Ligand ID: TE4


Drugbank ID:
DB09085
(Tetracaine)


Indication:
The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.

Get human targets for TE4 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TE4' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B  22
LEU D  19
ILE C  16
ILE E  16
LEU C  27
1.21A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 9
LEU A 309
PRO A 307
ASN A 281
ALA A 284
SER A 310
1.80A24.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
LEU G  96
ILE G 112
ILE C  73
VAL C  71
LEU C  22
1.16A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		2ajf ACE2
(Homo
sapiens)		5 / 12
LEU B 570
VAL B 573
LEU B 410
ILE B 407
LEU B 539
1.20A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL D1171
LEU E1168
ILE B 916
ILE C 916
LEU B 927
1.28A17.90
None
None
ACE  B 913 ( 3.9A)
ACE  C 913 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
LEU C 128
PRO C 126
ASN C 100
ALA C 103
SER C 129
1.74A26.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
LEU A  35
LEU A  45
ILE A  60
VAL A  12
LEU A  53
1.19A28.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		2gri NSP3
(SARSr)		5 / 12
LEU A  66
LEU A  90
ILE A  24
VAL A  58
PHE A  88
1.28A22.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 12
LEU A 114
LEU A  65
ILE A 131
LEU A 160
PHE A 111
1.29A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU D 331
VAL D 318
ILE D 327
ILE D 322
ILE D 295
1.20A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
LEU A 163
ILE A 167
LYS A 123
ILE A 157
LEU A  57
1.33A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU B 100
ALA B  71
GLU B  75
GLN B  76
SER B  77
1.64A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 570
VAL A 573
LEU A 410
ILE A 407
LEU A 539
1.17A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		3scj ACE2
(Homo
sapiens)		5 / 12
LEU A 570
VAL A 573
LEU A 410
ILE A 407
LEU A 539
1.09A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU A 100
ALA A  71
GLU A  75
GLN A  76
SER A  77
1.67A15.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 570
VAL A 573
LEU A 410
ILE A 407
LEU A 539
1.24A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 12
LEU B  96
ILE B 112
ILE A  73
VAL A  71
LEU A  22
1.26A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		5 / 12
LEU A  34
ILE A  33
ILE B  33
VAL B  29
LEU A  27
1.33A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL B 860
LEU B 920
ILE B 800
ILE B 704
VAL B 708
1.17A8.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 860
LEU A 920
ILE A 800
ILE A 704
VAL A 708
1.29A8.51
VAL  A 860 ( 0.6A)
LEU  A 920 ( 0.6A)
ILE  A 800 ( 0.7A)
ILE  A 704 ( 0.7A)
VAL  A 708 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 860
LEU B 920
ILE B 800
ILE B 704
VAL B 708
1.25A8.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B 124
ILE B 115
ILE B 152
ILE B 234
LEU B 194
1.27A8.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL A 860
LEU A 920
ILE A 800
ILE A 704
VAL A 708
1.22A9.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		6jyt HELICASE
(SARSr-CoV)		5 / 12
LEU A 219
VAL A 154
LEU A 227
LEU A 176
PHE A 200
1.28A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A 415
LEU A 427
ILE A 422
VAL A 233
PHE A 237
1.27A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		6m18 ACE2
(Homo
sapiens)		5 / 12
LEU B 570
VAL B 573
LEU B 410
ILE B 407
LEU B 539
1.21A11.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		6m1d ACE2
(Homo
sapiens)		5 / 9
LEU B 100
ASN B 103
ALA B  71
GLN B  76
SER B  77
1.67A12.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		6nur NSP12
(SARSr-CoV)		5 / 9
LEU A 708
ASN A 781
ASN A 703
ALA A 699
GLN A 468
1.75A9.95
None