Ligand ID: C41


Drugbank ID:
DB09026
(Aliskiren)


Indication:
For the treatment of hypertension, to lower blood pressure.

Get human targets for C41 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'C41' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
GLN B 299
GLY B 283
PHE B 291
GLY B   2
SER A 139
1.13A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
GLN A 299
GLY A 283
SER A 284
PHE A 291
SER B 139
1.16A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
VAL B 110
GLY B 104
SER B 105
TYR B  31
SER A   5
1.57A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN A 936
VAL B 934
ALA A 938
VAL C 934
ILE A1164
1.46A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 283
SER A 284
PHE A 291
GLY A   2
SER B 139
1.22A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 124
ALA A 210
PHE A   3
SER A 301
ILE A 152
1.38A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN A 939
GLY A 928
VAL A1158
ASP A 932
ILE B1164
1.43A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		1x7q HLA, A-11
(Homo
sapiens)		4 / 8
SER A  38
THR A  73
LEU A  81
THR A  64
1.41A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 127
VAL A 114
GLY B1002
ALA A   7
GLY A 138
1.45A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B1299
GLY B1283
SER B1284
PHE B1291
SER A 139
1.54A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 8
SER I  14
THR A  25
LEU B  19
THR I  21
1.27A11.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
GLN B 299
GLY B 283
SER B 284
PHE B 291
SER A 139
1.07A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
GLY B 124
ALA A 210
PHE A   3
SER A 301
ILE A 152
1.40A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
TYR E 491
SER A 331
PRO A 321
THR A 347
1.43A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 299
GLY A 283
SER A 284
PHE A 291
GLY A   2
1.31A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
VAL E 271
ALA F 314
PHE E 275
ASP E 298
GLY E 296
1.09A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 8
SER D 251
TYR D 269
THR D 264
LEU D 292
1.36A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 8
SER A  51
SER A  54
THR B  96
LEU B  13
1.28A11.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 8
SER B  51
SER B  54
THR A  96
LEU A  13
1.40A11.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 8
SER H  51
SER H  54
THR G  96
LEU G  13
1.30A11.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 8
SER E  51
SER E  54
THR F  96
LEU F  13
1.44A12.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN L 186
GLY L 153
VAL L 156
ASP L 152
SER L 189
1.47A19.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L  90
ASP L  92
SER L  95
VAL L  97
SER L  30
1.41A19.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLN H  39
ALA H  40
VAL H 109
GLY H 106
ILE H  34
1.48A23.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
GLN C 120
VAL C  37
GLY C  98
TYR C 114
SER C  81
1.58A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
TYR C 274
THR C 275
LEU C 254
THR A 198
1.36A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL B  13
GLY B 109
ALA B   9
ASP B 106
ILE B  99
1.48A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
TYR A 442
PRO B 178
LEU B 179
THR A 487
1.33A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
VAL B  12
GLY B   8
TYR B  94
PRO B  41
GLY B  10
1.58A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2hsx LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		5 / 12
GLN A  85
GLY A  94
VAL A  78
GLY A  87
SER A  89
1.48A14.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
GLN B 299
GLY B 283
SER B 284
PHE B 291
SER A 139
1.20A22.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
SER C 328
THR C 192
PRO C 190
LEU C 189
1.43A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
GLN B 299
GLY B 283
SER B 284
PHE B 291
SER A 139
1.34A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
TYR D 342
SER D 273
THR D 274
LEU D 297
1.44A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 299
GLY B 283
SER B 284
PHE B 291
SER A 139
1.12A22.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		2z9k 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 124
ALA A 210
PHE A   3
SER A 301
ILE A 152
1.29A22.29
DMS  A 813 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		3bgf F26G19 FAB
(Mus
musculus)		4 / 8
SER B 136
THR B 139
LEU C 136
THR B 189
1.41A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
TYR A 199
TYR A 454
THR A 453
LEU A 503
1.27A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  13
PHE A 150
VAL A 157
GLY A  11
SER B  10
1.58A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 124
ALA A 210
PHE A   3
SER A 301
ILE A 152
1.31A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 299
GLY A 283
SER A 284
PHE A 291
SER B 139
1.11A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 283
SER A 284
PHE A 291
GLY A   2
SER B 139
1.43A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  13
PHE A 150
VAL A 157
GLY A  11
SER B  10
1.54A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B  18
GLY B 146
SER B 147
PRO B  99
GLY B  29
1.39A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
SER A  86
TYR A  36
LEU A  65
THR A  91
1.42A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		3scj ACE2
(Homo
sapiens)		4 / 8
TYR B 199
TYR B 454
THR B 453
LEU B 503
1.27A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
TYR B 199
TYR B 454
THR B 453
LEU B 503
1.26A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		3scl ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
TYR E 491
SER A 331
PRO A 321
THR A 347
1.43A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN F 401
GLY F 391
ALA F 398
GLN F 492
ASP F 392
1.50A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  13
PHE A 150
VAL A 157
GLY A  11
SER B  10
1.54A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
SER A  86
TYR A  36
LEU A  65
THR A  91
1.36A23.10
None
None
GOL  A 405 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
VAL A 166
GLY B  76
SER A 112
PRO A 249
GLY A 164
1.55A23.10
None
None
NA  A 402 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  13
PHE A 150
VAL A 157
GLY A  11
SER B  10
1.54A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  13
PHE A 150
VAL A 157
GLY A  11
SER B  10
1.54A22.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 8
SER D  12
SER D  28
THR C   5
LEU C  14
THR D  16
1.74A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 8
SER D  12
SER D  28
THR C   5
LEU C  14
THR D  16
1.76A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA B 396
PHE B 384
VAL B 389
ASP B 352
GLY B 333
1.47A20.74
None
None
SAM  B 605 ( 4.8A)
SAM  B 605 (-2.2A)
SAM  B 605 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
VAL D 101
GLY C  -1
SER C   0
PRO D 142
GLY D 102
1.44A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
SER A  86
TYR A  36
LEU A  65
THR A  91
1.43A21.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA D 396
PHE D 384
VAL D 389
ASP D 352
GLY D 333
1.41A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLY O 109
ALA O   9
VAL O  13
ASP O 106
ILE O  99
1.44A16.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
TYR C 197
SER C 194
THR C 193
LEU C   7
1.40A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
SER D  86
TYR D  36
LEU D  65
THR D  91
1.23A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
VAL A 118
GLY A 115
TYR A 293
VAL A 315
GLY A 255
1.02A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
VAL A 118
GLY A 115
VAL A 315
GLY A 255
ILE A 290
1.50A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLN C 630
ASP C 600
GLN C 301
GLY C 634
ILE C 584
1.39A14.90
NAG  C1301 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
SER B 685
TYR C 771
SER C 861
THR C 865
1.24A14.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL C 308
ASP A 727
GLY A 726
PRO C 617
SER C 577
1.46A14.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
VAL A 118
GLY A 115
TYR A 293
VAL A 315
GLY A 255
1.01A14.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5x5f S PROTEIN
(MERS-CoV)		4 / 8
TYR A 438
THR A 574
LEU A 479
THR A 579
1.36A14.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLY C 959
PHE B 778
GLN C1110
GLY C 957
SER C 859
1.37A14.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR A 195
SER B 346
THR B 509
LEU B 504
1.33A15.04
TYR  A 195 ( 1.3A)
SER  B 346 ( 0.0A)
THR  B 509 ( 0.8A)
LEU  B 504 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN B1018
ASP B1023
GLY A 871
VAL B1022
GLY B1028
1.52A15.04
GLN  B1018 ( 0.6A)
ASP  B1023 ( 0.5A)
GLY  A 871 ( 0.0A)
VAL  B1022 ( 0.6A)
GLY  B1028 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
SER A  86
TYR A  36
LEU A  65
THR A  91
1.30A22.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR C 771
SER A 685
PRO C 774
LEU C 776
1.23A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6acj ACE2
(Homo
sapiens)		5 / 12
ASP D 216
GLY D 214
VAL D 209
ASP D 213
GLY D 211
1.51A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 205
ASP C 208
ALA C 249
PHE C 179
VAL C 206
1.43A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6acj ACE2
(Homo
sapiens)		5 / 12
ASP D 216
GLY D 214
VAL D 209
ASP D 213
GLY D 211
1.50A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 562
ASP A 572
GLY A 536
SER A 574
PHE A 551
1.35A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP C 560
GLY C 552
ALA A 834
GLN C 549
ILE C 570
1.48A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
SER C 303
SER C 279
LEU C 264
THR C 616
1.38A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN A 835
GLY C 534
PHE C 578
GLY C 536
SER C 574
1.52A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY C 552
VAL C 555
GLN C 549
SER C 574
ILE C 570
1.27A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6m18 ACE2
(Homo
sapiens)		4 / 8
TYR B 199
TYR B 454
THR B 453
LEU B 503
1.39A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m1d ACE2
(Homo
sapiens)		5 / 12
ASP D 669
ALA D 650
VAL D 685
GLY D 666
SER B 645
1.14A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL A 441
GLY A 434
PRO A  33
VAL A 440
GLY A 285
0.77A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL C 441
GLY C 434
VAL C 440
GLY C 285
SER C 291
1.15A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN B 766
GLY B 873
ALA B 765
GLY B 871
ILE C 687
1.32A14.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER L  97
SER L  25
THR L  74
THR L 102
1.23A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6nur NSP12
NSP8
(SARSr-CoV)		4 / 8
SER A 318
THR A 324
PRO B 116
LEU A 271
1.13A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6vw1 ACE2
(Homo
sapiens)		4 / 8
TYR A 199
TYR A 454
THR A 453
LEU A 503
1.29A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TYR H 176
SER L 176
SER L 131
THR L 180
1.76A21.82
None
GOL  L 301 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TYR L 173
SER L 174
THR L 164
PRO H 167
1.69A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
VAL H 198
GLY H 139
SER H 180
VAL H 152
SER H 120
1.62A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TYR L 186
SER H 177
SER L 176
THR H 165
1.53A19.71
None
GOL  L 301 (-3.1A)
GOL  L 301 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
SER L 176
THR L 178
LEU L 181
THR H 165
1.67A19.71
GOL  L 301 (-3.1A)
GOL  L 301 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR H  32
SER H  21
PRO C  49
THR H 114
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
SER B  21
TYR B  80
SER B  71
LEU H 163
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 202
GLY H 143
SER H 184
VAL H 156
SER H 124
1.66A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN C  95
GLY B 110
ALA C  40
GLN B 111
ILE B  93
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR L 179
SER L 180
THR L 170
PRO H 171
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR L 192
SER H 181
SER L 182
THR H 169
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL B 202
GLY B 143
SER B 184
VAL B 156
SER B 124
1.66A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
TYR H  95
THR B  78
LEU B   4
THR H 169
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR C 179
SER C 180
THR C 170
PRO B 171
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN L  95
GLY H 110
ALA L  40
GLN H 111
ILE H  93
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR C 192
SER B 181
SER C 182
THR B 169
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR L 179
SER L 180
THR L 170
PRO H 171
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR L 192
SER H 181
SER L 182
THR H 169
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 202
GLY H 143
SER H 184
VAL H 156
SER H 124
1.67A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN L  95
GLY H 110
ALA L  40
GLN H 111
ILE H  93
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
VAL H 202
GLY H 143
SER H 184
VAL H 156
SER H 124
1.66A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TYR L 192
SER H 181
SER L 182
THR H 169
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
TYR C  92
TYR C 179
SER C 177
THR C 115
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
TYR L  92
TYR L 179
SER L 177
THR L 115
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
VAL B 202
GLY B 143
SER B 184
VAL B 156
SER B 124
1.66A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TYR L 179
SER L 180
THR L 170
PRO H 171
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
GLN C  95
GLY B 110
ALA C  40
GLN B 111
ILE B  93
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TYR C 179
SER C 180
THR C 170
PRO B 171
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TYR C 192
SER B 181
SER C 182
THR B 169
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
GLN L  95
GLY H 110
ALA L  40
GLN H 111
ILE H  93
1.62A
None