND600_1
(BIFUNCTIONAL AAC/APH)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
SER A 318
ASN A 314
ASP A 274
GLU A 350
TYR A 346
1.60A14.09
None