Ligand ID: YMZ


Drugbank ID:
DB00358
(Mefloquine)


Indication:
For the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of Plasmodium falciparum (both chloroquine-susceptible and resistant strains) or by Plasmodium vivax. Also for the prophylaxis of Plasmodium falciparum and Plasmodium vivax malaria infections, including prophylaxis of chloroquine-resistant strains of Plasmodium falciparum.

Get human targets for YMZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'YMZ' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE E  13
GLU E  18
LEU F  19
ILE C  16
LEU D  26
1.61A17.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 6
ASN A 219
ALA A 220
PRO A 307
VAL A 218
1.55A21.43
19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
LEU A 305
ILE A 217
LEU A 291
ILE A 205
LEU A 235
1.62A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		2ajf ACE2
(Homo
sapiens)		5 / 11
LEU A 450
ILE A 233
GLU A 527
ILE A 446
LEU A 236
1.56A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		2ajf ACE2
(Homo
sapiens)		4 / 6
ASN B 188
ALA B 191
ASP B 198
TYR B 199
1.45A11.88
19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LYS C 914
GLU C 918
LEU F1168
ILE B 916
LEU E1175
1.65A14.02
ACE  C 913 ( 3.0A)
None
None
ACE  B 913 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU F1179
LYS B 914
LEU E1168
ILE A 916
LEU D1175
1.55A12.76
None
ACE  B 913 ( 2.9A)
None
None
ACE  B 913 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASN S 375
ALA S 350
ASP S 351
TYR S 352
1.59A22.07
20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 6
ASN C  38
ALA C  39
PRO C 126
VAL C  37
1.57A21.35
19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
LEU A 124
ILE A  36
LEU A 110
ILE A  24
LEU A  54
1.62A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
ASN B 216
VAL B 221
ASP B 215
TYR B 214
1.58A18.87
21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
VAL C 369
GLY E 326
TYR E 352
VAL E 328
PRO E 324
1.77A22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
LEU A 331
TYR A 230
GLU A 233
PHE A 232
LEU A 311
1.68A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
GLY B 329
VAL B 325
GLU B 324
MET B 323
ASP A 342
1.80A17.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU D 248
ILE D 295
GLU D 304
ILE D 235
LEU D 250
1.65A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU A 331
TYR A 230
GLU A 233
PHE A 232
LEU A 311
1.65A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ASN B 188
ALA B 191
ASP B 198
TYR B 199
1.49A11.88
19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE E 405
ASN E 409
TYR E 410
GLU E 341
ILE E 397
1.48A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU B 236
TYR B 587
GLU B 527
PHE B 523
LEU B 439
1.72A15.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		3e9s NSP3
(SARSr-CoV)		4 / 6
ASN A 216
VAL A 221
ASP A 215
TYR A 214
1.53A18.75
21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ILE B 286
LYS A 198
TYR C 239
GLU C 240
LEU A 202
1.69A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ALA A 206
PRO C 252
VAL C 297
TYR A 209
1.69A17.94
20.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASN A 133
ALA A 194
PRO A 184
ASP A 197
1.67A17.86
19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
ASN A 216
VAL A 221
ASP A 215
TYR A 214
1.47A18.87
21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU A 236
TYR A 587
GLU A 527
PHE A 523
LEU A 439
1.71A15.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ASN B 188
ALA B 191
ASP B 198
TYR B 199
1.51A10.78
19.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 11
LEU B  56
ILE B   3
LEU A 200
ILE B  23
ARG B  54
1.54A17.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
ASN A 267
ALA A 166
PRO A 250
TYR A 279
1.38A17.90
20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
ASN B 137
ALA B  96
PRO B 121
VAL B 136
1.49A13.81
19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 11
LEU A  75
ILE A  38
ASN A  10
PHE B  60
LEU B 192
1.44A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
LEU D 409
ASN D 306
GLU B 365
ILE D 298
LEU D 303
1.55A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 9
VAL A  42
TYR A  96
MET A  44
GLY B  44
PRO B  43
1.76A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
ASN B 137
ALA B  96
PRO B 121
VAL B 136
1.58A13.99
19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
ASN B 137
ALA B  96
PRO B 121
VAL B 136
1.65A13.81
19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
LEU N  75
ILE N  38
ASN N  10
PHE B  60
LEU B 192
1.51A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
ASN B 216
VAL B 221
ASP B 215
TYR B 214
1.51A19.00
21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		5x4r S PROTEIN
(MERS-CoV)		4 / 6
ASN A 104
ALA A 103
PRO A 297
TYR A 105
1.68A17.87
21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
ALA B 872
PRO A1051
ASP A1023
TYR A1029
1.66A6.98
16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		5x59 S PROTEIN
(MERS-CoV)		4 / 6
ASN C 104
ALA C 103
PRO C 297
TYR C 105
1.68A7.25
14.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
VAL A  98
GLY A 145
VAL A 140
ASP A 171
PRO A 143
1.63A11.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5x5c S PROTEIN
(MERS-CoV)		5 / 9
VAL B 518
TYR B 523
VAL B 396
ASP B 444
PRO B 394
1.72A10.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU A 264
TYR A  42
GLU A  45
PHE B 548
ILE A 272
1.64A10.17
LEU  A 264 ( 0.6A)
TYR  A  42 ( 1.3A)
GLU  A  45 ( 0.6A)
PHE  B 548 ( 1.3A)
ILE  A 272 ( 0.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
ASN A 216
VAL A 221
ASP A 215
TYR A 214
1.49A18.87
20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE B1086
ASN B1101
GLU B1074
PHE B1071
ILE B1063
1.56A10.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
VAL B  98
GLY B 145
VAL B 140
ASP B 171
PRO B 143
1.66A11.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		6acj ACE2
(Homo
sapiens)		5 / 11
LEU D 450
ILE D 233
GLU D 527
ILE D 446
LEU D 236
1.54A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ALA B 872
PRO C1051
ASP C1023
TYR C1029
1.33A6.91
16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ILE B 228
PHE B 185
LEU B 216
ILE B 116
LEU B 194
1.70A10.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASN A 409
TYR A 410
GLU A 452
PHE A 451
ARG A 342
1.37A10.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
VAL B  98
GLY B 145
VAL B 140
ASP B 171
PRO B 143
1.73A11.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ALA C 872
PRO B1051
ASP B1023
TYR B1029
1.38A6.77
16.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		6cs2 ACE2
(Homo
sapiens)		4 / 6
ASN D 188
ALA D 191
ASP D 198
TYR D 199
1.46A11.88
19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		6jyt HELICASE
(SARSr)		5 / 11
LEU A 325
ILE A 293
LEU A 363
ILE A 304
ARG A 303
1.41A15.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		6jyt HELICASE
(SARSr-CoV)		4 / 6
ASN A 562
ALA A 403
VAL A 563
ASP A 458
1.31A12.71
21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		6m0j ACE2
(Homo
sapiens)		4 / 6
ASN A 188
ALA A 191
ASP A 198
TYR A 199
1.49A10.78
19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
ILE A 133
ASN A 130
TYR A 128
LEU A 494
ARG A  57
1.60A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		6m17 ACE2
(Homo
sapiens)		5 / 11
LEU B 236
TYR B 587
GLU B 527
PHE B 523
LEU B 439
1.72A13.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		6m17 ACE2
(Homo
sapiens)		4 / 6
ASN D 188
ALA D 191
ASP D 198
TYR D 199
1.44A9.80
19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6nur NSP12
(SARSr-CoV)		5 / 9
VAL A 190
GLY A 230
VAL A 231
ASP A 198
GLY A 200
1.76A14.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_K_YMZK301_1
(60S RIBOSOMAL
PROTEIN L13,
PUTATIVE)		6nur NSP12
(SARSr-CoV)		5 / 11
LEU A 308
ILE A 307
ILE A 632
ARG A 631
LEU A 351
1.41A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		6nus NSP12
(SARSr-CoV)		4 / 6
ALA A 625
VAL A 166
ASP A 623
TYR A 619
1.68A9.22
17.41
None