Ligand ID: RLT


Drugbank ID:
DB06817
(Raltegravir)


Indication:
For the treatment of HIV-1 infection in conjunction with other antiretrovirals.

Get human targets for RLT in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RLT'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
GLN A  19
TYR A 118
PRO A 122
GLU A  14
1.73A21.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASP A 289
ASN A 203
ALA A 129
ASP A 197
1.65A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		1x7q HLA, A-11
(Homo
sapiens)		4 / 8
ASP A  61
GLN A  62
TYR A  59
PRO A  57
1.50A18.69
None
SO4  A4003 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		1x7q HLA, A-11
(Homo
sapiens)		4 / 7
ASP A  61
GLN A  62
TYR A  59
PRO A  57
1.37A18.69
None
SO4  A4003 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
ASP A 153
ASN A 151
TYR A 101
ASP A 155
1.48A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 7
ASP B 249
TYR C 350
GLN C 345
GLU C 344
1.19A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 8
ASP B 249
TYR C 350
GLN C 345
GLU C 344
1.32A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 6
ASP D 352
ASN D 353
TYR D 350
ASP A 249
1.50A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 6
ASP E 117
ASN E 113
ALA E 115
ASP E 139
1.57A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		2ajf ACE2
(Homo
sapiens)		4 / 7
ASP A 350
ASP A 382
GLN A 380
GLN A 388
1.65A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 110
PRO A 108
TYR A 182
GLU A 290
1.71A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASP A 153
ASN A 151
TYR A 101
ASP A 155
1.66A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2bx4 3C-LIKE PROTEINASE
(SARS-COV
Sin2774)		4 / 8
GLN A 110
PRO A 108
TYR A 182
GLU A 290
1.69A21.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 7
ASP C 342
ASP C 341
PRO C 345
GLN C 346
1.74A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 6
ASP A 121
ASN A  16
ALA A  18
TYR A  10
1.63A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
ASP C  77
ASP A  77
ALA A 154
TYR A 155
1.56A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
ASP C  77
ASP A  77
ALA A 154
TYR A 155
1.54A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
ASP J  64
GLN J  65
PRO J 100
GLN N  36
1.44A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 8
GLN A  52
PRO A  51
GLN A  55
GLU A  54
1.39A15.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 6
ASP B 182
ASN B 164
ALA B 166
TYR B 168
1.67A17.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 7
GLN D 221
TYR D 102
PRO D 227
GLU D 133
1.56A22.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 8
ASP B 182
GLN B 222
PRO B 228
TYR B 102
1.65A22.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
ASP C 393
ASP C 392
TYR D  32
GLN C 492
1.58A19.37
None
CL  C  20 ( 4.9A)
CL  C  20 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 8
ASP B 342
ASP B 341
PRO B 345
GLN B 346
1.67A12.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
ASP A 300
TYR A 193
GLN A 196
GLU A 210
1.50A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 6
ASP A 153
ASN A 151
TYR A 101
ASP A 155
1.55A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 6
ASP B 153
ASN B 151
TYR B 101
ASP B 155
1.47A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
ASP F 300
TYR F 193
GLN F 196
GLU F 210
1.58A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN B 110
PRO B 108
TYR B 182
GLU B 290
1.70A21.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 6
ASP A 480
ASN A 409
ALA A 339
ASP S 480
1.51A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
ASP B 431
GLN B 429
GLN B 287
GLU B 433
1.72A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
ASP B 350
GLN B 388
PRO B 389
GLN B  37
1.37A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ASP A 292
ASN A 290
TYR A 279
ASP A 367
1.52A15.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ASP A 292
ASN A 290
TYR A 279
ASP A 367
1.63A15.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASP B 153
ASN B 151
TYR B 101
ASP B 155
1.60A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASP A 153
ASN A 151
TYR A 101
ASP A 155
1.53A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
GLN A 107
PRO A 132
GLN B 244
GLU A 240
1.56A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 110
PRO A 108
TYR A 182
GLU A 290
1.66A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
ASN A 231
ALA A 234
TYR A 237
ASP B 229
1.58A19.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASP A 153
ASN A 151
TYR A 101
ASP A 155
1.61A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASP D 153
ASN D 151
TYR D 101
ASP D 155
1.44A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 110
PRO A 108
TYR A 182
GLU A 290
1.62A21.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASP A 153
ASN A 151
TYR A 101
ASP A 155
1.62A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		3sci ACE2
(Homo
sapiens)		4 / 6
ASP A 292
ASN A 290
TYR A 279
ASP A 367
1.61A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ASP B 509
ASN B 188
ALA B 191
TYR B 196
1.61A15.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
GLN B  81
TYR B  83
PRO B  84
GLN B  86
1.37A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
ASP B 350
GLN B 388
PRO B 389
GLN B  37
1.43A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		3to2 BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ASP B  34
GLN A  96
TYR A 118
GLN B   2
1.58A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ASP A 227
GLN A 224
PRO A 250
GLU A 198
1.34A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ASP A 227
GLN A 224
PRO A 250
GLU A 198
1.41A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3to2 BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ASP B  34
GLN A  96
TYR A 118
GLN B   2
1.54A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		4m0w UBIQUITIN
(Bos
taurus)		4 / 8
ASP B  52
GLN B  40
PRO B  37
GLU B  24
1.61A12.89
None
None
None
GOL  B 101 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		4 / 8
ASP A 165
GLN B  40
PRO B  38
GLU A 168
1.69A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		4 / 7
ASP A  23
GLN A  30
TYR A  28
GLN A  20
1.61A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
ASP A 293
ASN A 114
ALA A 115
TYR A 279
1.36A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
ASP A 293
ASN A 267
ALA A 166
TYR A 112
1.59A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 7
ASP A 217
GLN A 213
TYR A 209
GLN A 315
1.70A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ASP A 289
ASN A 203
ALA A 129
ASP A 197
1.50A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
ASP B  90
ASP B 273
ASN B 266
ALA B 267
1.35A16.12
 MG  B 604 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
ASP B  90
GLN B 254
GLN B 145
GLU B  92
1.65A22.95
 MG  B 604 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
ASP D 449
GLN D 343
PRO D 342
TYR B 361
1.54A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		4 / 6
ASP B  10
ASN A   3
ALA A   4
ASP B 126
1.49A16.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
ASP B  90
GLN B 254
GLN B 145
GLU B  92
1.72A22.45
 MG  B 604 (-2.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
ASP B  90
ASP B 273
ASN B 266
ALA B 267
1.43A16.28
 MG  B 604 (-2.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr)		4 / 6
ASP D  10
ASN C   3
ALA C   4
ASP D 126
1.48A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
ASP D 449
GLN D 343
PRO D 342
TYR B 361
1.56A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		4 / 6
ASP D  10
ASN C   3
ALA C   4
ASP D 126
1.42A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
ASP C  90
GLN C 254
GLN C 145
GLU C  92
1.62A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
ASP B  10
ASN N   3
ALA N   4
ASP B 126
1.48A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
ASP A  90
ASP A 273
ASN A 266
ALA A 267
1.49A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5r80 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
ASP A 153
ASN A 151
TYR A 101
ASP A 155
1.51A21.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		4 / 7
GLN C 102
PRO C 136
GLN C 134
GLU C 139
1.75A11.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
TYR D  73
PRO D 131
GLN D 134
GLU B 296
1.69A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		4 / 7
ASP C 103
GLN C 100
GLN C 111
GLU C 117
1.59A11.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		5x4r S PROTEIN
(MERS-CoV)		4 / 6
ASP A 108
ASN A 104
ALA A 103
ASP A  83
1.66A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
ASN A 627
ALA A 676
TYR A 677
ASP A 643
1.66A11.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 6
ASP B 343
ASN B 342
TYR B 361
ASP C 805
1.60A10.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
ASP A 108
ASN A 104
ALA A 103
ASP A  83
1.67A10.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		5x5c S PROTEIN
(MERS-CoV)		4 / 8
ASP B 510
ASP B 509
PRO C 430
GLN B 544
1.36A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
ASP C 644
ASP C 645
GLN C 377
GLU C 376
1.46A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASP B1100
ASP C1100
ASN C1101
ASP A1100
1.58A11.89
ASP  B1100 ( 0.5A)
ASP  C1100 ( 0.5A)
ASN  C1101 ( 0.6A)
ASP  A1100 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASP B1100
ASP C1100
ASN C1101
ASP A1100
1.48A11.89
ASP  B1100 ( 0.5A)
ASP  C1100 ( 0.5A)
ASN  C1101 ( 0.6A)
ASP  A1100 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
GLN A 895
TYR A 899
GLN B 902
GLU B 900
1.69A14.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASP A1100
ASP B1100
ASN B1101
ASP C1100
1.22A11.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASP A1100
ASP B1100
ASN B1101
ASP C1100
1.09A11.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6acg ACE2
(Homo
sapiens)		4 / 6
ASP D 509
ASN D 188
ALA D 191
TYR D 196
1.57A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6acg ACE2
(Homo
sapiens)		4 / 8
ASP D 350
ASP D 382
GLN D 380
GLN D 388
1.51A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASP C1109
TYR C1070
GLN B 895
GLU B 900
1.23A15.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6acg ACE2
(Homo
sapiens)		4 / 7
ASP D 350
ASP D 382
GLN D 380
GLN D 388
1.29A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ASP B1109
TYR B1070
GLN A 895
GLU A 900
1.38A15.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ASP C1100
ASP B1100
ASN B1101
ASP A1100
1.49A11.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ASP C1100
ASP B1100
ASN B1101
ASP A1100
1.37A11.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6cs2 ACE2
(Homo
sapiens)		4 / 7
ASP D 350
ASP D 382
GLN D 380
GLN D 388
1.49A20.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6cs2 ACE2
(Homo
sapiens)		4 / 6
ASN D 194
ALA D 191
TYR D 199
ASP D 206
1.69A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ASP A1128
PRO A1125
GLN A1124
GLU A1126
0.81A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ASP A1128
PRO A1125
GLN A1124
GLU A1126
1.11A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6jyt HELICASE
(SARSr)		4 / 6
ASP A 119
ALA B 117
TYR B 120
ASP A 113
1.17A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6jyt HELICASE
(SARSr-CoV)		4 / 6
ASP A 119
ALA B 117
TYR B 120
ASP A 113
1.21A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
ASP A 362
GLN A 364
GLN A 357
GLU A 358
1.41A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6m17 ACE2
(Homo
sapiens)		4 / 7
GLN B  81
TYR B  83
PRO B  84
GLN B  86
1.56A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
ASP C 152
PRO C 154
TYR C 162
PRO C 171
1.68A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6m18 ACE2
(Homo
sapiens)		4 / 8
ASP B 136
PRO B 138
GLN B 139
GLU B 140
1.46A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6m1d ACE2
(Homo
sapiens)		4 / 6
ASP D 719
ASN D 720
ALA D 627
ASP D 713
1.66A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASN A  39
ALA A  43
TYR A 728
ASP A 711
1.71A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 623
ALA A 625
TYR A 458
ASP A 452
1.61A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 7
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.52A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 865
PRO A 834
TYR A 831
PRO A 868
1.57A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 126
ALA A 130
TYR A 129
ASP A 208
1.67A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 8
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.47A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A  36
ALA A  46
TYR A 129
ASP A 208
1.77A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASN A  39
ALA A  43
TYR A 728
ASP A 208
1.29A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 221
ASN A  39
ALA A  43
TYR A 728
1.74A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A  36
ALA A  46
TYR A 129
ASP A 208
1.74A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 618
ASN A 790
ALA A 625
TYR A 458
1.36A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASN A 507
ALA A 502
TYR A 515
ASP A 499
1.64A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN H  39
PRO L  49
PRO L  45
GLU L 170
1.71A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6nur NSP12
(SARSr-CoV)		4 / 6
ASP A 623
ALA A 625
TYR A 458
ASP A 452
1.53A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6nur NSP12
NSP7
(SARSr-CoV)		4 / 7
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.62A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6nus NSP12
(SARSr-CoV)		4 / 8
ASP A 865
PRO A 834
TYR A 831
PRO A 868
1.60A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6nus NSP12
(SARSr-CoV)		4 / 6
ASP A 618
ASN A 790
ALA A 625
TYR A 458
1.32A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 614
GLN A 613
TYR A 612
GLN A 644
1.36A16.22
None
None
None
NAG  A1302 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR C1138
PRO C1143
GLN C1142
GLU C1144
1.42A16.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6vw1 ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
GLN E 506
PRO E 499
GLN A  42
GLU A  37
1.63A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6vw1 ACE2
(Homo
sapiens)		4 / 6
ASP B 509
ASN B 188
ALA B 191
TYR B 196
1.65A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
ASP A 105
GLN A 107
PRO A  98
GLU A 104
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6vxs NSP3
(SARS-CoV-2)		4 / 7
ASP A 105
GLN A 107
PRO A  98
GLU A 104
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6vxs NSP3
(SARS-CoV-2)		4 / 7
ASP B 105
GLN B 107
PRO B  98
GLU B 104
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
ASP B 105
GLN B 107
PRO B  98
GLU B 104
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
GLN A1106
TYR A1067
GLN A1071
GLU A1072
1.60A15.97
None
None
NAG  A1312 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
GLN B 176
PRO B 158
TYR B 179
GLU B 192
1.70A20.32
None
EDO  B 407 ( 4.9A)
None
EDO  B 410 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
GLN H  39
PRO L  44
PRO L  40
GLU L 165
1.61A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6w4h NSP16
(SARS-CoV-2)		4 / 8
ASP A6824
GLN A6826
PRO A7034
GLU A6971
1.60A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
GLN C6801
TYR C6851
PRO C6805
GLN C6847
1.80A16.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ASP A  76
ASN A 156
ALA A 153
TYR A  83
1.75A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
PRO C 248
TYR C 264
PRO C 299
GLN C 250
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
PRO A 247
PRO A 299
GLN A 250
GLU A 263
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
PRO B 247
PRO B 299
GLN B 250
GLU B 263
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6wiq NSP8
(SARS-CoV-2)		4 / 6
ASP B 112
ASN B 108
ALA B 110
ASP B 134
1.74A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ASP B 340
ASP B 343
ASN B 345
ALA E 267
1.61A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP E 343
ASP E 340
PRO F 258
GLN F 260
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ASP B 340
ASP B 343
ASN E 269
ALA E 267
1.80A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
GLN D 303
PRO D 302
TYR B 268
GLU D 290
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ASP B 340
ASP B 343
ASN B 345
ALA E 267
1.76A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP A 343
ASP A 340
PRO B 258
GLN B 260
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
GLN D 303
PRO D 302
TYR B 268
GLN D 294
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP F 343
ASP F 340
PRO E 258
GLN E 260
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP D 343
ASP D 340
PRO C 258
GLN C 260
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP B 343
ASP B 340
PRO A 258
GLN A 260
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLN C6801
TYR C6851
PRO C6805
GLN C6847
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLN A6801
TYR A6851
PRO A6805
GLN A6847
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
GLN C6801
TYR C6851
PRO C6805
GLN C6847
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ASP B 301
TYR B 194
GLN B 197
GLU B 211
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6wqd NSP8
(SARS-CoV-2)		4 / 6
ASP B 112
ASN B 108
ALA B 110
ASP B 134
1.74A19.74
None
EDO  B 301 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6wqd NSP8
(SARS-CoV-2)		4 / 6
ASP D 112
ASN D 108
ALA D 110
ASP D 134
1.67A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
PRO A 247
PRO A 299
GLN A 250
GLU A 263
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ASP B 112
ASN B 108
ALA B 110
ASP B 134
1.80A19.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
ASN A   8
ALA A  10
TYR A  71
ASP A 104
1.58A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
ASP H 107
GLN H   3
GLN B   1
GLU L  61
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
ASP B 107
GLN B   3
GLN H   1
GLU C  61
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
ASP C  66
ASP E 364
TYR E 365
PRO E 527
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
ASP B 107
GLN B   3
GLN H   1
GLU C  61
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASP E 442
ASN E 354
ALA E 352
TYR E 351
1.73A20.49
None
DMS  E 905 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
ASP H 107
GLN H   3
GLN B   1
GLU L  61
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
ASP C  66
ASP E 364
ASN E 388
ALA E 363
1.72A24.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
ASP L  66
ASP A 364
ASN A 388
ALA A 363
1.57A24.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASP E 442
ASN E 354
ALA E 352
TYR E 351
1.75A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASP E 442
ASN E 354
ALA E 352
TYR E 351
1.73A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASP A 442
ASN A 354
ALA A 352
TYR A 351
1.74A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A  67
ASN A 215
ALA A  97
TYR A 217
1.59A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A 126
ALA A 130
TYR A 129
ASP A 208
1.66A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 7
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A 221
ASN A  39
ALA A  43
TYR A 728
1.71A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A 760
ASN A 790
ALA A 625
TYR A 458
1.64A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASN A  39
ALA A  43
TYR A 728
ASP A 208
1.27A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A  36
ALA A  46
TYR A 129
ASP A 208
1.79A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASN A  39
ALA A  43
TYR A 728
ASP A 711
1.75A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASN A 507
ALA A 502
TYR A 515
ASP A 499
1.66A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 8
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A 618
ASN A 790
ALA A 625
TYR A 458
1.32A12.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
ASP A 289
ASN A 203
ALA A 129
ASP A 197
1.66A21.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 8
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ASP A 126
ALA A 130
TYR A 129
ASP A 208
1.66A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ASP A 618
ASN A 790
ALA A 625
TYR A 458
1.39A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 7
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ASP A  36
ALA A  46
TYR A 129
ASP A 208
1.76A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ASN A 507
ALA A 502
TYR A 515
ASP A 499
1.67A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 7
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASN A 507
ALA A 502
TYR A 515
ASP A 499
1.47A12.85
 U  T   8 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A 221
ASN A  39
ALA A  43
TYR A  38
1.79A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A 126
ALA A 130
TYR A 129
ASP A 208
1.63A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
PRO A 834
TYR A 877
GLN A 815
GLU A 811
1.78A
None
None
A  P  19 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A 126
ALA A 130
TYR A 129
ASP A 208
1.67A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 8
ASP A 445
GLN C  18
TYR A 546
GLN A 408
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A  36
ALA A  46
TYR A 129
ASP A 208
1.75A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A  36
ALA A  46
TYR A 129
ASP A 208
1.77A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A 623
ALA A 625
TYR A 458
ASP A 452
1.65A12.85
POP  A1003 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASN A  39
ALA A  43
TYR A 728
ASP A 208
1.42A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A 208
ASN A  39
ALA A  43
TYR A 728
1.69A12.85
None