 |
SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'Q1EFP6'
| DrReposER ID / Desc. | Drug | Hit PDBID |
Hit Macromolecule |
Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4X20_B_LOCB502_1 (TUBULIN BETA CHAIN) | Colchicine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 6 / 12 | LEU B 242LEU B 272ALA B 234ASN B 238VAL B 204ILE B 200 | 1.79A | 20.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RRZ_A_LURA705_1 (PROSTAGLANDIN G/HSYNTHASE 2) | Lumiracoxib | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | VAL B 125LEU B 115VAL B 13GLY B 11SER A 10 | 1.30A | 19.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UVV_B_9CRB501_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | ALA B 7GLN B 127ARG B 298ILE A 136CYH A 128 | 1.37A | 21.43 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6NJ9_K_SAMK500_0 (HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC) | S-Adenosylmethionine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | PRO B 122GLY B 143GLY B 29GLY B 146VAL B 42 | 1.10A | 19.86 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GWX_B_EPAB3_1 (PROTEIN (PEROXISOMEPROLIFERATORACTIVATED RECEPTOR(PPAR-DELTA))) | Icosapent | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | CYH B 22THR B 24THR B 25HIS B 41LEU B 27 | 1.39A | 23.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3IHZ_A_FK5A501_2 (70 KDAPEPTIDYLPROLYLISOMERASE, PUTATIVE) | Tacrolimus | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 8 | PHE A 223GLY A 258SER A 254ILE A 259 | 1.14A | 17.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JB2_A_SAMA1102_1 (STRUCTURAL PROTEINVP3) | S-Adenosylmethionine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 3 / 3 | ARG B 60ASP B 48ASP B 56 | 1.11A | 14.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GWX_A_EPAA1_2 (PROTEIN (PEROXISOMEPROLIFERATORACTIVATED RECEPTOR(PPAR-DELTA))) | Icosapent | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | CYH B 22THR B 24THR B 25HIS B 41LEU B 27 | 1.34A | 23.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_D_P06D801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) | Dabrafenib | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 8 | ILE A 259GLY A 258PHE A 294CYH A 265 | 1.10A | 22.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1LIN_A_TFPA155_1 (CALMODULIN) | Trifluoperazine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | GLN B 127GLU B 290MET A 6ALA A 7 | 1.67A | 16.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ADE_B_H4BB760_1 (NITRIC OXIDESYNTHASE, BRAIN) | Sapropterin | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | PHE A 8VAL A 104ARG A 298VAL A 157 | 1.56A | 21.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SUF_A_SUEA1201_1 (NS3 PROTEASE, NS4APROTEIN) | Grazoprevir | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | HIS B 172GLY B 170GLY A 2SER A 1ALA B 116 | 1.45A | 23.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RRW_A_LURA705_1 (PROSTAGLANDIN G/HSYNTHASE 2) | Lumiracoxib | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | VAL B 125LEU B 115VAL B 13GLY B 11SER A 10 | 1.30A | 19.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE) | Halofuginone | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | PHE B 103VAL B 157PRO B 99THR B 98SER B 94 | 1.55A | 23.20 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PNJ_B_CHDB502_0 (FERROCHELATASE,MITOCHONDRIAL) | Cholic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | ILE B 152PRO B 122GLY B 15MET B 17 | 1.26A | 21.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AOH_C_FRDC305_2 (POL POLYPROTEINPEPTIDE INHIBITOR) | Amphetamine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 5 | LEU A 253GLY A 302ALA A 210ILE A 213 | 1.32A | 18.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PD9_A_ADNA501_1 (NUPC FAMILY PROTEIN) | Adenosine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | ALA B 116VAL B 114TYR B 161PHE B 140SER A 1 | 1.39A | 21.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_A_P06A801_2 (SERINE/THREONINE-PROTEIN KINASE B-RAF) | Dabrafenib | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | ILE A 259GLY A 258PHE A 294CYH A 265 | 1.13A | 22.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EIK_B_CHDB1086_0 (CYTOCHROME C OXIDASEPOLYPEPTIDEVIA-HEARTCYTOCHROME C OXIDASESUBUNIT 1CYTOCHROME C OXIDASESUBUNIT 2) | Cholic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 10 | GLN A 127GLU A 290THR A 292PHE A 150GLY A 149 | 1.69A | 20.2322.7814.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SUE_B_SUEB1201_1 (NS3 PROTEASE, NS4APROTEIN) | Grazoprevir | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | HIS B 172GLY B 170GLY A 2SER A 1ALA B 116 | 1.49A | 23.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5B2S_A_ACTA107_0 (CRISPR-ASSOCIATEDENDONUCLEASE CAS9GUIDE RNA) | Acetic acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 3 / 3 | VAL A 186THR A 190ARG A 188 | 1.03A | 12.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y05_A_RALA802_1 (PROSTAGLANDINREDUCTASE 1) | Raloxifene | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | VAL A 68ASN A 28GLY A 146VAL A 42 | 0.96A | 22.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RBP_A_RTLA183_0 (PLASMARETINOL-BINDINGPROTEIN PRECURSOR) | Vitamin A | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 6 / 12 | LEU B 262LEU B 250PHE B 3ALA B 206VAL B 247LEU B 242 | 1.65A | 20.32 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATELYASE) | N-Acetyl-D-glucosamine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 5 | LEU B 30TYR B 101LEU B 177THR B 98 | 1.63A | 22.41 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PLW_A_SAMA203_1 (RIBOSOMAL RNAMETHYLTRANSFERASE,PUTATIVE) | S-Adenosylmethionine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 3 / 3 | SER B 158ASP B 155ASP B 153 | 0.98A | 20.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RHW_A_IVMA348_0 (AVERMECTIN-SENSITIVEGLUTAMATE-GATEDCHLORIDE CHANNELGLUCL ALPHA) | Ivermectin | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | ILE A 106ILE A 136GLY A 109THR A 292PHE A 294 | 1.58A | 24.32 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ADE_A_H4BA760_1 (NITRIC OXIDESYNTHASE, BRAIN) | Sapropterin | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 6 | VAL A 104ARG A 298VAL A 157PHE A 8 | 1.55A | 21.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HQB_A_PQNA2001_0 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1PHOTOSYSTEM IREACTION CENTERSUBUNIT IX) | Phylloquinone | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 10 | SER A 1GLY B 170ALA B 173GLY B 138LEU B 32 | 1.48A | 17.8410.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5OY0_A_PQNA841_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1PHOTOSYSTEM IREACTION CENTERSUBUNIT IX) | Phylloquinone | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 11 | PHE B 140SER A 1ALA B 173GLY B 138LEU B 32 | 1.63A | 17.8410.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KK6_A_CELA701_1 (PROSTAGLANDIN G/HSYNTHASE 1) | Celecoxib | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | GLN B 127VAL A 125PHE B 150ILE B 152GLY B 11 | 1.36A | 18.41 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RIA_A_IVMA348_0 (AVERMECTIN-SENSITIVEGLUTAMATE-GATEDCHLORIDE CHANNELGLUCL ALPHA) | Ivermectin | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | ILE A 136GLY A 109THR A 292PHE A 294ILE A 106 | 1.57A | 24.32 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NZY_A_CE3A1102_1 (DNA CROSS-LINKREPAIR 1A PROTEIN) | Cefotaxime | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | ASN A 151PHE A 150ARG A 298GLY B 124 | 1.25A | 22.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2E5D_A_NCAA1501_0 (NICOTINAMIDEPHOSPHORIBOSYLTRANSFERASE) | Nicotinamide | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | PHE A 294ARG A 298ALA A 206ASP A 295 | 1.68A | 20.85 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L6V_1_PQN12001_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1FUSION PROTEIN OFPHOTOSYSTEM ISUBUNIT III ANDSUBUNIT IX) | Phylloquinone | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 11 | PHE B 140SER A 1GLY B 170ALA B 173GLY B 138 | 1.51A | 17.8416.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EIJ_B_CHDB1086_0 (CYTOCHROME C OXIDASEPOLYPEPTIDEVIA-HEARTCYTOCHROME C OXIDASESUBUNIT 1CYTOCHROME C OXIDASESUBUNIT 2) | Cholic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 10 | GLN A 127GLU A 290THR A 292PHE A 150GLY A 149 | 1.68A | 20.2322.7814.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6E5Z_A_CCSA106_0 (PROTEIN/NUCLEIC ACIDDEGLYCASE DJ-1) | Carbocisteine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 10 | GLY B 195ASN B 133ALA B 194PRO B 168THR B 169 | 1.61A | 19.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4X30_A_T44A401_1 (THYROXINE-BINDINGGLOBULIN) | Levothyroxine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 9 | ALA A 206GLN A 244LEU A 227LEU A 250LEU A 242 | 1.78A | 23.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5B2T_A_ACTA108_0 (CRISPR-ASSOCIATEDENDONUCLEASE CAS9GUIDE RNA) | Acetic acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 3 / 3 | VAL A 186THR A 190ARG A 188 | 1.06A | 12.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AX9_A_SALA1341_1 (XANTHINEDEHYDROGENASE/OXIDASE) | Salicylic acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 8 | LEU B 141THR A 304VAL A 303ALA B 116 | 1.24A | 13.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PD5_A_GEOA501_1 (NUPC FAMILY PROTEIN) | Gemcitabine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | ALA B 116VAL B 114TYR B 161PHE B 140SER A 1 | 1.36A | 21.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F8D_A_BEZA1001_0 (HTH-TYPETRANSCRIPTIONALREGULATOR BENM) | Benzoic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 6 | VAL B 125SER B 113LEU A 115PHE B 8 | 1.12A | 24.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VL2_B_BEZB1162_0 (PEROXIREDOXIN-5) | Benzoic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | PRO B 39THR B 175GLY B 174LEU B 30 | 1.21A | 22.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QQC_E_AG2E671_1 (PYRUVOYL-DEPENDENTARGININEDECARBOXYLASE (EC4.1.1.19) (PVLARGDC)) | Agmatine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | ILE A 249GLN A 244LEU A 227LEU A 205 | 1.30A | 17.6710.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BJW_E_SVRE510_2 (PHOSPHOLIPASE A2) | Suramin | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 6 | VAL B 114GLN A 299GLY A 302ARG A 298 | 1.51A | 17.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JGS_A_SALA256_1 (MULTIPLE ANTIBIOTICRESISTANCE PROTEINMARR) | Salicylic acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 7 | VAL B 204LEU B 268LEU B 250VAL B 296 | 1.27A | 16.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1V55_B_CHDB4085_0 (CYTOCHROME C OXIDASEPOLYPEPTIDE ICYTOCHROME C OXIDASEPOLYPEPTIDE IICYTOCHROME C OXIDASEPOLYPEPTIDEVIA-HEART) | Cholic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 10 | GLN A 127GLU A 290THR A 292PHE A 150GLY A 149 | 1.68A | 20.2322.7814.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1H4O_G_BEZG1162_0 (PEROXIREDOXIN 5) | Benzoic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 8 | PRO B 39THR B 175GLY B 174LEU B 30 | 1.21A | 21.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WNV_B_QI9B602_0 (CYTOCHROME P450 2D6) | Quinine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 9 | PHE A 3LEU A 282LEU B 141SER B 139VAL A 296 | 1.60A | 22.34 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YU9_C_1E8C1101_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) | Ibrutinib | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | VAL B 296ALA B 210LEU B 208GLY B 302THR B 257 | 1.69A | 21.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FAL_A_REAA501_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Tretinoin | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 10 | ALA B 7GLN B 127ARG B 298ILE A 136CYH A 128 | 1.62A | 21.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2DYR_B_CHDB1086_0 (CYTOCHROME C OXIDASEPOLYPEPTIDEVIA-HEARTCYTOCHROME C OXIDASESUBUNIT 1CYTOCHROME C OXIDASESUBUNIT 2) | Cholic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 10 | GLN A 127GLU A 290THR A 292PHE A 150GLY A 149 | 1.68A | 20.2322.7814.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G1U_C_ADNC438_2 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 4 / 5 | GLN A 110THR A 111THR A 199HIS A 246 | 1.63A | 20.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2YHD_A_TESA1920_1 (ANDROGEN RECEPTOR) | Testosterone | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | ASN B 119LEU B 27GLY B 143MET B 162THR A 304 | 1.67A | 20.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TUF_A_AZ1A502_1 (DIAMINOPIMELATEDECARBOXYLASE) | Azelaic Acid | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 9 | SER A 1ARG A 4TYR B 126SER B 144TYR B 161 | 1.79A | 19.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TVT_A_ASCA302_0 (THAUMATIN-1) | Vitamin C | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 3 / 3 | ARG A 4GLN B 127GLU B 290 | 1.15A | 19.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HBP_A_RTLA184_0 (RETINOL BINDINGPROTEIN) | Vitamin A | 2gt7 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 11 | LEU B 262PHE B 3ALA B 206VAL B 247LEU B 242 | 1.73A | 20.33 | None |