Ligand ID: FLR


Drugbank ID:
DB00712
(Flurbiprofen)


Indication:
Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.

Get human targets for FLR in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'FLR' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.32A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B1125
LEU B1115
VAL B1013
GLY B1011
SER A  10
1.27A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
VAL B  73
VAL B  91
TYR B  37
VAL B  20
GLY B  29
1.40A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.29A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.42A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.27A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.36A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H 181
VAL L 134
LEU L 136
VAL H 142
LEU H 124
1.35A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		6 / 12
VAL B  64
ARG B  67
LEU B  18
TYR B  94
LEU B  81
GLY B  15
1.65A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL A  31
VAL A   5
LEU A   2
VAL A  10
GLY A  13
1.26A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL A  31
VAL A   5
LEU A   2
VAL A  10
GLY A  13
1.26A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL B  73
VAL B  91
TYR B  37
VAL B  20
GLY B  29
1.43A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.28A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.39A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.24A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.32A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.42A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
VAL F  31
VAL F   5
LEU F   2
VAL F  10
GLY F  13
1.39A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.29A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2w2g NSP3
(SARSr-CoV)		5 / 12
TYR A 495
VAL A 445
GLY A 446
ALA A 474
LEU A 475
1.29A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.26A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.27A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.40A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.43A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.29A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.28A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.40A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.22A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B  73
VAL B  91
TYR B  37
VAL B  20
GLY B  29
1.35A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.26A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.42A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.27A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
TYR F 356
LEU F 355
TYR F 367
VAL F 369
GLY F 418
LEU F 499
1.73A16.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3scj ACE2
(Homo
sapiens)		5 / 12
VAL A 244
TYR A 237
LEU A 240
GLY A 268
LEU A 444
1.42A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.26A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
TYR A 269
LEU B  73
GLY A 210
ALA A 247
SER A 246
1.17A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
TYR A 269
LEU B  73
GLY A 210
ALA A 247
SER A 246
1.17A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4twy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
TYR A  37
VAL A  20
GLY A  29
1.43A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.33A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 118
LEU D 152
VAL D  91
GLY D 110
ALA D 270
1.43A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 118
LEU D 152
VAL D  91
GLY D 110
ALA D 270
1.40A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
TYR A 269
LEU B  73
GLY A 210
ALA A 247
SER A 246
1.21A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
TYR A 269
LEU B  73
GLY A 210
ALA A 247
SER A 246
1.21A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
LEU D 508
ASN D 388
TYR D 392
PHE D 431
PRO D 429
1.72A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		5 / 12
VAL C 148
VAL C  98
TYR C  96
LEU C 107
LEU C 142
1.25A10.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
TYR B 269
LEU A 152
GLY B 210
ALA B 247
SER B 246
1.11A19.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
TYR B 269
LEU A 152
GLY B 210
ALA B 247
SER B 246
1.10A19.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		5 / 12
VAL C 146
VAL C  96
TYR C  94
LEU C 105
LEU C 140
1.33A9.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
VAL A 514
ARG A 505
GLY A 551
SER A 508
LEU A 507
1.29A17.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
LEU B1058
SER A 435
ASN A 436
TYR A 577
PRO A 586
1.79A13.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 708
LEU C 930
VAL C 763
ALA C1007
SER C1003
1.42A18.39
VAL  C 708 ( 0.6A)
LEU  C 930 ( 0.6A)
VAL  C 763 ( 0.6A)
ALA  C1007 ( 0.0A)
SER  C1003 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN A1090
TYR A1049
PHE A 700
PHE A1091
PRO A 697
1.74A13.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A1043
LEU A 930
VAL A 763
ALA A1007
SER A1003
1.32A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A1043
LEU A 930
VAL A 763
ALA A1007
SER A1003
1.32A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 861
PHE C 880
PHE C 784
PRO C 774
TYR B 689
1.75A14.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL C 497
LEU C 499
VAL C 328
GLY C 326
LEU C 355
1.42A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL A 306
LEU A  86
VAL A  50
GLY A  47
LEU A 286
1.38A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		6 / 12
VAL H  64
ARG H  67
LEU H  18
TYR H  94
LEU H  81
GLY H  15
1.68A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6nur NSP12
(SARSr-CoV)		5 / 12
LEU A 251
SER A 318
ASN A 314
TYR A 294
PHE A 313
1.75A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vw1 ACE2
(Homo
sapiens)		5 / 12
VAL B 244
TYR B 237
LEU B 240
GLY B 268
LEU B 444
1.43A21.82
None
None
None
EDO  B 705 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
VAL H 184
LEU H 138
LEU H 159
GLY H 190
SER H 188
1.64A14.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
VAL H 184
LEU H 138
LEU H 159
GLY H 190
SER H 188
1.64A14.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
TYR H  94
LEU H  81
VAL H 117
SER H  17
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
TYR H  94
LEU H  81
VAL H 117
SER H  17
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
TYR H  94
LEU H  81
VAL H 117
SER H  17
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
TYR H  94
LEU H  81
VAL H 117
SER H  17
1.55A
None