Ligand ID: ZIT


Drugbank ID:
DB00207
(Azithromycin)


Indication:
For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal

Get human targets for ZIT in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'ZIT'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ARG A  40
ASP A 176
LEU A 177
SER A 147
1.33A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 7
TYR B 126
PHE B 140
ALA B 173
GLY B 174
TYR B 182
1.79A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.41A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE B 259
GLY B 258
ASP B 216
ALA B 206
SER B   0
1.47A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 12
TYR B  26
VAL B  27
GLY A 239
THR A 240
PHE A 208
1.54A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		4 / 6
PRO A 185
HIS A 188
ALA A 246
TYR B  10
1.29A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 259
GLY A 258
TYR A 209
GLU A 270
ALA A 206
1.59A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.46A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
TYR B  37
VAL B  36
MET B  17
VAL B  18
GLY B 149
1.50A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
ILE B 259
GLY B 258
TYR B 209
GLU B 270
ALA B 206
1.64A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ILE D 205
VAL D 337
PHE D 314
ALA D 294
GLY D 261
1.42A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 5
PRO G 126
GLU H  65
ARG H  62
THR G 128
1.60A23.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
LEU E 122
LEU A  22
VAL A  27
ALA A  70
GLY E 118
1.22A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2ajf ACE2
(Homo
sapiens)		4 / 7
THR A 294
PHE A 369
ASP A 367
LEU A 370
1.26A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU E 443
LEU A  97
VAL A  93
TYR A  83
GLY E 464
1.32A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2ajf ACE2
(Homo
sapiens)		4 / 4
ASN B 580
ILE B 446
TYR B 587
PHE B 592
1.65A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2ajf ACE2
(Homo
sapiens)		5 / 12
ILE B 421
ASP B 543
HIS B 417
ALA B 372
ILE B 291
1.67A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 12
ILE E 397
GLY E 488
THR E 487
PHE E 483
TYR E 481
1.66A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ARG A  40
ASP A 176
LEU A 177
SER A 147
1.41A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
GLY H 322
HIS G 357
ARG G 278
ALA G 360
SER H 313
1.62A16.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
TYR B  37
VAL B  36
MET B  17
VAL B  18
GLY B 149
1.55A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		4 / 6
PRO L   8
GLU L  79
ALA L  14
LEU L 107
1.28A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 106
ALA L  19
VAL L  78
THR L  22
TYR L  87
1.36A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 7
THR B 147
ARG B 149
PHE B 117
LEU B 128
1.48A17.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
PRO A 224
HIS C 273
ALA C 262
LEU C 254
1.43A20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		4 / 6
GLU A  25
ALA A  31
LEU A  96
TYR A  86
1.06A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 4
ASN D 164
ILE C 405
TYR C 338
PHE C 460
1.55A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
PRO A 548
HIS A 613
ALA A 621
LEU A 648
1.37A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2k7x REPLICASE
POLYPROTEIN 1AB MAIN
PROTEASE
(SARS-COV
Sino1-11)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.47A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE C  85
ASP C 323
VAL C  77
VAL C 141
GLY C 156
1.65A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
ILE B 259
GLY B 258
TYR B 209
GLU B 270
ALA B 206
1.65A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
TYR B  37
VAL B  36
MET B  17
VAL B  18
GLY B 149
1.50A21.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
ILE B 259
GLY B 258
TYR B 209
GLU B 270
ALA B 206
1.66A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 5
ASP A 155
PRO B 122
ARG A 298
THR A 304
1.69A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 259
GLY A 258
TYR A 209
GLU A 270
ALA A 206
1.68A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PRO A 252
HIS A 246
GLU A 240
ALA A 129
1.42A22.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
TYR A  37
VAL A  36
MET A  17
VAL A  18
GLY A 149
1.51A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2w2g NSP3
(SARSr-CoV)		5 / 12
VAL B 478
ALA B 474
VAL B 457
GLY B 466
THR B 467
1.44A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2wct NSP3
(SARSr-CoV)		5 / 12
ILE B 484
TYR B 512
GLU D 535
ALA D 555
SER D 634
1.59A25.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		2wct NSP3
(SARSr-CoV)		4 / 7
GLU B 403
PHE B 406
GLY A 446
TYR A 443
1.26A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A 112
VAL A  96
VAL A 290
GLY A 155
PHE A 149
1.42A20.85
None
None
None
None
SAH  A1293 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
ASN A 101
ILE A  68
TYR A 152
PHE A 150
1.74A22.09
SAH  A1293 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A 171
TYR A 181
HIS A 225
ALA A 178
TYR A 132
1.66A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A 112
VAL A  96
VAL A 290
GLY A 155
PHE A 149
1.39A20.85
None
None
None
None
SFG  A1298 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A 171
TYR A 181
HIS A 225
ALA A 178
TYR A 132
1.68A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
ASN A 101
ILE A  68
TYR A 152
PHE A 150
1.72A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2z9l 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
ASP A 155
PRO B 122
ARG A 298
THR A 304
1.71A19.23
None
None
DMS  A 605 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
TYR A  37
VAL A  36
MET A  17
VAL A  18
GLY A 149
1.48A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE B 259
GLY B 258
TYR B 209
GLU B 270
ALA B 206
1.67A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
ILE L  75
LEU L  21
LEU L  54
VAL L  58
GLY L  99
1.33A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
THR A 294
PHE A 369
ASP A 367
LEU A 370
1.38A17.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
HIS A 378
GLU A 406
LEU A 529
TYR A 521
1.35A17.53
 ZN  A 901 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ILE B 421
ASP B 543
HIS B 417
ALA B 372
ILE B 291
1.52A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
GLU B 398
GLY B 200
TYR B 196
TYR B 202
1.25A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3d0i ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
ASN B  33
ILE F 405
TYR F 440
PHE F 460
1.61A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
GLU D 270
PHE B 223
TYR A 237
TYR D 237
1.31A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 4
ASN B 238
ILE B 286
TYR C 239
PHE C 291
1.50A17.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
PRO A   6
ALA B  30
LEU B  29
TYR B  87
1.37A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
TYR B  37
VAL B  36
MET B  17
VAL B  18
GLY B 149
1.50A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
TYR A  37
VAL A  36
MET A  17
VAL A  18
GLY A 149
1.50A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE B 259
GLY B 258
TYR B 209
GLU B 270
ALA B 206
1.63A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 213
LEU A 282
GLU B 166
ALA B 116
TYR B 118
1.40A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ARG A  40
ASP A 176
LEU A 177
SER A 147
1.29A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		5 / 12
TYR B  26
VAL B  27
GLY A 239
THR A 240
PHE A 208
1.46A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		4 / 7
TYR F   6
ALA A 158
GLY A 162
TYR A 159
1.23A4.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3i6k BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		4 / 6
PRO E 185
HIS E 188
ALA E 246
TYR F  10
1.33A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		4 / 6
PRO D 185
HIS D 188
ALA D 246
TYR E  10
1.37A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 281
LEU C 220
VAL C 212
GLU A 270
TYR A 239
1.24A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
TYR C  37
VAL C  36
MET C  17
VAL C  18
GLY C 149
1.52A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 259
GLY A 258
GLU A 270
ARG A 217
ALA A 214
1.57A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
THR A  35
ARG A  88
LEU A  87
SER A  65
1.36A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE B 259
GLY B 258
TYR B 209
GLU B 270
ALA B 206
1.59A20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
THR B 171
ARG B 167
ASP B 165
SER A 246
1.35A20.60
None
None
GRM  B 801 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A 112
VAL A  96
VAL A 290
GLY A 155
PHE A 149
1.36A21.08
None
None
None
None
SAM  A 302 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
ASN A 101
ILE A  68
TYR A 152
PHE A 150
1.74A22.35
SAM  A 302 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3sci ACE2
(Homo
sapiens)		4 / 6
HIS A 378
GLU A 406
LEU A 529
TYR A 521
1.33A18.50
 ZN  A 901 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3sci ACE2
(Homo
sapiens)		4 / 7
THR A 294
PHE A 369
ASP A 367
LEU A 370
1.37A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3scj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU E 443
LEU A  97
VAL A  93
TYR A  83
GLY E 464
1.32A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
HIS A 378
GLU A 406
LEU A 529
TYR A 521
1.27A18.32
 ZN  A 901 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE F 397
GLY F 488
THR F 487
PHE F 483
TYR F 481
1.61A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3scl ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
ASN B  33
ILE F 405
TYR F 440
PHE F 460
1.58A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
GLU B 398
GLY B 200
TYR B 196
TYR B 202
1.29A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
THR A 294
PHE A 369
ASP A 367
LEU A 370
1.34A18.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 7
ALA A  88
GLY A  37
TYR A  84
TYR A  55
1.31A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 7
THR A 119
ARG A 283
PHE A 266
ASP A 309
1.42A21.39
None
None
PO4  A 404 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE B 259
GLY B 258
TYR B 209
GLU B 270
ALA B 206
1.66A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
GLU B 166
ALA B 145
GLY B 143
TYR B 118
1.33A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 4
ASN D 422
ILE B 363
TYR B 351
PHE B 367
1.48A19.42
G3A  D 606 ( 3.9A)
None
None
SAH  B 605 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ASP D 402
ALA D 504
VAL D 305
PHE D 436
TYR D 392
1.54A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
ASP D 243
GLU D  77
ARG D  76
THR D  75
1.55A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ASP D 402
ALA D 504
VAL D 305
PHE D 436
TYR D 392
1.49A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 4
ASN D 422
ILE B 363
TYR B 351
PHE B 367
1.62A19.57
None
None
None
SAM  B 605 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
ASP D 243
GLU D  77
ARG D  76
THR D  75
1.67A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
TYR D 392
PHE D 436
ALA D 430
GLY D 417
1.28A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 5
ASP B 243
GLU B  77
ARG B  76
THR B  75
1.74A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
TYR B 392
PHE B 436
ALA B 430
GLY B 417
1.35A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ASP A 402
ALA A 504
VAL A 305
PHE A 436
TYR A 392
1.49A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  25
PHE A  66
LEU A  58
SER A  81
1.59A17.33
None
None
None
K1Y  A 404 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 243
PHE A 230
LEU A 205
SER A 267
1.77A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.78A17.65
None
None
DMS  A 403 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.75A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.77A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.60A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  36
VAL A  18
GLY A 143
PHE A 140
TYR A 126
1.79A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
TYR D 138
ALA D 142
THR B  11
PHE B  56
TYR B  28
1.32A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
THR C 431
PHE C 483
ASP C 429
SER C 336
1.51A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 843
LEU A 944
TYR A 989
ALA A 748
GLY A 751
1.23A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5x4r S PROTEIN
(MERS-CoV)		4 / 7
TYR A  77
ALA A 113
GLY A 115
TYR A 293
1.48A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5x4r S PROTEIN
(MERS-CoV)		4 / 6
PRO A 196
ALA A 146
LEU A 172
TYR A 207
1.36A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5x4r S PROTEIN
(MERS-CoV)		4 / 4
ASN A 104
ILE A 300
TYR A  87
PHE A 228
1.71A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ILE A 300
ASP A 213
HIS A 208
ALA A 146
ILE A  31
1.54A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ILE A 296
VAL A 170
ALA A 197
GLY A 198
TYR A 201
1.35A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
ARG C 449
ARG C 444
ASP C 454
SER A 113
1.08A12.72
NAG  A1310 ( 4.4A)
NAG  A1310 (-2.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ILE B 637
GLY B 625
GLU B 285
ALA B 609
ILE B 621
1.44A12.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5x59 S PROTEIN
(MERS-CoV)		4 / 7
TYR B 928
ALA A 678
GLY A 716
TYR B 905
1.26A12.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5x59 S PROTEIN
(MERS-CoV)		4 / 4
ASN C 104
ILE C 300
TYR C  87
PHE C 228
1.71A12.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL C1076
TYR A 886
ALA A 872
GLY C1028
TYR C1049
1.22A13.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
TYR A 886
ALA A 872
GLY C1028
TYR C1049
1.24A13.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ILE C1000
ASP C 849
VAL C1042
VAL C 763
GLY B 655
1.51A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
ILE C 296
VAL C 170
ALA C 197
GLY C 198
TYR C 201
1.35A12.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
PRO C 196
ALA C 146
LEU C 172
TYR C 207
1.37A11.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
ILE A 955
VAL A1103
VAL A 853
GLY C1120
THR C1121
1.59A11.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
ILE B 300
ASP B 213
HIS B 208
ALA B 146
ILE B  31
1.53A12.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
THR A  10
PHE A  57
LEU A  81
SER A  86
1.50A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR A 886
ALA A 872
GLY B1028
TYR B1049
1.20A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
GLU A 184
ALA A 275
LEU A 264
TYR A 197
1.43A12.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6acg ACE2
(Homo
sapiens)		4 / 7
GLU D 398
GLY D 200
TYR D 196
TYR D 202
1.19A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6acg ACE2
(Homo
sapiens)		5 / 12
ILE D 421
GLY D 422
HIS D 373
ALA D 413
SER D 547
1.56A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6acg ACE2
(Homo
sapiens)		4 / 4
ASN D 394
ILE D 513
TYR D 515
PHE D 525
1.44A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6acj ACE2
(Homo
sapiens)		6 / 12
ILE D 291
LEU D 439
LEU D 424
VAL D 293
GLU D 430
TYR D 587
1.62A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
ASP B1100
GLU B1074
ARG B1073
THR B1102
1.58A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
THR A1048
PHE A1034
LEU A1045
SER A 785
1.46A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 637
GLY A 625
GLU A 285
ALA A 609
ILE A 621
1.67A12.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
ASN A 347
ILE C 219
TYR C 163
PHE C 193
1.78A12.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 397
GLY A 488
THR A 487
PHE A 483
TYR A 481
1.44A12.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 843
LEU C 944
TYR C 989
ALA C 748
GLY C 751
1.25A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
TYR B 886
ALA B 872
GLY A1028
TYR A1049
1.28A13.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
PRO C 223
ALA B 350
LEU B 377
TYR B 383
1.06A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
THR C 517
ARG C 315
PHE C 527
SER C 574
1.30A13.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ILE A 656
GLY A 653
ASP A 643
HIS A 641
MET B 851
1.47A12.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL A1076
TYR B 886
ALA B 872
GLY A1028
TYR A1049
1.17A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
TYR B 886
ALA B 872
GLY A1028
TYR A1049
1.09A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B 606
ALA B 577
VAL B 307
GLY C 839
THR C 841
1.56A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6cs2 ACE2
(Homo
sapiens)		4 / 7
THR D 294
PHE D 369
ASP D 367
LEU D 370
1.28A17.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ILE D 421
ASP D 543
HIS D 417
ALA D 372
ILE D 291
1.59A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
PRO B  14
GLU A 232
ALA A 245
LEU A 215
1.46A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
PRO A 185
HIS A 188
ALA A 246
TYR B  10
1.35A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6jyt HELICASE
(SARSr-CoV)		5 / 12
ILE A 304
TYR A 355
SER A 259
ILE A 258
TYR A 269
1.60A16.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6jyt HELICASE
(SARSr-CoV)		4 / 7
PHE B 106
ALA B  18
GLY B  17
TYR B  48
1.29A18.62
None
ZN  B 703 (-2.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6jyt HELICASE
(SARSr-CoV)		4 / 4
ASN B 361
ILE B 399
TYR B 398
PHE B 422
1.55A16.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6jyt HELICASE
(SARSr-CoV)		4 / 6
PRO A 364
ALA A 313
LEU A 317
TYR A 398
1.44A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6lu7 MAIN PROTEASE
(SARS-CoV-2)		5 / 12
TYR A  37
VAL A  36
MET A  17
VAL A  18
GLY A 149
1.47A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.76A21.15
None
None
DMS  A 403 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.71A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.61A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.71A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6lzg ACE2
(Homo
sapiens)		4 / 6
HIS A 378
GLU A 406
LEU A 529
TYR A 521
1.26A17.70
 ZN  A 704 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.71A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.58A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.77A21.08
None
None
DMS  A 401 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.70A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6m17 ACE2
(Homo
sapiens)		4 / 4
ASN B 580
ILE B 446
TYR B 587
PHE B 592
1.69A16.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 4
ASN A 258
ILE A 251
TYR A 322
PHE A  74
1.68A17.70
NAG  A 703 (-1.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
TYR A 129
ALA A 399
GLY A 397
TYR A  60
1.38A17.73
LEU  A 707 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m17 ACE2
SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ILE C 422
VAL D 749
VAL D 745
THR C 180
PHE C 400
1.62A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 5
ASP C 164
PRO C 154
GLU C 179
ARG C 178
1.72A17.58
None
None
None
NAG  C 702 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ILE C 462
LEU C 208
PHE C  48
PHE C 289
GLY C  99
1.36A17.73
None
None
LEU  C 707 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m18 ACE2
(Homo
sapiens)		4 / 7
THR B 294
PHE B 369
LEU B 370
SER B 411
1.30A16.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ILE C 287
GLY C 285
ALA C 498
SER C 303
TYR C  41
1.58A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m18 ACE2
(Homo
sapiens)		4 / 7
GLU D 398
GLY D 200
TYR D 196
TYR D 202
1.31A16.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m18 ACE2
(Homo
sapiens)		4 / 6
HIS B 378
GLU B 406
LEU B 529
TYR B 521
1.06A15.11
 ZN  B 914 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6m1d ACE2
(Homo
sapiens)		5 / 12
GLY D 422
ASP D 543
HIS D 417
ALA D 311
ILE D 291
1.54A16.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.68A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PRO C  39
GLU C  14
ALA C  70
LEU C  75
1.73A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE C 291
ARG C 131
ASP C 289
SER C 284
1.64A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE B 291
ARG B 131
ASP B 289
SER B 284
1.65A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
TYR D 126
ALA D 173
GLY D 174
TYR D 182
1.79A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR B 111
PHE B 150
ARG B 298
SER D  10
1.76A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 259
GLY A 258
TYR A 209
GLU A 270
ALA A 206
1.70A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.76A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.69A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE D 291
ARG D 131
ASP D 289
SER D 284
1.65A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE C 152
VAL C 303
GLU A  14
ALA A   7
GLY C 124
1.67A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PRO B 293
GLU B 270
LEU B 227
TYR B 239
1.70A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PRO B  39
GLU B  14
ALA B  70
LEU B  75
1.79A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
TYR B 126
ALA B 173
GLY B 174
TYR B 182
1.76A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR D 243
PHE D 230
LEU D 205
SER D 267
1.77A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.74A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE B 259
GLY B 258
TYR B 209
GLU B 270
ALA B 206
1.70A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE C 152
GLU C  14
PHE A 150
ALA A   7
GLY C 124
1.71A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 243
PHE A 230
LEU A 205
SER A 267
1.77A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  25
PHE A  66
LEU A  58
SER A  81
1.62A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.76A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.77A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.60A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 171
ASP A 161
TYR A 787
ALA A 625
TYR A 458
1.57A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m71 NSP12
(SARS-CoV-2)		4 / 6
PRO A 461
GLU A 278
ALA A 253
LEU A 261
1.75A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 7
THR B 137
PHE B 147
LEU A 389
SER B 151
1.77A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 171
ASP A 161
LEU A 131
TYR A 787
ALA A 625
1.48A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 786
VAL A 472
PHE A 753
ALA A 762
TYR A 619
1.36A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
LEU C  40
VAL C  11
GLU A 436
ALA A 423
GLY A 427
1.52A13.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 888
LEU A 862
ASP A 865
PHE A 428
PHE A 429
1.70A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 782
ALA A 706
GLY A 774
TYR A 770
1.30A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 4
ASN B 118
ILE A 450
TYR A 453
PHE A 504
1.43A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
THR A 687
ARG A 631
PHE A 694
ASP A 760
1.54A15.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
(SARS-CoV-2)		4 / 7
TYR A  87
PHE A 219
ALA A  95
GLY A 214
1.39A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE D 120
LEU D 103
PHE D  92
ALA C  65
GLY C  64
1.59A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
THR A 259
ARG A 285
LEU A 251
SER A 318
1.69A15.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m71 NSP12
(SARS-CoV-2)		4 / 6
PRO A 461
HIS A 347
ALA A 656
LEU A 655
1.20A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 579
ASP A 760
VAL A 693
VAL A 476
PHE A 812
1.75A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ILE A 548
LEU C  40
PHE A 415
ALA A 423
TYR A 884
1.63A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 786
VAL A 472
PHE A 753
ALA A 762
GLY A 616
1.63A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6m71 NSP12
(SARS-CoV-2)		6 / 12
ILE A 244
LEU A 240
ASP A 465
LEU A 142
ALA A  46
GLY A  44
1.74A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 739
GLU B 730
ARG C 977
ALA C 954
ILE B 979
1.66A12.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE C 800
MET C1032
VAL C1047
GLY C 867
THR C 865
1.57A12.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A1076
TYR C 886
ALA C 872
GLY A1028
TYR A1049
1.30A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR C 886
ALA C 872
GLY A1028
TYR A1049
1.20A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6nur NSP12
NSP8
(SARSr-CoV)		4 / 4
ASN B 118
ILE A 450
TYR A 453
PHE A 504
1.65A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6nur NSP12
(SARSr-CoV)		4 / 7
GLU A 136
TYR A 163
PHE A 793
ALA A 797
1.21A16.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6nur NSP12
(SARSr-CoV)		4 / 7
THR A 687
ARG A 631
PHE A 694
ASP A 760
1.47A16.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6nur NSP12
(SARSr-CoV)		6 / 12
ILE A 171
ASP A 161
LEU A 131
TYR A 787
ALA A 625
TYR A 458
1.71A16.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6nur NSP12
(SARSr)		4 / 7
PHE A 782
ALA A 706
GLY A 774
TYR A 770
1.26A16.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6nus NSP12
(SARSr-CoV)		4 / 6
PRO A 461
HIS A 347
ALA A 656
LEU A 655
1.18A15.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6nus NSP12
(SARSr-CoV)		4 / 4
ASN A 459
ILE A 244
TYR A 788
PHE A 793
1.69A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE C 670
GLY C 667
HIS C 655
SER C 691
ILE C 692
1.68A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 806
ASP C 808
VAL C 785
GLU C 819
PHE C1062
1.20A11.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
ASP C 389
PRO A 986
GLU A 988
ARG A 983
1.74A11.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 106
GLY A 268
TYR A  91
TYR A 266
1.31A11.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
ASN B 544
ILE B 358
TYR B 365
PHE B 429
1.73A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vw1 ACE2
(Homo
sapiens)		4 / 7
GLU B 398
GLY B 200
TYR B 196
TYR B 202
1.27A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B  79
HIS B 119
ALA B 124
SER B  84
TYR B  68
1.40A
None
NHE  B 203 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ASP B  66
VAL B  77
ALA A  70
GLY A  73
TYR A  68
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY A  79
HIS A 119
ALA A 124
SER A  84
TYR A  68
1.46A
SO4  A 201 ( 4.8A)
NHE  A 202 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE B  23
VAL B 155
PHE B 132
ALA B 112
GLY B  79
1.50A
None
SO4  B 204 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6vxs NSP3
(SARS-CoV-2)		4 / 6
PRO B  74
HIS A 119
GLU A 120
ALA A  89
1.69A
None
NHE  A 202 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 545
ASP B 578
GLU B 583
ALA B 520
ILE B 587
1.60A12.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE C 106
GLY C 268
TYR C  91
TYR C 266
1.35A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 270
LEU C 293
PHE C 220
ALA C 222
TYR C  37
1.40A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE C 106
GLY C 268
TYR C  91
TYR C 266
1.36A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
PRO A 217
GLU A 191
ARG A 190
THR A  95
1.55A13.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 270
LEU C 293
PHE C 220
ALA C 222
TYR C  37
1.34A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C1093
GLU C1072
SER A 884
ILE A 896
MET A 900
1.43A12.51
None
NAG  C1315 (-4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
GLU A 261
ALA A 256
GLY A 254
TYR A 238
1.24A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w02 NSP3
(SARS-CoV-2)		5 / 12
ASP B  22
LEU B  12
VAL B  16
ALA B 129
GLY B 130
1.41A22.18
APR  B 201 (-3.4A)
None
None
APR  B 201 (-3.6A)
APR  B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w02 NSP3
(SARS-CoV-2)		4 / 7
THR A 146
ARG A 148
PHE A 116
LEU A 127
1.50A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
TYR L  87
PHE L  98
ALA H  93
GLY H 104
1.72A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ILE H  98
GLY H  97
TYR C 380
ASP H  54
SER C 375
1.55A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
THR L 129
ASP H 144
LEU H 175
SER H 115
1.74A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
PRO L  59
GLU L 165
ALA L  12
LEU L  11
1.43A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
GLU L  55
ALA H  93
GLY H  95
TYR L  91
1.63A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
PHE L  98
ALA L  34
TYR L  32
TYR L  92
1.63A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
PHE C 400
ALA C 419
GLY C 416
TYR C 421
1.69A18.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
ILE H  30
GLY H  28
ASP H  54
GLU H  56
ILE H  34
1.36A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H  97
TYR C 380
ASP H  54
SER C 375
ILE H  30
1.44A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
TYR C 423
PHE C 464
GLY C 381
TYR C 380
1.63A18.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ILE H  30
ASP H  54
LEU C 368
PHE C 347
TYR C 508
1.63A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ASP C 389
LEU C 335
PHE C 338
PHE C 342
TYR C 369
1.79A18.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w4h NSP16
(SARS-CoV-2)		4 / 4
ASN A6899
ILE A6866
TYR A6950
PHE A6948
1.73A19.88
SAM  A7102 (-4.0A)
None
None
ACT  A7104 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6969
TYR A6979
HIS A7023
ALA A6976
TYR A6930
1.67A
None
None
None
None
KCX  A6935 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
PHE A6901
ALA B4324
GLY B4322
TYR B4349
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6891
ARG A6884
LEU A6924
SER A6927
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6951
VAL A6916
PHE A6901
ALA A6877
TYR A6845
1.67A
None
None
None
None
SAM  A7104 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A7005
LEU A6848
LEU A6978
ALA A6870
GLY A6879
1.51A
None
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
ASN A6899
ILE A6866
TYR A6950
PHE A6948
1.77A
SAM  A7104 (-4.3A)
None
None
EDO  A7102 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6889
ARG A6884
LEU A7050
SER A6964
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6926
LEU A6924
ASP A6923
LEU A6978
GLY A7076
1.71A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6951
VAL A6916
PHE A6901
ALA A6877
GLY A6879
1.71A
None
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
THR B4300
PHE A7043
ASP A7044
SER A7038
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 243
PHE A 230
LEU A 205
SER A 267
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 259
GLY A 258
TYR A 209
GLU A 270
ALA A 206
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
VAL A 155
PHE A 116
ALA A 112
GLY A  78
1.77A21.61
None
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  79
HIS B 119
ALA B 124
SER B  84
TYR B  68
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 7
THR B 146
ARG B 148
PHE B 116
LEU B 127
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A  23
VAL A 155
PHE A 132
ALA A 112
GLY A  79
1.38A
AMP  A 201 ( 4.0A)
AMP  A 201 ( 4.4A)
AMP  A 201 ( 4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 7
THR A 146
ARG A 148
PHE A 116
LEU A 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ASP A  22
LEU A  12
VAL A  16
ALA A 129
GLY A 130
1.46A
AMP  A 201 ( 3.7A)
None
None
AMP  A 201 ( 3.4A)
AMP  A 201 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w6y NSP3
(SARS-CoV-2)		4 / 7
TYR B 152
PHE B   6
ALA B  21
TYR B 161
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 7
PHE C6901
ALA D4324
GLY D4322
TYR D4349
1.74A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6925
LEU C6924
ASP C6923
LEU C6981
GLY C7076
1.79A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR A6889
ARG A6884
LEU A7050
SER A6964
1.58A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR C6891
ARG C6884
LEU C6924
SER C6927
1.61A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6887
VAL C7094
PHE A6901
ALA A6877
GLY A6879
1.56A16.23
None
None
None
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR A6891
ARG A6884
LEU A6924
SER A6927
1.56A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 7
THR D4300
PHE C7043
ASP C7044
SER C7038
1.58A17.73
None
None
None
FMT  C7111 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6969
TYR C6979
HIS C7023
ALA C6976
TYR C6930
1.63A21.16
None
None
None
None
FMT  C7107 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 7
THR B4300
PHE A7043
ASP A7044
SER A7038
1.63A17.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6926
LEU C6924
ASP C6923
LEU C6978
GLY C7076
1.71A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
VAL A7094
PHE C6901
ALA C6877
GLY C6879
1.59A16.23
None
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 7
PHE A6901
ALA B4324
GLY B4322
TYR B4349
1.76A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w75 NSP16
(SARS-CoV-2)		4 / 4
ASN A6899
ILE A6866
TYR A6950
PHE A6948
1.72A21.16
SAM  A7102 ( 4.1A)
None
FMT  A7109 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR C6889
ARG C6884
LEU C7050
SER C6964
1.61A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w75 NSP16
(SARS-CoV-2)		4 / 4
ASN C6899
ILE C6866
TYR C6950
PHE C6948
1.70A21.16
SAM  C7105 ( 4.1A)
None
None
FMT  C7115 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A7005
LEU A6848
LEU A6978
ALA A6870
GLY A6879
1.50A16.23
None
None
None
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C7005
LEU C6848
LEU C6978
ALA C6870
GLY C6879
1.51A16.23
None
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU A6909
VAL C7092
PHE A6901
ALA B4324
GLY B4322
1.51A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU A6909
VAL C7092
PHE A6901
ALA B4324
GLY B4323
1.73A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6951
VAL A6916
PHE A6901
ALA A6877
GLY A6879
1.67A16.23
None
None
None
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6969
TYR A6979
HIS A7023
ALA A6976
TYR A6930
1.66A21.16
None
None
None
None
FMT  A7103 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6981
VAL C6916
ALA C6960
GLY C6962
TYR C7009
1.79A16.23
None
None
None
None
NA  C7103 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
VAL A7092
PHE C6901
ALA D4324
GLY D4322
1.42A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
VAL A7092
PHE C6901
ALA D4324
GLY D4323
1.64A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6951
VAL A6916
PHE A6901
ALA A6877
TYR A6845
1.70A16.23
None
None
None
None
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
TYR A  83
ALA A 139
GLY A 142
TYR A  95
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
TYR B  83
ALA B 139
GLY B 142
TYR B  95
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
GLU B 307
ALA B 204
LEU B 199
TYR B 233
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PRO C  96
GLU B 161
ALA C  86
LEU C  87
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
GLU C 263
TYR C 296
GLY C 287
TYR B 268
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ILE C 123
VAL C 165
THR C 210
PHE C 216
TYR C 213
1.74A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PRO B  33
GLU B 161
ALA B 149
LEU B 150
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
TYR C  95
ALA C  86
TYR C  83
TYR C  56
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
GLU A 307
ALA A 204
LEU A 199
TYR A 233
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A  77
ALA A 149
LEU A 150
TYR A 171
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A  96
GLU C 161
ALA A  86
LEU A  87
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PRO B  96
GLU A 161
ALA B  86
LEU B  87
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
TYR B  95
ALA B  86
TYR B  83
TYR B  56
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C  42
PHE C  55
LEU C  36
SER C  49
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
GLU A 167
ALA A 116
LEU A 120
TYR A 154
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 259
PHE A 241
LEU A 125
SER A 170
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
GLU A 263
TYR A 296
GLY A 287
TYR C 268
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  42
PHE A  55
LEU A  36
SER A  49
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
GLU C 167
ALA C 116
LEU C 120
TYR C 154
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B  42
PHE B  55
LEU B  36
SER B  49
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C 259
PHE C 241
LEU C 125
SER C 170
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PRO C  77
ALA C 149
LEU C 150
TYR C 171
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PRO C  96
ALA C 149
LEU C 152
TYR C 136
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
ARG A 166
PHE A 173
LEU A 178
SER A 239
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B 259
PHE B 241
LEU B 125
SER B 170
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
TYR C  83
ALA C 139
GLY C 142
TYR C  95
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
GLU B 263
TYR B 296
GLY B 287
TYR A 268
1.47A
None
None
CL  B 502 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PRO B  96
ALA B 149
LEU B 152
TYR B 136
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wcf NSP3
(SARS-CoV-2)		5 / 12
GLY A  79
HIS A 119
ALA A 124
SER A  84
TYR A  68
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wcf NSP3
(SARS-CoV-2)		4 / 7
TYR A 152
PHE A   6
ALA A  21
TYR A 161
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ASP A 157
LEU A  12
VAL A  16
ALA A 134
GLY A 133
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wen NSP3
(SARS-CoV-2)		4 / 7
TYR A 152
PHE A   6
ALA A  21
TYR A 161
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wen NSP3
(SARS-CoV-2)		5 / 12
ILE A  23
VAL A 155
PHE A 132
ALA A 112
GLY A  79
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wen NSP3
(SARS-CoV-2)		5 / 12
ASP A  22
LEU A  12
VAL A  16
ALA A 129
GLY A 130
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wen NSP3
(SARS-CoV-2)		4 / 7
THR A 146
ARG A 148
PHE A 116
LEU A 127
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wen NSP3
(SARS-CoV-2)		5 / 12
ILE A  18
ASP A 157
VAL A  16
ALA A  38
GLY A  48
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A  79
HIS A 119
ALA A 124
SER A  84
TYR A  68
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wey NSP3
(SARS-CoV-2)		5 / 12
GLY A 283
HIS A 323
ALA A 328
SER A 288
TYR A 272
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wey NSP3
(SARS-CoV-2)		5 / 12
ASP A 226
LEU A 216
VAL A 220
ALA A 333
GLY A 334
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wey NSP3
(SARS-CoV-2)		4 / 7
TYR A 356
PHE A 210
ALA A 225
TYR A 365
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wey NSP3
(SARS-CoV-2)		5 / 12
ILE A 227
VAL A 359
PHE A 336
ALA A 316
GLY A 283
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wey NSP3
(SARS-CoV-2)		4 / 7
THR A 350
ARG A 352
PHE A 320
LEU A 331
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE B 120
LEU B 103
PHE B  92
ALA A  65
GLY A  64
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B 103
VAL A  53
PHE B  92
ALA A  65
GLY A  64
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ILE D 357
GLY C 321
ASP D 288
GLU D 290
ILE D 304
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ILE E 357
GLY F 321
ASP E 288
GLU E 290
ILE E 304
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY C 284
ARG C 262
ALA C 264
ILE D 337
TYR C 333
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
HIS D 356
GLU D 290
ALA D 264
TYR B 268
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU A6909
VAL C7092
PHE A6901
ALA B4324
GLY B4323
1.69A
None
FMT  C7107 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6969
TYR C6979
HIS C7023
ALA C6976
TYR C6930
1.64A
None
None
None
None
FMT  C7104 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
THR D4300
PHE C7043
ASP C7044
SER C7038
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A7005
LEU A6848
LEU A6978
ALA A6870
GLY A6879
1.50A
None
None
None
None
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR C6889
ARG C6884
LEU C7050
SER C6964
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU A6909
VAL C7092
PHE A6901
ALA B4324
GLY B4322
1.51A
None
FMT  C7107 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
THR B4300
PHE A7043
ASP A7044
SER A7038
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6887
VAL C7094
PHE A6901
ALA A6877
GLY A6879
1.55A
None
None
None
None
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
PHE A6901
ALA B4324
GLY B4322
TYR B4349
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C7005
LEU C6848
LEU C6978
ALA C6870
GLY C6879
1.52A
None
None
None
None
SAH  C7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6887
VAL A7094
PHE C6901
ALA C6877
GLY C6879
1.63A
None
None
None
None
SAH  C7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR C6891
ARG C6884
LEU C6924
SER C6927
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
PHE C6901
ALA D4324
GLY D4322
TYR D4349
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6891
ARG A6884
LEU A6924
SER A6927
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
ILE A6951
LEU A6981
VAL A6916
ALA A6960
GLY A6962
TYR A7009
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6889
ARG A6884
LEU A7050
SER A6964
1.58A
 NA  A7101 ( 4.8A)
None
FMT  A7107 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU C6909
VAL A7092
PHE C6901
ALA D4324
GLY D4322
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU C6909
VAL A7092
PHE C6901
ALA D4324
GLY D4323
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6951
VAL A6916
PHE A6901
ALA A6877
GLY A6879
1.66A
None
None
None
None
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
ASN A6899
ILE A6866
TYR A6950
PHE A6948
1.73A
SAH  A7102 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6969
TYR A6979
HIS A7023
ALA A6976
TYR A6930
1.67A
None
None
None
FMT  A7108 ( 3.9A)
FMT  A7103 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
TYR C 112
PHE C 110
ALA C 134
GLY C  69
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
HIS A  59
ALA A 173
LEU A 161
TYR A 109
1.79A
 ZN  B 202 (-2.6A)
None
None
MES  B 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A7005
LEU A6848
LEU A6978
ALA A6870
GLY A6879
1.50A
None
None
None
None
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6969
TYR C6979
HIS C7023
ALA C6976
TYR C6930
1.64A
None
None
None
None
FMT  C7104 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 7
PHE A6901
ALA B4324
GLY B4322
TYR B4349
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6951
VAL A6916
PHE A6901
ALA A6877
GLY A6879
1.65A
None
None
None
None
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C7005
LEU C6848
LEU C6978
ALA C6870
GLY C6879
1.52A
None
None
None
None
SFG  C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU A6909
VAL C7092
PHE A6901
ALA B4324
GLY B4322
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU A6909
VAL C7092
PHE A6901
ALA B4324
GLY B4323
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wkq NSP16
(SARS-CoV-2)		4 / 4
ASN C6899
ILE C6866
TYR C6950
PHE C6948
1.73A
SFG  C7103 ( 4.2A)
None
None
FMT  C7105 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 7
THR D4300
PHE C7043
ASP C7044
SER C7038
1.57A
None
None
None
FMT  C7111 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
VAL A7094
PHE C6901
ALA C6877
GLY C6879
1.61A
None
None
None
None
SFG  C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wkq NSP16
(SARS-CoV-2)		4 / 4
ASN A6899
ILE A6866
TYR A6950
PHE A6948
1.73A
SFG  A7103 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6887
VAL C7094
PHE A6901
ALA A6877
GLY A6879
1.57A
None
None
None
None
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
THR A6891
ARG A6884
LEU A6924
SER A6927
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
THR C6891
ARG C6884
LEU C6924
SER C6927
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6969
TYR A6979
HIS A7023
ALA A6976
TYR A6930
1.67A
None
None
None
None
FMT  A7105 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 7
PHE C6901
ALA D4324
GLY D4322
TYR D4349
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
VAL A7092
PHE C6901
ALA D4324
GLY D4322
1.46A
None
NA  A7102 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
VAL A7092
PHE C6901
ALA D4324
GLY D4323
1.67A
None
NA  A7102 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6951
VAL A6916
PHE A6901
ALA A6877
TYR A6845
1.71A
None
None
None
None
SFG  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 7
THR B4300
PHE A7043
ASP A7044
SER A7038
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
THR C6889
ARG C6884
LEU C7050
SER C6964
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
THR A6889
ARG A6884
LEU A7050
SER A6964
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PRO A 271
GLU A  42
ALA A  55
LEU A  50
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A  86
ASP A 324
VAL A  78
VAL A 142
GLY A 157
1.71A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PRO B 271
GLU B  42
ALA B  55
LEU B  50
1.53A
None
EDO  B 411 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
GLU A 261
ALA A 256
GLY A 254
TYR A 238
1.10A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B  86
ASP B 324
VAL B  78
VAL B 142
GLY B 157
1.76A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
GLU B 261
ALA B 256
GLY B 254
TYR B 238
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 259
GLY A 258
TYR A 209
GLU A 270
ALA A 206
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 243
PHE A 230
LEU A 205
SER A 267
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLU D 120
PHE A 156
ALA A  52
GLY A  51
1.61A
APR  A 201 ( 4.7A)
APR  A 201 (-4.7A)
APR  A 201 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY C  79
HIS C 119
ALA C 124
SER C  84
TYR C  68
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
TYR B 152
PHE B   6
ALA B  21
TYR B 161
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLU B 120
PHE C 156
ALA C  52
GLY C  47
1.60A
None
APR  C 201 (-4.7A)
APR  C 201 ( 4.2A)
APR  C 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY B  79
HIS B 119
ALA B 124
SER B  84
TYR B  68
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLU D 120
PHE A 156
ALA A  52
GLY A  47
1.56A
APR  A 201 ( 4.7A)
APR  A 201 (-4.7A)
APR  A 201 ( 4.2A)
APR  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY D  79
HIS D 119
ALA D 124
SER D  84
TYR D  68
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
TYR D 152
PHE D   6
ALA D  21
TYR D 161
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  79
HIS A 119
ALA A 124
SER A  84
TYR A  68
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLU B 120
PHE C 156
ALA C  52
GLY C  51
1.77A
None
APR  C 201 (-4.7A)
APR  C 201 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6891
ARG A6884
LEU A6924
SER A6927
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6889
ARG A6884
LEU A7050
SER A6964
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
ASN A6899
ILE A6866
TYR A6950
PHE A6948
1.71A
SAH  A7101 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
THR B4300
PHE A7043
ASP A7044
SER A7038
1.60A
SO4  B4403 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A7005
LEU A6848
LEU A6978
ALA A6870
GLY A6879
1.51A
None
None
None
None
SAH  A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6969
TYR A6979
HIS A7023
ALA A6976
TYR A6930
1.67A
None
None
None
None
GTA  A7102 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
PHE A6901
ALA B4324
GLY B4322
TYR B4349
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
THR B  89
PHE B  92
ASP A  67
SER A  61
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
ARG B 111
PHE B  92
LEU B  95
SER A  57
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
THR B  89
PHE B  92
LEU A  71
SER A  61
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
THR D  84
ARG D  80
LEU C  17
SER C  25
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE D 120
LEU D 103
PHE D  92
ALA C  65
GLY C  64
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
THR D  89
PHE D  92
LEU C  71
SER C  61
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 103
VAL C  53
PHE D  92
ALA C  65
GLY C  64
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 259
GLY A 258
TYR A 209
GLU A 270
ALA A 206
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
PRO A  77
ALA A 149
LEU A 150
TYR A 171
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
THR A  42
PHE A  55
LEU A  36
SER A  49
1.50A
None
None
None
PO4  A 503 (-2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
THR A 259
PHE A 241
LEU A 125
SER A 170
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
TYR A  83
ALA A 139
GLY A 142
TYR A  95
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
PRO A  33
GLU A 161
ALA A 149
LEU A 150
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
PRO A  96
ALA A 149
LEU A 152
TYR A 136
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
GLU A 167
ALA A 116
LEU A 120
TYR A 154
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
GLU A 167
ALA A 116
LEU A 117
TYR A 154
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6xez NSP12
(SARS-CoV-2)		4 / 7
PHE A 782
ALA A 706
GLY A 774
TYR A 770
1.37A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 259
GLY A 258
TYR A 209
GLU A 270
ALA A 206
1.66A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  36
VAL A  18
GLY A 143
PHE A 140
TYR A 126
1.79A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  25
PHE A  66
LEU A  58
SER A  81
1.63A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.59A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 243
PHE A 230
LEU A 205
SER A 267
1.80A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.75A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.76A17.97
None
None
DMS  A 406 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ILE D 107
ASP D 112
VAL C  53
TYR D 149
PHE D 147
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
THR B  89
PHE B  92
LEU A  71
SER A  61
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
THR D  89
PHE D  92
LEU C  71
SER C  61
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ILE B 120
LEU B 103
PHE B  92
ALA A  65
GLY A  64
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B 103
VAL A  53
PHE B  92
ALA A  65
GLY A  64
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ILE D 120
LEU D 103
PHE D  92
ALA C  65
GLY C  64
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D 103
VAL C  53
PHE D  92
ALA C  65
GLY C  64
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
THR A  51
ARG A  49
ARG A  53
ASP A  63
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
TYR A  47
PHE A  26
GLY A 130
TYR A 132
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR L  93
PHE L 104
ALA H  97
TYR H  94
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
GLU C  61
TYR C  55
GLY B  98
TYR B  32
1.57A
None
DMS  A 905 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
ILE B  30
GLY B  28
ASP B  55
GLU B  57
ILE B  34
1.20A
None
None
MLI  B 302 ( 4.1A)
MLI  B 302 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
PHE L 104
ALA L  40
TYR L  38
TYR L  98
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
GLU C 219
ALA B 129
LEU B 128
TYR C 198
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR L  93
PHE L 104
ALA H  97
GLY H 110
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ILE H 102
GLY H 101
TYR E 380
ASP H  55
ILE H  30
1.59A
None
None
None
MLI  E 908 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
PHE C 104
ALA C  40
TYR C  38
TYR C  98
1.62A
None
None
None
DMS  C 303 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 400
ALA A 419
GLY A 416
TYR A 421
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
PRO C  65
GLU C 171
ALA C  12
LEU C  11
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
PRO L  46
GLU B  10
LEU B   4
TYR B  80
1.79A
1PE  L1603 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H 101
TYR H  52
GLU C  87
SER E 371
TYR E 369
1.77A
None
None
None
DMS  E 901 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
PRO L  65
GLU L 171
ALA L  12
LEU L  11
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ILE B 102
GLY B 101
TYR A 380
ASP B  55
ILE B  30
1.59A
None
None
None
MLI  B 302 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR C  93
PHE C 104
ALA B  97
GLY B 110
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H 101
TYR E 380
ASP H  55
SER E 375
ILE H  30
1.61A
None
None
MLI  E 908 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR C  93
PHE C 104
ALA B  97
TYR B  94
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
TYR H 180
PHE H 150
ALA H  88
TYR H  94
1.70A
None
MLI  H 301 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
GLU L  61
TYR L  55
GLY H  98
TYR H  32
1.54A
None
DMS  L1601 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 400
ALA E 419
GLY E 416
TYR E 421
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY B 101
TYR A 380
ASP B  55
SER A 375
ILE B  30
1.63A
None
None
MLI  B 302 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY B 101
TYR B  52
GLU L  87
SER A 371
TYR A 369
1.71A
None
None
None
DMS  A 901 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
GLU L  61
TYR L  55
GLY H  98
TYR H  32
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ILE H 102
GLY H 101
TYR E 380
ASP H  55
ILE H  30
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR L  93
PHE L 104
ALA H  97
TYR H  94
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
PRO L  65
GLU L 171
ALA L  12
LEU L  11
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR E 423
PHE E 464
GLY E 381
TYR E 380
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H 101
TYR E 380
ASP H  55
SER E 375
ILE H  30
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
TYR H 180
PHE H 150
ALA H  88
TYR H  94
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
PHE L 104
ALA L  40
TYR L  38
TYR L  98
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 400
ALA E 419
GLY E 416
TYR E 421
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
GLU H 152
TYR H 149
PHE H 150
GLY H  42
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ILE H  30
ASP H  55
LEU E 368
PHE E 347
TYR E 508
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  25
PHE A  66
LEU A  58
SER A  81
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 243
PHE A 230
LEU A 205
SER A 267
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
GLU C  61
TYR C  55
GLY B  98
TYR B  32
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
GLU L  61
TYR L  55
GLY H  98
TYR H  32
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
PHE C 104
ALA C  40
TYR C  38
TYR C  98
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR C  93
PHE C 104
ALA B  97
GLY B 110
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 400
ALA A 419
GLY A 416
TYR A 421
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR L  93
PHE L 104
ALA H  97
TYR H  94
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
PHE L 104
ALA L  40
TYR L  38
TYR L  98
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 400
ALA E 419
GLY E 416
TYR E 421
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR L  93
PHE L 104
ALA H  97
GLY H 110
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY B 101
TYR A 380
ASP B  55
SER A 375
ILE B  30
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ILE B 102
GLY B 101
TYR A 380
ASP B  55
ILE B  30
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR C  93
PHE C 104
ALA B  97
TYR B  94
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H 101
TYR E 380
ASP H  55
SER E 375
ILE H  30
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ILE H 102
GLY H 101
TYR E 380
ASP H  55
ILE H  30
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  25
PHE A  66
LEU A  58
SER A  81
1.72A
PK8  A 401 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.50A
None
None
None
PEG  A 404 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  79
HIS B 119
ALA B 124
SER B  84
TYR B  68
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
HIS A 119
ALA A 124
SER A  84
TYR A  68
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP D  22
LEU D  12
VAL D  16
ALA D 129
GLY D 130
1.43A
EDO  D 209 ( 3.2A)
None
None
EDO  D 205 (-4.5A)
EDO  D 205 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  23
VAL B 155
PHE B 132
ALA B 112
GLY B  79
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU E  26
TYR E   9
PHE E   6
GLY E   0
1.64A
None
None
None
MG  E 201 (-2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E  79
HIS E 119
ALA E 124
SER E  84
TYR E  68
1.56A
EPE  E 203 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  79
HIS D 119
ALA D 124
SER D  84
TYR D  68
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
TYR C 161
ALA B  70
GLY B  73
TYR B  68
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  79
HIS C 119
ALA C 124
SER C  84
TYR C  68
1.56A
EPE  C 202 (-3.4A)
EDO  C 207 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR A 146
ARG A 148
PHE A 116
LEU A 127
1.53A
None
None
None
EDO  A 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR D 146
ARG D 148
PHE D 116
LEU D 127
1.50A
None
EDO  D 202 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR B 146
ARG B 148
PHE B 116
LEU B 127
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E  18
LEU E 160
VAL E  16
ALA E 134
GLY E 133
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR C 146
ARG C 148
PHE C 116
LEU C 127
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C  22
LEU C  12
VAL C  16
ALA C 129
GLY C 130
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
TYR C 152
PHE C   6
ALA C  21
TYR C 161
1.73A
EDO  C 203 (-4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
VAL C 155
PHE C 132
ALA C 112
GLY C  79
1.44A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR E 146
ARG E 148
PHE E 116
LEU E 127
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
TYR A 152
PHE A   6
ALA A  21
TYR A 161
1.78A
None
None
None
EDO  A 203 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP D  22
LEU D  12
VAL D  16
ALA D 129
GLY D 130
1.34A
APR  D 201 (-3.6A)
None
None
APR  D 201 (-3.4A)
APR  D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  79
HIS D 119
ALA D 124
SER D  84
TYR D  68
1.43A
EDO  D 203 (-3.1A)
None
None
None
EDO  D 202 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP A  22
LEU A  12
VAL A  16
ALA A 129
GLY A 130
1.36A
APR  A 201 (-3.4A)
None
None
APR  A 201 ( 3.7A)
APR  A 201 ( 3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
HIS A 119
ALA A 124
SER A  84
TYR A  68
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  79
HIS C 119
ALA C 124
SER C  84
TYR C  68
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR B 146
ARG B 148
PHE B 116
LEU B 127
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP E  22
LEU E  12
VAL E  16
ALA E 129
GLY E 130
1.40A
APR  E 201 (-3.4A)
None
None
APR  E 201 (-3.5A)
APR  E 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
TYR C 152
PHE C   6
ALA C  21
TYR C 161
1.74A
None
None
None
EDO  C 203 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C  22
LEU C  12
VAL C  16
ALA C 129
GLY C 130
1.42A
APR  C 201 (-3.5A)
None
None
APR  C 201 (-3.6A)
APR  C 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B  22
LEU B  12
VAL B  16
ALA B 129
GLY B 130
1.37A
APR  B 201 (-3.4A)
None
None
APR  B 201 (-3.6A)
APR  B 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR A 146
ARG A 148
PHE A 116
LEU A 127
1.51A
None
EDO  A 206 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  23
ASP B 157
VAL B  36
PHE B 132
GLY E 103
1.66A
APR  B 201 (-4.1A)
None
None
APR  B 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR D 146
ARG D 148
PHE D 116
LEU D 127
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  79
HIS B 119
ALA B 124
SER B  84
TYR B  68
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E  79
HIS E 119
ALA E 124
SER E  84
TYR E  68
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
TYR D 152
PHE D   6
ALA D  21
TYR D 161
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR E 146
ARG E 148
PHE E 116
LEU E 127
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU E  26
TYR E   9
PHE E   6
GLY E   0
1.68A
None
None
None
MG  E 202 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
TYR C 161
ALA B  70
GLY B  73
TYR B  68
1.48A
EDO  C 203 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C  67
LEU C  88
VAL C  24
ALA D  52
GLY D  47
1.60A
None
None
None
EDO  D 204 ( 3.7A)
APR  D 201 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR C 146
ARG C 148
PHE C 116
LEU C 127
1.51A
None
EDO  C 205 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR B 146
ARG B 148
PHE B 116
LEU B 127
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  18
LEU A 160
VAL A  16
ALA A 134
GLY A 133
1.67A
None
None
None
EDO  A 205 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR A 146
ARG A 148
PHE A 116
LEU A 127
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  79
HIS B 119
ALA B 124
SER B  84
TYR B  68
1.54A
None
EDO  B 203 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
HIS A 119
ALA A 124
SER A  84
TYR A  68
1.52A
EDO  A 204 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  18
LEU B 160
ASP B 157
LEU B 169
ALA A  56
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  79
HIS C 119
ALA C 124
SER C  84
TYR C  68
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU B  26
TYR B   9
PHE B   6
GLY B   0
1.52A
None
None
None
MG  B 201 ( 2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C  22
LEU C  12
VAL C  16
ALA C 129
GLY C 130
1.38A
None
None
None
None
MES  C 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		4 / 6
HIS A  41
ALA C   2
LEU A 167
TYR A 182
1.76A
None
02J  C   1 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A  87
PHE A 219
ALA A  95
GLY A 214
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
ILE A 548
LEU C  40
PHE A 415
ALA A 423
TYR A 884
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		5 / 12
ILE A 171
ASP A 161
TYR A 787
ALA A 625
TYR A 458
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASP A 194
LEU A 245
VAL A 182
TYR A 238
GLY A 203
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 7
THR A 259
ARG A 285
LEU A 251
SER A 318
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 693
ALA A 634
MET A 633
VAL A 637
TYR A 788
1.75A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 4
ASN B 118
ILE A 450
TYR A 453
PHE A 504
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		6 / 12
ILE A 244
LEU A 240
ASP A 465
LEU A 142
ALA A  46
GLY A  44
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A 546
PHE A 441
ALA A 840
GLY A 841
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 782
ALA A 706
GLY A 774
TYR A 770
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		5 / 12
ILE A 171
ASP A 161
LEU A 131
TYR A 787
ALA A 625
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE D 120
LEU D 103
PHE D  92
ALA C  65
GLY C  64
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 6
PRO A 323
HIS A 256
ALA A 176
LEU A 172
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 6
PRO A 461
HIS A 347
ALA A 656
LEU A 655
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLY A 679
ARG A 553
SER A 451
TYR A 453
MET A 542
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 7
THR A 687
ARG A 631
PHE A 694
ASP A 760
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		4 / 7
GLU A 136
TYR A 163
PHE A 793
ALA A 797
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 786
VAL A 472
PHE A 753
ALA A 762
TYR A 619
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 786
VAL A 472
PHE A 753
ALA A 762
GLY A 616
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 6
PRO A 328
ALA A 400
LEU A 388
TYR A 453
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 6
PRO A 328
HIS A 381
ALA A 400
LEU A 388
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 291
ARG A 131
ASP A 289
SER A 284
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PRO A  39
GLU A  14
ALA A  70
LEU A  75
1.79A
None
None
DMS  A 403 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PRO A 293
GLU A 270
LEU A 227
TYR A 239
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
TYR A 126
ALA A 173
GLY A 174
TYR A 182
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ILE A 244
LEU A 240
ASP A 465
LEU A 142
GLY A  44
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
THR A 276
ARG A 279
LEU A 282
SER A 255
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
THR A 687
ARG A 631
PHE A 694
ASP A 760
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PRO A 328
ALA A 400
LEU A 388
TYR A 453
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PRO A 832
GLU A 857
LEU A 885
TYR A 915
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ILE A 548
LEU C  40
PHE A 415
ALA A 423
TYR A 884
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ASP A 761
LEU A 829
VAL A 827
PHE A 594
GLY A 590
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ILE A 171
ASP A 161
TYR A 787
ALA A 625
TYR A 458
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE D 119
LEU D 128
LEU C  35
ALA D 102
TYR D 149
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 884
ALA A 878
TYR A 877
TYR A 831
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PRO A 328
HIS A 381
ALA A 400
LEU A 388
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ILE A 307
VAL A 299
VAL A 354
THR A 567
PHE A 571
1.72A15.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A  87
PHE A 219
ALA A  95
GLY A 214
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 782
ALA A 706
GLY A 774
TYR A 770
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PRO A 323
HIS A 256
ALA A 176
LEU A 172
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASP A 211
LEU A 245
PHE A  45
ALA A  34
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASP A 211
TYR A 237
PHE A  45
ALA A  34
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ILE A 171
ASP A 161
LEU A 131
TYR A 787
ALA A 625
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
THR A 259
ARG A 285
LEU A 251
SER A 318
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 7
THR D 145
PHE D 147
ASP D 143
SER D 151
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 786
VAL A 472
PHE A 753
ALA A 762
GLY A 616
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
GLU A 436
ALA A 423
LEU A 883
TYR A 877
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PRO A 809
GLU A 917
ALA A 866
LEU A 869
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 786
VAL A 472
PHE A 753
ALA A 762
TYR A 619
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 4
ASN B 118
ILE A 450
TYR A 453
PHE A 504
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
THR A 276
ARG A 279
LEU A 282
SER A 255
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
GLU A 136
TYR A 163
PHE A 793
ALA A 797
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 653
PHE A 652
ALA A 660
GLY A 327
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASP A 211
LEU A 245
PHE A  45
ALA A  34
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A  87
PHE A 219
ALA A  95
GLY A 214
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
LEU C  40
VAL C  11
GLU A 436
ALA A 423
GLY A 427
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
THR A 259
ARG A 285
LEU A 251
SER A 318
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PRO A 830
HIS A 872
GLU A 876
LEU A 885
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 884
ALA A 878
TYR A 877
TYR A 831
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ILE A 171
ASP A 161
TYR A 787
ALA A 625
TYR A 458
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ILE A 171
ASP A 161
LEU A 131
TYR A 787
ALA A 625
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PRO A 328
HIS A 381
ALA A 400
LEU A 388
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
THR A 687
ARG A 631
PHE A 694
ASP A 760
1.78A
F86  P 102 (-3.6A)
None
None
F86  P 102 ( 3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 207
ASP A  36
LEU A 119
TYR A 217
PHE A 219
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 103
ASP B  99
LEU A 673
VAL A 398
GLY B 113
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PRO A 832
GLU A 857
LEU A 885
TYR A 915
1.68A
None
U  T  17 ( 4.5A)
None
U  T  16 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ASP A 258
VAL A 190
GLU A 254
TYR A 286
PHE A 317
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		6 / 12
ILE A 244
LEU A 240
ASP A 465
LEU A 142
ALA A  46
GLY A  44
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 786
VAL A 472
PHE A 753
ALA A 762
TYR A 619
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PRO A 809
GLU A 917
ALA A 866
LEU A 869
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 4
ASN B 118
ILE A 450
TYR A 453
PHE A 504
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 782
ALA A 706
GLY A 774
TYR A 770
1.30A15.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ILE A 589
ASP A 684
ALA A 634
VAL A 693
GLY A 679
1.73A15.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PRO A 323
HIS A 256
ALA A 176
LEU A 172
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 7
ARG A 836
PHE A 843
ARG A 858
SER C  15
1.45A
 U  P  18 ( 2.9A)
None
U  P  17 ( 3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ASP A 194
LEU A 245
VAL A 182
TYR A 238
GLY A 203
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 546
PHE A 441
ALA A 840
GLY A 841
1.76A
None
None
U  P  18 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 786
VAL A 472
PHE A 753
ALA A 762
GLY A 616
1.56A
None
None
None
None
MG  A1005 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PRO A 328
ALA A 400
LEU A 388
TYR A 453
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 679
ARG A 553
SER A 451
TYR A 453
MET A 542
1.64A
None
POP  A1003 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASP A 211
TYR A 237
PHE A  45
ALA A  34
1.43A
None