Ligand ID: 115


Drugbank ID:
DB01095
(Fluvastatin)


Indication:
To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of primary hypercholesterolemia and mixed dyslidipidemia.

Get human targets for 115 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '115' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 270
ASN A 274
LEU A 272
ALA A 234
1.77A17.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 270
ASN A 274
LEU A 272
ALA A 234
1.76A17.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
VAL B 350
SER B 349
ASN B 450
ASP B 442
1.70A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.45A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.43A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.45A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.31A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.14A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP7
(SARS-CoV-2)		4 / 8
CYH C   8
HIS C  36
ALA C  42
LEU C  41
1.52A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.30A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 672
VAL A 398
SER A 397
ASP A 390
1.51A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.33A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.15A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.35A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.39A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.15A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.38A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP7
(SARS-CoV-2)		4 / 8
CYH C   8
HIS C  36
ALA C  42
LEU C  41
1.50A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP7
(SARS-CoV-2)		4 / 8
CYH C   8
HIS C  36
ALA C  42
LEU C  41
1.51A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.36A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.59A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.33A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.31A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
CYH C 738
ASN C 856
LEU C 858
LEU C 959
1.36A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER B 383
SER C 982
ASN B 542
ASP B 389
1.60A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.53A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.65A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.28A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.29A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.40A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.41A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.40A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.40A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.39A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.49A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.28A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.39A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.48A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.49A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN C  30
LEU C 216
ALA C  93
LEU C 189
1.33A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN B  30
LEU B 216
ALA B  93
LEU B 189
1.24A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ARG C 457
SER C 459
ASN C 422
ASP C 467
1.64A15.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w4b NSP9
(SARS-CoV-2)		4 / 8
ASN B  97
LEU B  95
ALA B  44
LEU B  43
1.43A13.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w4h NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.77A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
HIS A7023
ALA A7002
LEU A7004
1.74A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
HIS A7023
ALA A7002
LEU A7004
1.74A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
ALA B  89
LEU B  88
1.71A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A  92
HIS A 119
LEU A 122
ALA A 124
1.66A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
ALA A  89
LEU A  88
1.70A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B  92
HIS B 119
LEU B 122
ALA B 124
1.65A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
ALA B  89
LEU B  88
1.71A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B  92
HIS B 119
LEU B 122
ALA B 124
1.64A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
ALA A  89
LEU A  88
1.70A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.62A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A  92
HIS A 119
LEU A 122
ALA A 124
1.73A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
LEU A 122
ALA A 124
1.77A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.63A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B  92
HIS B 119
LEU B 122
ALA B 124
1.71A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
LEU A 122
ALA A 124
1.76A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
ALA A  89
LEU A  88
1.71A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A  92
HIS A 119
LEU A 122
ALA A 124
1.67A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.62A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
ALA B  89
LEU B  88
1.72A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.47A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.50A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.80A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.51A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.47A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.47A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.50A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
CYH C 155
LEU C 113
ALA C 116
LEU C 117
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
VAL A  41
ASN A  88
ASP A  37
LYS A  91
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
VAL C  41
ASN C  88
ASP C  37
LYS C  91
0.93A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
CYH C 155
LEU C 113
ALA C 116
LEU C 117
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
VAL A  41
ASN A  88
ASP A  37
LYS A  91
1.10A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
VAL B  41
ASN B  88
ASP B  37
LYS B  91
0.95A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
VAL A  41
ASN A  88
ASP A  37
LYS A  91
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
CYH C 155
LEU C 113
ALA C 116
LEU C 117
0.99A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
CYH B 155
LEU B 113
ALA B 116
LEU B 117
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
ASN A  96
LEU A  94
ALA A  43
LEU A  42
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
ASN A  96
LEU A  94
ALA A  43
LEU A  42
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
ASN A  96
LEU A  94
ALA A  43
LEU A  42
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
HIS A 138
LEU A 109
ALA A 112
LEU A 127
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
HIS A 138
LEU A 109
ALA A 112
LEU A 127
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 249
LEU A 247
LEU A 279
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 249
LEU A 247
LEU A 279
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 298
LEU A 247
LEU A 279
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
HIS A 342
LEU A 313
ALA A 316
LEU A 331
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 249
LEU A 247
LEU A 279
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
CYH A 347
ASN A 321
LEU A 326
ALA A 328
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
HIS A 342
LEU A 313
ALA A 316
LEU A 331
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
CYH A 347
ASN A 321
LEU A 326
ALA A 328
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 298
LEU A 247
LEU A 279
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 298
LEU A 247
LEU A 279
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
CYH A 347
ASN A 321
LEU A 326
ALA A 328
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER F 312
VAL E 270
ASN B 345
ASP E 297
1.61A11.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL C6965
SER C6964
ASN C7008
ASP C6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.80A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
VAL A 166
SER A 162
ASP A 273
LYS A  71
1.71A19.01
None
EDO  A 408 ( 3.7A)
EDO  A 408 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL A 166
SER A 162
ASP A 273
LYS A  71
1.60A
None
EDO  A 408 ( 3.7A)
EDO  A 408 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL A 166
SER A 162
ASP A 273
LYS A  71
1.59A
None
EDO  A 408 ( 3.7A)
EDO  A 408 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.71A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
CYH C 143
ASN C 117
LEU C 122
ALA C 124
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.59A
GTA  A7102 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.59A
GTA  A7102 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.59A
GTA  A7102 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
CYH A 284
ASN A  99
LEU A 118
ALA A 114
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
CYH A 284
ASN A  99
LEU A 118
ALA A 114
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
ASN A 128
LEU A 132
ALA A 135
LEU A 150
1.61A
PO4  A 504 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
CYH A 284
ASN A  99
LEU A 118
ALA A 114
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
VAL A  41
ASN A  88
ASP A  37
LYS A  91
0.92A19.50
None
GOL  A 507 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
ASN A 128
LEU A 132
ALA A 135
LEU A 150
1.61A
PO4  A 504 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
ASN A 128
LEU A 132
ALA A 135
LEU A 150
1.60A
PO4  A 504 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 270
ASN A 274
LEU A 272
ALA A 234
1.79A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 270
ASN A 274
LEU A 272
ALA A 234
1.78A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS C  36
LEU C  40
ALA B  86
LEU C  41
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS C  36
LEU C  40
ALA B  86
LEU C  41
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS C  36
LEU C  40
ALA B  86
LEU C  41
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASN A  35
LEU A 119
ALA A 133
LEU A  16
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASN A  35
LEU A 119
ALA A 133
LEU A  16
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASN A  35
LEU A 119
ALA A 133
LEU A  16
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 9
ASN A  35
LEU A 119
ALA A 133
LEU A  16
LEU A 127
1.09A14.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.33A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.35A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.33A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.34A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH E 143
ASN E 117
LEU E 122
ALA E 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.34A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
HIS B 138
LEU B 109
ALA B 112
LEU B 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.32A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.35A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH C 143
ASN C 117
LEU C 122
ALA C 124
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
HIS C 138
LEU C 109
ALA C 112
LEU C 127
1.57A
EDO  C 208 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
HIS B 138
LEU B 109
ALA B 112
LEU B 127
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH D 143
ASN D 117
LEU D 122
ALA D 124
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH E 143
ASN E 117
LEU E 122
ALA E 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.32A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.33A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.34A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH E 143
ASN E 117
LEU E 122
ALA E 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.33A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.35A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
HIS C 138
LEU C 109
ALA C 112
LEU C 127
1.57A
EDO  C 208 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.28A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.28A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.30A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.39A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.39A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.40A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 8
CYH A 659
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 8
CYH A 659
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 8
CYH A 659
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 9
CYH A 659
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.68A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.56A
 ZN  A1002 (-2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.58A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 665
LEU A 673
ALA A 382
LEU A 401
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.56A
 ZN  A1002 (-2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP8
(SARS-CoV-2)		4 / 8
ASN D 176
LEU D 180
ALA D 181
LEU D 184
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.55A
 ZN  A1002 (-2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 665
LEU A 673
ALA A 382
LEU A 401
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.62A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 8
VAL C  16
SER C  15
ASN A 414
LYS A 417
1.67A11.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.61A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
CYH D 142
ASN D 109
ALA D 188
LEU D 128
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.73A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 7
VAL C  16
SER C  15
ASN A 414
LYS A 417
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.61A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 7
VAL C  16
SER C  15
ASN A 414
LYS A 417
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
CYH D 142
ASN D 109
ALA D 188
LEU D 128
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
CYH D 142
ASN D 109
ALA D 188
LEU D 128
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
ASN D 176
LEU D 180
ALA D 181
LEU D 184
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.55A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 8
VAL C  16
SER C  15
ASN A 414
LYS A 849
1.68A11.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 7
VAL C  16
SER C  15
ASN A 414
LYS A 849
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
LEU A 638
ALA A 634
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 610
HIS A 752
ALA A 771
LEU A 775
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 610
HIS A 752
ALA A 771
LEU A 775
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
LEU A 638
ALA A 634
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.54A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.54A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
LEU A 638
ALA A 634
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 7
VAL C  16
SER C  15
ASN A 414
LYS A 849
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.62A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.58A
None