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| Ligand ID: 29Q Drugbank ID: DB00579(Mazindol) Indication:Used in short-term (a few weeks) treatment of exogenous obesity in conjunction with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in patients with a body mass index of 30 kg of body weight per height in meters squared (kg/m2) or in patients with a body mass index of 27 kg/m2 in the presence of risk factors such as hypertension, diabetes, or hyperlipidemia. |
| DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 6m71 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.42A | 20.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 6m71 | NSP12 (SARS-CoV-2) | 5 / 9 | VAL A 42ALA A 43PHE A 48SER A 709GLY A 44 | 1.54A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 6m71 | NSP12 (SARS-CoV-2) | 5 / 9 | VAL A 880ALA A 878TYR A 877PHE A 428SER A 434 | 1.75A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_B_29QB603_1 (TRANSPORTER) | 6m71 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.45A | 20.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 6m71 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.51A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 6m71 | NSP12 (SARS-CoV-2) | 5 / 9 | VAL A 96ALA A 97TYR A 217GLY A 220PHE A 219 | 1.62A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 6m71 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.48A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 6vsb | SPIKE GLYCOPROTEIN (SARS-CoV-2) | 5 / 9 | ASP B 53VAL B 36ALA B 222TYR B 37PHE B 275 | 1.40A | 18.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 6vsb | SPIKE GLYCOPROTEIN (SARS-CoV-2) | 5 / 9 | ASP B 53VAL B 36ALA B 222TYR B 37PHE B 275 | 1.46A | 18.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 6vxx | SPIKE GLYCOPROTEIN (SARS-CoV-2) | 5 / 9 | ASP B 53VAL B 36ALA B 222TYR B 37PHE B 275 | 1.51A | 18.43 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 6vxx | SPIKE GLYCOPROTEIN (SARS-CoV-2) | 5 / 9 | ASP B 53VAL B 36ALA B 222TYR B 37PHE B 275 | 1.41A | 18.41 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 6vyb | SPIKE GLYCOPROTEIN (SARS-CoV-2) | 5 / 9 | ASP C 53VAL C 36ALA C 222TYR C 37PHE C 275 | 1.38A | 18.41 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 6vyb | SPIKE GLYCOPROTEIN (SARS-CoV-2) | 5 / 9 | ASP C 53VAL C 36ALA C 222TYR C 37PHE C 275 | 1.46A | 18.43 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 6wkp | NUCLEOCAPSID PROTEIN (SARS-CoV-2) | 5 / 9 | ASP C 81ALA B 173TYR B 172GLY B 60SER C 79 | 1.75A | 12.08 | NoneNoneNoneNone ZN C 201 (-3.5A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 6wkp | NUCLEOCAPSID PROTEIN (SARS-CoV-2) | 5 / 9 | ASP C 81ALA B 173TYR B 172GLY B 60SER C 79 | 1.79A | 13.36 | NoneNoneNoneNone ZN C 201 (-3.5A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7btf | NSP12 (SARS-CoV-2) | 5 / 9 | VAL A 96ALA A 97TYR A 217GLY A 220PHE A 219 | 1.64A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 7btf | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.54A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_B_29QB603_1 (TRANSPORTER) | 7btf | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.52A | 20.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7btf | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.52A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 7btf | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.48A | 20.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7btf | NSP12 (SARS-CoV-2) | 5 / 9 | VAL A 42ALA A 43PHE A 48SER A 709GLY A 44 | 1.44A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7bv1 | NSP12 (SARS-CoV-2) | 5 / 9 | VAL A 880ALA A 878TYR A 877PHE A 428SER A 434 | 1.78A | 20.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 7bv1 | NSP12NSP7 (SARS-CoV-2) | 5 / 9 | ASP C 5VAL A 424ALA A 423TYR A 420SER C 4 | 1.61A | 10.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 7bv1 | NSP12NSP7 (SARS-CoV-2) | 5 / 9 | ASP C 5VAL A 424ALA A 423TYR A 420SER C 4 | 1.68A | 10.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7bv1 | NSP12NSP7 (SARS-CoV-2) | 5 / 9 | ASP C 5VAL A 424ALA A 423TYR A 420SER C 4 | 1.63A | 10.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 7bv1 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.49A | 20.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 7bv1 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.41A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_B_29QB603_1 (TRANSPORTER) | 7bv1 | NSP12NSP7 (SARS-CoV-2) | 5 / 9 | ASP C 5VAL A 424ALA A 423TYR A 420SER C 4 | 1.67A | 10.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_B_29QB603_1 (TRANSPORTER) | 7bv1 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.45A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7bv1 | NSP12 (SARS-CoV-2) | 5 / 9 | VAL A 42ALA A 43PHE A 48SER A 709GLY A 44 | 1.51A | 20.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7bv1 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.46A | 20.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7bv2 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.54A | 20.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_A_29QA603_1 (TRANSPORTER) | 7bv2 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.49A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMF_B_29QB603_1 (TRANSPORTER) | 7bv2 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.54A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_B_29QB603_1 (TRANSPORTER) | 7bv2 | NSP12 (SARS-CoV-2) | 5 / 9 | VAL A 42ALA A 43PHE A 48SER A 709GLY A 44 | 1.48A | 20.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MME_A_29QA603_1 (TRANSPORTER) | 7bv2 | NSP12 (SARS-CoV-2) | 5 / 9 | ASP A 717VAL A 776ALA A 771TYR A 770GLY A 774 | 1.57A | 20.04 | None |